-
2
-
-
32644444158
-
The epidemiology of aplastic anemia in Thailand
-
Issaragrisil S, Kaufman D, Anderson T, et al. The epidemiology of aplastic anemia in Thailand. Blood 2006; 107:1299-1307.
-
(2006)
Blood
, vol.107
, pp. 1299-1307
-
-
Issaragrisil, S.1
Kaufman, D.2
Anderson, T.3
-
3
-
-
22244476102
-
Incidence of aplastic anemia and agranulocytosis in Latin America: The LATIN study
-
Hamerschlak N, Maluf E, Pasquini R, et al. Incidence of aplastic anemia and agranulocytosis in Latin America: the LATIN study. Sao Paulo Medical Journal 2005; 123:101-104.
-
(2005)
Sao Paulo Medical Journal
, vol.123
, pp. 101-104
-
-
Hamerschlak, N.1
Maluf, E.2
Pasquini, R.3
-
4
-
-
0002847708
-
Drugs and chemicals
-
Young NS, Alter BP, editors, Philadelphia, PA: W.B. Saunders;
-
Young NS. Drugs and chemicals. In: Young NS, Alter BP, editors. Aplastic anemia, acquired and inherited. Philadelphia, PA: W.B. Saunders; 1994 . pp. 100-132.
-
(1994)
Aplastic anemia, acquired and inherited
, pp. 100-132
-
-
Young, N.S.1
-
5
-
-
0020549118
-
Anticonvulsant- induced aplastic anemia: Increased susceptibility to toxic drug metabolites in vitro
-
Gerson WT, Fine DG, Spielberg SP, Sensenbrenner LL. Anticonvulsant- induced aplastic anemia: increased susceptibility to toxic drug metabolites in vitro. Blood 1983; 61:889-893.
-
(1983)
Blood
, vol.61
, pp. 889-893
-
-
Gerson, W.T.1
Fine, D.G.2
Spielberg, S.P.3
Sensenbrenner, L.L.4
-
6
-
-
0842333177
-
Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking GSTT1 gene
-
Sutton JF, Stacey M, Kearsey SE, et al. Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking GSTT1 gene. Pediatric Blood Cancer 2004; 42:122-126.
-
(2004)
Pediatric Blood Cancer
, vol.42
, pp. 122-126
-
-
Sutton, J.F.1
Stacey, M.2
Kearsey, S.E.3
-
7
-
-
24944547455
-
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1. GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients
-
Dufour C, Syahn J, Bacigalupo A, et al. Genetic polymorphisms of CYP3A4, GSTT1, GSTM1. GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. Haematologica 2005; 90:1027-1031.
-
(2005)
Haematologica
, vol.90
, pp. 1027-1031
-
-
Dufour, C.1
Syahn, J.2
Bacigalupo, A.3
-
8
-
-
2942535837
-
Analysis of T-cell repertoire in hepatitis-associated aplastic anemia
-
Lu J, Basu A, Melenhorst J, et al. Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood 2004; 103:4588-4593.
-
(2004)
Blood
, vol.103
, pp. 4588-4593
-
-
Lu, J.1
Basu, A.2
Melenhorst, J.3
-
9
-
-
0033950194
-
Hematopoietic cell destruction by immune mechanisms in aquired aplastic anemia
-
Young NS. Hematopoietic cell destruction by immune mechanisms in aquired aplastic anemia. Semin Hematol 2000; 37:3-14.
-
(2000)
Semin Hematol
, vol.37
, pp. 3-14
-
-
Young, N.S.1
-
10
-
-
0037103384
-
Intracellular interferon- y in circulating and marrow T cells detected by flow cytometry and the response to imunosuppressive therapy in patients with aplastic anemia
-
Sloand EM, Kim S, Maciejewski JP, et al. Intracellular interferon- y in circulating and marrow T cells detected by flow cytometry and the response to imunosuppressive therapy in patients with aplastic anemia. Blood 2002; 100:1185-1191.
-
(2002)
Blood
, vol.100
, pp. 1185-1191
-
-
Sloand, E.M.1
Kim, S.2
Maciejewski, J.P.3
-
11
-
-
33646546357
-
-
Solomou EE, Keyvanfar K, Young NS. T-bet, a Th1 transcription factor, is upregulated in T cells from patients with aplastic anemia. Blood 2006; 107:3983-3991.
-
Solomou EE, Keyvanfar K, Young NS. T-bet, a Th1 transcription factor, is upregulated in T cells from patients with aplastic anemia. Blood 2006; 107:3983-3991.
-
-
-
-
12
-
-
3242782610
-
In-vivo dominant immune responses in aplastic anaemia: Molecular tracking of putatively pathogenetic T-cell clones by TCR [beta]-CDR3 sequencing
-
Risitano AM, Maciejewski JP, Green S, et al. In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR [beta]-CDR3 sequencing. The Lancet 2004; 364:355-364.
