The importance of the presence of a 5′-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of l-glutamate as assessed psychophysically

Journal of Neuroscience

Volumn 34, Issue 39, 2014, Pages 13234-13245

  Smith, Kimberly R ^a   Spector, Alan C ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Amino acids; Gustatory; Psychophysics; Taste receptors; Taste sensitivity

Indexed keywords

AMILORIDE; AMINO ACID; GLUTAMIC ACID; HETERODIMER; INOSINE PHOSPHATE; LYSINE; RIBONUCLEOTIDE; SACCHARIN; SODIUM CHLORIDE; T1R1 HETERODIMER; T1R3 HETERODIMER; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GLUTAMATE SODIUM; PROTEIN SUBUNIT; SODIUM CHANNEL BLOCKING AGENT; TASTE RECEPTORS, TYPE 1; TASTE RECEPTORS, TYPE 2;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; EXPERIMENTAL BEHAVIORAL TEST; FEMALE; GENE DELETION; GENOTYPE; GUSTOMETER; MALE; MOUSE; NONHUMAN; PERCEPTION; PSYCHOPHYSICS; REAL TIME POLYMERASE CHAIN REACTION; REINFORCEMENT; STIMULUS; TASTE ACUITY; TRAINING; WATER CONTROL TEST; AGONISTS; ANIMAL; C57BL MOUSE; GENETICS; HABITUATION; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; TASTE; TASTE BUD;

AMILORIDE; ANIMALS; FEMALE; HABITUATION, PSYCHOPHYSIOLOGIC; INOSINE MONOPHOSPHATE; LYSINE; MALE; MICE; MICE, INBRED C57BL; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; SODIUM CHANNEL BLOCKERS; SODIUM GLUTAMATE; TASTE; TASTE BUDS; TASTE PERCEPTION;

EID: 84907291737     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0417-14.2014     Document Type: Article

References (43)

