Animal versus human oral drug bioavailability: Do they correlate?

European Journal of Pharmaceutical Sciences

Volumn 57, Issue 1, 2014, Pages 280-291

  Musther, Helen ^a   Olivares Morales, Andrés ^b   Hatley, Oliver J D ^b   Liu, Bo ^a   Rostami Hodjegan, Amin ^a,b  

^a CERTARA UK LIMITED   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Drug development; First in man pharmacokinetics; Oral drug absorption

Indexed keywords

ACARBOSE; ACEBUTOLOL; ACETYLSALICYLIC ACID; ACICLOVIR; ADEFOVIR; ALPRAZOLAM; AMITRIPTYLINE; AMLODIPINE; AMOSULALOL; AMOXICILLIN; AZATHIOPRINE; AZITHROMYCIN; CEFIXIME; CEFUROXIME AXETIL; CHLORPHENIRAMINE; CLONAZEPAM; CYCLOSPORIN; DAPSONE; DIAZEPAM; DOXAZOSIN; ERYTHROMYCIN; ESTRADIOL VALERATE; ESTRAMUSTINE PHOSPHATE; ETHAMBUTOL; ETHIMIZOLE; ETHINYLESTRADIOL; ETHOSUXIMIDE; PHENAZONE; TRANILAST; UNINDEXED DRUG; DRUG;

AREA UNDER THE CURVE; ARTICLE; DATA BASE; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; HUMAN; MOUSE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; SPECIES DIFFERENCE; ANIMAL; ANIMAL MODEL; BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PHARMACOKINETICS; PROCEDURES; STATISTICAL MODEL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIOPHARMACEUTICS; HUMANS; LINEAR MODELS; MODELS, ANIMAL; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SPECIES SPECIFICITY;

EID: 84899944508     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.08.018     Document Type: Article

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