The pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption

Experimental Biology and Medicine

Volumn 233, Issue 6, 2008, Pages 651-664

  Patterson, Jannine K ^a   Lei, Xin Gen ^a   Miller, Dennis D ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Diet; Human; Model; Nutrition; Pig

Indexed keywords

CALCIUM; IRON; PREBIOTIC AGENT; PROBIOTIC AGENT; ZINC;

ATOMIC ABSORPTION SPECTROMETRY; DIET; DIET SUPPLEMENTATION; EXPERIMENTAL MODEL; GASTROINTESTINAL ABSORPTION; HUMAN; IRON ABSORPTION; MINERAL INTAKE; MINERAL METABOLISM; NONHUMAN; NUTRIENT AVAILABILITY; NUTRIENT UPTAKE; NUTRITIONAL REQUIREMENT; NUTRITIONAL SCIENCE; SHORT SURVEY; SWINE; URINARY EXCRETION; ABSORPTION; ANIMAL; ANIMAL MODEL; AUDIOVISUAL EQUIPMENT; BIOAVAILABILITY; GASTROINTESTINAL TRACT; HISTOLOGY; MALE; PATHOLOGY; RAT; REVIEW; SPECIES DIFFERENCE; THEORETICAL MODEL;

SUIDAE; SUS;

ABSORPTION; ANIMALS; BIOLOGICAL AVAILABILITY; DIET; GASTROINTESTINAL TRACT; HUMANS; MALE; MODELS, ANATOMIC; MODELS, ANIMAL; MODELS, THEORETICAL; NUTRITIONAL SCIENCES; PROBIOTICS; RATS; SPECIES SPECIFICITY; SWINE;

EID: 46449118663     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0709-MR-262     Document Type: Short Survey

References (134)

1. Shu Q, Freeman Q, Gill HS. Probiotic treatment using Bifidobacterium lactis HN019 reduces weanling diarrhea associated with rotavirus and Escherichia coli infection in a piglet model. J Pediatr Gastr Nutr 33:171-177, 2001.
2. Koning F, Gilissen L, Wijmenga C. Gluten: a two edged sword. Immunopathogenesis of celiac disease. Springer Semin Immun 27: 217-232, 2005.
3. Macfarlane S, Fume E, Kennedy A, Cummings JH, Macfarlane GT. Mucosal bacteria in ulcerative colitis. Brit J Nutr 93(Suppl 1):S67-S72, 2005.
4. Green PHR, Jabri B. Celiac disease. Annu Rev Med 57:207-221, 2006.
5. Byrnes SE, Brand-Miller JC, Denyer GS. Amylopectin starch promotes the development of insulin resistance in rats. J Nutr 125(6):1430-1437, 1995.
6. Benito P, Miller D. Iron absorption and bioavailability: an updated review. Nutr Res 18(3):581-603, 1998.
7. Lopez HW, Levrat-Verny MA, Coudray C, Besson C, Krespine V, Messager A, Demigne C, Remesy C. Class 2 resistant starches lower plasma and liver lipids and improve mineral retention in rats. J Nutr 131(4):1283-1289, 2001.
8. Griffin IJ. Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans. J Anal At Spectrom 17:1186-1193, 2002.
9. Jenkins DJA, Kendall CWC, Augustin LSA, Franceschi S, Hamidi M, Marchie A, Jenkins AL, Axelsen M. Glycemic index: overview of implications in health and disease. Am J Clin Nutr 76(1):266S-273S, 2002.
10. Leeds AR. Glycemic index and heart disease. Am J Clin Nutr 76(1):286S-289S, 2002.
11. Brennan CS, Tudorica CM. The role of complex carbohydrates in and non-starch polysaccharides in the regulation of postprandial glucose and insulin responses in cereal foods. Journal of Nutraceuticals, Functional & Medical Foods 4(2):49-55, 2003.
