-
1
-
-
84860535483
-
Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes
-
Balasubramaniyan N, Ananthanarayanan M, and Suchy FJ (2012) Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes. Am J Physiol Gastrointest Liver Physiol 302:G937-G947.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
-
-
Balasubramaniyan, N.1
Ananthanarayanan, M.2
Suchy, F.J.3
-
3
-
-
56749130032
-
Structure of the intact PPAR-gamma-RXR-nuclear receptor complex on DNA
-
Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, and Rastinejad F (2008) Structure of the intact PPAR-gamma-RXR-nuclear receptor complex on DNA. Nature 456:350-356.
-
(2008)
Nature
, vol.456
, pp. 350-356
-
-
Chandra, V.1
Huang, P.2
Hamuro, Y.3
Raghuram, S.4
Wang, Y.5
Burris, T.P.6
Rastinejad, F.7
-
4
-
-
32244444118
-
Structural basis for the methylation site specificity of SET7/9
-
DOI 10.1038/nsmb1045, PII NSMB1045
-
Couture JF, Collazo E, Hauk G, and Trievel RC (2006) Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol 13:140-146. (Pubitemid 43214717)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.2
, pp. 140-146
-
-
Couture, J.-F.1
Collazo, E.2
Hauk, G.3
Trievel, R.C.4
-
5
-
-
80052591715
-
Substrate and product specificities of SET domain methyltransferases
-
Del Rizzo PA and Trievel RC (2011) Substrate and product specificities of SET domain methyltransferases. Epigenetics 6:1059-1067.
-
(2011)
Epigenetics
, vol.6
, pp. 1059-1067
-
-
Del Rizzo, P.A.1
Trievel, R.C.2
-
6
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
DOI 10.1016/S1097-2765(03)00104-7
-
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, and Edwards PA et al. (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell 11: 1079-1092. (Pubitemid 36566328)
-
(2003)
Molecular Cell
, vol.11
, Issue.4
, pp. 1079-1092
-
-
Downes, M.1
Verdecia, M.A.2
Roecker, A.J.3
Hughes, R.4
Hogenesch, J.B.5
Kast-Woelbern, H.R.6
Bowman, M.E.7
Ferrer, J.-L.8
Anisfeld, A.M.9
Edwards, P.A.10
Rosenfeld, J.M.11
Alvarez, J.G.A.12
Noel, J.P.13
Nicolaou, K.C.14
Evans, R.M.15
-
7
-
-
85023202760
-
Comparative protein structure modeling using Modeller
-
Eswar N, Webb B, Marti-Renom MA, Madhusudhan MS, Eramian D, Shen MY, Pieper U, and Sali A (2006) Comparative protein structure modeling using Modeller. Curr Protoc Bioinformatics 15:5.6.1-5.6.30.
-
(2006)
Curr Protoc Bioinformatics
, vol.15
, pp. 561-5630
-
-
Eswar, N.1
Webb, B.2
Marti-Renom, M.A.3
Madhusudhan, M.S.4
Eramian, D.5
Shen, M.Y.6
Pieper, U.7
Sali, A.8
-
8
-
-
58049206267
-
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP
-
Fang S, Tsang S, Jones R, Ponugoti B, Yoon H, Wu SY, Chiang CM, Willson TM, and Kemper JK (2008) The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem 283:35086-35095.
-
(2008)
J Biol Chem
, vol.283
, pp. 35086-35095
-
-
Fang, S.1
Tsang, S.2
Jones, R.3
Ponugoti, B.4
Yoon, H.5
Wu, S.Y.6
Chiang, C.M.7
Willson, T.M.8
Kemper, J.K.9
-
9
-
-
0346971105
-
Performance comparison of generalized Born and Poisson methods in the calculation of electrostatic solvation energies for protein structures
-
Feig M, Onufriev A, Lee MS, Im W, Case DA, and Brooks CL, 3rd (2004) Performance comparison of generalized Born and Poisson methods in the calculation of electrostatic solvation energies for protein structures. J Comput Chem 25:265-284.
