Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2′-deoxyguanosine

Biochemistry

Volumn 53, Issue 41, 2014, Pages 6584-6594

  Zafar, Maroof K ^a   Ketkar, Amit ^a   Lodeiro, Maria F ^b   Cameron, Craig E ^b   Eoff, Robert L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; ERROR PRONES; KINETIC ANALYSIS;

DEOXYGUANOSINE DERIVATIVE; DNA POLYMERASE; MAGNESIUM ION; MANGANESE; SINGLE STRANDED DNA; TETRAHYDROFURAN DERIVATIVE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; DNA; DNA DIRECTED DNA POLYMERASE; DNA PRIMASE; MAGNESIUM; MULTIFUNCTIONAL ENZYME; PRIMER DNA; PRIMPOL PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ANISOTROPY; ARTICLE; CATALYSIS; DISSOCIATION CONSTANT; DNA ADDUCT; DNA BINDING; DNA SYNTHESIS; DNA TEMPLATE; DNA TRANSCRIPTION; ENZYME ACTIVITY; ENZYME KINETICS; FLUORESCENCE; HUMAN; MICHAELIS CONSTANT; MITOCHONDRIAL DNA REPLICATION; POLYMERIZATION; PURIFICATION; STEADY STATE; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DNA DAMAGE; ENZYME SPECIFICITY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; UPREGULATION;

BIOCATALYSIS; DEOXYGUANOSINE; DNA; DNA DAMAGE; DNA PRIMASE; DNA PRIMERS; DNA-DIRECTED DNA POLYMERASE; HUMANS; KINETICS; MAGNESIUM; MANGANESE; MODELS, MOLECULAR; MULTIFUNCTIONAL ENZYMES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC; UP-REGULATION;

EID: 84908102039     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501024u     Document Type: Article

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