12. Lopez MAA, Martos FC. Iron availability: an updated review. Int J Food Sci Nutr 55(8):597-606, 2004.
13. Albin DM, Tappenden KA. Advances in methods to evaluate gastrointestinal transport function. Curr Opin Clin Nutr 4:351-354, 2001.
14. Asrar FM, O'Connor DL. Bacterially synthesised folate and supplemental folic acid are absorbed across the large intestine of piglets. J Nutr Biochem 16:587-593, 2005.
15. Guarner F. Inulin and oligofructose: impact on intestinal diseases and disorders. Brit J Nutr 93(Suppl 1):S61-S65, 2005.
16. Hurrell RF. Preventing iron deficiency through food fortification. Nutr Rev 55(6):210-222, 1997.
17. Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr 68:442S-446S, 1998.
18. Slavin JL. Health benefits of oligosaccharides. Journal of Nutraceut- icals, Functional & Medical Foods 1(4):43-55, 1999.
19. South PK, Lei X, Miller DD. Meat enhances nonheme iron absorption in pigs. Nutr Res 20(12):1749-1759, 2000.
20. Kanauchi O, Mitsuyama K, Araki Y, Andoh A. Modification of the intestinal flora in the treatment of inflammatory bowel disease. Curr Pharm Design 9(4):333-346, 2003.
21. Greger JL. Using animals to assess bioavailability of minerals: implications for human nutrition. J Nutr 122(10):2047-2052. 1992.
22. Martin LJM, Dumon HJW, Champ MMJ. Production of short-chain fatty acids from resistant starch in a pig model. J Sci Food Agric 77:71-80, 1998.
23. McCracken VJ, Lorenz RG. The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota. Cell Microbiol 3(1):1-11, 2001.
24. Corpet DE, Pierre F. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Eur J Cancer 41: 1911-1922, 2005.
25. Domeneghini C, Di Giancamillo A, Bosi G, Arrighi S. Can nutraceuticals affect the structure of intestinal mucosa? Qualitative and quantitative microanatomy in L-glutamine diet-supplemented weaning piglets. Vet Res Commun 30:331-342, 2006.
26. Crump MH. A comparison of the structure and function of the large intestine in man (homo sapiens), dog (canis familiaris) and pig (sus domesticus). In: Stevens CE, Ed. Literature Reviews of Selected Topics in Comparative Gastroenterology. New York: New York State Veterinary College, pp1-24, 1975.
27. Miller ER, Ullrey DE. The pig as a model for human nutrition. Ann Rev Nutr 7:361-382, 1987.
28. Bloor CM, White FC, Roth DM. The pig as a model of myocardial ischemia and gradual coronary artery occlusion. In: Swindle MM, Moody DC, Phillips LD, Eds. Swine as Models in Biomedical Research. Iowa: Iowa State University Press/AMES, pp163-184, 1992.
29. Laber KE, Whary MT, Bingel SA, Goodrich JA, Smith AC, Swindle MM. Biology and diseases of swine. In: Fox JG, Anderson LC, Loew FM, Quimby FW, Eds. Laboratory Animal Medicine (2nd ed.). Amsterdam: Academic Press (Elsevier Science), pp615-673, 1992.
30. Kien CL, Ailabouni AH, Murray RD, Powers PA, McClead RE, Kepner J. Technical note: pig model for studying nutrient assimilation by the intestine and colon. J Anim Sci 75:2161-2164, 1997.
31. Pointillart A, Coxam V, Seve B, Colin C, Lacroix CH, Gueguen L. Availability of calcium from skim milk, calcium sulfate and calcium carbonate for bone mineralization in pigs. Reprod Nutr Dev 40:49-61, 2000.
32. Olsen AK, Bladbjerg EM, Marckmann P, Larsen LF, Hansen AK. The Gottingen minipig as a model for postprandial hyperlipidaemia in man: experimental observations. Lab Anim 36:438-444, 2002.
33. Boullion RD, Mokelke EA, Wamhoff BR, Otis CR, Wenzel J, Dixon JL, Sturek M. Porcine model of diabetic dyslipidaemia: insulin and feed algorithms for mimicking diabetes mellitus in humans. Comparative Med 53(1):42-52, 2003.
