Proanthocyanidins improves lead-induced cognitive impairments by blocking endoplasmic reticulum stress and nuclear factor-κB-mediated inflammatory pathways in rats

Food and Chemical Toxicology

Volumn 72, Issue , 2014, Pages 295-302

  Liu, Chan Min ^a   Ma, Jie Qiong ^b   Liu, Si Si ^a   Zheng, Gui Hong ^a   Feng, Zhao Jun ^a   Sun, Jian Mei ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING   (China)

Author keywords

Beta amyloid; Brain inflammation; Endoplasmic reticulum stress; Lead; Oxidative stress; Proanthocyanidins

Indexed keywords

AMYLOID BETA PROTEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2; INOSITOL REQUIRING PROTEIN 1; INTERLEUKIN 1BETA; LEAD ACETATE; MEMBRANE PROTEIN; PROANTHOCYANIDIN; PROTEIN IRE1; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RNA LIKE ENDOPLASMIC RETICULUM KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; ERN2 PROTEIN, RAT; LEAD; NEUROPROTECTIVE AGENT; PROTEIN SERINE THREONINE KINASE; PTGS2 PROTEIN, RAT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ENCEPHALITIS; ENDOPLASMIC RETICULUM STRESS; MALE; METABOLIC PARAMETERS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TOTAL ANTIOXIDANT CAPACITY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; HIPPOCAMPUS; LIPID PEROXIDATION; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHOSPHORYLATION; WISTAR RAT;

ADMINISTRATION, ORAL; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; CYCLOOXYGENASE 2; ENDOPLASMIC RETICULUM STRESS; HIPPOCAMPUS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEAD; LIPID PEROXIDATION; MALE; MEMBRANE PROTEINS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PHOSPHORYLATION; PROANTHOCYANIDINS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TAU PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907301126     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.07.033     Document Type: Article

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