A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 2, 2014, Pages 290-298

  Béduneau, Arnaud ^a   Tempesta, Camille ^a   Fimbel, Stéphane ^a   Pellequer, Yann ^a   Jannin, Vincent ^b   Demarne, Frédéric ^b   Lamprecht, Alf ^a,c  

^a UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^b GATTEFOSSÉ SAS   (France)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Caco 2 cells; Drug absorption model; Goblet cells; In vitro intestinal barrier; Mucus; Seeding procedure

Indexed keywords

LUCIFER YELLOW; MUCIN; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123; ABCB1 PROTEIN, HUMAN; ISOQUINOLINE DERIVATIVE;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CACO 2 CELL LINE; COCULTURE; ELECTRIC RESISTANCE; GOBLET CELL; HT 29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; PROTEIN EXPRESSION; TRANSEPITHELIAL ELECTRICAL RESISTANCE; CELL COMMUNICATION; CONFOCAL MICROSCOPY; CULTURE TECHNIQUE; IMPEDANCE; INTESTINAL SECRETIONS; INTESTINE ABSORPTION; INTESTINE MUCOSA; METABOLISM; PERMEABILITY; SECRETION (PROCESS); TIME; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL COMMUNICATION; CELL CULTURE TECHNIQUES; COCULTURE TECHNIQUES; ELECTRIC IMPEDANCE; GOBLET CELLS; HT29 CELLS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINAL SECRETIONS; ISOQUINOLINES; MICROSCOPY, CONFOCAL; MUCINS; P-GLYCOPROTEINS; PERMEABILITY; RHODAMINE 123; TIME FACTORS;

EID: 84902385868     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.03.017     Document Type: Article

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