34. Eklund G, Tallkvist J, Oskarsson A. A piglet model for studies of gastrointestinal uptake of cadmium in neonates. Toxicol Lett 146: 237-247, 2004.
35. Labib S, Erb A, Kraus M, Wickert T, Richling E. The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids. Mol Nutr Food Res 48:326-332, 2004.
36. Xi S, Yin W, Wang Z, Kusunoki M, Lian X, Koike T, Fan J, Zhang Q. A minipig model of high-fat/high-sucrose diet-induced diabetes and artherosclerosis. Int J Exp Path 85:223-231, 2004.
37. Mullen Y, Taura Y, Nagata M, Miyazawa K, Stein E. Swine as a model for pancreatic beta cell transplantation. In: Swindle MM, Moody DC, Phillips LD, Eds. Swine as Models in Biomedical Research. Iowa: Iowa State University Press/AMES, pp6-34, 1992.
38. Rowan AM, Moughan PJ, Wilson MN, Maher K, Tasman-Jones C. Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man. Brit J Nutr 71:29-42, 1994.
39. Martin LJM, Dumon HJW, Champ MMJ. Production of short-chain fatty acids from resistant starch in a pig model. J Sci Food Agric 77: 71-80, 1998.
40. Perks SM, Miller DD. Adding ascorbic acid to iron-fortified cows milk does not enhance iron bioavailability to piglets. Nutr Res 16(6): 969-975, 1996.
41. Tumbleson ME, Kalish PR. Serum biochemical and haematological parameters in crossbred swine from birth through eight weeks of age. Can J Comp Med 36:202-209, 1972.
42. Lorenz JM. Assessing fluid and electrolyte status in the newborn. Clin Chem 43(1):205-210, 1997.
43. Jankov RP, Boerkoel CF, Hellmann J, Sirkin WL, Tumer Z, Horn N, Feigenbaum A. Lethal neonatal Menkes' disease with severe vasculopathy and fractures. Acta Pediatr 87:1297-1300, 1998.
44. Emmans GC, Kyriazakis I. Growth and body composition. In: Kyriazakis I, Ed. A Quantitative Biology of the Pig. Oxon, UK: CAB International, pp181-198, 1999.
45. Reid ME, Sausais L, Oyen R, Storry JR, Shukla H, Hsu T, Lim SM. First example of hemolytic disease of the newborn caused by Anti-Or and confirmation of the molecular basis of Or. Vox Sang. 79:180-182, 2000.
46. Xu XG, Chao TC, Bozkurt A. VIP-Man: an image-based whole-body adult male model constructed from color photographs of the visible human project for multi-particle monte carlo calculations. Health Phys 78(5):476-486, 2000.
47. Chwen LT, Heng LK, Lee TH, Kong MC, Yoon CP. The effects of iron supplementation in preweaning piglets. Mal J Nutr 7(1&2):41-49, 2001.
48. Van Rens BTTM, Van Der Lende T. Litter size and piglet traits of gilts with different prolactin receptor genotypes. Theriogenology 57:883-893, 2002.
49. Sheng HP, Huggins RA, Garza C. Chemical maturation in growing guinea pigs. Am J Physiol Regulatory Integrative Comp Physiol 242: 390-393, 1982.
50. Martini FH, Ober WC, Garrison CW, Welch K, Hutchings RT. Fundamentals of Anatomy and Physiology (4th ed.). London:Prentice-Hall International, pp861-917, 1998.
51. Mochizuki S, Makita T. Differences in intestinal length between specific-pathogen-free (SPF) and conventional swine. J Vet Med Sci 60(5):545-548, 1998.
52. Wright AB, McKelvey GM, Wood AKW, Post EJ. Sonographic observations of the gastroduodenal junction in neonatal piglets. Ultrasound Med Biol 24(9):1337-1344, 1998.
