Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa

Journal of Neuroscience

Volumn 34, Issue 40, 2014, Pages 13336-13348

  Tam, Beatrice M ^a   Noorwez, Syed M ^b   Kaushal, Shalesh ^b,d   Kono, Masahiro ^c   Moritz, Orson L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Retina Specialty Institute   (United States)

Author keywords

Cell death; Glycosylation; Instability; Misfolding; Retinitis pigmentosa; Rhodopsin

Indexed keywords

COMPLEMENTARY DNA; RESTRICTION ENDONUCLEASE; RETINOL; RHODOPSIN; SCOTOPSIN; T17M RHODOPSIN; T4K RHODOPSIN; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; BLEACHING; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA SEQUENCE; DOT HYBRIDIZATION; EXPRESSION VECTOR; FOOD DEPRIVATION; GENETIC TRANSFECTION; HEK293 CELL LINE; HERMOSTABILITY; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIGHT EXPOSURE; NONHUMAN; PHOTOACTIVATION; PHOTORECEPTOR; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RETINA DEGENERATION; RETINITIS PIGMENTOSA; RETINOL DEPRIVATION; SEQUENCE ANALYSIS; UPREGULATION; XENOPUS LAEVIS; ANALYSIS OF VARIANCE; ANIMAL; CHLOROCEBUS AETHIOPS; COMPLICATION; COS 1 CELL LINE; DIET THERAPY; DISEASE MODEL; GENETICS; LIGHT; METABOLISM; MUTATION; NONPARAMETRIC TEST; PATHOLOGY; RETINA ROD OUTER SEGMENT; RETINAL DEGENERATION; TRANSGENIC ANIMAL;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CERCOPITHECUS AETHIOPS; COS CELLS; DISEASE MODELS, ANIMAL; HUMANS; LIGHT; MICROSCOPY, CONFOCAL; MUTATION; RETINAL DEGENERATION; RETINITIS PIGMENTOSA; RHODOPSIN; ROD CELL OUTER SEGMENT; STATISTICS, NONPARAMETRIC; TRANSFECTION; VITAMIN A; WHEAT GERM AGGLUTININS; XENOPUS LAEVIS;

EID: 84907484404     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1655-14.2014     Document Type: Article

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