Characterisation of a K390R ITK kinase dead transgenic mouse - Implications for ITK as a therapeutic target

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Deakin, Angela ^a   Duddy, Graham ^a   Wilson, Steve ^a   Harrison, Steve ^a   Latcham, Judi ^a   Fulleylove, Mick ^a   Fung, Sylvia ^a   Smith, Jason ^a   Pedrick, Mike ^a   McKevitt, Tom ^a   Felton, Leigh ^a   Morley, Joanne ^a   Quint, Diana ^a   Fattah, Dilniya ^a   Hayes, Brian ^a   Gough, Jade ^a   Solari, Roberto ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; F ACTIN; INTERLEUKIN 2 INDUCIBLE TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CD3 ANTIGEN; EMT PROTEIN-TYROSINE KINASE; ENZYME INHIBITOR; ICOS PROTEIN, MOUSE; IMMUNOGLOBULIN G; INDUCIBLE T CELL COSTIMULATOR; LYMPHOCYTE ANTIGEN RECEPTOR; OVALBUMIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BLOOD LEVEL; CD3+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GAMMA DELTA T LYMPHOCYTE; GENE; GENE FREQUENCY; IMMUNOPHENOTYPING; INTERLEUKIN 2 INDUCIBLE TYROSINE KINASE GENE; LYMPHOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN TARGETING; TH2 CELL; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BLOOD; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE COUNT; METABOLISM; PNEUMONIA; SPLEEN; T LYMPHOCYTE; TRANSGENIC MOUSE; WESTERN BLOTTING;

MUS MUSCULUS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD3; BLOTTING, WESTERN; CYTOKINES; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN G; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; LYMPHOCYTE COUNT; MALE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; PNEUMONIA; POINT MUTATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPLEEN; T-LYMPHOCYTES; TH2 CELLS;

EID: 84907588749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107490     Document Type: Article

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