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European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2919-2927

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3- thienyl)nicotinonitrile scaffold

(6) Brandt, Wiebke a Mologni, Luca b Preu, Lutz a Lemcke, Thomas c Gambacorti Passerini, Carlo b Kunick, Conrad a

a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG (Germany)

b UNIVERSITY OF MILANO BICOCCA (Italy)

c UNIVERSITY OF HAMBURG (Germany)

Author keywords

Antiproliferative activity; Cancer cell line; Enzyme inhibition; RET tyrosine kinase

Indexed keywords

2 [(2 OXO 2 PHENYLETHYL)SULFANYL] 4 (3 THIENYL) 5,6,7,8 TETRAHYDROQUINOLINE 3 CARBONITRILE; 2 AMINO 6 [(2 OXO 2 PHENYLETHYL)SULFANYL] 4 (3 THIENYL)PYRIDINE 3,5 DICARBONITRILE; 2 AMINO 6 [[2 (4 CHLOROPHENYL) 2 OXOETHYL]SULFANYL] 4 (3 THIENYL)PYRIDINE 3,5 DICARBONITRILE; PROTEIN RET; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; THYROID CARCINOMA;

CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRILES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RET;

EID: 77954349443 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.03.017 Document Type: Article

Times cited : (48)

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