A twin study of autism symptoms in Sweden

Molecular Psychiatry

Volumn 16, Issue 10, 2011, Pages 1039-1047

  Ronald, A ^a   Larsson, H ^b   Anckarsater H ^c   Lichtenstein, P ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

autism; behavior; genetics; triad; twin

Indexed keywords

ARTICLE; AUTISM; CHILD; CLINICAL ASSESSMENT; COHORT ANALYSIS; COMMUNICATION DISORDER; COMPULSION; CONTROLLED STUDY; DATA ANALYSIS; ENVIRONMENTAL FACTOR; FACTORIAL ANALYSIS; FEMALE; GENETICS; HEREDITY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; MULTIVARIATE ANALYSIS; PARENTAL ATTITUDE; POPULATION RESEARCH; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SAMPLE; SCHOOL CHILD; SOCIAL BEHAVIOR; STRUCTURAL EQUATION MODELING; SWEDEN; SYMPTOM; TWINS;

AUTISTIC DISORDER; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; COHORT STUDIES; COMMUNICATION; DISEASES IN TWINS; FACTOR ANALYSIS, STATISTICAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MODELS, STATISTICAL; RISK FACTORS; SOCIAL BEHAVIOR;

EID: 80053133322     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.82     Document Type: Article

References (37)

1. Bolton P, Macdonald H, Pickles A, Rios P, Goode S, Crowson M et al. A case-control family history study of autism. J Child Psychol Psychiatry 1994; 35: 877-900. (Pubitemid 24213267)
2. Happé F, Ronald A. Fractionable autism triad: a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev 2008; 18: 287-304.
3. Happé F, Ronald A, Plomin R. Time to give up on a single explanation for autism. Nat Neurosci 2006; 9: 1218-1220. (Pubitemid 44454258)
4. Mandy WP, Skuse DH. Research review: what is the association between the social-communication element of autism and repetitive interests, behaviours and activities? J Child Psychol Psychiatry 2008; 49: 795-808.
5. Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008; 9: 341-355. (Pubitemid 351556064)
6. Constantino JN, Przybeck T, Friesen D, Todd RD. Reciprocal social behavior in children with and without pervasive developmental disorders. J Dev Behav Pediatr 2000; 21: 2-11.
7. Constantino JN, Gruber CP, Davis S, Hayes S, Passanante N, Przybeck T. The factor structure of autistic traits. J Child Psychol Psychiatry 2004; 45: 719-726. (Pubitemid 38559438)
8. Lecavalier L, Gadow KD, DeVincent CJ, Houts C, Edwards MC. Deconstructing the PDD clinical phenotype: internal validity of the DSM-IV. J Child Psychol Psychiatry 2009; 50: 1246-1254.
9. Mazefsky CA, Goin-Kochel RP, Riley BP, Maes HH. Genetic and environmental influences on symptom domains in twins and siblings with autism. Res Autism Spectr Disord 2008; 2: 320-331. (Pubitemid 351598072)
10. Ronald A, Happé F, Bolton P, Butcher LM, Price TS, Wheelwright S et al. Genetic heterogeneity between the three components of the autism spectrum: a twin study. J Am Acad Child Adolesc Psychiatry 2006; 45: 691-699. (Pubitemid 43833102)
11. Ronald A, Happé F, Price TS, Baron-Cohen S, Plomin R. Phenotypic and genetic overlap between autistic traits at the extremes of the general population. J Am Acad Child Adolesc Psychiatry 2006; 45: 1206-1214. (Pubitemid 44465641)
12. Dworzynski K, Happé F, Bolton P, Ronald A. Relationship between symptom domains in autism spectrum disorders: a population based twin study. J Autism Dev Disord 2009; 39: 1197-1210.
13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. APA: Washington, DC, 1994.
14. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, Pedersen NL. The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J Int Med 2002; 252: 184-205.
15. Anckarsater H, Larson T, Hansson SL, Carlstrom E, Stahlberg O, Gillberg C et al. Child neurodevelopmental and behavioural problems are intercorrelated and dimensionally distributed in the general population. Open Psychiatry J 2008; 2: 5-11.
