Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Harashima, Nanae ^a   Minami, Takafumi ^b   Uemura, Hirotsugu ^b   Harada, Mamoru ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

2 5A system; Caspase 2; Poly(I:C); Reactive oxygen species; Renal cell carcinoma

Indexed keywords

ACETYLCYSTEINE; BETA INTERFERON; CASPASE 2; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYCLIN D1; DNA; GAMMA HISTONE H2AX; HISTONE H2AX; INNATE ADJUVANT RECEPTOR; MESSENGER RNA; MYC PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN BID; PROTEIN NOXA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RECEPTOR; RNA; UNCLASSIFIED DRUG; 2-5A-DEPENDENT RIBONUCLEASE; ANTINEOPLASTIC AGENT; RIBONUCLEASE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENAL CELL CARCINOMA CELL LINE; RNA INTERFERENCE; VIRUS INFECTION; CARCINOMA, RENAL CELL; CELL CYCLE; DRUG EFFECTS; GENE EXPRESSION REGULATION; KIDNEY NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, RENAL CELL; CELL CYCLE; CELL LINE, TUMOR; ENDORIBONUCLEASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-BETA; KIDNEY NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; POLY I-C; REACTIVE OXYGEN SPECIES; TRANSFECTION;

EID: 84908112090     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-217     Document Type: Article

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