Engineering a "steric doorstop" in rhodopsin: Converting an inverse agonist to an agonist

Biochemistry

Volumn 46, Issue 43, 2007, Pages 12248-12252

  McKee, Timothy D ^a,c   Lewis, Margaret R ^b   Kono, Masahiro ^b  

^a BRANDEIS UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c Satori Pharmaceuticals Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CHROMOPHORES; CONFORMATIONS; CRYSTAL STRUCTURE;

HYDROXYLAMINES; INACTIVE METARHODOPSINS; MUTATION; RETINOID CHROMOPHORES;

PROTEINS;

11 CIS RETINAL; AMINO ACID; APOPROTEIN; HYDROXYLAMINE; LIGAND; METHYL GROUP; MUTANT PROTEIN; RETINOID; RHODOPSIN; THREONINE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; STEREOSPECIFICITY; WILD TYPE;

ANIMALS; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; MODELS, MOLECULAR; MUTATION; PROTEIN ENGINEERING; RHODOPSIN; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 35649004285     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701003b     Document Type: Article

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