Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adults

Psychological Medicine

Volumn 41, Issue 11, 2011, Pages 2423-2433

  Lundstrom S ^a,b   Chang, Z ^c   Kerekes, N ^b,d   Gumpert, C H ^c   Rastam M ^a,d   Gillberg, C ^d   Lichtenstein, P ^c   Anckarsater H ^a,d  

^a LUND UNIVERSITY   (Sweden)

^b Swedish Prison and Probation Service R and D Unit   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Autism; autistic traits; epidemiology; genetics; twin

Indexed keywords

ADDICTION; ADOLESCENT; ADULT; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; CHILD; COHORT ANALYSIS; COMORBIDITY; DEPRESSION; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MALE; MENTAL DISEASE; RISK; SWEDEN; TWINS;

ADOLESCENT; ADULT; ANXIETY DISORDERS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; COHORT STUDIES; COMORBIDITY; DEPRESSIVE DISORDER; DISEASES IN TWINS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MENTAL DISORDERS; RISK; SUBSTANCE-RELATED DISORDERS; SWEDEN;

EID: 80054934048     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291711000377     Document Type: Article

References (52)

1. Anckarsäter H, Nilsson T, Saury JM, Rastam M, Gillberg C (2008). Autism spectrum disorders in institutionalized subjects. Nordic Journal of Psychiatry 62, 160-167. (Pubitemid 351943602)
2. APA (1994). Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, 4th edn. American Psychiatric Association: Washington, DC.
3. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T (2006). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 368, 210-215. (Pubitemid 44037796)
4. Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E (2001). The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders 31, 5-17.
5. Blazer D, Hughes D, George LK (1987). Stressful life events and the onset of a generalized anxiety syndrome. American Journal of Psychiatry 144, 1178-1183. (Pubitemid 17147522)
6. Boomsma DI, Saviouk V, Hottenga JJ, Distel MA, de Moor MH, Vink JM, Geels LM, van Beek, JH, Bartels M, de Geus EJ, Willemsen G (2010). Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS One 5, e10621.
7. Carpenter JS, Andrykowski MA, Wilson J, Hall LA, Rayens MK, Sachs B, Cunningham LLC (1998). Psychometrics for two short forms of the Center for Epidemiologic Studies-Depression Scale. Issues in Mental Health Nursing 19, 481-494. (Pubitemid 128475582)
8. Constantino JN, Todd RD (2003). Autistic traits in the general population: a twin study. Archives of General Psychiatry 60, 524-530. (Pubitemid 36539062)
9. Donno R, Parker G, Gilmour J, Skuse DH (2010). Social communication deficits in disruptive primary-school children. British Journal of Psychiatry 196, 282-298.
10. Doris A, Ebmeier K, Shajahan P (1999). Depressive illness. Lancet 354, 1369-1375. (Pubitemid 29481640)
11. Focquaert F, Steven MS, Wolford GL, Colden A, Gazzaniga MS (2007). Empathizing and systemizing cognitive traits in the sciences and humanities. Personality and Individual Differences 43, 619-625.
12. Folstein S, Rutter M (1977). Infantile autism: a genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry 18, 297-321.
13. Frisell T, Lichtenstein P, Rahman Q, Langstrom N (2010). Psychiatric morbidity associated with same-sex sexual behaviour: influence of minority stress and familial factors. Psychological Medicine 40, 315-324.
14. Furberg H, Lichtenstein P, Pedersen NL, Thornton L, Bulik CM, Lerman C, Sullivan PF (2008). The STAGE cohort: a prospective study of tobacco use among Swedish twins. Nicotine and Tobacco Research 10, 1727-1735.
15. Ghaziuddin M, Greden J (1998). Depression in children with autism/pervasive developmental disorders: a case-control family history study. Journal of Autism and Developmental Disorders 28, 111-115. (Pubitemid 28194011)
16. Gillberg C (1992). The Emanuel Miller Memorial Lecture 1991. Autism and autistic-like conditions: subclasses among disorders of empathy. Journal of Child Psychology and Psychiatry 33, 813-842.
