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Volumn 11, Issue 10, 2014, Pages 1575-1590

Intravitreal drug delivery in retinal disease: Are we out of our depth?

Author keywords

Drug delivery; Intravitreal delivery; Nanoparticles; Retina; Retinal barriers; Retinal models

Indexed keywords

NANOCARRIER; NANOPARTICLE; VIRUS VECTOR; DRUG; EYE DROPS;

EID: 84907201808     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.927864     Document Type: Review
Times cited : (53)

References (103)
  • 2
    • 79952450877 scopus 로고    scopus 로고
    • Drug delivery to the posterior segment of the eye
    • Thrimawithana TR, Young S, Bunt CR, et al. Drug delivery to the posterior segment of the eye. Drug Discov Today 2011;16(5):270-7
    • (2011) Drug Discov Today , vol.16 , Issue.5 , pp. 270-277
    • Thrimawithana, T.R.1    Young, S.2    Bunt, C.R.3
  • 3
    • 68249126178 scopus 로고    scopus 로고
    • Intravitreal injection of therapeutic agents
    • Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of therapeutic agents. Retina 2009;29(7):875-912
    • (2009) Retina , vol.29 , Issue.7 , pp. 875-912
    • Peyman, G.A.1    Lad, E.M.2    Moshfeghi, D.M.3
  • 4
    • 84923867273 scopus 로고    scopus 로고
    • In: Chen J, Cranton W, Fihn M, editors. Handbook of visual display technology. Canopus Publishing Ltd; Bristol, UK
    • Garhart C, Lakshminarayan V. Anatomy of the eye. In: Chen J, Cranton W, Fihn M, editors. Handbook of visual display technology. Canopus Publishing Ltd; Bristol, UK: 2012. p. 73-83
    • (2012) Anatomy of the Eye , pp. 73-83
    • Garhart, C.1    Lakshminarayan, V.2
  • 6
    • 76349103967 scopus 로고    scopus 로고
    • Phagocytosis of retinal rod and cone photoreceptors
    • Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology 2010;25(1):8-15
    • (2010) Physiology , vol.25 , Issue.1 , pp. 8-15
    • Kevany, B.M.1    Palczewski, K.2
  • 8
    • 0027260894 scopus 로고
    • Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms
    • McKay
    • Liversidge J, McKay D, Mullen G, Forrester J. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell Immunol 1993;149(2):315-30
    • (1993) Cell Immunol , vol.149 , Issue.2 , pp. 315-330
    • Liversidge, J.D.1    Mullen, G.2    Forrester, J.3
  • 9
    • 21244451958 scopus 로고    scopus 로고
    • The retinal pigment epithelium in visual function
    • Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005;85(3):845-81
    • (2005) Physiol Rev , vol.85 , Issue.3 , pp. 845-881
    • Strauss, O.1
  • 10
    • 0030201340 scopus 로고    scopus 로고
    • The Müller cell: A functional element of the retina
    • Newman E, Reichenbach A. The Müller cell: A functional element of the retina. Trends Neurosci 1996;19(8):307-12
    • (1996) Trends Neurosci , vol.19 , Issue.8 , pp. 307-312
    • Newman, E.1    Reichenbach, A.2
  • 11
    • 0033622189 scopus 로고    scopus 로고
    • Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light
    • Barnett NL, Pow DV, Robinson SR. Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light. Glia 2000;30(1):64-73
    • (2000) Glia , vol.30 , Issue.1 , pp. 64-73
    • Barnett, N.L.1    Pow, D.V.2    Robinson, S.R.3
  • 12
    • 85051380573 scopus 로고    scopus 로고
    • 3 edition. Elsevier St Louis, MO Retina In: Remington LA editor. Clinical anatomy and physiology of the visual system. 3 edition. Elsevier St Louis, MO
    • Remington LA. Retina. In: Remington LA, editor. Clinical anatomy and physiology of the visual system. 3 edition. Elsevier; St Louis, MO: 2012. p. 61-92