-
(2004)
J Comput Chem
, vol.25
, pp. 265-284
-
-
Feig, M.1
Onufriev, A.2
Lee, M.S.3
Im, W.4
Case, D.A.5
Brooks III, C.L.6
-
10
-
-
4143114765
-
Acetylation of nuclear receptors in cellular growth and apoptosis
-
DOI 10.1016/j.bcp.2004.05.037, PII S0006295204003776
-
Fu M, Wang C, Zhang X, and Pestell RG (2004) Acetylation of nuclear receptors in cellular growth and apoptosis. Biochem Pharmacol 68:1199-1208. (Pubitemid 39094285)
-
(2004)
Biochemical Pharmacology
, vol.68
, Issue.6
, pp. 1199-1208
-
-
Fu, M.1
Wang, C.2
Zhang, X.3
Pestell, R.G.4
-
11
-
-
80054980515
-
Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes fromGanoderma lucidum
-
Grienke U, Mihály-Bison J, Schuster D, Afonyushkin T, Binder M, Guan SH, Cheng CR, Wolber G, Stuppner H, and Guo DA et al. (2011) Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes fromGanoderma lucidum. Bioorg Med Chem 19:6779-6791.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 6779-6791
-
-
Grienke, U.1
Mihály-Bison, J.2
Schuster, D.3
Afonyushkin, T.4
Binder, M.5
Guan, S.H.6
Cheng, C.R.7
Wolber, G.8
Stuppner, H.9
Guo, D.A.10
-
12
-
-
84865484646
-
Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms
-
Hollman DA, Milona A, van Erpecum KJ, and van Mil SW (2012) Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms. Biochim Biophys Acta 1821:1443-1452.
-
(2012)
Biochim Biophys Acta
, vol.1821
, pp. 1443-1452
-
-
Hollman, D.A.1
Milona, A.2
Van Erpecum, K.J.3
Van Mil, S.W.4
-
13
-
-
0032910957
-
CREB-Binding protein acetylates hematopoietic transcription factor GATA- 1 at functionally important sites
-
Hung HL, Lau J, Kim AY, Weiss MJ, and Blobel GA (1999) CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol Cell Biol 19:3496-3505. (Pubitemid 29193809)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.5
, pp. 3496-3505
-
-
Hung, H.-L.1
Lau, J.2
Kim, A.Y.3
Weiss, M.J.4
Blobel, G.A.5
-
14
-
-
79958285869
-
Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications
-
Kemper JK (2011) Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications. Biochim Biophys Acta 1812:842-850.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 842-850
-
-
Kemper, J.K.1
-
15
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, and Veenstra TD (2009) FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab 10:392-404.
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
Tsang, S.7
Wu, S.Y.8
Chiang, C.M.9
Veenstra, T.D.10
-
16
-
-
32944469082
-
A decade of histone acetylation: Marking eukaryotic chromosomes with specific codes
-
DOI 10.1093/jb/mvi184
-
Kimura A, Matsubara K, and Horikoshi M (2005) A decade of histone acetylation: Marking eukaryotic chromosomes with specific codes. J Biochem 138: 647-662. (Pubitemid 43258858)
-
(2005)
Journal of Biochemistry
, vol.138
, Issue.6
, pp. 647-662
-
-
Kimura, A.1
Matsubara, K.2
Horikoshi, M.3
-
17
-
-
30844445030
-
FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine
-
DOI 10.1194/jlr.M500417-JLR200
-
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, and Edwards PA (2006) FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res 47:201-214. (Pubitemid 43107463)
-
(2006)
Journal of Lipid Research
, vol.47
, Issue.1
, pp. 201-214
-
-
Lee, H.1
Zhang, Y.2
Lee, F.Y.3
Nelson, S.F.4
Gonzalez, F.J.5
Edwards, P.A.6
-
18
-
-
34948883324
-
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
-
DOI 10.1016/j.molcel.2007.07.032, PII S109727650700620X
-
Li X, Zhang S, Blander G, Tse JG, Krieger M, and Guarente L (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 28: 91-106. (Pubitemid 47531974)
-
(2007)
Molecular Cell
, vol.28
, Issue.1
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
19
-
-
0042388117
-
Revisiting the structure and functions of the linker histone C-terminal tail domain
-
DOI 10.1139/o03-041
-
Lu X and Hansen JC (2003) Revisiting the structure and functions of the linker histone C-terminal tail domain. Biochem Cell Biol 81:173-176. (Pubitemid 37076239)
-
(2003)
Biochemistry and Cell Biology
, vol.81
, Issue.3
, pp. 173-176
-
-
Lu, X.1
Hansen, J.C.2
-
21
-
-
33749578940
-
Statistical potential for assessment and prediction of protein structures
-
DOI 10.1110/ps.062416606
-
Shen MY and Sali A (2006) Statistical potential for assessment and prediction of protein structures. Protein Sci 15:2507-2524. (Pubitemid 44771688)
-
(2006)
Protein Science
, vol.15
, Issue.11
, pp. 2507-2524
-
-
Shen, M.-Y.1
Sali, A.2
-
22
-
-
44449136869
-
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation
-
DOI 10.1073/pnas.0710981105
-
Soisson SM, Parthasarathy G, Adams AD, Sahoo S, Sitlani A, Sparrow C, Cui J, and Becker JW (2008) Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc Natl Acad Sci USA 105: 5337-5342. (Pubitemid 351753864)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.14
, pp. 5337-5342
-
-
Soisson, S.M.1
Parthasarathy, G.2
Adams, A.D.3
Sahoo, S.4
Sitlani, A.5
Sparrow, C.6
Cui, J.7
Becker, J.W.8
-
23
-
-
0033636892
-
Acetylation regulates transcription factor activity at multiple levels
-
Soutoglou E, Katrakili N, and Talianidis I (2000) Acetylation regulates transcription factor activity at multiple levels. Mol Cell 5:745-751.