17. Gillberg C, Cederlund M, Lamberg K, Zeijlon L (2006). Brief report: 'the autism epidemic'. The registered prevalence of autism in a Swedish urban area. Journal of Autism and Developmental Disorders 36, 429-435. (Pubitemid 43828667)
18. Gilmour J, Hill B, Place M, Skuse DH (2004). Social communication deficits in conduct disorder: a clinical and community survey. Journal of Child Psychology and Psychiatry 45, 967-978. (Pubitemid 38961495)
19. Halleröd SL, Larson T, Stahlberg O, Carlström E, Gillberg C, Anckarsäter H, Rastam M, Lichtenstein P, Gillberg C (2010). The Autism-Tics, ADHD and other Comorbidities (A-TAC) telephone interview: convergence with the Child Behavior Checklist (CBCL). Nordic Journal of Psychiatry 64, 218-224.
20. Hallett V, Ronald A, Happe F (2009). Investigating the association between autistic-like and internalizing traits in a community-based twin sample. Journal of the American Academy of Child and Adolescent Psychiatry 48, 618-627.
21. Hansson SL, Svanstrom Rojvall A, Rastam M, Gillberg C, Anckarsäter H (2005). Psychiatric telephone interview with parents for screening of childhood autism-tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): preliminary reliability and validity. British Journal of Psychiatry 187, 262-267. (Pubitemid 41306108)
22. Hoekstra RA, Bartels M, Hudziak JJ, Van Beijsterveldt TC, Boomsma DI (2007). Genetic and environmental covariation between autistic traits and behavioral problems. Twin Research and Human Genetics 10, 853-860. (Pubitemid 350292300)
23. Hofvander B, Delorme R, Chaste P, Nyden A, Wentz E, Stahlberg O, Herbrecht E, Stopin A, Anckarsäter H, Gillberg C, Rastam M, Leboyer M (2009). Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry 9, 35.
24. Kadesjö B, Gillberg C, Hagberg B (1999). Brief report : autism and Asperger syndrome in seven-year-old children: a total population study. Journal of Autism and Developmental Disorders 29, 327-331. (Pubitemid 29400361)
25. Kanne SM, Christ SE, Reiersen AM (2009). Psychiatric symptoms and psychosocial difficulties in young adults with autistic traits. Journal of Autism and Developmental Disorders 39, 827-833.
26. Kendler KS, Gardner CO, Gatz M, Pedersen NL (2007). The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychological Medicine 37, 453-462.
27. Larson T, Anckarsäter H, Gillberg C, Stahlberg O, Carlstrom E, Kadesjo B, Rastam M, Lichtenstein P, Gillberg C (2010). The Autism-Tics, ADHD and other Comorbidities inventory (A-TAC): further validation of a telephone interview for epidemiological research. BMC Psychiatry 10, 1-11.
28. Lee DO, Ousley OY (2006). Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology 16, 737-746. (Pubitemid 46175429)
29. Lichtenstein P, Carlstrom E, Rastam M, Gillberg C, Anckarsäter H (2010). The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. American Journal of Psychiatry. Published online: 4 August 2010. doi:10.1176/appi.ajp.2010.10020223.
30. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, Pedersen NL (2002). The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine 252, 184-205.
31. Lundström S, Haworth CM, Carlström E, Gillberg C, Mill J, Rastam M, Hultman CM, Ronald A, Anckarsäter H, Plomin R, Lichtenstein P, Reichenberg A (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies. Journal of Child Psychology and Psychiatry, and Allied Disciplines 51, 850-856.
32. Neale MC, Boker SM, Xie G, Maes HH (2003). Mx Statistical Modeling, 6th edn. VCU Box 900126, Richmond, VA 23298, Department of Psychiatry.
33. Oliveira G, Ataide A, Marques C, Miguel TS, Coutinho AM, Mota-Vieira L, Gonçalves E, Lopes NM, Rodrigues V, Carmona da Mota H, Vicente AM (2007). Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions. Developmental Medicine and Child Neurology 49, 726-733. (Pubitemid 47456446)