    • (2012) Clinical anatomy and physiology of the visual system , pp. 61-92
    • Remington, L.A.1    Remington, L.A.2
  • 13
    • 0034003134 scopus 로고    scopus 로고
    • Structural macromolecules and supramolecular organisation of the vitreous gel
    • Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res 2000;19(3):323-44
    • (2000) Prog Retin Eye Res , vol.19 , Issue.3 , pp. 323-344
    • Bishop, P.N.1
  • 14
    • 72049123996 scopus 로고    scopus 로고
    • The vitreous gel: More than meets the eye
    • e1
    • Holekamp NM. The vitreous gel: More than meets the eye. Am J Ophthalmol 2010;149(1):32-6; e1
    • (2010) Am J Ophthalmol , vol.149 , Issue.1 , pp. 32-36
    • Holekamp, N.M.1
  • 16
    • 84860257625 scopus 로고    scopus 로고
    • World Health Organization. Available from
    • World Health Organization. Priority Eye Diseases 2014. 2014. Available from: Http://www.who.int/blindness/causes/priority/en/index.html
    • (2014) Priority Eye Diseases 2014
  • 17
    • 84904395607 scopus 로고    scopus 로고
    • Pathophysiology of diabetic retinopathy
    • Tarr JM, Kaul K, Chopra M, et al. Pathophysiology of diabetic retinopathy. ISRN Ophthalmol 2013;2013:1-13
    • (2013) ISRN Ophthalmol , vol.2013 , pp. 1-13
    • Tarr, J.M.1    Kaul, K.2    Chopra, M.3
  • 18
    • 84875706425 scopus 로고    scopus 로고
    • Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma
    • Medeiros FA, Lisboa R, Weinreb RN, et al. Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma. Ophthalmology 2013;120(4):736-44
    • (2013) Ophthalmology , vol.120 , Issue.4 , pp. 736-744
    • Medeiros, F.A.1    Lisboa, R.2    Weinreb, R.N.3
  • 19
    • 59849104241 scopus 로고    scopus 로고
    • Molecular pathology of age-related macular degeneration
    • Ding X, Patel M, Chan CC. Molecular pathology of age-related macular degeneration. Prog Retin Eye Res 2009;28(1):1-18
    • (2009) Prog Retin Eye Res , vol.28 , Issue.1 , pp. 1-18
    • Ding, X.1    Patel, M.2    Chan, C.C.3
  • 20
    • 80051912678 scopus 로고    scopus 로고
    • Intraocular pressure: Modulation as treatment for glaucoma
    • e2
    • Caprioli J, Varma R. Intraocular pressure: Modulation as treatment for glaucoma. Am J Ophthalmol 2011;152(3):340-4; e2
    • (2011) Am J Ophthalmol , vol.152 , Issue.3 , pp. 340-344
    • Caprioli, J.1    Varma, R.2
  • 21
    • 84907219278 scopus 로고    scopus 로고
    • Age-related macular degeneration: Guidelines for management
    • Royal College of Ophthalmologists.
    • Royal College of Ophthalmologists. Age-related macular degeneration: Guidelines for management. The Royal College of Ophthalmologists Scientific Department; London: 2009
    • (2009) The Royal College of Ophthalmologists Scientific Department London
  • 23
    • 77955242157 scopus 로고    scopus 로고
    • In vitro permeation of bevacizumab through human sclera: Effect of iontophoresis application
    • Pescina S, Ferrari G, Govoni P, et al. In vitro permeation of bevacizumab through human sclera: Effect of iontophoresis application. J Pharm Pharmacol 2010;62(9):1189-94
    • (2010) J Pharm Pharmacol , vol.62 , Issue.9 , pp. 1189-1194
    • Pescina, S.1    Ferrari, G.2    Govoni, P.3
  • 24
    • 35048821557 scopus 로고    scopus 로고
    • Transport barriers in transscleral drug delivery for retinal diseases
    • Kim SH, Lutz RJ, Wang NS, Robinson MR. Transport barriers in transscleral drug delivery for retinal diseases. Ophthalmic Res 2007;39(5):244-54
