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Volumn 96, Issue 16, 2004, Pages 1231-1239

Role of MEN2A-derived RET in maintenace and proliferation of medullary thyroid carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CELL CYCLE PROTEIN; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; PROTEIN RET; AKT1 PROTEIN, HUMAN; BROXURIDINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RET PROTEIN, HUMAN; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

EID: 4344566311     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/djh226     Document Type: Article
Times cited : (66)

References (45)
  • 1
    • 0035952364 scopus 로고    scopus 로고
    • Thyroid cancer
    • Gimm O. Thyroid cancer. Cancer Lett 2001;163:143-56.
    • (2001) Cancer Lett. , vol.163 , pp. 143-156
    • Gimm, O.1
  • 2
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995
    • Hundahl SA, Fleming ID, Fremgen AN, Menck HR. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995. Cancer 1998;83:2638-48.
    • (1998) Cancer , vol.83 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.N.3    Menck, H.R.4
  • 4
    • 0027231568 scopus 로고
    • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    • Mulligan LM, Kwok JB, Healey CS, Elsdon MJ, Eng C, Gardner E, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 1993;363:458-60.
    • (1993) Nature , vol.363 , pp. 458-460
    • Mulligan, L.M.1    Kwok, J.B.2    Healey, C.S.3    Elsdon, M.J.4    Eng, C.5    Gardner, E.6
  • 5
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 1995;15:1613-9.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 6
    • 0035479144 scopus 로고    scopus 로고
    • The RET receptor: Function in development and dysfunction in congenital malformation
    • Manie S, Santoro M, Fusco A, Billaud M. The RET receptor: function in development and dysfunction in congenital malformation. Trends Genet 2001;17:580-9.
    • (2001) Trends Genet. , vol.17 , pp. 580-589
    • Manie, S.1    Santoro, M.2    Fusco, A.3    Billaud, M.4
  • 7
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994;367:380-3.
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 8
    • 0031720932 scopus 로고    scopus 로고
    • The MEN II syndromes and the role of the ret proto-oncogene
    • Ponder BA, Smith D. The MEN II syndromes and the role of the ret proto-oncogene. Adv Cancer Res 1996;70:179-222.
    • (1996) Adv. Cancer Res. , vol.70 , pp. 179-222
    • Ponder, B.A.1    Smith, D.2
  • 9
    • 0032894774 scopus 로고    scopus 로고
    • RET proto-oncogene in the development of human cancer
    • Eng C. RET proto-oncogene in the development of human cancer. J Clin Oncol 1999;17:380-93.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 380-393
    • Eng, C.1
  • 10
    • 0033729031 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2 and RET: From neoplasia to neurogenesis
    • Hansford D, Mulligan LM. Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis. J Med Genet 2000;37:817-27.
    • (2000) J. Med. Genet , vol.37 , pp. 817-827
    • Hansford, D.1    Mulligan, L.M.2
  • 11
    • 0034849573 scopus 로고    scopus 로고
    • The GDNF/RET signaling pathway and human diseases
    • Takahashi M. The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev 2001;12:361-73.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 361-373
    • Takahashi, M.1
  • 12
    • 0032241463 scopus 로고    scopus 로고
    • Signal transduction by the receptor tyrosine kinase Ret
    • van Weering DH, Bos JL. Signal transduction by the receptor tyrosine kinase Ret. Recent Results Cancer Res 1998;154:271-81.