1. Chaudhari N, Yang H, Lamp C, Delay E, Cartford C, Than T, Roper S (1996) The taste of monosodium glutamate: membrane receptors in taste buds. J Neurosci 16:3817-3826. Medline
2. Chaudhari N, Landin AM, Roper SD (2000) A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 3:113-119. CrossRef Medline
3. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF (2003) Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301:850-853. CrossRef Medline
4. Delay ER, Hernandez NP, Bromley K, Margolskee RF (2006) Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice. Chem Senses 31:351-357. CrossRef Medline
5. Delay ER, Mitzelfelt JD, Westburg AM, Gross N, Duran BL, EschleBK (2007) Comparison of L-monosodium glutamate and L-amino acid taste in rats. Neuroscience 148:266 -278. CrossRef Medline
6. Eylam S, Spector AC (2002) The effect of amiloride on operantly conditioned performance in an NaCl taste detection task and NaCl preference in C57BL/6J mice. Behav Neurosci 116:149 -159. CrossRef Medline
7. Eylam S, Spector AC (2003) Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J mice.ChemSenses 28:447- 458. CrossRef Medline
8. Eylam S, Spector AC (2005) Taste discrimination between NaCl and KCl is disrupted by amiloride in inbred mice with amiloride-insensitive chorda tympani nerves. Am J Physiol Regul Integr Comp Physiol 288:R1361- R1368. CrossRef Medline
9. Eylam S, Tracy T, Garcea M, Spector AC (2003) Amiloride is an ineffective conditioned stimulus in taste aversion learning in C57BL/6J and DBA/2J mice. Chem Senses 28:681- 689. CrossRef Medline
10. Formaker BK, Stapleton JR, Roper SD, Frank ME (2004) Responses of the rat chorda tympani nerve to glutamate-sucrose mixtures. Chem Senses 29:473- 482. CrossRef Medline
11. Glendinning JI, Bloom LD, Onishi M, Zheng KH, Damak S, Margolskee RF, Spector AC (2005) Contribution of alpha-gustducin to tasteguided licking responses of mice. Chem Senses 30:299 -316. CrossRef Medline
12. Heyer BR, Taylor-Burds CC, Tran LH, Delay ER (2003) Monosodium glutamate and sweet taste: generalization of conditioned taste aversion between glutamate and sweet stimuli in rats. Chem Senses 28:631- 641. CrossRef Medline
13. Inoue M, Beauchamp GK, Bachmanov AA (2004) Gustatory neural responses to umami taste stimuli in C57BL/6ByJ and 129P3/J mice. Chem Senses 29:789 -795. CrossRef Medline
14. Kawai M, Sekine-Hayakawa Y, Okiyama A, Ninomiya Y (2012) Gustatory sensation of l- and d-amino acids in humans. Amino Acids 43:2349 -2358. CrossRef Medline
15. Kitagawa J, Takahashi Y, Matsumoto S, Shingai T (2007) Response properties of the pharyngeal branch of the glossopharyngeal nerve for umami taste in mice and rats. Neurosci Lett 417:42- 45. CrossRef Medline
16. Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hübner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y (2013) Taste responses in mice lacking taste receptor subunit T1R1. J Physiol 591:1967-1985. CrossRef Medline
17. Lemon CH, Margolskee RF (2009) Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons. J Neurophysiol 101:2459 -2471. CrossRef Medline
18. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99:4692- 4696. CrossRef Medline
19. Markison S, Spector AC (1995) Amiloride is an ineffective conditioned stimulus in taste aversion learning. Chem Senses 20:559 -563. CrossRef Medline
20. Mouritsen OG, Khandelia H (2012) Molecular mechanism of the allosteric enhancement of the umami taste sensation. FEBS J 279:3112-3120. CrossRef Medline
21. Murata Y, Beauchamp GK, Bachmanov AA (2009) Taste perception of monosodium glutamate and inosine monophosphate by 129P3/J and C57BL/6ByJ mice. Physiol Behav 98:481- 488. CrossRef Medline
22. Nakashima K, Eddy MC, Katsukawa H, Delay ER, Ninomiya Y (2012) Behavioral responses to glutamate receptor agonists and antagonists implicate the involvement of brain-expressed mGluR4 and mGluR1 in taste transduction for umami in mice. Physiol Behav 105:709 -719. CrossRef Medline
23. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106:381-390. CrossRef Medline
24. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002) An amino-acid taste receptor. Nature 416:199 -202. CrossRef Medline
25. Ninomiya Y, FunakoshiM (1989) Behavioural discrimination between glutamate and the four basic taste substances in mice. Comp Biochem Physiol A Comp Physiol 92:365-370. CrossRef Medline
26. Ninomiya Y, Tanimukai T, Yoshida S, FunakoshiM (1991) Gustatory neural responses in preweanling mice. Physiol Behav 49:913-918. CrossRef Medline
27. Ninomiya Y, Kurenuma S, Nomura T, Uebayashi H, Kawamura H (1992) Taste synergism between monosodium glutamate and 5ʹ-ribonucleotide in mice. Comp Biochem Physiol A Comp Physiol 101:97-102. CrossRef Medline
28. Ninomiya Y, Kajiura H, Ishibashi T, Imai Y (1994) Different responsiveness of the chorda tympani and glossopharyngeal nerves to L-lysine in mice. Chem Senses 19:617- 626. CrossRef Medline
29. Pritchard TC, Scott TR (1982) Amino acids as taste stimuli: II. Quality coding. Brain Res 253:93-104. CrossRef Medline
30. Ruiz C, Gutknecht S, Delay E, Kinnamon S (2006) Detection of NaCl and KCl in TRPV1 knockout mice. Chem Senses 31:813-820. CrossRef Medline
31. Sako N, Harada S, Yamamoto T (2000) Gustatory information of umami substances in three major taste nerves. Physiol Behav 71:193-198. CrossRef Medline
32. San Gabriel A, Maekawa T, Uneyama H, Torii K (2009) Metabotropic glutamate receptor type 1 in taste tissue. Am J Clin Nutr 90:743S-746S. CrossRef Medline
33. Schiffman SS, Sennewald K, Gagnon J (1981) Comparison of taste qualities and thresholds of D- and L-amino acids. Physiol Behav 27:51-59. CrossRef Medline
34. Spector AC, Glendinning JI (2009) Linking peripheral taste processes to behavior. Curr Opin Neurobiol 19:370 -377. CrossRef Medline
35. Stratford JM, Finger TE (2011) Central representation of postingestive chemosensory cues in mice that lack the ability to taste. J Neurosci 31:9101- 9110. CrossRef Medline
36. Tokita K, Yamamoto T, Boughter JD Jr (2012) Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice. J Neurophysiol 107:1545-1555. CrossRef Medline
37. Treesukosol Y, Spector AC (2012) Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal. Am J Physiol Regul Integr Comp Physiol 303:R218 -R235. CrossRef Medline
38. Treesukosol Y, Lyall V, Heck GL, DeSimone JA, Spector AC (2007) A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice. Am J Physiol Regul Integr Comp Physiol 292:R1799 -R1809. CrossRef Medline
39. Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X (2004) Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci U S A 101:14258 -14263. CrossRef Medline
40. Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, Margolskee RF, Ninomiya Y (2012) Umami taste in mice uses multiple receptors and transduction pathways. J Physiol 590:1155-1170. CrossRef Medline
41. Yasuo T, Kusuhara Y, Yasumatsu K, Ninomiya Y (2008) Multiple receptor systems for glutamate detection in the taste organ. Biol Pharm Bull 31: 1833-1837. CrossRef Medline
42. Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, Liu H, Tachdjian C, Li X (2008) Molecular mechanism for the umami taste synergism. Proc Natl Acad Sci U S A 105:20930 -20934. CrossRef Medline
43. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS (2003) The receptors for mammalian sweet and umami taste. Cell 115:255-266. CrossRef Medline