-
(2004)
The Lancet
, vol.364
, pp. 355-364
-
-
Risitano, A.M.1
Maciejewski, J.P.2
Green, S.3
-
13
-
-
34548848237
-
-
Solomou EE, Rezvani K, Mielke S, et al. Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood 2007; 110:1603-1606. Regulatory T cells were decreased at presentation in almost all patients; a regulatory T-cell defect was implicated in autoimmune marrow failure as had been suggested by animal studies and in a few other human autoimmune diseases.
-
Solomou EE, Rezvani K, Mielke S, et al. Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood 2007; 110:1603-1606. Regulatory T cells were decreased at presentation in almost all patients; a regulatory T-cell defect was implicated in autoimmune marrow failure as had been suggested by animal studies and in a few other human autoimmune diseases.
-
-
-
-
14
-
-
33947631521
-
-
Chen J, Ellison FM, Eckhaus MA, et al. Minor antigen H60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells. J Immunol 2007; 178:4159-4168. In an immune-mediated murine model for aplastic anemia, a single minor histocompatibility mismatch triggered an immune response leading to massive bone marrow destruction. Immunosuppressive drug treatment or enhancement of regulatory T-cell function protected animals from the development of bone marrow failure.
-
Chen J, Ellison FM, Eckhaus MA, et al. Minor antigen H60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells. J Immunol 2007; 178:4159-4168. In an immune-mediated murine model for aplastic anemia, a single minor histocompatibility mismatch triggered an immune response leading to massive bone marrow destruction. Immunosuppressive drug treatment or enhancement of regulatory T-cell function protected animals from the development of bone marrow failure.
-
-
-
-
15
-
-
0028033610
-
Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia
-
Nakao S, Takamatsu H, Chuhjo T, et al. Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia. Blood 1994; 84:4257-4261.
-
(1994)
Blood
, vol.84
, pp. 4257-4261
-
-
Nakao, S.1
Takamatsu, H.2
Chuhjo, T.3
-
16
-
-
0035895062
-
Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and PNH/aplastic anemia syndrome
-
Maciejewski JP, Follmann D, Rivera CE, et al. Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and PNH/aplastic anemia syndrome. Blood 2001; 98:3513-3519.
-
(2001)
Blood
, vol.98
, pp. 3513-3519
-
-
Maciejewski, J.P.1
Follmann, D.2
Rivera, C.E.3
-
17
-
-
0036956560
-
Clinical relevance of the TNF-alpha promoter/enhancer polymorphism in patients with aplastic anemia
-
Demeter J, Messer G, Schrezenmeier H. Clinical relevance of the TNF-alpha promoter/enhancer polymorphism in patients with aplastic anemia. Ann Hematol 2002; 81:566-569.
-
(2002)
Ann Hematol
, vol.81
, pp. 566-569
-
-
Demeter, J.1
Messer, G.2
Schrezenmeier, H.3
-
18
-
-
4544309058
-
Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population
-
Dufour C, Capasso M, Svahn J, et al. Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. Br J Haematol 2004; 126:682-685.
-
(2004)
Br J Haematol
, vol.126
, pp. 682-685
-
-
Dufour, C.1
Capasso, M.2
Svahn, J.3
-
20
-
-
0029609759
-
Increased apoptosis in aplastic anemia bone marrow progenitor cells: Possible pathophysiologic significance
-
Philpott NJ, Scopes J, Marsh JCW, et al. Increased apoptosis in aplastic anemia bone marrow progenitor cells: possible pathophysiologic significance. Exp Hematol 1995; 23:1642-1648.
-
(1995)
Exp Hematol
, vol.23
, pp. 1642-1648
-
-
Philpott, N.J.1
Scopes, J.2
Marsh, J.C.W.3
-
21
-
-
0030805088
-
Increased apoptotic cells in bone marrow biopsies from patients with aplastic anaemia
-
Callera F, Falcao RP. Increased apoptotic cells in bone marrow biopsies from patients with aplastic anaemia. Br J Haematol 1997; 98:18-20.
-
(1997)
Br J Haematol
, vol.98
, pp. 18-20
-
-
Callera, F.1
Falcao, R.P.2
-
22
-
-
0029048258
-
Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anemia
-
Maciejewski JP, Selleri C, Sato T, et al. Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anemia. BR J Haematol 1995; 91:245-252.
-
(1995)
BR J Haematol
, vol.91
, pp. 245-252
-
-
Maciejewski, J.P.1
Selleri, C.2
Sato, T.3
-
23
-
-
10244227886
-
Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
-
Chen G, Zeng W, Miyazato A, et al. Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities. Blood 2004; 104:4210-4218.
-
(2004)
Blood
, vol.104
, pp. 4210-4218
-
-
Chen, G.1
Zeng, W.2
Miyazato, A.3
-
24
-
-
0032525092
-
Progressive telomere shortening in aplastic anemia
-
Ball SE, Gibson FM, Rizzo S, et al. Progressive telomere shortening in aplastic anemia. Blood 1998; 91:3582-3592.
