Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma

Journal of Clinical Immunology

Volumn 32, Issue 6, 2012, Pages 1292-1304

  Lee, Taehoon ^a   Kwon, Hyouk Soo ^a   Bang, Bo Ram ^b   Lee, Yoon Su ^a   Park, Mi Young ^b   Moon, Keun Ai ^b   Kim, Tae Bum ^a   Lee, Ki Young ^c   Moon, Hee Bom ^a   Cho, You Sook ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Institute for Life Sciences   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

airway remodeling; antioxidants; asthma; grape seed extract; Proanthocyanidins

Indexed keywords

CHEMOKINE; EOTAXIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GLUTATHIONE; GRAPE SEED EXTRACT; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; PLATELET DERIVED GROWTH FACTOR; PROANTHOCYANIDIN; TRANSFORMING GROWTH FACTOR BETA; CCL11 PROTEIN, MOUSE; GRAPE SEED PROANTHOCYANIDINS; NONSTEROID ANTIINFLAMMATORY AGENT; OVALBUMIN;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG FIBROSIS; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TREATMENT DURATION; ACUTE DISEASE; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; CYTOLOGY; DISEASE MODEL; FIBROSIS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; INFLAMMATION; LUNG; METABOLISM; MONONUCLEAR CELL; PATHOLOGY;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL11; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; GENE EXPRESSION; GLUTATHIONE; GRAPE SEED EXTRACT; INFLAMMATION; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; LEUKOCYTES, MONONUCLEAR; LUNG; MICE; MICE, INBRED BALB C; OVALBUMIN; PROANTHOCYANIDINS;

EID: 84878215290     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-012-9742-8     Document Type: Article

References (62)