34. Pine DS, Guyer AE, Goldwin M, Towbin KA, Leibenluft E (2008). Autism spectrum disorder scale scores in pediatric mood and anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry 47, 652-661.
35. Plomin R, Haworth CM, Davis OS (2009). Common disorders are quantitative traits. Nature Reviews Genetics 10, 872-878.
36. Reiersen AM, Constantino JN, Grimmer M, Martin NG, Todd RD (2008). Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins. Twin Research and Human Genetics 11, 579-585.
37. Rommelse NN, Altink ME, Fliers EA, Martin NC, Buschgens CJ, Hartman CA, Buitelaar JK, Faraone SV, Sergeant JA, Oosterlaan J (2009). Comorbid problems in ADHD: degree of association, shared endophenotypes, and formation of distinct subtypes. Implications for a future DSM. Journal of Abnormal Child Psychology 37, 793-804.
38. Ronald A, Edelson LR, Asherson P, Saudino KJ (2010). Exploring the relationship between autistic-like traits and ADHD behaviors in early childhood: findings from a community twin study of 2-year-olds. Journal of Abnormal Child Psychology 38, 185-196.
39. Ronald A, Happé F, Bolton P, Butcher LM, Price TS, Wheelwright S, Baron-Cohen S, Plomin R (2006). Genetic heterogeneity between the three components of the autism spectrum: a twin study. Journal of the American Academy of Child and Adolescent Psychiatry 45, 691-699. (Pubitemid 43833102)
40. Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R (2008). Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of Child Psychology and Psychiatry, and Allied Disciplines 49, 535-542. (Pubitemid 351503093)
41. Roohi J, DeVincent CJ, Hatchwell E, Gadow KD (2009). Association of a monoamine oxidase-a gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism and Developmental Disorders 39, 67-74.
42. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry 47, 921-929.
43. Sizoo B, van den Brink W, Koeter M, Gorissen van Eenige M, van Wijngaarden-Cremers P, van der Gaag RJ (2010). Treatment seeking adults with autism or ADHD and co-morbid substance use disorder: prevalence, risk factors and functional disability. Drug and Alcohol Dependence 107, 44-50.
44. Stahlberg O, Anckarsäter H, Nilsson T (2010). Mental health problems in youths committed to juvenile institutions: prevalences and treatment needs. European Child and Adolescent Psychiatry 19, 893-903.
45. St Pourcain B, Wang K, Glessner JT, Golding J, Steer C, Ring SM, Skuse DH, Grant SF, Hakonarson H, Davey Smith G (2010). Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population. American Journal of Psychiatry 167, 1364-1372.
46. Sullivan PF, Eaves LJ (2002). Evaluation of analyses of univariate discrete twin data. Behavior Genetics 32, 221-227. (Pubitemid 34755947)
47. Szatmari P, MacLean JE, Jones MB, Bryson SE, Zwaigenbaum L, Bartolucci G, Mahoney WJ, Tuff L (2000). The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: a family history study. Journal of Child Psychology and Psychiatry, and Allied Disciplines 41, 579-586. (Pubitemid 30461898)
48. Tyrer P, Baldwin D (2006). Generalised anxiety disorder. Lancet 368, 2156-2166. (Pubitemid 44894560)
49. Weiss LA, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, Tanzi RE, Stefansson K, Santangelo SL, Gusella JF, Sklar P, Wu BL, Daly MJ; Autism Consortium (2008). Association between microdeletion and microduplication at 16p11.2 and autism. New England Journal of Medicine 358, 667-675. (Pubitemid 351240746)
50. Wentz E, Gillberg IC, Anckarsäter H, Gillberg C, Rastam M (2009). Reproduction and offspring status 18 years after teenage-onset anorexia nervosa-a controlled community-based study. International Journal of Eating Disorders 42, 483-491.
51. Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R, Stefansson H, Stefansson K, Magnusson P, Gudmundsson OO, Gustafsson O, Holmans P, Owen MJ, O'Donovan M, Thapar A (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376, 1401-1408.
52. Wing L (1981). Asperger's syndrome: a clinical account. Psychological Medicine 11, 115-129. (Pubitemid 11148565)