    • (1998) Recent Results Cancer Res. , vol.154 , pp. 271-281
    • van Weering, D.H.1    Bos, J.L.2
  • 13
    • 0034967978 scopus 로고    scopus 로고
    • Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
    • Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, et al. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 2001;21:4177-87.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 4177-4187
    • Melillo, R.M.1    Santoro, M.2    Ong, S.H.3    Billaud, M.4    Fusco, A.5    Hadari, Y.R.6
  • 14
    • 0034671913 scopus 로고    scopus 로고
    • Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-RET receptor tyrosine kinase
    • Besset V, Scott RP, Ibanez CF. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-RET receptor tyrosine kinase. J Biol Chem 2000;275:39159-66.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39159-39166
    • Besset, V.1    Scott, R.P.2    Ibanez, C.F.3
  • 15
    • 0034603172 scopus 로고    scopus 로고
    • Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
    • Segouffin-Cariou C, Billaud M. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. J Biol Chem 2000;275:3568-76.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3568-3576
    • Segouffin-Cariou, C.1    Billaud, M.2
  • 16
    • 85047697611 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    • Baldassarre G, Bruni P, Boccia A, Salvatore G, Melillo RM, Motti ML, et al. Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1). Oncogene 2002;21:1739-49.
    • (2002) Oncogene , vol.21 , pp. 1739-1749
    • Baldassarre, G.1    Bruni, P.2    Boccia, A.3    Salvatore, G.4    Melillo, R.M.5    Motti, M.L.6
  • 19
    • 0038235732 scopus 로고    scopus 로고
    • Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model
    • Drosten M, Stiewe T, Putzer BM. Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model. Hum Gene Ther 2003;14:971-82.
    • (2003) Hum. Gene. Ther. , vol.14 , pp. 971-982
    • Drosten, M.1    Stiewe, T.2    Putzer, B.M.3
  • 20
    • 0038277091 scopus 로고    scopus 로고
    • p73 is effective in p53-null pancreatic cancer cells resistant to wildtype TP53 gene replacement
    • Rodicker F, Putzer BM. p73 is effective in p53-null pancreatic cancer cells resistant to wildtype TP53 gene replacement. Cancer Res 2003;63:2737-41.
    • (2003) Cancer Res. , vol.63 , pp. 2737-2741
    • Rodicker, F.1    Putzer, B.M.2
  • 21
    • 0033869428 scopus 로고    scopus 로고
    • Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy
    • Putzer BM, Stiewe T, Crespo F, Esche H. Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy. Gene Ther 2000;7:1317-25.
    • (2000) Gene Ther. , vol.7 , pp. 1317-1325
    • Putzer, B.M.1    Stiewe, T.2    Crespo, F.3    Esche, H.4
  • 22
    • 0035811591 scopus 로고    scopus 로고
    • C-cell and thyroid epithelial tumours and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET
    • Reynolds L, Jones K, Winton DJ, Cranston A, Houghton C, Howard L, et al. C-cell and thyroid epithelial tumours and altered follicular development in transgenic mice expressing the long isoform of MEN 2A RET. Oncogene 2001;20:3986-94.
    • (2001) Oncogene , vol.20 , pp. 3986-3994
    • Reynolds, L.1    Jones, K.2    Winton, D.J.3    Cranston, A.4    Houghton, C.5    Howard, L.6
  • 23
    • 0029086344 scopus 로고
    • Intratumoral injection of an adenovirus expressing interkeukin 2 induced regression and immunity in murine breast cancer model
    • Addison CL, Braciak T, Ralston R, Muller WJ, Gauldie J, Graham FL. Intratumoral injection of an adenovirus expressing interkeukin 2 induced regression and immunity in murine breast cancer model. Proc Natl Acad Sci U S A 1995;92:8522-6.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 8522-8526
    • Addison, C.L.1    Braciak, T.2    Ralston, R.3    Muller, W.J.4    Gauldie, J.5    Graham, F.L.6
  • 24
    • 0041438719 scopus 로고    scopus 로고
    • Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model
    • Cranston AN, Ponder BA. Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model. Cancer Res 2003;63:4777-80.
    • (2003) Cancer Res. , vol.63 , pp. 4777-4780
    • Cranston, A.N.1    Ponder, B.A.2
  • 25
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 26
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
    • Chang F, Lee JT, Navolanic PM, Steelman RS, Shelton JG, Blalock WL, et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003;17:590-603.
