A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

European Journal of Pharmaceutical Sciences

Volumn 63, Issue , 2014, Pages 167-177

  Westerhout, Joost ^a   Van De Steeg, Evita ^a   Grossouw, Dimitri ^a   Zeijdner, Evelijn E ^a   Krul, Cyrille A M ^a   Verwei, Miriam ^a   Wortelboer, Heleen M ^a  

^a TNO   (Netherlands)

Author keywords

Caco 2; Food effect; Human intestine; Intestinal absorption; InTESTine ; Porcine intestine

Indexed keywords

ACEBUTOLOL; ATENOLOL; CANDESARTAN; CETIRIZINE; CIMETIDINE; CIPROFLOXACIN; DIAZEPAM; DIGOXIN; FAMOTIDINE; HYDROCORTISONE; IBUPROFEN; INDOMETACIN; MANNITOL; MELAGATRAN; METOPROLOL; MUCIN; OXPRENOLOL; PHENAZONE; PINDOLOL; PROPRANOLOL; RANITIDINE; SALAZOSULFAPYRIDINE; SALICYLIC ACID; TESTOSTERONE; VERAPAMIL;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; DOMESTIC PIG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG TRANSPORT; ELECTRIC RESISTANCE; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; NONHUMAN; PASSIVE TRANSPORT; PREDICTION; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; HT 29 CELL LINE; INTESTINE; JEJUNUM; METABOLISM; PERMEABILITY; PIG; TUMOR CELL CULTURE;

ANIMALS; ATENOLOL; CACO-2 CELLS; CIMETIDINE; HT29 CELLS; HUMANS; INTESTINAL ABSORPTION; INTESTINES; JEJUNUM; MANNITOL; PERMEABILITY; RANITIDINE; SWINE; TUMOR CELLS, CULTURED;

EID: 84907328560     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.07.003     Document Type: Article

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