IL-13 overexpression in mouse lungs triggers systemic genotoxicity in peripheral blood

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 769, Issue , 2014, Pages 100-107

  Chapman, Aaron M ^a   Malkin, Daniel J ^a   Camacho, Jessica ^a   Schiestl, Robert H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asthma; Genotoxicity; IL 13

Indexed keywords

INTERLEUKIN 13;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BLOOD; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; DNA STRAND BREAKAGE; ERYTHROBLAST; GENE OVEREXPRESSION; GENOTOXICITY; INFLAMMATION; LEUKOCYTE; MICRONUCLEUS; MOUSE; NITRATION; NONHUMAN; OXIDATIVE STRESS; ANIMAL; DISEASE MODEL; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; TH2 CELL; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; DNA DAMAGE; INFLAMMATION; INTERLEUKIN-13; LEUKOCYTES; LUNG; MICE; MICE, TRANSGENIC; TH2 CELLS; UP-REGULATION;

EID: 84907528998     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2014.06.007     Document Type: Article

References (49)

1. Akinbami L.J., Moorman J.E., Liu X. Asthma prevalence, health care use, and mortality: United States, 2005-2009. Natl. Health Stat. Rep. 2011, 32:1-14.
2. Miller A.L. The etiologies, pathophysiology, and alternative/complementary treatment of asthma. Altern. Med. Rev. 2001, 6:20-47.
3. Romanet-Manent S., Charpin D., Magnan A., Lanteaume A., Vervloet D. Allergic vs nonallergic asthma: what makes the difference. Allergy 2002, 57:607-613.
4. Fireman P. Understanding asthma pathophysiology. Allergy Asthma Proc. 2003, 24:79-83.
5. Hyde D.M., Miller L.A., Schelegle E.S., et al. Asthma: a comparison of animal models using stereological methods. Eur. Respir. Rev. 2006, 15:122-135.
6. Bradley B.L., Azzawi M., Jacobson M., et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 1991, 88:661-674.
7. Henderson W.R., Lewis D.B., Albert R.K., et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J. Exp. Med. 1996, 184:1483-1494.
8. Zimmermann N., King N.E., Laporte J., et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J. Clin. Invest. 2003, 111:1863-1874.
9. Harrington L.E., Hatton R.D., Mangan P.R., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6:1123-1132.
10. Akdis M., Burgler S., Crameri R., et al. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases. J. Allergy Clin. Immunol. 2011, 127:701-721. (e770).
11. Chatila T.A. Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends Mol. Med. 2004, 10:493-499.
12. Jiang H., Harris M.B., Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 2000, 105:1063-1070.
13. Cohn L., Elias J.A., Chupp G.L. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 2004, 22:789-815.
14. Medoff B.D., Thomas S.Y., Luster A.D. T cell trafficking in allergic asthma: the ins and outs. Annu. Rev. Immunol. 2008, 26:205-232.
15. Munitz A., Brandt E.B., Mingler M., Finkelman F.D., Rothenberg M.E. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7240-7245.
16. Wills-Karp M., Luyimbazi J., Xu X., et al. Interleukin-13: central mediator of allergic asthma. Science 1998, 282:2258-2261.
17. Westbrook A.M., Wei B., Braun J., Schiestl R.H. Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res. 2009, 69:4827-4834.
18. Zhu Z., Ma B., Homer R.J., Zheng T., Elias J.A. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 2001, 276:25222-25229.
19. Zheng T., Zhu Z., Wang Z., et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 2000, 106:1081-1093.
20. Goldstine J.V., Nahas S., Gamo K., et al. Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity. DNA Rep. (Amst.) 2006, 5:432-443.
21. Muslimovic A., Ismail I.H., Gao Y., Hammarsten O. An optimized method for measurement of gamma-H2AX in blood mononuclear and cultured cells. Nat. Protoc. 2008, 3:1187-1193.
22. Hayashi M., Tice R.R., MacGregor J.T., et al. In vivo rodent erythrocyte micronucleus assay. Mutat. Res. 1994, 312:293-304.
23. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