-
(1998)
Blood
, vol.91
, pp. 3582-3592
-
-
Ball, S.E.1
Gibson, F.M.2
Rizzo, S.3
-
25
-
-
0035865618
-
Telomere length in leukocyte subpopulations of patients with aplastic anemia
-
Brummendorf TH, Maciejewski JP, Young NS, Lansdorp PL. Telomere length in leukocyte subpopulations of patients with aplastic anemia. Blood 2001; 97:895-900.
-
(2001)
Blood
, vol.97
, pp. 895-900
-
-
Brummendorf, T.H.1
Maciejewski, J.P.2
Young, N.S.3
Lansdorp, P.L.4
-
26
-
-
0344851536
-
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA
-
Fogarty PF, Yamaguchi H, Wiestner A, et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet 2003; 362:1628-1630.
-
(2003)
Lancet
, vol.362
, pp. 1628-1630
-
-
Fogarty, P.F.1
Yamaguchi, H.2
Wiestner, A.3
-
27
-
-
15944422499
-
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia
-
Yamaguchi H, Calado RT, Ly H, et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 2005; 352:1413-1424.
-
(2005)
N Engl J Med
, vol.352
, pp. 1413-1424
-
-
Yamaguchi, H.1
Calado, R.T.2
Ly, H.3
-
28
-
-
0033362103
-
X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene
-
Knight SW, Heiss NS, Vulliamy TJ, et al. X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene. Am J Hum Genet 1999; 65:50-58.
-
(1999)
Am J Hum Genet
, vol.65
, pp. 50-58
-
-
Knight, S.W.1
Heiss, N.S.2
Vulliamy, T.J.3
-
29
-
-
0035960043
-
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
-
Vulliamy T, Marrone A, Goldman F, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 2001; 413:432-435.
-
(2001)
Nature
, vol.413
, pp. 432-435
-
-
Vulliamy, T.1
Marrone, A.2
Goldman, F.3
-
30
-
-
38849168568
-
Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraa-Hreidarsson syndrome
-
Marrone A, Walne A, Tamary H, et al. Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraa-Hreidarsson syndrome. Blood 2007; 110:4198-4205.
-
(2007)
Blood
, vol.110
, pp. 4198-4205
-
-
Marrone, A.1
Walne, A.2
Tamary, H.3
-
31
-
-
38949103402
-
Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene
-
Du HY, Pumbo E, Manley P, et al. Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. Blood 2008; 111:1128-1130.
-
(2008)
Blood
, vol.111
, pp. 1128-1130
-
-
Du, H.Y.1
Pumbo, E.2
Manley, P.3
-
32
-
-
34548039210
-
-
Calado RT, Graf SA, Wilkerson KL, et al. Mutations in the SBDS gene in acquired aplastic anemia. Blood 2007; 110:1141-1146. Heterozygosity for SBDS mutations previously described in Shwachman-Diamond syndrome, were identified in young patients with idiopathic acquired aplastic anemia.
-
Calado RT, Graf SA, Wilkerson KL, et al. Mutations in the SBDS gene in acquired aplastic anemia. Blood 2007; 110:1141-1146. Heterozygosity for SBDS mutations previously described in Shwachman-Diamond syndrome, were identified in young patients with idiopathic acquired aplastic anemia.
-
-
-
-
33
-
-
26844504636
-
Paroxysmal nocturnal hemoglobinuria: Current issues in pathophysiology and treatment
-
Young NS. Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment. Curr Hematol Rep 2005; 4:103-109.
-
(2005)
Curr Hematol Rep
, vol.4
, pp. 103-109
-
-
Young, N.S.1
-
34
-
-
1042303646
-
Evolution of clonal cytogenetic abnormalities in aplastic anemia
-
Maciejewski JP, Selleri C. Evolution of clonal cytogenetic abnormalities in aplastic anemia. Leuk Lymphoma 2004; 45:433-440.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 433-440
-
-
Maciejewski, J.P.1
Selleri, C.2
-
35
-
-
23044473715
-
Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome
-
Sloand EM, Mainwaring L, Fuhrer M, et al. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood 2005; 106:841-851.
-
(2005)
Blood
, vol.106
, pp. 841-851
-
-
Sloand, E.M.1
Mainwaring, L.2
Fuhrer, M.3
-
36
-
-
33947224233
-
CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
-
Resistance to apoptosis underlies clonal expansion of CD34 cells from patients with trisomy 8 myelodysplastic syndrome
-
Sloand EM, Pfannes L, Chen G, et al. CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins. Blood 2007; 109:2399-2405. Resistance to apoptosis underlies clonal expansion of CD34 cells from patients with trisomy 8 myelodysplastic syndrome.
