The co-occurrence of autistic and ADHD dimensions in adults: An etiological study in 17 770 twins

Translational Psychiatry

Volumn 4, Issue , 2014, Pages

  Polderman, T J C ^a   Hoekstra, R A ^b   Posthuma, D ^a,c   Larsson, H ^d  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b OPEN UNIVERSITY   (United Kingdom)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; FEMALE; GENETIC CORRELATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; TWINS; COMMUNITY SAMPLE; COMORBIDITY; DSM-5; GENETICS; QUESTIONNAIRE; SELF REPORT; SEX DIFFERENCE; STEREOTYPY;

EID: 84907312146     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2014.84     Document Type: Article

References (62)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th edn, American Psychiatric Publishing: Arlington, VA, USA, 2013.
2. Billstedt E, Gillberg IC, Gillberg C. Autism in adults: symptom patterns and early childhood predictors. Use of the DISCO in a community sample followed from childhood. J Child Psychol Psychiatry 2007; 48: 1102-1110. (Pubitemid 350086153)
3. Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 2006; 36: 159-165. (Pubitemid 43126140)
4. Brugha TS, McManus S, Bankart J, Scott F, Purdon S, Smith J et al. Epidemiology of autism spectrum disorders in adults in the community in England. Arch Gen Psychiatry 2011; 68: 459-465.
5. Simon V, Czobor P, Bálint S, Mészáros A. Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry 2009; 194: 204-211.
6. Ronald A, Hoekstra RA. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am J Med Genet Part B Neuropsychiatr Genet 2011; 156B: 255-274.
7. Nikolas MA, Burt SA. Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: a meta-analysis. J Abnorm Psychol 2010; 119: 1-17.
8. Hoekstra RA, Bartels M, Verweij CJH, Boomsma DI. Heritability of autistic traits in the general population. Arch Pediatr Adolesc Med 2007; 161: 372-377. (Pubitemid 46556368)
9. Boomsma DI, Saviouk V, Hottenga J-J, Distel MA, de Moor MHM, Vink JM et al. Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS ONE 2010; 12: e10621.
10. Larsson H, Asherson P, Chang Z, Ljung T, Friedrichs B, Larsson J-O et al. Genetic and environmental influences on adult attention deficit hyperactivity disorder symptoms: a large Swedish population-based study of twins. Psychol Med 2013; 43: 197-207.
11. Lai M-C, Lombardo MV, Baron-Cohen S. Autism. Lancet 2014; 383 : 896-910.
12. Holden SE, Jenkins-Jones S, Poole CD, Morgan CL, Coghill D, Currie CJ. The prevalence and incidence, resource use and financial costs of treating people with attention deficit/hyperactivity disorder (ADHD) in the United Kingdom (1998 to 2010). Child Adolesc Psychiatry Mental Health 2013; 7: 34.
13. Anckarsäter H, Stahlberg O, Larson T, Hakansson C, Jutblad S-B, Niklasson L et al. The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. Am J Psychiatry 2006; 163: 1239-1244. (Pubitemid 44464453)
14. Ronald A, Edelson LR, Asherson P, Saudino KJ. Exploring the relationship between autistic-like traits and ADHD behaviors in early childhood: findings from a community twin study of 2-year-olds. J Abnorm Child Psychol 2010; 38: 185-196.
15. Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R. Evidence for overlapping genetic in fluences on autistic and ADHD behaviours in a community twin sample. J Child Psychol Psychiatry 2008; 49: 535 -542.
16. Lichtenstein P, Carlström E, Råstam M, Gillberg C, Anckarsäter H. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am J Psychiatry 2010; 167: 1357-1363.
17. Ronald A, Larsson H, Anckarsäter H, Lichtenstein P. Symptoms of autism and adhd: a Swedish twin study examining their overlap. J Abnorm Psychol 2014; 123: 440-451.
18. Reiersen AM, Constantino JN, Grimmer M, Martin NG, Todd RD. Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Res Hum Genet 2008; 11: 579-585.