53. Smith AC, Swindle MM. Preparation of swine for the laboratory. ILAR J 47(4):358-363, 2006.
54. Schantz LD, Laber-Laird K, Bingel S, Swindle M. Pigs: Applied anatomy of the gastrointestinal tract. In: Jensen SL, Gregersen H, Eds. Essentials of Experimental Surgery: Gastroenterology. New York: Harwood Academic Publishers, pp2611-2619, 1996.
55. Cooper DA, Berry DA, Spendel VA, Kiorpes AL, Peters JC. The domestic pig as a model for evaluating Olestra's nutritional effects. J Nutr 127:1555S-1565S, 1997.
56. Mroz Z, Jongbloed AW, Partanen KH, Vreman K, Kemme PA, Kogut J. The effects of calcium benzoate in diets with or without organic acids on dietary buffering capacity, apparent digestibility, retention of nutrients, and manure characteristics in swine. J Anim Sci 78:2622-2632, 2000.
57. Armstrong TA, Spears JW. Effect of dietary boron on growth performance, calcium and phosphorus metabolism, and bone mechanical properties in growing barrows. J Anim Sci 79:3120-3127, 2001.
58. Veum TL, Ledoux DR, Raboy V, Ertl DS. Low-phytic acid corn improves nutrient utilization for growing pigs. J Anim Sci 79:2873-2880, 2001.
59. Veum TL, Ledoux DR, Bollinger DW, Raboy V, Cook A. Low-phytic acid barley improves calcium and phosphorus utilization and growth performance in growing pigs. J Anim Sci 80:2663-2670, 2002.
60. Pointillart A, Colin C, Lacroix HC, Gueguen L. Mineral bioavail- ability and bone mineral contents in pigs given calcium carbonate postprandially. Bone 17(4):357-362, 1995.
61. Wolf RL, Cauley JA, Baker CE, Ferrell RE, Charron M, Caggiula AW, Salamone LM, Heaney RP, Kuller LH. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr 72:466-471, 2000.
62. Kaji M, Gotoh M, Takagi Y, Masuda H, Kimura Y, Uenoyama Y. Studies to determine the usefulness of the zinc clearance test to diagnose marginal zinc deficiency and the effects of oral zinc supplementation for short children. J Am Coll Nutr 17(4):388-391, 1998.
63. King LE, Frentzel JW, Mann JJ, Fraker PJ. Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained. J Am Coll Nutr 24(6):494-502, 2005.
64. Poulson HD, Larsen T. Zinc excretion and retention in growing pigs fed increasing levels of zinc oxide. Livest Prod Sci 43:235-242, 1995.
65. Carlson MS, Borne CA, Wu C, Huntington E, Bollinger DW, Veum TL. Evaluation of various inclusion rates of organic zinc either as polysaccharide or proteinate complex on the growth performance, plasma, and excretion of nursery pigs. J Anim Sci 82:1359-1366, 2004.
66. Fairweather-Tait SJ, Fox TE, Wharf SG, Eagles J, Kennedy H. Zinc absorption in adult men from a chicken sandwich made with white or wholemeal bread, measured by a double-label stable-isotope technique. Brit J Nutr 67411-419, 1992.
67. Turnlund JR, King JC, Keyes WR, Gong B, Michel MC. A stable isotope study of zinc absorption in young men: effects of phytate and α-cellulose. Am J Clin Nutr 40:1071-1077, 1984.
68. 67Copper in young pigs. J Nutr 129:181-187, 1999.
69. Apgar GA, Kornegay ET. Mineral balance of finishing pigs fed copper sulfate or a copper-lysine complex at growth-stimulating levels. J Anim Sci 74:1594-1600, 1996.
70. Cheng J, Kornegay ET, Schell T. Influence of dietary lysine on the utilisation of zinc from zinc sulfate and a zinc-lysine complex by young pigs. J Anim Sci 76:1064-1074, 1998.
71. Maekawa AA, Glahn RP, Lei XL, Miller DD. Effect of bread baking on the bioavailability of hydrogen-reduced iron powder added to unenriched refined wheat flour. J Agric Food Chem 54:8362-8368, 2006.