24. Smith C.C., O'Donovan M.R., Martin E.A. hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis 2006, 21:185-190.
25. Hamelmann E., Tadeda K., Oshiba A., Gelfand E.W. Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness - a murine model. Allergy 1999, 54:297-305.
26. Mora J., Riggs E.K., Fu J., et al. Expression of the high affinity IgE receptor by neutrophils of individuals with allergic asthma is both minimal and insensitive to regulation by serum IgE. Clin. Immunol. 2009, 132:132-140.
27. Wang X.H., Zhao W., Liu S.G., Feng X.P. Correlation of IL-4 and IL-13 gene polymorphisms with asthma and total serum IgE levels. Zhonghua Jie He He Hu Xi Za Zhi 2009, 32:161-164.
28. Elias J.A., Zheng T., Lee C.G., et al. Transgenic modeling of interleukin-13 in the lung. Chest 2003, 123:339s-345s.
29. Westbrook A.M., Schiestl R.H. ATM-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer Res. 2010, 70:1875-1884.
30. Bonner W.M., Redon C.E., Dickey J.S., et al. GammaH2AX and cancer. Nat. Rev. Cancer. 2008, 8:957-967.
31. Hasbal C., Aksu B.Y., Himmetoglu S., et al. DNA damage and glutathione level in children with asthma bronchiale: effect of antiasthmatic therapy. Pediatr. Allergy Immunol. 2010, 21:e674-e678.
32. Luzina I.G., Keegan A.D., Heller N.M., Rook G.A., Shea-Donohue T., Atamas S.P. Regulation of inflammation by interleukin-4: a review of alternatives. J. Leukoc. Biol. 2012, 92:753-764.
33. Bosse Y., Lemire M., Poon A.H., et al. Asthma and genes encoding components of the vitamin D pathway. Respir. Res. 2009, 10:98.
34. Grunig G., Warnock M., Wakil A.E., et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998, 282:2261-2263.
35. Conroy D.M., Humbles A.A., Rankin S.M., et al. The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation. Mem. Inst. Oswaldo Cruz 1997, 92(Suppl. 2):183-191.
36. Ma B., Liu W., Homer R.J., et al. Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 2006, 176:4968-4978.
37. Wynn T.A. IL-13 effector functions. Annu. Rev. Immunol. 2003, 21:425-456.
38. Vanoirbeek J.A., Tarkowski M., De Vooght V., Nemery B., Hoet P.H. Immunological determinants in a mouse model of chemical-induced asthma after multiple exposures. Scand. J. Immunol. 2009, 70:25-33.
39. Humbles A.A., Conroy D.M., Marleau S., et al. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J. Exp. Med. 1997, 186:601-612.
40. Valdiglesias V., Giunta S., Fenech M., Neri M., Bonassi S. gammaH2AX as a marker of DNA double strand breaks and genomic instability in human population studies. Mutat. Res. 2013, 753(1):24-40.
41. Yamamoto M.L., Reliene R., Oshima J., Schiestl R.H. Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice. Mutat. Res. 2008, 644:11-16.
42. Evans M.D., Dizdaroglu M., Cooke M.S. Oxidative DNA damage and disease: induction, repair and significance. Mutat. Res. 2004, 567:1-61.
43. Fortini P., Pascucci B., Parlanti E., D'Errico M., Simonelli V., Dogliotti E. 8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways. Mutat. Res. 2003, 531:127-139.
44. Westbrook A.M., Wei B., Braun J., Schiestl R.H. Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice. Int. J. Cancer 2011, 129:1815-1825.
45. Kamath A.V., Pavord I.D., Ruparelia P.R., Chilvers E.R. Is the neutrophil the key effector cell in severe asthma. Thorax 2005, 60:529-530.
46. Boffetta P., Ye W., Boman G., Nyren Lung cancer risk in a population-based cohort of patients hospitalized for asthma in Sweden. Eur. Respir. J. 2002, 19:127-133.
47. Brown D.W., Young K.E., Anda R.F., Felitti V.J., Giles W.H. Re: asthma and the risk of lung cancer. findings from the Adverse Childhood Experiences (ACE). Cancer Causes Cont. 2006, 17:349-350.
48. Garcia Sanz M.T., Gonzalez Barcala F.J., Alvarez Dobano J.M., Valdes Cuadrado L. Asthma and risk of lung cancer. Clin. Transl. Oncol. 2011, 13:728-730.
49. Zeyrek D., Cakmak A., Atas A., Kocyigit A., Erel O. DNA damage in children with asthma bronchiale and its association with oxidative and antioxidative measurements. Pediatr. Allergy Immunol. 2009, 20:370-376.