19. Lundström S, Chang Z, Kerekes N, Gumpert CH, Råstam M, Gillberg C et al. Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adults. Psychol Med 2011; 41: 2423-2433.
20. Happé F, Ronald A. The "fractionable autism triad": a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev 2008; 18: 287-304.
21. Ronald A, Larsson H, Anckarsäter H, Lichtenstein P. A twin study of autism symptoms in Sweden. Mol Psychiatry 2011; 16: 1039 -1047.
22. Greven CU, Rijsdijk FV, Plomin R. A twin study of ADHD symptoms in early adolescence: hyperactivity-impulsivity and inattentiveness show substantial genetic overlap but also genetic specificity. J Abnorm Child Psychol 2011; 39: 265-275.
23. McLoughlin G, Rijsdijk F, Asherson P, Kuntsi J. Parents and teachers make different contributions to a shared perspective on hyperactive-impulsive and inattentive symptoms: a multivariate analysis of parent and teacher ratings on the symptom domains of ADHD. Behav Genet 2011; 41: 668-679.
24. Polderman TJC, Hoekstra RA, Vinkhuyzen AAE, Sullivan PF, van der Sluis S, Posthuma D. Attentional switching forms a genetic link between attention problems and autistic traits in adults. Psychol Med 2013; 43: 1985-1996.
25. Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E et al. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet 2006; 9: 875-882. (Pubitemid 46093773)
26. Furberg H, Lichtenstein P, Pedersen NL, Thornton L, Bulik CM, Lerman C et al. The STAGE cohort: A prospective study of tobacco use among Swedish twins. Nictone Tob Res 2008; 10: 1727-1735.
27. Cortina JM. What is coefficient alpha? An examination of theory and applications. J Appl Psychol 1993; 78: 98-104.
28. Hall JG. Twinning. Lancet 2003; 362 : 735-743. (Pubitemid 37101075)
29. Plomin R, DeFries JC, McClearn GE, McGuffin P. Behavior Genetics 5th edn., Worth: New York, USA, 2008.
30. Neale MC Boker SM Xie G Maes HHM. Mx:Statistical Modeling. Department of Psychiatry, Virginia Common Wealth University: Richmond, VA, 2006.
31. Rijsdijk F. Statistical genetics: gene mapping through linkage and association. In: Ferreira M, Neale B, Medland S, Posthuma D (eds). Statistical Genetics: Gene Mapping through Linkage and Association. London: Taylor & Francis, 2007, pp 43-58.
32. Sullivan PF, Eaves LJ. Evaluation of analyses of univariate discrete twin data. Behav Genet 2002; 32: 221-227. (Pubitemid 34755947)
33. Mosconi MW, Kay M, D'Cruz A-M, Seidenfeld A, Guter S, Stanford LD et al. Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders. Psychol Med 2009; 39: 1559-1566.
34. Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a metaanalytic review. Biol Psychiatry 2005; 57: 1336-1346. (Pubitemid 40798553)
35. Lipszyc J, Schachar R. Inhibitory control and psychopathology: a meta-analysis of studies using the stop signal task. J Int Neuropsychol Soc JINS 2010; 16: 1064-1076.
36. Rommelse NNJ, Geurts HM, Franke B, Buitelaar JK, Hartman CA. A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neurosci Biobehav Rev 2011; 35: 1363-1396.
37. Geurts HM, Ridderinkhof KR, Scholte HS. The relationship between grey-matter and ASD and ADHD traits in typical adults. J Autism Dev Disord 2013; 43: 1630-1641.
38. Ronemus M, Iossifov I, Levy D, Wigler M. The role of de novo mutations in the genetics of autism spectrum disorders. Nat Rev Genet 2014; 15: 133-141.
39. Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R et al. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 2010; 376: 1401-1408.
40. Taurines R, Schwenck C, Westerwald E, Sachse M, Siniatchkin M, Freitag C. ADHD and autism: differential diagnosis or overlapping traits? A selective review. Atten Deficit Hyperact Disord 2012; 4: 115-139.
41. Lee SH, Ripke S, Neale BM, Faraone SV et al. Cross-Disorder Group of the Psychiatric Genomics Consortium Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984-994.
