Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1480-1483

  Akritopoulou Zanze, Irini ^a   Wakefield, Brian D ^a   Gasiecki, Alan ^a   Kalvin, Douglas ^a,b   Johnson, Eric F ^a   Kovar, Peter ^a   Djuric, Stevan W ^a  

^a ABBOTT LABORATORIES   (United States)

^b NONE   (United States)

Author keywords

Egfr inhibitors; Gsk3 inhibitors; Imidazopyridines; Imidazopyrimidine; Kinase inhibitors; Kinase scaffolds; MCR; multicomponent reactions; Rock2 inhibitors; Van Leusen reactions

Indexed keywords

AURORA B KINASE; AURORA KINASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; P21 ACTIVATED KINASE 4; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE PIM 1; PYRIMIDINE DERIVATIVE; RHO KINASE; RHO KINASE 2; RHO KINASE INHIBITOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; SUBSTITUTION REACTION;

DRUG DESIGN; HETEROCYCLIC COMPOUNDS; INDAZOLES; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951723545     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.001     Document Type: Article

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