Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism

Neuropharmacology

Volumn 86, Issue , 2014, Pages 228-240

  Kivell, Bronwyn ^a,d   Uzelac, Zeljko ^b   Sundaramurthy, Santhanalakshmi ^c   Rajamanickam, Jeyaganesh ^c   Ewald, Amy ^a   Chefer, Vladimir ^d   Jaligam, Vanaja ^d   Bolan, Elizabeth ^d   Simonson, Bridget ^a   Annamalai, Balasubramaniam ^e   Mannangatti, Padmanabhan ^c   Prisinzano, Thomas E ^f   Gomes, Ivone ^g   Devi, Lakshmi A ^g   Jayanthi, Lankupalle D ^c   Sitte, Harald H ^b   Ramamoorthy, Sammanda ^c   Shippenberg, Toni S ^d  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f UNIVERSITY OF KANSAS   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Dopamine transporter; Dysphoric; Kappa opioid receptor; Pro depressant; Salvinorin A; Serotonin transporter; Trafficking

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; DOPAMINE TRANSPORTER; KAPPA OPIATE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; NORADRENALIN TRANSPORTER; SALVINORIN A; SEROTONIN TRANSPORTER; CLERODANE DERIVATIVE; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38; SLC6A2 PROTEIN, HUMAN; SLC6A4 PROTEIN, HUMAN; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; KAPPA OPIATE RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOAMINE DERIVATIVE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NORBINALTORPHIMINE; PERTUSSIS TOXIN; TRANS 4 [4 (DIMETHYLAMINO) STYRYL]N METHYLPYRIDINIUM IODIDE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN REGION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; UPREGULATION; AGONISTS; CELL MEMBRANE; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; ANIMAL TISSUE; BIOACCUMULATION; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL LINE; CELL SURFACE; DOPAMINERGIC TRANSMISSION; EM4 CELL LINE; EMBRYO; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM;

CELL MEMBRANE; CORPUS STRIATUM; DITERPENES, CLERODANE; DOPAMINE; DOPAMINE AGENTS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, OPIOID, KAPPA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84907359962     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.07.016     Document Type: Article

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