CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 808-812

  Chen, Yan ^a   Wang, Zaizhu ^a   Wang, Ping ^a   Li, Dengwen ^a   Zhou, Jun ^a   Wu, Shian ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

dCYLD; Drosophila; Hippo; Phosphorylation; Signaling

Indexed keywords

DEUBIQUITINASE; CYLD PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; HPO PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; THREONINE; TRANSACTIVATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; YORKIE PROTEIN, DROSOPHILA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; ENZYME ACTIVITY; ENZYME LOCALIZATION; HIPPO GENE; IMMUNOPRECIPITATION; MALE; NONHUMAN; PLASMID; PROTEIN PHOSPHORYLATION; REGULATOR GENE; SIGNAL TRANSDUCTION; TRANSGENE; TUMOR SUPPRESSOR GENE; ANIMAL; CELL LINE; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; CELL LINE; CYTOPLASM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; THREONINE; TRANS-ACTIVATORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84907507646     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.005     Document Type: Article

References (40)

1. G. Halder, and R.L. Johnson Hippo signaling: growth control and beyond Development 138 2011 9 22
2. K. Harvey, and N. Tapon The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network Nat. Rev. Cancer 7 2007 182 191
3. D. Pan The hippo signaling pathway in development and cancer Dev. Cell 19 2010 491 505
4. S. Wu, J. Huang, J. Dong, and D. Pan Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts Cell 114 2003 445 456
5. R.S. Udan, M. Kango-Singh, R. Nolo, C. Tao, and G. Halder Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway Nat. Cell Biol. 5 2003 914 920
6. K.F. Harvey, C.M. Pfleger, and I.K. Hariharan The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis Cell 114 2003 457 467
7. S. Pantalacci, N. Tapon, and P. Leopold The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila Nat. Cell Biol. 5 2003 921 927
8. Z.C. Lai, X. Wei, T. Shimizu, E. Ramos, M. Rohrbaugh, N. Nikolaidis, L.L. Ho, and Y. Li Control of cell proliferation and apoptosis by mob as tumor suppressor, mats Cell 120 2005 675 685
9. J. Huang, S. Wu, J. Barrera, K. Matthews, and D. Pan The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP Cell 122 2005 421 434
10. G.R. Bignell, W. Warren, S. Seal, M. Takahashi, E. Rapley, R. Barfoot, H. Green, C. Brown, P.J. Biggs, S.R. Lakhani, C. Jones, J. Hansen, E. Blair, B. Hofmann, R. Siebert, G. Turner, D.G. Evans, C. Schrander-Stumpel, F.A. Beemer, A. van Den Ouweland, D. Halley, B. Delpech, M.G. Cleveland, I. Leigh, J. Leisti, and S. Rasmussen Identification of the familial cylindromatosis tumour-suppressor gene Nat. Genet. 25 2000 160 165
11. R. Massoumi CYLD: a deubiquitination enzyme with multiple roles in cancer Future Oncol. 7 2011 285 297
12. S.M. Nijman, T.T. Huang, A.M. Dirac, T.R. Brummelkamp, R.M. Kerkhoven, A.D. D'Andrea, and R. Bernards The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway Mol. Cell 17 2005 331 339
13. T.R. Brummelkamp, S.M. Nijman, A.M. Dirac, and R. Bernards Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB Nature 424 2003 797 801
14. A. Kovalenko, C. Chable-Bessia, G. Cantarella, A. Israel, D. Wallach, and G. Courtois The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination Nature 424 2003 801 805
15. E. Trompouki, E. Hatzivassiliou, T. Tsichritzis, H. Farmer, A. Ashworth, and G. Mosialos CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members Nature 424 2003 793 796
16. R. Massoumi, K. Chmielarska, K. Hennecke, A. Pfeifer, and R. Fassler Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling Cell 125 2006 665 677
17. W. Reiley, M. Zhang, and S.C. Sun Negative regulation of JNK signaling by the tumor suppressor CYLD J. Biol. Chem. 279 2004 55161 55167
18. L. Xue, T. Igaki, E. Kuranaga, H. Kanda, M. Miura, and T. Xu Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila Dev. Cell 13 2007 446 454
19. W.W. Reiley, M. Zhang, W. Jin, M. Losiewicz, K.B. Donohue, C.C. Norbury, and S.C. Sun Regulation of T cell development by the deubiquitinating enzyme CYLD Nat. Immunol. 7 2006 411 417
