Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa

Journal of Neuroscience

Volumn 26, Issue 46, 2006, Pages 11929-11937

  Chen, Jiayan ^a   Shi, Guang ^a,c   Concepcion, Francis A ^a   Xie, Guifu ^b   Oprian, Daniel ^b   Chen, Jeannie ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blindness; GPCR; Light damage; Photoreceptor; Retina; Retinal degeneration

Indexed keywords

OPSIN; PROTEIN K296E; RETINA S ANTIGEN; RHODOPSIN; TRANSDUCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; GENE MUTATION; MORPHOLOGY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN BINDING; RETINA ROD; RETINITIS PIGMENTOSA;

ANIMALS; ARRESTIN; CELL COMPARTMENTATION; CELL DEATH; CHROMOSOME DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; GENES, DOMINANT; HUMANS; LIGHT; MACROMOLECULAR SUBSTANCES; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; PROTEIN BINDING; RETINITIS PIGMENTOSA; RHODOPSIN; RODS (RETINA); SIGNAL TRANSDUCTION; TRANSDUCIN;

EID: 33751096461     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3212-06.2006     Document Type: Article

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