-
(2007)
Blood
, vol.109
, pp. 2399-2405
-
-
Sloand, E.M.1
Pfannes, L.2
Chen, G.3
-
37
-
-
0036566542
-
Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia
-
Maciejewski JP, Risitano AM, Sloand EM, et al. Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia. Blood 2002; 99:3129-3135.
-
(2002)
Blood
, vol.99
, pp. 3129-3135
-
-
Maciejewski, J.P.1
Risitano, A.M.2
Sloand, E.M.3
-
38
-
-
0036682934
-
Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children
-
Kojima S, Ohara A, Tsuchida M, et al. Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children. Blood 2002; 100:786-790.
-
(2002)
Blood
, vol.100
, pp. 786-790
-
-
Kojima, S.1
Ohara, A.2
Tsuchida, M.3
-
39
-
-
33947594348
-
-
Socie G, Mary J-Y, Schrezenmeier H, et al. Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT). Blood 2007; 109:2794-2796. In this retrospective study, an increased incidence of evolution to myelodysplasia and leukemia was observed in aplastic anemia patients who received initial immunosuppressive therapy with G-CSF compared with those who did not receive G-CSF with initial immunosuppression.
-
Socie G, Mary J-Y, Schrezenmeier H, et al. Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT). Blood 2007; 109:2794-2796. In this retrospective study, an increased incidence of evolution to myelodysplasia and leukemia was observed in aplastic anemia patients who received initial immunosuppressive therapy with G-CSF compared with those who did not receive G-CSF with initial immunosuppression.
-
-
-
-
40
-
-
33749248679
-
Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor
-
Sloand EM, Yong ASM, Ramkissoon S, et al. Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor. Proc Natl Acad Sci 2006; 103:14483-14488.
-
(2006)
Proc Natl Acad Sci
, vol.103
, pp. 14483-14488
-
-
Sloand, E.M.1
Yong, A.S.M.2
Ramkissoon, S.3
-
41
-
-
41949106823
-
-
Sloand EM, Scheinberg P, Fenlon E, et al. Monosomy 7 detected by FISH at disease presentation is a marker for non-response to immunosuppression. ASH Annual Meeting Abstracts 2007; 110:506a.
-
Sloand EM, Scheinberg P, Fenlon E, et al. Monosomy 7 detected by FISH at disease presentation is a marker for non-response to immunosuppression. ASH Annual Meeting Abstracts 2007; 110:506a.
-
-
-
-
43
-
-
0029070615
-
Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry
-
Bourdage JS, Hamlin DM. Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. Transplantation 1995; 59:1194-1200.
-
(1995)
Transplantation
, vol.59
, pp. 1194-1200
-
-
Bourdage, J.S.1
Hamlin, D.M.2
-
44
-
-
0022444360
-
Biological and immunological characterization of ATG and ALG
-
Raefsky EL, Gascon P, Gratwohl A, et al. Biological and immunological characterization of ATG and ALG. Blood 1986; 68:712-719.
-
(1986)
Blood
, vol.68
, pp. 712-719
-
-
Raefsky, E.L.1
Gascon, P.2
Gratwohl, A.3
-
45
-
-
0025865140
-
Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group
-
Frickhofen N, Kaltwasser JP, Schrezenmeier H, et al. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group. N Eng J Med 1991; 324:1297-1304.
-
(1991)
N Eng J Med
, vol.324
, pp. 1297-1304
-
-
Frickhofen, N.1
Kaltwasser, J.P.2
Schrezenmeier, H.3
-
46
-
-
0033965723
-
Immunosuppressive treatment of aplastic anemia with antithymocyte globuillin and cyclosporine
-
Frickhofen N, Rosenfeld SJ. Immunosuppressive treatment of aplastic anemia with antithymocyte globuillin and cyclosporine. Semin Hematol 2000; 37:56-68.
-
(2000)
Semin Hematol
, vol.37
, pp. 56-68
-
-
Frickhofen, N.1
Rosenfeld, S.J.2
-
47
-
-
0037420270
-
Antithymocyte globulin and cyclosporine for severe aplastic anemia. Association between hematologic response and long-term outcome
-
Rosenfeld S, Follman D, Nunez O, Young NS. Antithymocyte globulin and cyclosporine for severe aplastic anemia. Association between hematologic response and long-term outcome. JAMA 2003; 289:1130-1135.
-
(2003)
JAMA
, vol.289
, pp. 1130-1135
-
-
Rosenfeld, S.1
Follman, D.2
Nunez, O.3
Young, N.S.4
-
48
-
-
17644440714
-
-
Bacigalupo A, Bruno B, Saracco P, et al. Antilymphocyte globuilin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO). Blood 2000; 95:1931-1934.
-
Bacigalupo A, Bruno B, Saracco P, et al. Antilymphocyte globuilin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO). Blood 2000; 95:1931-1934.
-
-
-
-
49
-
-
0034665668
-
Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia
-
Kojima S, Hibi S, Kosaka Y, et al. Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. Blood 2000; 96:2049-2054.