72. Atkinson SA, Shah JK, Webber CE, Gibson IL, Gibson RS. A multielement isotopic tracer assessment of true fractional absorption of minerals from formula with additives of calcium, phosphorus, zinc, copper and iron in young piglets. J Nutr 123(9):1586-1593, 1993.
73. Cook JD, Monsen ER. Food iron absorption in human subjects. III. Comparison of the effect of animal proteins on nonheme iron absorption. Am J Clin Nutr 29:859-867, 1976.
74. Reddy MB, Cook JD. Assessment of dietary determinants of nonheme-iron absorption in humans and rats. Am J Clin Nutr 54:723-728, 1991.
75. Engelmann MDM, Davidsson L, Sandstrom B, Walczyk T, Hurrell RF, Michaelsen KF. The influence of meat on nonheme iron absorption in infants. Pediatr Res 43(6):768-773, 1998.
76. Pointillart A, Denis I, Colin C, Lacroix H. Vitamin C supplementation does not modify bone mineral content or mineral absorption in growing pigs. J Nutr 127:1514-1518, 1997.
77. Hallberg L. Bioavailability of dietary iron in man. Ann Rev Nutr 1: 123-147, 1981.
78. Consaul JR, Lee K. Extrinsic tagging in iron bioavailability research: a critical review. J Agric Food Chem 31:684-689, 1983.
79. Hallberg L, Brune M, Rosander L. Effect of ascorbic acid on iron absorption from different types of meals: studies with ascorbate rich foods and synthetic ascorbic acid given in different amounts with different meals. Hum Nutr Appl Nutr 40A:97-113, 1986.
80. Hunt JR, Gallagher SK, Johnson LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr 59(6):1381-1385, 1994.
81. Lynch SR. Interaction of iron with other nutrients. Nutr Rev 55(4): 102-110, 1997.
82. Stahl CH, Han YM, Roneker KR, House WA, Lei XG. Phytase improves iron bioavailability for hemoglobin synthesis in young pigs. J Anim Sci 77:2135-2142, 1999.
83. Diaz M, Rosado JL, Allen LH, Abrams S, Garcia OP. The efficacy of a local ascorbic acid-rich food in improving iron absorption from Mexican diets: a field study using stable isotopes. Am J Clin Nutr 78:436-440, 2003.
84. Landers BR, Devitt PG, Jamieson GG. A modified Thomas cannula for duodenal cannulation in pigs [for digestion research]. Aust Vet J 66(6):182-183, 1989.
85. Finley JW, Caton JS, Zhou Z, Davison KL. A surgical model for determination of true absorption and biliary excretion of manganese in conscious swine fed commercial diets. J Nutr 127:2334-2341, 1997.
86. Kammlott E, Karthoff J, Stemme K, Gregory P, Kamphues J. Digestibility rates of major and trace elements in pancreatic duct-ligated pigs. J Anim Physiol An N 89:109-112, 2005.
87. Abrams SA. New approaches to iron fortification: role of bioavailability studies. Am J Clin Nutr 80:1104-1105, 2004.
88. Lynch SR. Iron overload: prevalence and impact on health. Nutr Rev 53(9):255-260, 1995.
89. Conrad ME, Umbreit JN, Moore EG. Iron absorption and transport. Am J Med Sci 318(4):213-229, 1999.
90. Haile DJ. Regulation of genes of iron metabolism by the iron-response proteins. Am J Med Sci 318(4):230-240, 1999.
91. Diamond J. Evolutionary design of intestinal nutrient absorption: enough but not too much. NIPS 6:92-96, 1991.
92. Litwin CM, Calderwood SB. Role of iron regulation in virulence genes. Clin Microbial Rev 6(2):137-149, 1993.
93. Ratledge C, Dover LG. Iron metabolism in pathogenic bacteria. Annu Rev Microbiol 54:881-941, 2000.
94. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102(3):783-788, 2003.
95. Fleming RE. Advances in understanding the molecular basis for the regulation of dietary iron absorption. Curr Opin Gastroenterol 21:201-206, 2005.