    • (2007) Ophthalmic Res , vol.39 , Issue.5 , pp. 244-254
    • Kim, S.H.1    Lutz, R.J.2    Wang, N.S.3    Robinson, M.R.4
  • 25
    • 84875946501 scopus 로고    scopus 로고
    • Treatment of acute posterior uveitis in a porcine model by injection of triamcinolone acetonide into the suprachoroidal space using microneedles
    • Gilger BC, Abarca EM, Salmon JH, Patel S. Treatment of acute posterior uveitis in a porcine model by injection of triamcinolone acetonide into the suprachoroidal space using microneedles. Invest Ophthalmol Vis Sci 2013;54(4):2483-92
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , Issue.4 , pp. 2483-2492
    • Gilger, B.C.1    Abarca, E.M.2    Salmon, J.H.3    Patel, S.4
  • 26
    • 78651245667 scopus 로고    scopus 로고
    • Suprachoroidal drug delivery to the back of the eye using hollow microneedles
    • Patel SR, Lin AS, Edelhauser HF, Prausnitz MR. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res 2011;28(1):166-76
    • (2011) Pharm Res , vol.28 , Issue.1 , pp. 166-176
    • Patel, S.R.1    Lin, A.S.2    Edelhauser, H.F.3    Prausnitz, M.R.4
  • 27
    • 84878631466 scopus 로고    scopus 로고
    • Suprachoroidal delivery in a rabbit ex vivo eye model: Influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes
    • Kadam RS, Williams J, Tyagi P, et al. Suprachoroidal delivery in a rabbit ex vivo eye model: Influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes. Mol Vis 2013;19:1198-210
    • (2013) Mol Vis , vol.19 , pp. 1198-1210
    • Kadam, R.S.1    Williams, J.2    Tyagi, P.3
  • 28
    • 84875033813 scopus 로고    scopus 로고
    • In: Kompella UB, Edelhauser HF, editors. Drug product development for the back of the eye. 2. Springer; New York
    • Wilson CG, Tan LE, Mains J. Principles of retinal drug delivery from within the vitreous. In: Kompella UB, Edelhauser HF, editors. Drug product development for the back of the eye. 2. Springer; New York: 2011. p. 125-58
    • (2011) Principles of Retinal Drug Delivery from Within the Vitreous , pp. 125-158
    • Wilson, C.G.1    Tan, L.E.2    Mains, J.3
  • 29
    • 6944239162 scopus 로고    scopus 로고
    • Regional mapping of molecular components of human liquid vitreous by dynamic light scattering
    • Bettelheim FA, Zigler Jr. J.S. Regional mapping of molecular components of human liquid vitreous by dynamic light scattering. Exp Eye Res 2004;79(5):713-18
    • (2004) Exp Eye Res , vol.79 , Issue.5 , pp. 713-718
    • Bettelheim, F.A.1    Zigler, J.S.2
  • 30
    • 0023192357 scopus 로고
    • Ageing of the vitreous
    • Sebag J. Ageing of the vitreous. Eye 1987;1(2):254-62
    • (1987) Eye , vol.1 , Issue.2 , pp. 254-262
    • Sebag, J.1
  • 31
    • 79953270200 scopus 로고    scopus 로고
    • Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein fluorescein dextran and fluorescent microparticles
    • Tan LE, Orilla W, Hughes PM, et al. Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein, fluorescein dextran, and fluorescent microparticles. Invest Ophthalmol Vis Sci 2011;52(2):1111-18
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.2 , pp. 1111-1118
    • Tan, L.E.1    Orilla, W.2    Hughes, P.M.3
  • 32
    • 78650794789 scopus 로고    scopus 로고
    • Intravitreal therapy for neovascular agerelated macular degeneration and interindividual variations in vitreous pharmacokinetics
    • Laude A, Tan LE, Wilson CG, et al. Intravitreal therapy for neovascular agerelated macular degeneration and interindividual variations in vitreous pharmacokinetics. Prog Retin Eye Res 2010;29(6):466-75
