Caspase-2 as a tumour suppressor

Cell Death and Differentiation

Volumn 20, Issue 9, 2013, Pages 1133-1139

  Puccini, J ^a,b   Dorstyn, L ^a,b,c   Kumar, S ^a,b,c  

^a CENTRE FOR CANCER BIOLOGY   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

cancer; caspase 2; DNA damage response; genomic instability; tumour suppression

Indexed keywords

CASPASE 2; CASPASE 8; SIGNAL PEPTIDE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; CANCER PROGNOSIS; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRESS; CELL TRANSFORMATION; CHROMOSOME 7Q; COLORECTAL CANCER; DNA DAMAGE; GENE ACTIVATION; GENOMIC INSTABILITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; STOMACH CANCER; TUMOR SUPPRESSOR GENE;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; CASPASE 2; CELL CYCLE; CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; GENES, TUMOR SUPPRESSOR; MICE; MICE, KNOCKOUT; NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 84882262182     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.87     Document Type: Review

References (49)

1. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev 1994; 8: 1613-1626.
2. Kumar S, Tomooka Y, Noda M. Identification of a set of genes with developmentally downregulated expression in the mouse brain. Biochem Biophys Res Commun 1992; 185: 1155-1161.
3. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. Elegans cell death gene ced-3. Cell 1993; 75: 653-660.
4. Kumar S. ICE-like proteases in apoptosis. Trends Biochem Sci 1995; 20: 198-202.
5. Kumar S. Caspase function in programmed cell death. Cell Death Differ 2007; 14: 32-43.
6. Dorstyn L, Colussi PA, Quinn LM, Richardson H, Kumar S. DRONC, an ecdysoneinducible Drosophila caspase. Proc Natl Acad Sci USA 1999; 96: 4307-4312.
7. Colussi PA, Harvey NL, Kumar S. Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain. J Biol Chem 1998; 273: 24535-24542.
8. Baliga BC, Colussi PA, Read SH, Dias MM, Jans DA, Kumar S. Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J Biol Chem 2003; 278: 4899-4905.
9. Kumar S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer 2009; 9: 897-903.
10. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A et al. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 1998; 12: 1304-1314.
11. Kumar S, White DL, Takai S, Turczynowicz S, Juttner CA, Hughes TP. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. Hum Genet 1995; 95: 641-644.
12. Estrov Z, Thall PF, Talpaz M, Estey EH, Kantarjian HM, Andreeff M et al. Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia. Blood 1998; 92: 3090-3097.
13. Hofmann WK, de Vos S, Tsukasaki K, Wachsman W, Pinkus GS, Said JW et al. Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood 2001; 98: 787-794.
14. Faderl S, Thall PF, Kantarjian HM, Talpaz M, Harris D, Van Q et al. Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia. Clin Can Res 1999; 5: 4041-4047.
15. Ho LH, Taylor R, Dorstyn L, Cakouros D, Bouillet P, Kumar S. A tumor suppressor function for caspase-2. Proc Natl Acad Sci USA 2009; 106: 5336-5341.
16. O'Reilly LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL et al. Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ 2002; 9: 832-841.
17. Marsden VS, Ekert PG, Van Delft M, Vaux DL, Adams JM, Strasser A. Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9. J Cell Biol 2004; 165: 775-780.
18. Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP et al. Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell 2009; 35: 830-840.
19. Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S. Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene 2008; 27: 3393-3404.
20. Troy CM, Rabacchi SA, Hohl JB, Angelastro JM, Greene LA, Shelanski ML. Death in the balance: alternative participation of the caspase-2 and-9 pathways in neuronal death induced by nerve growth factor deprivation. J Neurosci 2001; 21: 5007-5016.
21. Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S. Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death Differ 2012; 19: 1370-1380.
22. Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B et al. Caspase-2 deficiency enhances aging-related traits in mice. Mech Ageing Dev 2007; 128: 213-221.
23. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
24. Olsson M, Zhivotovsky B. Caspases and cancer. Cell Death Differ 2011; 18: 1441-1449.
25. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA et al. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 2000; 6: 529-535.
26. Krelin Y, Zhang L, Kang TB, Appel E, Kovalenko A, Wallach D. Caspase-8 deficiency facilitates cellular transformation in vitro. Cell Death Differ 2008; 15: 1350-1355.
27. Fava LL, Bock FJ, Geley S, Villunger A. Caspase-2 at a glance. J Cell Sci 2012; 125: 5911-5915.
28. Kim MS, Kim HS, Jeong EG, Soung YH, Yoo NJ, Lee SH. Somatic mutations of caspase-2 gene in gastric and colorectal cancers. Pathol Res Pract 2011; 207: 640-644.
29. Holleman A, den Boer ML, Kazemier KM, Beverloo HB, von Bergh AR, Janka-Schaub GE et al. Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia. Blood 2005; 106: 1817-1823.
30. Ren K, Lu J, Porollo A, Du C. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. J Biol Chem 2012; 287: 14792-14802.
31. Kim MS, Chung NG, Yoo NJ, Lee SH. Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers. Eur J Haematol 2011; 86: 449-450.
32. Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S et al. Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ 2012; 19: 1288-1298.
33. Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M et al. PIDDosomeindependent tumor suppression by Caspase-2. Cell Death Differ 2012; 19: 1722-1732.
34. Parsons MJ, McCormick L, Janke L, Howard A, Bouchier-Hayes L, Green DR. Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ 2013; 20: 1174-1182.
35. Strange R, Li F, Saurer S, Burkhardt A, Friis RR. Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 1992; 115: 49-58.
36. Oliver TG, Meylan E, Chang GP, XueW, Burke JR, Humpton TJ et al. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell 2011; 43: 57-71.
37. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008; 133: 864-877.
38. Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J et al. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 2012; 47: 681-893.
39. Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007; 28: 739-745.
40. Lobrich M, Jeggo PA. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 2007; 7: 861-869.
41. Gordon DJ, Resio B, Pellman D. Causes and consequences of aneuploidy in cancer. Nat Rev Genet 2012; 13: 189-203.
42. Castedo M, Perfettini JL, Roumier T, Valent A, Raslova H, Yakushijin K et al. Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene 2004; 23: 4362-4370.
43. Mansilla S, Priebe W, Portugal J. Mitotic catastrophe results in cell death by caspasedependent and caspase-independent mechanisms. Cell Cycle 2006; 5: 53-60.
44. Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 2011; 12: 385-392.
45. Baliga BC, Read SH, Kumar S. The biochemical mechanism of caspase-2 activation. Cell Death Differ 2004; 11: 1234-1241.
46. Butt AJ, Harvey NL, Parasivam G, Kumar S. Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions. J Biol Chem 1998; 273: 6763-6768.
47. Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC et al. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 2005; 123: 89-103.
48. Shin S, Lee Y, Kim W, Ko H, Choi H, Kim K. Caspase-2 primes cancer cells for TRAILmediated apoptosis by processing procaspase-8. EMBO J 2005; 24: 3532-3542.
49. Andersen JL, Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian MR et al. Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J 2009; 28: 3216-3227.