-
(2000)
Blood
, vol.96
, pp. 2049-2054
-
-
Kojima, S.1
Hibi, S.2
Kosaka, Y.3
-
50
-
-
0037441586
-
Antithymocyte globulin with or without cyclosporin A. 11-year follow-up of a randomized trial comparing treatments of aplastic anemia
-
Frickhofen N, Heimpel H, Kaltwasser JP, Schrezenmaier H. Antithymocyte globulin with or without cyclosporin A. 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood 2003; 101:1236-1242.
-
(2003)
Blood
, vol.101
, pp. 1236-1242
-
-
Frickhofen, N.1
Heimpel, H.2
Kaltwasser, J.P.3
Schrezenmaier, H.4
-
51
-
-
24744440150
-
Immunosuppressive therapy for aplastic anemia in children: A more severe disease predicts better survival
-
Fuhrer M, Rampf U, Baumann I, et al. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood 2005; 106:2102-2104.
-
(2005)
Blood
, vol.106
, pp. 2102-2104
-
-
Fuhrer, M.1
Rampf, U.2
Baumann, I.3
-
52
-
-
7344242596
-
Relapse and clonal disease in children with aplastic anemia (AA) after immunosuppressive therapy (IST): The SAA 94 experience
-
Fuhrer M, Burdach S, Ebell W, et al. Relapse and clonal disease in children with aplastic anemia (AA) after immunosuppressive therapy (IST): the SAA 94 experience. Klinische Padiatrie 1998; 210:173-179.
-
(1998)
Klinische Padiatrie
, vol.210
, pp. 173-179
-
-
Fuhrer, M.1
Burdach, S.2
Ebell, W.3
-
53
-
-
41949106495
-
-
Scheinberg P, Wu CO, Nunez O, Young NS. Long term outcome of pediatric patients with severe aplastic anemia treated with anti-thymocyte globulin and cyclosporine. ASH Annual Meeting Abstracts 2007; 110:505a.
-
Scheinberg P, Wu CO, Nunez O, Young NS. Long term outcome of pediatric patients with severe aplastic anemia treated with anti-thymocyte globulin and cyclosporine. ASH Annual Meeting Abstracts 2007; 110:505a.
-
-
-
-
54
-
-
34147220089
-
Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia
-
Scheinberg P, Fischer SH, Li L, et al. Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood 2007; 109:3219-3224.
-
(2007)
Blood
, vol.109
, pp. 3219-3224
-
-
Scheinberg, P.1
Fischer, S.H.2
Li, L.3
-
55
-
-
0021703266
-
Differential effects of horse ATG and rabbit ATG on T cell and T cell subset levels measured by monoclonal antibodies
-
Thomas FT, Griesedieck C, Thomas J. Differential effects of horse ATG and rabbit ATG on T cell and T cell subset levels measured by monoclonal antibodies. Transpl Proc 1984; 16:1561-1563.
-
(1984)
Transpl Proc
, vol.16
, pp. 1561-1563
-
-
Thomas, F.T.1
Griesedieck, C.2
Thomas, J.3
-
56
-
-
43549114342
-
-
+ regulatory T cells in vitro. Blood 2008; 4 Feb [Epub ahead of print].
-
+ regulatory T cells in vitro. Blood 2008; 4 Feb [Epub ahead of print].
-
-
-
-
57
-
-
0032734041
-
Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosuppressive therapy. Gruppo Italiano Trapianto di Midollo Osseo (GITMO)
-
Di Bona E, Rodeghiero F, Bruno B, et al. Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosuppressive therapy. Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Br J Haematol 1999; 107:330-334.
-
(1999)
Br J Haematol
, vol.107
, pp. 330-334
-
-
Di Bona, E.1
Rodeghiero, F.2
Bruno, B.3
-
58
-
-
0031937535
-
Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia
-
Tichelli A, Passweg J, Nissen C, et al. Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia. Br J Haematol 1998; 100:393-400.
-
(1998)
Br J Haematol
, vol.100
, pp. 393-400
-
-
Tichelli, A.1
Passweg, J.2
Nissen, C.3
-
59
-
-
33646684489
-
Retreatment with rabbit antithymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia
-
Scheinberg P, Nunez O, Young NS. Retreatment with rabbit antithymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia. Br J Haematol 2006; 133:622-627.
-
(2006)
Br J Haematol
, vol.133
, pp. 622-627
-
-
Scheinberg, P.1
Nunez, O.2
Young, N.S.3
-
60
-
-
0027373569
-
Relapse of aplastic anaemia after immunosuppressive treatment: A report from the European Bone Marrow Transplantation Group SAA Working Party
-
Schrezenmeier H, Marin P, Raghavachar A, et al. Relapse of aplastic anaemia after immunosuppressive treatment: a report from the European Bone Marrow Transplantation Group SAA Working Party. Br J Haematol 1993; 85:371-377.