42. D'Onofrio BM, Rickert ME, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A et al. Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry 2014; 71: 432-438.
43. Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G et al. Rate of de novo mutations and the importance of father's age to disease risk. Nature 2012; 488: 471-475.
44. Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol 2009; 8: 110-124.
45. Losh M, Esserman D, Anckarsäter H, Sullivan PF, Lichtenstein P. Lower birth weight indicates higher risk of autistic traits in discordant twin pairs. Psychol Med 2012; 42: 1091 -1102.
46. Ronald A, Happé F, Dworzynski K, Bolton P, Plomin R. Exploring the relation between prenatal and neonatal complications and later autistic-like features in a representative community sample of twins. Child Dev 2010; 81: 166-182.
47. Groen-Blokhuis MM, Middeldorp CM, van Beijsterveldt CEM, Boomsma DI. Evidence for a causal association of low birth weight and attention problems. J Am Acad Child Adolesc Psychiatry 2011; 50: e2.
48. Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJS. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 2002; 288: 728-737. (Pubitemid 34848226)
49. D'Onofrio BM, Class QA, Rickert ME, Larsson H, Långström N, Lichtenstein P. Preterm birth and mortality and morbidity: a population-based quasiexperimental study. JAMA Psychiatry 2013; 70: 1231-1240.
50. Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 2014; 4: e360.
51. Elia J, Laracy S, Allen J, Nissley-Tsiopinis J, Borgmann-Winter K. Epigenetics: genetics versus life experiences. Curr Top Behav Neurosci 2012; 9: 317-340.
52. Wong CCY, Meaburn EL, Ronald A, Price TS, Jeffries AR, Schalkwyk LC et al. Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Mol Psychiatry 2014; 19: 495-503.
53. Jacquemont S, Coe BP, Hersch M, Duyzend MH, Krumm N, Bergmann S et al. A higher mutational burden in females supports a "female protective model" in neurodevelopmental disorders. Am J Hum Genet 2014; 94: 415-425.
54. Lundström S, Chang Z, Råstam M, Gillberg C, Larsson H, Anckarsäter H et al. Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variation. Arch Gen Psychiatry 2012; 69: 46 -52.
55. Robinson EB, Koenen KC, McCormick MC, Munir K, Hallett V, Happé F et al. Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5%, and 1%). Arch Gen Psychiatry 2011; 68: 1113-1121.
56. Larsson H, Anckarsater H, Råstam M, Chang Z, Lichtenstein P. Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs. J Child Psychol Psychiatry 2012; 53: 73-80.
57. Van der Sluis S, Posthuma D, Nivard MG, Verhage M, Dolan CV. Power in GWAS: lifting the curse of the clinical cut-off. Mol Psychiatry 2013; 18: 2-3.
58. Ronald A, Happé F, Bolton P, Butcher LM, Price TS, Wheelwright S et al. Genetic heterogeneity between the three components of the autism spectrum: a twin study. J Am Acad Child Adolesc Psychiatry 2006; 45: 691-699. (Pubitemid 43833102)
59. Ronald A, Happé F, Price TS, Baron-Cohen S, Plomin R. Phenotypic and genetic overlap between autistic traits at the extremes of the general population. J Am Acad Child Adolesc Psychiatry 2006; 45: 1206-1214. (Pubitemid 44465641)
60. Hoekstra RA, Vinkhuyzen AAE, Wheelwright S, Bartels M, Boomsma DI, Baron-Cohen S et al. The construction and validation of an abridged version of the autism-spectrum quotient (AQ-Short). J Autism Dev Disord 2011; 41: 589-596.
61. Lecavalier L, Aman MG, Scahill L, McDougle CJ, McCracken JT, Vitiello B et al. Validity of the autism diagnostic interview-revised. Am J Ment Retard 2006; 111: 199-215.
62. Chang Z, Lichtenstein P, Asherson PJ, Larsson H. Developmental twin study of attention problems: high heritabilities throughout development. JAMA Psychiatry 2013; 70 : 311 -318.