Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26007-26020

  Diver, Melinda M ^a,b   Long, Stephen B ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b Weill Graduate School of Medical Sciences of Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES;

CYTOSOLIC; EMBEDDED REGIONS; ENZYMATIC MECHANISMS; INTEGRAL MEMBRANE; METHYLTRANSFERASES; MUTATIONAL ANALYSIS; POTENTIAL SUBSTRATE; SUBSTRATE RECOGNITION;

SUBSTRATES;

PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; S ADENOSYLMETHIONINE; CYSTEINE; INSECT PROTEIN; PROTEIN BINDING; PROTEIN METHYLTRANSFERASE; PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE;

AMINO ACID SUBSTITUTION; ANOPHELES GAMBIAE; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; HUMAN; HUMAN CELL; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; SEQUENCE ANALYSIS; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; KINETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANOPHELES GAMBIAE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CYSTEINE; HEK293 CELLS; HUMANS; INSECT PROTEINS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN METHYLTRANSFERASES; S-ADENOSYLMETHIONINE; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84907218653     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.585125     Document Type: Article

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