-
(1993)
Br J Haematol
, vol.85
, pp. 371-377
-
-
Schrezenmeier, H.1
Marin, P.2
Raghavachar, A.3
-
61
-
-
41949089180
-
-
Scheinberg P, Wu CO, Nunez O, Young NS. Marked Improvement in shortand long-term survival in severe aplastic anemia patients treated with immunosuppression in the past 18 years. ASH Annual Meeting Abstracts 2007; 110:506a.
-
Scheinberg P, Wu CO, Nunez O, Young NS. Marked Improvement in shortand long-term survival in severe aplastic anemia patients treated with immunosuppression in the past 18 years. ASH Annual Meeting Abstracts 2007; 110:506a.
-
-
-
-
62
-
-
41949142572
-
-
Scheinberg P, Wu CO, Nunez O, Young NS. Predicting response and survival for severe aplastic anemia patients treated with immunosuppression. ASH Annual Meeting Abstracts 2007; 110:504a.
-
Scheinberg P, Wu CO, Nunez O, Young NS. Predicting response and survival for severe aplastic anemia patients treated with immunosuppression. ASH Annual Meeting Abstracts 2007; 110:504a.
-
-
-
-
63
-
-
33646688643
-
Treatment of severe aplastic anaemia with combined immunosuppression: Antithymocyte globulin, ciclosporin and mycophenolate mofetil
-
Scheinberg P, Nunez O, Wu C, Young NS. Treatment of severe aplastic anaemia with combined immunosuppression: antithymocyte globulin, ciclosporin and mycophenolate mofetil. Br J Haematol 2006; 133:606-611.
-
(2006)
Br J Haematol
, vol.133
, pp. 606-611
-
-
Scheinberg, P.1
Nunez, O.2
Wu, C.3
Young, N.S.4
-
64
-
-
22244476435
-
Granulocyte-macrophage colony stimulating factor and immunosuppression in the treatment of pediatric acquired severe aplastic anemia
-
Jeng MR, Naidu PE, Rieman MD, et al. Granulocyte-macrophage colony stimulating factor and immunosuppression in the treatment of pediatric acquired severe aplastic anemia. Pediatr Blood Cancer 2005; 45:170-175.
-
(2005)
Pediatr Blood Cancer
, vol.45
, pp. 170-175
-
-
Jeng, M.R.1
Naidu, P.E.2
Rieman, M.D.3
-
65
-
-
0036456675
-
Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia
-
Gluckman E, Rokicka-Milewska R, Hann I, et al. Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia. Br J Haematol 2002; 119:1075-1082.
-
(2002)
Br J Haematol
, vol.119
, pp. 1075-1082
-
-
Gluckman, E.1
Rokicka-Milewska, R.2
Hann, I.3
-
66
-
-
0034605715
-
High-dose cyclophosphamide in severe aplastic anemia: A randomized trial
-
Tisdale JF, Dunn DE, Geller NL, et al. High-dose cyclophosphamide in severe aplastic anemia: a randomized trial. Lancet 2000; 356:1554-1559.
-
(2000)
Lancet
, vol.356
, pp. 1554-1559
-
-
Tisdale, J.F.1
Dunn, D.E.2
Geller, N.L.3
-
67
-
-
34548840525
-
-
Teramura M, Kimura A, Iwase S, et al. Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan. Blood 2007; 110:1756-1761. In this prospective randomized study comparing horse ATG+cyclosporine with or without G-CSF, no differences in the incidence of infections, clonal evolution or survival were observed between the two groups; however, a higher response rate and a lower relapse rate were observed in the G-CSF treated patients.
-
Teramura M, Kimura A, Iwase S, et al. Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan. Blood 2007; 110:1756-1761. In this prospective randomized study comparing horse ATG+cyclosporine with or without G-CSF, no differences in the incidence of infections, clonal evolution or survival were observed between the two groups; however, a higher response rate and a lower relapse rate were observed in the G-CSF treated patients.
-
-
-
-
68
-
-
0033768674
-
Long-term outcome of acquired aplastic anaemia in children: Comparison between immunosuppressive therapy and bone marrow transplantation
-
Kojima S, Horibe K, Inaba J, et al. Long-term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation. Br J Haematol 2000; 111:321-328.
-
(2000)
Br J Haematol
, vol.111
, pp. 321-328
-
-
Kojima, S.1
Horibe, K.2
Inaba, J.3
-
69
-
-
4744352533
-
Natural history of moderate aplastic anemia in children
-
Howard SC, Naidu PE, Hu XJ, et al. Natural history of moderate aplastic anemia in children. Pediatr Blood Cancer 2004; 43:545-551.
-
(2004)
Pediatr Blood Cancer
, vol.43
, pp. 545-551
-
-
Howard, S.C.1
Naidu, P.E.2
Hu, X.J.3
-
70
-
-
0033120316
-
Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: A report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anemia Working Party
-
Marsh J, Schrezenmeier H, Marin P, et al. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: A report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anemia Working Party. Blood 1999; 93:2191-2195.
