Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens

Steroids

Volumn 76, Issue 13, 2011, Pages 1465-1473

  Höglund, Camilla ^a   Sneitz, Nina ^a   Radominska Pandya, Anna ^b   Laakonen, Liisa ^a   Finel, Moshe ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Estradiol; Estriol; Ethinylestradiol; Glucuronidation

Indexed keywords

1 NAPHTHOL; 4 NITROPHENOL; ALANINE; ENTACAPONE; ESTRADIOL; ESTRIOL; ESTROGEN; ETHINYLESTRADIOL; GLUCURONOSYLTRANSFERASE 1A10; GLYCINE; LEUCINE; PHENYLALANINE; SCOPOLETIN; TYROSINE; VALINE;

ARTICLE; BINDING SITE; CATALYST; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; GLUCURONIDATION; MOLECULAR MODEL; MUTANT; PROTEIN STRUCTURE;

ALCOHOLS; AMINO ACID SEQUENCE; COUMARINS; ESTROGENS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 80053571497     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.07.017     Document Type: Article

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