Nuclear Retention of the Tumor Suppressor cPML by the Homeodomain Protein TGIF Restricts TGF-β Signaling

Molecular Cell

Volumn 23, Issue 4, 2006, Pages 547-559

  Seo, Su Ryeon ^a   Ferrand, Nathalie ^a   Faresse, Nourdine ^a   Prunier, Céline ^c   Abécassis, Lucile ^b   Pessah, Marcia ^a   Bourgeade, Marie Francoise ^b   Atfi, Azeddine ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

SIGNALING

Indexed keywords

CYTOPLASMIC PROMYELOCYTIC LEUKEMIA PROTEIN; HOMEODOMAIN PROTEIN; PROTEIN C JUN; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH INTERACTING FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN RESTRICTION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DOGS; DOWN-REGULATION; EPITHELIAL CELLS; HOMEODOMAIN PROTEINS; HUMANS; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 33747174594     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.06.018     Document Type: Article

References (30)

1. Bohmann D., Bos T.J., Admon A., Nishimura T., Vogt P.K., and Tjian R. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238 (1987) 1386-1392
2. Chen X., Weisberg E., Fridmacher V., Watanabe M., Naco G., and Whitman M. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389 (1997) 85-89
3. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 103 (2000) 239-252
4. Dennler S., Prunier C., Ferrand N., Gauthier J.M., and Atfi A. c-Jun inhibits TGF-β-mediated transcription by repressing Smad3 transcriptional activity. J. Biol. Chem. 275 (2000) 28858-28865
5. Derynck R., Akhurst R.J., and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29 (2001) 117-129
6. Gripp K.W., Wotton D., Edwards M.C., Roessler E., Ades L., Meinecke P., Richieri-Costa A., Zackai E.H., Massague J., Muenke M., and Elledge S.J. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat. Genet. 25 (2000) 205-208
7. Heldin C.H., Miyazono K., and ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390 (1997) 465-471
8. Jonk L.J., Itoh S., Heldin C.H., ten Dijke P., and Kruijer W. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a TGF-β, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 273 (1998) 21145-21152
9. Lin H.K., Bergmann S., and Pandolfi P.P. Cytoplasmic PML function in TGF-β signalling. Nature 431 (2004) 205-211
10. Macías-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., and Wrana J.L. MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87 (1996) 1215-1224
11. Massague J., and Chen Y.G. Controlling TGF-β signaling. Genes Dev. 14 (2000) 627-644
12. Melhuish T.A., and Wotton D. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275 (2000) 39762-39766
13. Pessah M., Prunier C., Marais J., Ferrand N., Mazars A., Lallemand F., Gauthier J.M., and Atfi A. c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. Proc. Natl. Acad. Sci. USA 98 (2001) 6198-6203
14. Piazza F., Gurrieri C., and Pandolfi P.P. The theory of APL. Oncogene 20 (2001) 7216-7222
15. Prunier C., Ferrand N., Frottier B., Pessah M., and Atfi A. Mechanism for mutational inactivation of the tumor suppressor Smad2. Mol. Cell. Biol. 21 (2001) 3302-3313
16. Ramana C.V., Gil M.P., Han Y., Ransohoff R.M., Schreiber R.D., and Stark G.R. Stat1-independent regulation of gene expression in response to IFN-γ. Proc. Natl. Acad. Sci. USA 98 (2001) 6674-6679
17. Salomoni P., and Pandolfi P.P. The role of PML in tumor suppression. Cell 108 (2002) 165-170
18. Salomoni P., Bernardi R., Bergmann S., Changou A., Tuttle S., and Pandolfi P.P. The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. Blood 105 (2005) 3686-3690
19. Seo S.R., Lallemand F., Ferrand N., Pessah M., L'Hoste S., Camonis J., and Atfi A. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 23 (2004) 3780-3792
20. Shi Y., and Massague J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
21. Stroschein S.L., Wang W., Zhou S., Zhou Q., and Luo K. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 286 (1999) 771-774
22. Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., and Wrana J.L. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95 (1998) 779-791
23. Ventura J.J., Kennedy N.J., Lamb J.A., Flavell R.A., and Davis R.J. c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol. Cell. Biol. 23 (2003) 2871-2882
24. Ventura J.J., Kennedy N.J., Flavell R.A., and Davis R.J. JNK regulates autocrine expression of TGF-β1. Mol. Cell 15 (2004) 269-278
25. Verrecchia F., Pessah M., Atfi A., and Mauviel A. TNF-α inhibits TGF-β/Smad signaling in human dermal fibroblasts via AP-1 activation. J. Biol. Chem. 275 (2000) 30226-30231
26. Whitman M. Smads and early developmental signaling by the TGFβ superfamily. Genes Dev. 12 (1998) 2445-2462
27. Wotton D., Lo R.S., Lee S., and Massague J. A Smad transcriptional corepressor. Cell 97 (1999) 29-39
28. Wotton D., Knoepfler P.S., Laherty C.D., Eisenman R.N., and Massague J. The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ. 12 (2001) 457-463
29. Wrana J.L. Regulation of Smad activity. Cell 100 (2000) 189-192
30. Yu L., Hebert M.C., and Zhang Y.E. TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J. 21 (2002) 3749-3759