20. D.V. Tauriello, A. Haegebarth, I. Kuper, M.J. Edelmann, M. Henraat, M.R. Canninga-van Dijk, B.M. Kessler, H. Clevers, and M.M. Maurice Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl Mol. Cell 37 2010 607 619
21. Y. Zhao, A.M. Thornton, M.C. Kinney, C.A. Ma, J.J. Spinner, I.J. Fuss, E.M. Shevach, and A. Jain The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor beta (TGF-beta) signaling and the development of regulatory T cells J. Biol. Chem. 286 2011 40520 40530
22. J.H. Lim, H. Jono, K. Komatsu, C.H. Woo, J. Lee, M. Miyata, T. Matsuno, X. Xu, Y. Huang, W. Zhang, S.H. Park, Y.I. Kim, Y.D. Choi, H. Shen, K.S. Heo, H. Xu, P. Bourne, T. Koga, H. Xu, C. Yan, B. Wang, L.F. Chen, X.H. Feng, and J.D. Li CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt Nat. Commun. 3 2012 771
23. S.J. Simonson, Z.H. Wu, and S. Miyamoto CYLD: a DUB with many talents Dev. Cell 13 2007 601 603
24. K. Saito, T. Kigawa, S. Koshiba, K. Sato, Y. Matsuo, A. Sakamoto, T. Takagi, M. Shirouzu, T. Yabuki, E. Nunokawa, E. Seki, T. Matsuda, M. Aoki, Y. Miyata, N. Hirakawa, M. Inoue, T. Terada, T. Nagase, R. Kikuno, M. Nakayama, O. Ohara, A. Tanaka, and S. Yokoyama The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma Structure 12 2004 1719 1728
25. T. Tsichritzis, P.C. Gaentzsch, S. Kosmidis, A.E. Brown, E.M. Skoulakis, P. Ligoxygakis, and G. Mosialos A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense Development 134 2007 2605 2614
26. J. Gao, L. Huo, X. Sun, M. Liu, D. Li, J.T. Dong, and J. Zhou The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration J. Biol. Chem. 283 2008 8802 8809
27. S.A. Wickstrom, K.C. Masoumi, S. Khochbin, R. Fassler, and R. Massoumi CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin EMBO J. 29 2010 131 144
28. Y. Yang, M. Liu, D. Li, J. Ran, J. Gao, S. Suo, S.C. Sun, and J. Zhou CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation Proc. Natl. Acad. Sci. U.S.A. 111 2014 2158 2163
29. Y. Jin, L. Dong, Y. Lu, W. Wu, Q. Hao, Z. Zhou, J. Jiang, Y. Zhao, and L. Zhang Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control J. Biol. Chem. 287 2012 5784 5796
30. S. Wu, Y. Liu, Y. Zheng, J. Dong, and D. Pan The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway Dev. Cell 14 2008 388 398
31. C. Florindo, J. Perdigao, D. Fesquet, E. Schiebel, J. Pines, and A.A. Tavares Human Mob1 proteins are required for cytokinesis by controlling microtubule stability J. Cell Sci. 125 2012 3085 3090
32. E.P. Lucas, I. Khanal, P. Gaspar, G.C. Fletcher, C. Polesello, N. Tapon, and B.J. Thompson The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells J. Cell Biol. 201 2013 875 885
33. W. Li, J. Cooper, L. Zhou, C. Yang, H. Erdjument-Bromage, D. Zagzag, M. Snuderl, M. Ladanyi, C.O. Hanemann, P. Zhou, M.A. Karajannis, and F.G. Giancotti Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the Hippo pathway kinases Lats1 and 2 in the nucleus Cancer Cell 26 2014 48 60
34. C.L. Poon, J.I. Lin, X. Zhang, and K.F. Harvey The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway Dev. Cell 21 2011 896 906
35. J.C. Boggiano, P.J. Vanderzalm, and R.G. Fehon Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway Dev. Cell 21 2011 888 895
36. S.C. Sun CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes Cell Death Differ. 17 2010 25 34
37. L. Sun, J. Gao, L. Huo, X. Sun, X. Shi, M. Liu, D. Li, C. Zhang, and J. Zhou Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B J. Pathol. 221 2010 425 432
38. P.S. Ribeiro, F. Josue, A. Wepf, M.C. Wehr, O. Rinner, G. Kelly, N. Tapon, and M. Gstaiger Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling Mol. Cell 39 2010 521 534
39. H.L. Huang, S. Wang, M.X. Yin, L. Dong, C. Wang, W. Wu, Y. Lu, M. Feng, C. Dai, X. Guo, L. Li, B. Zhao, Z. Zhou, H. Ji, J. Jiang, Y. Zhao, X.Y. Liu, and L. Zhang Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association PLoS Biol. 11 2013 e1001620
40. B. Zhao, L. Li, L. Wang, C.Y. Wang, J. Yu, and K.L. Guan Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis Genes Dev. 26 2012 54 68