Effects of RNase L Mutations Associated with Prostate Cancer on Apoptosis Induced by 2′,5′-Oligoadenylates

Cancer Research

Volumn 63, Issue 20, 2003, Pages 6795-6801

  Xiang, Ying ^a   Wang, Zhengfu ^a   Murakami, Junko ^a   Plummer, Sarah ^a   Klein, Eric A ^a   Carpten, John D ^b   Trent, Jeffrey M ^b   Isaacs, William B ^c   Casey, Graham ^a   Silverman, Robert H ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b The Transl Genomics Research Inst   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLIC ACID; RIBONUCLEASE; RIBONUCLEASE L; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RISK; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MISSENSE MUTATION; PRIORITY JOURNAL; PROSTATE CARCINOMA; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ADENINE NUCLEOTIDES; APOPTOSIS; BONE NEOPLASMS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DIMERIZATION; ENDORIBONUCLEASES; ENZYME ACTIVATION; HUMANS; LYMPHATIC METASTASIS; MALE; MUTATION, MISSENSE; OLIGORIBONUCLEOTIDES; PROSTATIC NEOPLASMS;

EID: 0142157676     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Carpten, J., Nupponen, N., Isaacs, S., Sood, R., Robbins, C., Xu, J., Faruque, M., Moses, T., Ewing, C., Gillanders, E., Hu, P., Bujnovszky, P., Makalowska, I., Baffoc-Bonnie, A., Faith, D., Smith, J., Stephan, D., Wiley, K., Brownstein, M., Gildea, D., Kelly, B., Jenkins, R., Hostetter, G., Matikainen, M., Schleutker, J., Klinger, K., Connors, T., Xiang, Y., Wang, Z., De Marzo, A., Papadopoulos, N., Kallioniemi, O. P., Burk, R., Meyers, D., Gronberg, H., Meltzer, P., Silverman, R., Bailey-Wilson, J., Walsh, P., Isaacs, W., and Trent, J. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat. Genet., 30: 181-184, 2002.
2. Silverman, R. H. Implications for RNase L in prostate cancer biology. Biochemistry, 42: 1805-1812, 2003.
3. Kerr, I. M., and Brown, R. E. pppA2′p5′A2′p5′A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells. Proc. Natl. Acad. Sci. USA, 75: 256-260, 1978.
4. Knight, M., Cayley, P. J., Silverman, R. H., Wreschner, D. H., Gilbert, C. S., Brown, R. E., and Kerr, I. M. Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells. Nature (Lond.). 288: 189-192, 1980.
5. Player, M. R., and Torrence, P. F. The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation. Pharmacol. Ther., 78: 55-113, 1998.
6. Padgett, R. A., Konarska, M. M., Grabowski, P. J., Hardy, S. F., and Sharp, P. A. Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors. Science, 225: 898-903, 1984.
7. Iaouye, S., Hsu, M. Y., Xu, A., and Inouye, M. Highly specific recognition of primer RNA structures for 2′-OH priming reaction by bacterial reverse transcriptases. J. Biol. Chem., 274: 31236-31244, 1999.
8. Dong, B., and Silverman, R. H. A bipartite model of 2-5A-dependent RNase L. J. Biol. Chem., 272: 22236-22242, 1997.
9. Dong, B., Niwa, M., Walter, P., and Silverman, R. H. Basis for regulated RNA cleavage by functional analysis of RNase L and IreIp. RNA, 7: 361-373, 2001.
10. Zhou, A., Hassel, B. A., and Silverman, R. H. Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell, 72: 753-765, 1993.
11. Rokman, A., Ikonen, T., Seppala, E. H., Nupponen, N., Autio, V., Mononen, N., Bailey-Wilson, J., Trent, J., Carpten, J., Matikainen, M. P., Koivisto, P. A., Tammela, T. L., Kallioniemi, O. P., and Schleutker, J. Germline alterations of the RNASEL gene, a candidate HPC1 gene at Iq25, in patients and families with prostate cancer. Am. J. Hum. Genet., 70: 1299-1304, 2002.