-
(2000)
Mol Cell
, vol.5
, pp. 745-751
-
-
Soutoglou, E.1
Katrakili, N.2
Talianidis, I.3
-
25
-
-
36749060688
-
Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants
-
Sumimoto H, Kamakura S, and Ito T (2007) Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants. Sci STKE 2007:re6.
-
(2007)
Sci STKE
, vol.2007
-
-
Sumimoto, H.1
Kamakura, S.2
Ito, T.3
-
26
-
-
33745194374
-
Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter
-
Sun AQ, Balasubramaniyan N, Chen H, Shahid M, and Suchy FJ (2006) Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter. J Biol Chem 281:16410-16418.
-
(2006)
J Biol Chem
, vol.281
, pp. 16410-16418
-
-
Sun, A.Q.1
Balasubramaniyan, N.2
Chen, H.3
Shahid, M.4
Suchy, F.J.5
-
27
-
-
1942437477
-
+-dependent bile acid transporter: Protein-protein interaction and intracellular trafficking
-
DOI 10.1074/jbc.M312838200
-
Sun AQ, Balasubramaniyan N, Liu CJ, Shahid M, and Suchy FJ (2004) Association of the 16-kDa subunit c of vacuolar proton pump with the ileal Na1-dependent bile acid transporter: Protein-protein interaction and intracellular trafficking. J Biol Chem 279:16295-16300. (Pubitemid 38509324)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.16
, pp. 16295-16300
-
-
Sun, A.-Q.1
Balasubramaniyan, N.2
Liu, C.-J.3
Shahid, M.4
Suchy, F.J.5
-
28
-
-
34447540180
-
Protein-protein interactions and membrane localization of the human organic solute transporter
-
DOI 10.1152/ajpgi.00457.2006
-
Sun AQ, Balasubramaniyan N, Xu K, Liu CJ, Ponamgi VM, Liu H, and Suchy FJ (2007) Protein-protein interactions and membrane localization of the human organic solute transporter. Am J Physiol Gastrointest Liver Physiol 292:G1586-G1593. (Pubitemid 47080612)
-
(2007)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.292
, Issue.6
-
-
Sun, A.-Q.1
Balasubramaniyan, N.2
Xu, K.3
Chuan, J.L.4
Ponamgi, V.M.5
Liu, H.6
Suchy, F.J.7
-
29
-
-
84867928062
-
Advances in drug design with RXR modulators
-
Vaz B and de Lera AR (2012) Advances in drug design with RXR modulators. Expert Opin Drug Discov 7:1003-1016.
-
(2012)
Expert Opin Drug Discov
, vol.7
, pp. 1003-1016
-
-
Vaz, B.1
De Lera, A.R.2
-
30
-
-
0037421847
-
Structure and catalytic mechanism of the human histone methyltransferase SET7/9
-
DOI 10.1038/nature01378
-
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, and Gamblin SJ (2003) Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421:652-656. (Pubitemid 36227675)
-
(2003)
Nature
, vol.421
, Issue.6923
, pp. 652-656
-
-
Xiao, B.1
Jing, C.2
Wilson, J.R.3
Walker, P.A.4
Vasisht, N.5
Kelly, G.6
Howell, S.7
Taylor, I.A.8
Blackburn, M.G.9
Gamblin, S.J.10
-
31
-
-
0032544123
-
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases
-
Zhang W and Bieker JJ (1998) Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci USA 95:9855-9860.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9855-9860
-
-
Zhang, W.1
Bieker, J.J.2
-
32
-
-
37349010675
-
FXR signaling in metabolic disease
-
DOI 10.1016/j.febslet.2007.11.015, PII S0014579307011593
-
Zhang Y and Edwards PA (2008) FXR signaling in metabolic disease. FEBS Lett 582: 10-18. (Pubitemid 350297240)
-
(2008)
FEBS Letters
, vol.582
, Issue.1
, pp. 10-18
-
-
Zhang, Y.1
Edwards, P.A.2
|