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European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 714-723

Identification of two novel RET kinase inhibitors through MCR-based drug discovery: Design, synthesis and evaluation

(5) Frett, Brendan a Moccia, Marialuisa c Carlomagno, Francesca c Santoro, Massimo c Li, Hong Yu a,b

a UNIVERSITY OF ARIZONA (United States)

b UNIVERSITY OF ARIZONA (United States)

c UNIVERSITY OF NAPLES FEDERICO II (Italy)

Author keywords

Kinase; Lead discovery; MCR; Medicinal chemistry; RET; Targeted therapeutics

Indexed keywords

N [5 (TERT BUTYL)ISOXAZOL 3 YL] 2 [3 (IMIDAZO[1,2 B]PYRIDAZIN 6 YLOXY)PHENYL]ACETAMIDE; N [5 (TERT BUTYL)ISOXAZOL 3 YL] 2 [4 (IMIDAZO[1,2 A]PYRIDIN 6 YL)PHENY])ACETAMIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR; REARRANGED DURING TRANSFECTION KINASE; UNCLASSIFIED DRUG; PROTEIN RET;

ARTICLE; CHEMICAL REACTION; ENZYME INHIBITION; MULTICOMPONENT REACTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG DEVELOPMENT; HUMAN; METABOLISM; SYNTHESIS;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907817021 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2014.09.023 Document Type: Article

Times cited : (22)

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