12. Rennert, H., Bercovich, D., Hubert, A., Abeliovich, D., Rozovsky, U., Bar-Shira, A., Soloviov, S., Schreiber, L., Matzkin, H., Rennert, G., Kadouri, L., Peretz, T., Yaron, Y., and Orr-Urtreger, A. A novel founder mutation in the RNASEL gene, 471de1AAAG, is associated with prostate cancer in Ashkenazi Jews. Am. J. Hum. Genet., 71: 981-984, 2002.
13. Kotar, K., Hamel, N., Thiffault, I., and Foulkes, W. D. The RNASEL 471dc1AAAG allele and prostate cancer in Ashkenazi Jewish men. J. Med. Genet., 40: e22, 2003.
14. Wang, L., McDonnell, S. K., Elkins, D. A., Slager, S. L., Christensen, E., Marks, A. F., Cunningham, J. M., Peterson, B. J., Jacobsen, S. J., Cerhan, J. R., Blute, M. L., Schaid, D. J., and Thibodcant, S. N. Analysis of the RNASEL gene in familial and sporadic prostate cancer. Am. J. Hum. Genet., 71: 116-123, 2002.
15. Casey, G., Neville, P. J., Plummer, S. J., Xiang, Y., Krumroy, L. M., Klein, E. A., Catalona, W. J., Nupponen, N., Carpten, J. D., Trent, J. M., Silverman, R. H., and Witte, J. S. RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Nat. Genet., 32: 581-583, 2002.
16. Chen, H., Griffin, A. R., Wu, Y. Q., Tornsho, L. P., Zuhlke, K. A., Lange, E. M., Gruber, S. B., and Cooney, K. A. RNASEL mutations in hereditary prostate cancer. J. Med. Genet., 40: e21, 2003.
17. Rusch, L., Dong, B., and Silverman, R. H. Monitoring activation of ribonuclease L by 2′, 5′-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells. Methods Enzymol., 342: 10-20, 2001.
18. Carroll, S. S., Chen, E., Viscount, T., Geib, J., Sardana, M. K., Gehman, J., and Kuo, L. C. Cleavage of oligoribonucleotides by the 2′, 5′-oligoadenylate-dependent ribonuclease L. J. Biol. Chem., 271: 4988-4992, 1996.
19. Rusch, L., Zhou, A., and Silverman, R. H. Caspase-dependent apoptosis by 2′, 5′-oligoadenylate activation of RNase L is enhanced by IFN-β. J. Interferon Cytokine Res., 20: 1091-1000, 2000.
20. Dong, B., and Silverman, R. H. 2-5A-dependent RNase molecules dimerize during activation by 2-5A. J. Biol. Chem., 270: 4133-4137, 1995.
21. Nolan-Sorden, N. L., Lesiak, K., Bayard, B., Torrence, P. F., and Silverman, R. H. Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser. Anal. Biochem., 184: 298-304, 1990.
22. Dong, B., Xu, L., Zhou, A., Hassel, B. A., Lee, X., Torrence, P. F., and Silverman, R. H. Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase. J. Biol. Chem., 269: 14153-14158, 1994.
23. Eppstein, D. A., Schryver, B. B., and Marsh, Y. V. Stereoconfiguration markedly affects the biochemical and biological properties of phosphorothioate analogs of 2-5A core, (A2′p5′)2A. J. Biol. Chem., 261: 5999-6003, 1986.
24. Kariko, K., Li, S. W., Sobol, R. W., Jr., Suhadolnik, R. J., Charubala, R., and Pfleiderer, W. Phosphorothioate analogues of 2′, 5′-oligoadenylate. Activation of 2′, 5′ -oligoadenylate-dependent endoribonuclease by 2′, 5′ -phosphorothioate cores and 5′-monophosphates. Biochemistry, 26: 7136-7142, 1987.
25. Beigelman, L., Matulic-Adamic, J., Haeberli, P., Usman, N., Dong, B., Silverman, R. H., Khamnei, S., and Torrence, P. F. Synthesis and biological activities of a phosphorodithioate analog of 2′, 5′-oligoadenylate. Nucleic Acids Res., 23: 3989-3994, 1995.
26. Krause, D., Lesiak, K., Imai, J., Sawai, H., Torrence, P. F., and Silverman, R. H. Activation or 2-5A-dependent RNase by analogs of 2-5A (5′-O-triphosphoryladenylyl(2′-5′)adenylyl(2′-5′) adenosine) using 2′, 5′-tetraadenylale (core)-cellulose. J. Biol. Chem., 261: 6836-6839, 1986.
27. Dong, B., and Silverman, R. H. Alternative function of a protein kinase homology domain in 2′, 5′-oligoadenylate dependent RNase L. Nucleic Acids Res., 27: 439-445, 1999.