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3    Steelman, R.S.4    Shelton, J.G.5    Blalock, W.L.6
  • 27
    • 0033848878 scopus 로고    scopus 로고
    • Integrating the MAP kinase signal into the G1 phase cell cycle machinery
    • Roovers K, Assoian RK. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 2000;22:818-26.
    • (2000) Bioessays , vol.22 , pp. 818-826
    • Roovers, K.1    Assoian, R.K.2
  • 28
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999;401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 29
    • 0034423508 scopus 로고    scopus 로고
    • The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
    • Grossmann M, O'Reilly LA, Gugasyan R, Strasser A, Adams JM, Gerondakis S. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J 2000;19:6351-60.
    • (2000) EMBO J. , vol.19 , pp. 6351-6360
    • Grossmann, M.1    O'Reilly, L.A.2    Gugasyan, R.3    Strasser, A.4    Adams, J.M.5    Gerondakis, S.6
  • 30
    • 0034320568 scopus 로고    scopus 로고
    • Mechanisms of apoptosis
    • Reed JC. Mechanisms of apoptosis. Am J Pathol 2000;157:1415-30.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1415-1430
    • Reed, J.C.1
  • 32
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002;4:E131-6.
    • (2002) Nat. Cell Biol. , vol.4
    • Shaulian, E.1    Karin, M.2
  • 33
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell cycle regulation by Ras and PKB through p27kip1. Nature 2000;404:782-7.
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 35
    • 0034941567 scopus 로고    scopus 로고
    • Akt-dependent phophorylation of p21 (Cip1) regulates PCNA binding and proliferation of endothelial cells
    • Rossig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S. Akt-dependent phophorylation of p21 (Cip1) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol 2001;21:5644-57.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 5644-5657
    • Rossig, L.1    Jadidi, A.S.2    Urbich, C.3    Badorff, C.4    Zeiher, A.M.5    Dimmeler, S.6
  • 36
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998;12:3499-511.
    • (1998) Genes Dev. , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 37
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 2001;98:247-52.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Vande Woude, G.F.5    Testa, J.R.6
  • 39
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol 3-kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL. Herceptin-induced inhibition of phosphatidylinositol 3-kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res 2002;62:4132-41.
    • (2002) Cancer Res. , vol.62 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 40
    • 0037302770 scopus 로고    scopus 로고
    • Oncogenic signaling pathways activated by RON receptor tyrosine kinase
    • Danilkovitch-Miagkova A. Oncogenic signaling pathways activated by RON receptor tyrosine kinase. Curr Cancer Drug Targets 2003;3:31-40.
    • (2003) Curr. Cancer Drug Targets , vol.3 , pp. 31-40
    • Danilkovitch-Miagkova, A.1
  • 41
    • 0031749287 scopus 로고    scopus 로고
    • Bcl-2 and c-Myc, but not bax and p53, are expressed during human medullary thyroid carcinoma tumorigenesis
    • Wang DG, Liu WH, Johnston CF, Sloan JM, Buchanan KD. Bcl-2 and c-Myc, but not bax and p53, are expressed during human medullary thyroid carcinoma tumorigenesis. Am J Pathol 1998;152:1407-13.
    • (1998) Am. J. Pathol. , vol.152 , pp. 1407-1413
    • Wang, D.G.1    Liu, W.H.2    Johnston, C.F.3    Sloan, J.M.4    Buchanan, K.D.5
  • 42
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl-2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM. The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 44
    • 0141592764 scopus 로고    scopus 로고
    • CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth
    • Strock CL, Park JI, Rosen M, Dionne C, Ruggeri B, Jones-Bolin S, et al. CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res 2003;63:5559-63.
    • (2003) Cancer Res. , vol.63 , pp. 5559-5563
    • Strock, C.L.1    Park, J.I.2    Rosen, M.3    Dionne, C.4    Ruggeri, B.5    Jones-Bolin, S.6


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