-
(1999)
Blood
, vol.93
, pp. 2191-2195
-
-
Marsh, J.1
Schrezenmeier, H.2
Marin, P.3
-
71
-
-
0242579305
-
Recombinant humanized anti-IL-2 receptor antibody (Daclizumab) produces responses in patients with moderate aplastic anemia
-
Maciejewski JP, Sloand EM, Nunez O, et al. Recombinant humanized anti-IL-2 receptor antibody (Daclizumab) produces responses in patients with moderate aplastic anemia. Blood 2003; 102:3584-3586.
-
(2003)
Blood
, vol.102
, pp. 3584-3586
-
-
Maciejewski, J.P.1
Sloand, E.M.2
Nunez, O.3
-
72
-
-
0033960663
-
Current status of allogeneic bone marrow transplantation in acquired aplastic anemia
-
Horowitz MM. Current status of allogeneic bone marrow transplantation in acquired aplastic anemia. Semin in Hematol 2000; 37:30-42.
-
(2000)
Semin in Hematol
, vol.37
, pp. 30-42
-
-
Horowitz, M.M.1
-
73
-
-
33750628439
-
Current concepts in the pathophysiology and treatment of aplastic anemia
-
Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 2006; 108:2509-2519.
-
(2006)
Blood
, vol.108
, pp. 2509-2519
-
-
Young, N.S.1
Calado, R.T.2
Scheinberg, P.3
-
74
-
-
0032525179
-
Long-term outcome after marrow transplantation for severe aplastic anemia
-
Deeg HJ, Leisenring W, Storb R, et al. Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 1998; 91:3637-3645.
-
(1998)
Blood
, vol.91
, pp. 3637-3645
-
-
Deeg, H.J.1
Leisenring, W.2
Storb, R.3
-
75
-
-
34547595111
-
Platelet transfusions
-
Stroncek DF, Rebulla P. Platelet transfusions. Lancet 2007; 370:427-438.
-
(2007)
Lancet
, vol.370
, pp. 427-438
-
-
Stroncek, D.F.1
Rebulla, P.2
-
76
-
-
34547408352
-
Red blood cell transfusion in clinical practice
-
Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007; 370:415-426.
-
(2007)
Lancet
, vol.370
, pp. 415-426
-
-
Klein, H.G.1
Spahn, D.R.2
Carson, J.L.3
-
77
-
-
33644505809
-
Allografting in patients with severe, refractory aplastic anemia using peripheral blood stem cells and a fludarabine-based conditioning regimen: The Mexican experience
-
Gomez-Almaguer D, Vela-Ojeda J, Jaime-Perez JC, et al. Allografting in patients with severe, refractory aplastic anemia using peripheral blood stem cells and a fludarabine-based conditioning regimen: The Mexican experience. Am J Hematol 2006; 81:157-161.
-
(2006)
Am J Hematol
, vol.81
, pp. 157-161
-
-
Gomez-Almaguer, D.1
Vela-Ojeda, J.2
Jaime-Perez, J.C.3
-
78
-
-
33645454939
-
Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation
-
Srinivasan R, Takahashi Y, McCoy JP, et al. Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation. Br J Haematol 2006; 133:305-314.
-
(2006)
Br J Haematol
, vol.133
, pp. 305-314
-
-
Srinivasan, R.1
Takahashi, Y.2
McCoy, J.P.3
-
79
-
-
34248376573
-
Bone marrow transplantation for severe aplastic anemia: A randomized controlled study of conditioning regimens
-
In this prospective randomized study, conditioning with cyclophosphamide+ATG was not shown to be superior to cyclophosphamide alone in aplastic anemia patients
-
Champlin RE, Perez WS, Passweg JR, et al. Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens. Blood 2007; 109:4582-4585. In this prospective randomized study, conditioning with cyclophosphamide+ATG was not shown to be superior to cyclophosphamide alone in aplastic anemia patients.
-
(2007)
Blood
, vol.109
, pp. 4582-4585
-
-
Champlin, R.E.1
Perez, W.S.2
Passweg, J.R.3
-
80
-
-
34548050458
-
-
Schrezenmeier H, Passweg JR, Marsh JCW, et al. Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia. Blood 2007; 110:1397-1400. In this retrospective study, aplastic anemia patients younger than 20 years of age had a higher incidence of chronic GVHD with peripheral blood progenitor mobilization compared with those who received a bone marrow graft.
-
Schrezenmeier H, Passweg JR, Marsh JCW, et al. Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia. Blood 2007; 110:1397-1400. In this retrospective study, aplastic anemia patients younger than 20 years of age had a higher incidence of chronic GVHD with peripheral blood progenitor mobilization compared with those who received a bone marrow graft.
-
-
-
-
81
-
-
33645240407
-
Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia
-
Passweg JR, Perez WS, Eapen M, et al. Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. Bone Marrow Transplant 2006; 37:641-649.