96. Imbert M, Blondeau R. On the iron requirement of lactobacilli grown in chemically defined medium. Curr Microbiol 37:64-66, 1998.
97. Elli M, Zink R, Rytz A, Reniero R, Morelli L. Iron requirement of Lactobacillus spp. in completely chemically defined growth media. J Appl Microbiol 88:695-703, 2000.
98. Gibson GR, Probert HM, Van Loo J, Rastall RA, Roberfroid MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259-275, 2004.
99. Rastall RA, Gibson GR, Gill HS, Guarner F, Klaenhammer TR, Pot B, Reid G, Rowland IR, Sanders ME. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiol Ecol 52:145-152, 2005.
100. Rolfe RD. The role of probiotic cultures in the control of gastrointestinal health. J Nutr 130:396S-402S, 2000.
101. Scheppach W, Luehrs H, Menzel T. Beneficial health effects of low-digestible carbohydrate consumption. Brit J Nutr 85(Suppl 1):S23-S30, 2001.
102. Hart AL, Stagg AJ, Frame M, Graffner H, Glise H, Falk P, Kamm MA. The role of the gut flora in health and disease, and its modification as therapy. Aliment Pharm Therap 16(8):1383-1393, 2002.
103. Silvi S, Rumney CJ, Cresci A, Rowland IR. Resistant starch modifies gut microflora and microbial metabolism in human flora-associated rats inoculated with faeces from Italian and UK donors. J Appl Microbiol 86:521-530, 1999.
104. Kleessen B, Stoof G, Proll J, Schmiedl D, Noack J, Blaut M. Feeding resistant starch affects fecal and cecal microflora and short chain fatty acids in rats. J Anim Sci 75:2453-2462, 1997.
105. Tannock GW. Studies of the intestinal microflora: a prerequisite for the development of probiotics. Int Dairy J 8(5-6):527-533, 1998.
106. Qiao H, Duffy LC, Griffiths E, Dryja D, Leavens A, Rossman J, Rich G, Riepenhoff-Talty M, Locniskar M. Immune responses in Rhesus rotavirus-challenged Balb/c mice treated with bifidobacteria and prebiotic supplements. Pediatr Res 51(6):750-755, 2002.
107. Wang X, Brown IL, Khaled D, Mahoney MC, Evans AJ, Conway PL. Manipulation of colonic bacteria and volatile fatty acid production by dietary high amylase maize (amylomaize) starch granules. J Appl Microbiol 93:390-397, 2002.
108. Hass R, Busche R, Luciano L, Reale E, Engelhardt WV. Lack of butyrate is associated with induction of bax and subsequent apoptosis in the proximal colon of guinea pig. Gastroenterology 112:875-881, 1997.
109. Ahmad MS, Krishnan S, Ramakrishna BS, Mathan M, Pulimood AB, Murthy SN. Buyrate and glucose metabolism by colonocytes in experimental colitis in mice. Gut 46:493-499, 2000.
110. Coudray C, Bellanger J, Castiglia-Delav C, Remesy C, Vermorel M, Rayssignuier Y. Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. Eur J Clin Nutr 51:375-380, 1997.
111. Petkevicius S, Bach Knudsen KE, Murrell KD. Effects of Oesophagostomum dentatum and dietary carbohydrates on morphology of the large intestine of pigs. Vet Parasitol 116:125-138, 2003.
112. Yeung CK, Glahn RP, Welch, RM, Miller DD. Prebiotics and iron bioavailability - is there a connection? J Food Sci 70(5):88-92, 2005.
113. Greger JL. Nondigestible carbohydrates and mineral bioavailability. J Nutr 129:1434S-1435S, 1999.
114. Scholz-Ahrens KE, Schaafsma G, van den Heuvel EGHM, Schre- zenmeir J. Effects of prebiotics on mineral metabolism. Am J Clin Nutr 73(Suppl):459S-464S, 2001.
115. Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ. A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralisation in young adolescents. Am J Clin Nutr 82:471-476, 2005.