1. Bateman and Boulet, Global strategy for asthma management and prevention (2010 update), www.ginaasthma.com. 2010.
2. Expert Panel Report 3 (EPR-3). Guidelines for the diagnosis and management of asthma-summary report 2007. J Allergy Clin Immunol. 2007;120(5 Suppl):S94-138.
3. Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med. 1990;9(3):235-43.
4. Bowler RP, Crapo JD. Oxidative stress in airways: is there a role for extracellular superoxide dismutase? Am J Respir Crit Care Med. 2002;166(12 Pt 2):S38-43.
5. Henderson WR, et al. A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model. J Immunol. 2002;169(9):5294-9.
6. Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol. 2003;36(1):95-109.
7. Rahman I, Yang SR, Biswas SK. Current concepts of redox signaling in the lungs. Antioxid Redox Signal. 2006;8(3-4):681-9.
8. Fitzpatrick AM, et al. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol. 2009;123(1):146-152.e8.
9. Fitzpatrick AM, et al. Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. J Allergy Clin Immunol. 2009;124(5):990-6.e1-9.
10. Comhair SA, et al. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med. 2005;172(3):306-13.
11. Lasmar L, et al. Adherence rate to inhaled corticosteroids and their impact on asthma control. Allergy. 2009;64(5):784-9.
12. Rachelefsky G. Inhaled corticosteroids and asthma control in children: assessing impairment and risk. Pediatrics. 2009;123(1):353-66.
13. Riedl MA, Nel AE. Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol. 2008;8(1):49-56.
14. Shaheen SO, et al. Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax. 2007;62(6):483-90.
15. Garcia V, et al. Dietary intake of flavonoids and asthma in adults. Eur Respir J. 2005;26(3):449-52.
16. Ram FS, Rowe BH, Kaur B. Vitamin C supplementation for asthma. Cochrane Database Syst Rev. 2004;3:CD000993.
17. Pearson PJ, et al. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax. 2004;59(8):652-6.
18. Fogarty A, et al. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin Exp Allergy. 2003;33(10):1355-9.
19. Ariga T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors. 2004;21(1-4):197-201.
20. Li BY, et al. Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy. J Cell Biochem. 2008;104(2):668-79.
21. Guler A, et al. Proanthocyanidin prevents myocardial ischemic injury in adult rats. Med Sci Monit. 2011;17(11):BR326-331.
22. Ulusoy S, et al. Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy. Nephrol (Carlton). 2012;17(4):372-9.
23. Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis. 2006;27(8):1682-91.
24. Han Y. Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candida albicans. Phytomedicine. 2007;14(11):733-8.
25. Cho ML, et al. Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunol Lett. 2009;124(2):102-10.
26. Henriet JP. Veno-lymphatic insufficiency. 4,729 patients undergoing hormonal and procyanidol oligomer therapy. Phlebologie. 1993;46(2):313-25.
27. Bagchi D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000;148(2-3):187-97.
28. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52(4):673-751.
29. Xia EQ, et al. Biological activities of polyphenols from grapes. Int J Mol Sci. 2010;11(2):622-46.
30. Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother Res. 2009;23(9):1197-204.
31. Zhou DY, et al. Grape seed proanthocyanidin extract attenuates airway inflammation and hyperresponsiveness in a murine model of asthma by downregulating inducible nitric oxide synthase. Planta Med. 2011;77(14):1575-81.
32. Kheradmand F, et al. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol. 2002;169(10):5904-11.
33. Barrett EG, et al. Cigarette smoke-induced airway hyperresponsiveness is not dependent on elevated immunoglobulin and eosinophilic inflammation in a mouse model of allergic airway disease. Am J Respir Crit Care Med. 2002;165(10):1410-8.
34. Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol. 2010;11(7):577-84.
35. D'Amato G, et al. Urban air pollution and climate change as environmental risk factors of respiratory allergy: an update. J Investig Allergol Clin Immunol. 2010;20(2):95-102. quiz following 102.
36. D'Amato G, et al. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Respir J. 2002;20(3):763-76.
37. Fogarty A, et al. Dietary vitamin E, IgE concentrations, and atopy. Lancet. 2000;356(9241):1573-4.
38. Grievink L, et al. Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study. Thorax. 1998;53(3):166-71.
39. Wood LG, et al. Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma. Lipids. 2000;35(9):967-74.
40. Rahman I, et al. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med. 1996;154(4 Pt 1):1055-60.
41. Vachier I, et al. Increased oxygen species generation in blood monocytes of asthmatic patients. Am Rev Respir Dis. 1992;146(5 Pt 1):1161-6.
42. Chanez P, et al. Generation of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester. Eur Respir J. 1990;3(9):1002-7.
43. Kelly FJ, et al. Altered lung antioxidant status in patients with mild asthma. Lancet. 1999;354(9177):482-3.
44. Kharitonov SA, et al. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343(8890):133-5.
45. Nadeem A, et al. Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol. 2003;111(1):72-8.
46. Kongerud J, et al. Ascorbic acid is decreased in induced sputum of mild asthmatics. Inhal Toxicol. 2003;15(2):101-9.
47. Hasselmark L, et al. Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma. Allergy. 1990;45(7):523-7.
48. Pearson DJ, et al. Selenium status in relation to reduced glutathione peroxidase activity in aspirin-sensitive asthma. Clin Exp Allergy. 1991;21(2):203-8.
49. Smith LJ, et al. Reduced superoxide dismutase in lung cells of patients with asthma. Free Radic Biol Med. 1997;22(7):1301-7.
50. Picado C, et al. Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity. Allergy. 2001;56(1):43-9.
51. Ercan H, et al. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. J Allergy Clin Immunol. 2006;118(5):1097-104.
52. Rusznak C, Devalia JL, Davies RJ. The impact of pollution on allergic disease. Allergy. 1994;49(18 Suppl):21-7.
53. Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J. 2000;16(3):534-54.
54. Meister A. Glutathione metabolism and its selective modification. J Biol Chem. 1988;263(33):17205-8.
55. Yang G, et al. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling. Cytokine. 2004;28(6):224-32.
56. Cang CX, Luan B. Expression of basic fibroblast growth factor and nuclear factor-kappaB and the effect of budesonide on their expression in rats with asthma. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11(5):393-6.
57. Lewis CC, et al. Airway fibroblasts exhibit a synthetic phenotype in severe asthma. J Allergy Clin Immunol. 2005;115(3):534-40.
58. Puddicombe SM, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 2000;14(10):1362-74.
59. Vignola AM, et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med. 1997;156(2 Pt 1):591-9.
60. Kabuyama Y, et al. Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis. Genes Cells. 2007;12(11):1235-44.
61. Hackett TL. Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma. Curr Opin Allergy Clin Immunol. 2012;12(1):53-9.
62. Lee T, et al. Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study. Respir Res. 2011;12:1.