-
(2006)
Bone Marrow Transplant
, vol.37
, pp. 641-649
-
-
Passweg, J.R.1
Perez, W.S.2
Eapen, M.3
-
82
-
-
0036682485
-
Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: The Japan marrow Donor Program
-
Kojima S, Matsuyama T, Kato S, et al. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan marrow Donor Program. Blood 2002; 100:799-805.
-
(2002)
Blood
, vol.100
, pp. 799-805
-
-
Kojima, S.1
Matsuyama, T.2
Kato, S.3
-
83
-
-
0032619794
-
Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy
-
Deeg HJ, Seidel K, Casper J, et al. Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy. Biol Blood Marrow Transplant 1999; 5:243-252.
-
(1999)
Biol Blood Marrow Transplant
, vol.5
, pp. 243-252
-
-
Deeg, H.J.1
Seidel, K.2
Casper, J.3
-
84
-
-
38349051039
-
Recent improvement in outcome of unrelated donor transplantation for aplastic anemia
-
This retrospective study attributes the better outcome of unrelated donor transplantation in recent years to better supportive care, in particular the routine use of high molecular HLA typing for donor selection
-
Viollier R, Socie G, Tichelli A, et al. Recent improvement in outcome of unrelated donor transplantation for aplastic anemia. Bone Marrow Transplant 2008; 41:45-50. This retrospective study attributes the better outcome of unrelated donor transplantation in recent years to better supportive care, in particular the routine use of high molecular HLA typing for donor selection.
-
(2008)
Bone Marrow Transplant
, vol.41
, pp. 45-50
-
-
Viollier, R.1
Socie, G.2
Tichelli, A.3
-
85
-
-
33845269315
-
Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia
-
Kennedy-Nasser AA, Leung KS, Mahajan A, et al. Comparable outcomes of matched-related and alternative donor stem cell transplantation for pediatric severe aplastic anemia. Biol Blood Marrow Transplant 2006; 12:1277-1284.
-
(2006)
Biol Blood Marrow Transplant
, vol.12
, pp. 1277-1284
-
-
Kennedy-Nasser, A.A.1
Leung, K.S.2
Mahajan, A.3
-
86
-
-
34447334234
-
-
Maury S, Balere-Appert M-L, Chir Z, et al. Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient. Haematologica 2007; 92:589-596. This retrospective study shows that survival after unrelated stem-cell transplantation for SAA has improved significantly over the past 15 years. The better survival was attributed to better donor selection due to high-resolution HLA matching. Results for young patients who are fully HLA-matched at the allelic level with their donor were comparable to those observed after a matched sibling donor.
-
Maury S, Balere-Appert M-L, Chir Z, et al. Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient. Haematologica 2007; 92:589-596. This retrospective study shows that survival after unrelated stem-cell transplantation for SAA has improved significantly over the past 15 years. The better survival was attributed to better donor selection due to high-resolution HLA matching. Results for young patients who are fully HLA-matched at the allelic level with their donor were comparable to those observed after a matched sibling donor.
-
-
-
-
87
-
-
33748157848
-
Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy
-
Deeg HJ, O'Donnell M, Tolar J, et al. Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy. Blood 2006; 108:1485-1491.
-
(2006)
Blood
, vol.108
, pp. 1485-1491
-
-
Deeg, H.J.1
O'Donnell, M.2
Tolar, J.3
-
88
-
-
28544434394
-
Fludarabine, cyclophosphamide and antithymocyte globulin for alternative donor tranplants in acquired severe aplastic anemia: A report from the EBMT-SAA Working Party
-
Bacigalupo A, Locatelli F, Lanino E, et al. Fludarabine, cyclophosphamide and antithymocyte globulin for alternative donor tranplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party. Bone Marrow Transplant 2005: 1-4.
-
(2005)
Bone Marrow Transplant
, pp. 1-4
-
-
Bacigalupo, A.1
Locatelli, F.2
Lanino, E.3
-
89
-
-
38949154848
-
-
Kosaka Y, Yagasaki H, Sano K, et al. Prospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia. Blood 2008; 111:1054-1059. This Japanese multicenter randomized study compares the efficacy of a repeat course of immunosuppression to an alternative donor HSCT as second-line therapy in children who are unresponsive to initial ATG. Although no survival difference was observed between the two groups, patients who underwent HSCT had a superior failure free survival (broadly defined by the authors as survival with response) compared to those who received a repeat course of immunosuppression.
-
Kosaka Y, Yagasaki H, Sano K, et al. Prospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia. Blood 2008; 111:1054-1059. This Japanese multicenter randomized study compares the efficacy of a repeat course of immunosuppression to an alternative donor HSCT as second-line therapy in children who are unresponsive to initial ATG. Although no survival difference was observed between the two groups, patients who underwent HSCT had a superior failure free survival (broadly defined by the authors as survival with response) compared to those who received a repeat course of immunosuppression.
-
-
-
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