116. Brommage R, Binacua C, Antille S, Carrie AL. Intestinal calcium absorption in rats is stimulated by dietary lactulose and other resistant sugars. J Nutr 123:2186-2194, 1993.
117. Ohta A, Ohtsuki M, Baba S, Takizawa T, Adachi T, Kimura S. Effects of frcutooligosaccharides on the absorption of iron, calcium and magnesium in iron-deficient anemic rats. J Nutr Sci Vitaminol 41:281-291, 1995.
118. De Schrijver R, Vanhoof K, Vande Ginste J. Nutrient utilization in rats and pigs fed enzyme resistant starch. Nutr Res 19(9):1349-1361, 1999.
119. Hayashi K, Hara H, Asvarujanon P, Aoyama Y, Luangpituksa P. Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats. Brit J Nutr 86:443-451, 2001.
120. Yasuda K, Roneker KR, Miller DD, Welch RM, Lei XG. Supplemental dietary inulin affects the bioavailability of iron in corn and soybean meal to young pigs. J Nutr 136:3033-3038, 2006.
121. Houdijk JGM, Bosch MW, Tamminga S, Verstegen MWA, Berenpas EB, Knoop H. Apparent ileal and total-tract nutrient digestion by pigs as affected by dietary nondigestible oligosaccharides. J Anim Sci 77: 148-158, 1999.
122. Morais MB, Feste A, Miller RG, Lifschitz CH. Effect of resistant and digestible starch on intestinal absorption of calcium, iron and zinc in infant pigs. Pediatr Res 39(5):872-876, 1996.
123. Rideout TC, Fan MZ. Nutrient utilisation in response to dietary supplementation of chicory inulin in pigs. J Sci Food Agric 84:1005-1012, 2004.
124. Murray RD, Ailabouni AH, Powers PA, McClung HJ, Li BUK, Heitlinger LA, Sloan HR. Absorption of lactose from colon of newborn piglet. Am J Physiol 261:G1-G8, 1991.
125. Darragh AJ, Cranwell PD, Moughan PJ. Absorption of lysine and methionine from the proximal colon of the piglet. Brit J Nutr 71:739-752, 1994.
126. Murray RD, Ailabouni A, Heitlinger LA, Li BUK, McClung HJ, Powers P, Gutt J, Kien LC. Galactose-containing carbohydrates are preferentially absorbed in the neonatal pig colon. Pediatr Res 39(4):656-660, 1996.
127. Liu J, Bollinger DW, Ledoux DR, Veum TL. Effects of dietary calcium:phosphorus ratios on apparent absorption of calcium and phosphorus in the small intestine, cecum and colon of pigs. J Anim Sci 78:106-109, 2000.
128. Gu Y, Schinckel AP, Martin TG. Growth, development, and carcass composition in five genotypes of swine. J Anim Sci 70:1719-1729, 1992.
129. Wiseman TG, Mahan DC, Moeller SJ, Peters JC, Fastinger ND, Ching S, Kim YY. Phenotypic measurements and various indices of lean and fat tissue development in barrows and gilts of two genetic lines from twenty to one hundred twenty-five kilograms of body weight. J Anim Sci 85:1816-1824, 2007.
130. Widdowson EM. Chemical composition of newly born mammals. Nature 166:626-628, 1950.
131. Grande F, Keys A. Body weight, body composition, and calorie status. In: Goodhart RS, Shils ME, Eds. Modern Nutrition in Health and Disease (6th ed.) Philadelphia: Lea & Febiger, pp3-34, 1980.
132. West DB, York B. Dietary fat, genetic predisposition, and obesity: lessons from animal models. Am J Clin Nutr 67(3 Suppl):505S-512S, 1998.
133. Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, Saint-Paul MC, Huet PM, Sadoul JL, Gugenheim J, Srai SK, Tran A, Le Marchand-Brustel Y. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 131(3):788-796, 2006.
134. Frazer DM, Anderson GJ. Intestinal iron absorption and its regulation. Am J Physiol Gastrointest Liver Physiol 289:G631-G635, 2005.