16. Hansson SL, Svanstrom Rojvall A, Rastam M, Gillberg C, Gillberg C, Anckarsater H. Psychiatric telephone interview with parents for screening of childhood autism-tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): preliminary reliability and validity. Br J Psychiatry 2005; 187: 262-267. (Pubitemid 41306108)
17. Larson T, Anckarsäter H, Gillberg C, Stahlberg O, Carlström E, Kadesjö B et al. The Autism-Tics, AD/HD and other Comorbidities inventory (A-TAC): further validation of a telephone interview for epidemiological research. BMC Psychiatry 2010; 10.
18. Muthén L, Muthén B. Mplus. Statistical Analyses With Latent Variables, User's Guide. Muthén & Muthén: Los Angeles, 2006.
19. Plomin R, DeFries JC, McClearn GE, McGuffin P. Behavioral Genetics, 4th edn. Worth: New York, 2008.
20. Shrout PE, Fleiss J. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979; 86: 420-428.
21. Neale MC, Boker SM, Xie G, Maes HH. Mx Statistical Modeling, 6th edn. 2003.
22. Akaike H. Factor analysis and AIC. Psychometrika 1989; 52: 330-332.
23. Raftery AE In: Marsden PV (ed). Sociological Methodology. Blackwell: Oxford, 1995 pp 111-196.
24. Simonoff E, Pickles A, Hervas A, Silberg JL, Rutter M, Eaves L. Genetic influences on childhood hyperactivity: contrast effects imply parental rating bias, not sibling interaction. Psychol Med 1998; 28: 825-837. (Pubitemid 28393562)
25. Hoekstra RA, Bartels M, Verweij CJ, Boomsma DI. Heritability of autistic traits in the general population. Arch Pediatr Adolesc Med 2007; 161: 372-377. (Pubitemid 46556368)
26. Constantino JN, Todd RD. Intergenerational transmission of subthreshold autistic traits in the general population. Biol Psychiatry 2005; 57: 655-660. (Pubitemid 40409704)
27. Constantino JN, Todd RD. Autistic traits in the general population: a twin study. Arch Gen Psychiatry 2003; 60: 524-530. (Pubitemid 36539062)
28. Constantino JN, Todd RD. Genetic structure of reciprocal social behavior. Am J Psychiatry 2000; 157: 2043-2045.
29. Ronald A, Happé F, Plomin R. A twin study investigating the genetic and environmental aetiologies of parent, teacher and child ratings of autistic-like traits and their overlap. Eur Child Adolesc Psychiatry 2008; 17: 473-483.
30. Ronald A, Happé F, Plomin R. The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism. Dev Sci 2005; 8: 444-458. (Pubitemid 41137417)
31. Skuse DH, Mandy WP, Scourfield J. Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders Checklist. Br J Psychiatry 2005; 187: 568-572. (Pubitemid 41752747)
32. Edelson LR, Saudino KJ. Genetic and environmental influences on autistic-like behaviors in 2-year-old twins. Behav Genet 2009; 39: 255-264.
33. Derks EM, Dolan CV, Boomsma DI. Effects of censoring on parameter estimates and power in genetic modeling. Twin Res 2004; 7: 659-669. (Pubitemid 39643568)
34. Najman JM, Williams GM, Nikles J, Spence S, Bor W, O'Callaghan M et al. Bias influencing maternal reports of child behaviour and emotional state. Soc Psychiatry Psychiatr Epidemiol 2001; 36: 186-194. (Pubitemid 32694462)
35. Brune CW, Kim SJ, Salt J, Leventhal BL, Lord C, Cook Jr EH. 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. Am J Psychiatry 2006; 163: 2148-2156. (Pubitemid 46114236)
36. Liu XQ, Paterson AD, Szatmari P, Consortium AGP. Genome-wide linkage analyses of quantitative and categorical autism subphenotypes. Biol Psychiatry 2008; 64: 561-570.
37. Ronald A, Butcher LM, Docherty SL, Davis OSP, Schalkwyk LC, Craig IW et al. Genome-wide association study of social and nonsocial autistic-like traits in the general population using pooled DNA, 500K SNP microarrays and both community and diagnosed autism replication samples. Behav Genet 2010; 40: 31-45.