    • (2010) Prog Retin Eye Res , vol.29 , Issue.6 , pp. 466-475
    • Laude, A.1    Tan, L.E.2    Wilson, C.G.3
  • 33
    • 0036845775 scopus 로고    scopus 로고
    • Hydraulic flow and vascular clearance influences on intravitreal drug delivery
    • Missel PJ. Hydraulic flow and vascular clearance influences on intravitreal drug delivery. Pharm Res 2002;19(11):1636-47
    • (2002) Pharm Res , vol.19 , Issue.11 , pp. 1636-1647
    • Missel, P.J.1
  • 34
    • 84874001319 scopus 로고    scopus 로고
    • Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo
    • Xu Q, Boylan N, Suk J, et al. Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo. J Control Release 2013;167(1):76-84
    • (2013) J Control Release , vol.167 , Issue.1 , pp. 76-84
    • Xu, Q.1    Boylan, N.2    Suk, J.3
  • 35
    • 84889566066 scopus 로고    scopus 로고
    • Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
    • Martens TF, Vercauteren D, Forier K, et al. Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy. Nanomedicine 2013;8(12):1955-68
    • (2013) Nanomedicine , vol.8 , Issue.12 , pp. 1955-1968
    • Martens, T.F.1    Vercauteren, D.2    Forier, K.3
  • 36
    • 77954440564 scopus 로고    scopus 로고
    • Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane
    • Candiello J, Cole GJ, Halfter W. Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane. Matrix Biol 2010;29(5):402-10
    • (2010) Matrix Biol , vol.29 , Issue.5 , pp. 402-410
    • Candiello, J.1    Halfter, W.2
  • 37
    • 84866235159 scopus 로고    scopus 로고
    • Nanoscale topographic and biomechanical studies of the human internal limiting membrane
    • Henrich P, Monnier C, Halfter W, et al. Nanoscale topographic and biomechanical studies of the human internal limiting membrane. Invest Ophthalmol Vis Sci 2012;53(6):2561-70
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , Issue.6 , pp. 2561-2570
    • Henrich, P.1    Monnier, C.2    Halfter, W.3
  • 38
    • 79551508943 scopus 로고    scopus 로고
    • Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes
    • Goldenberg DT, Giblin FJ, Cheng M, et al. Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes. Retina 2011;31(2):393-400
    • (2011) Retina , vol.31 , Issue.2 , pp. 393-400
    • Goldenberg, D.T.1    Giblin, F.J.2    Cheng, M.3
  • 39
    • 80053371459 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    • Meyer C, Krohne T, Holz F. Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans. Retina 2011;31(9):1877-84
    • (2011) Retina , vol.31 , Issue.9 , pp. 1877-1884
    • Meyer, C.1    Krohne, T.2    Holz, F.3
  • 40
    • 73849132937 scopus 로고    scopus 로고
    • Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous
    • Dalkara D, Kolstad KD, Caporale N, et al. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Mol Ther 2009;17(12):2096-102
    • (2009) Mol Ther , vol.17 , Issue.12 , pp. 2096-2102
    • Dalkara, D.1    Kolstad, K.D.2    Caporale, N.3
  • 41
    • 84866297372 scopus 로고    scopus 로고
    • MRI study of subconjunctival and intravitreal injections
    • Li SK, Hao J, Liu H, Lee JH. MRI study of subconjunctival and intravitreal injections. J Pharm Sci 2012;101(7):2353-63
    • (2012) J Pharm Sci , vol.101 , Issue.7 , pp. 2353-2363
    • Li, S.K.1    Hao, J.2    Liu, H.3    Lee, J.H.4
  • 42
    • 84884540152 scopus 로고    scopus 로고
    • Ocular silicon distribution and clearance following intravitreal injection of porous silicon microparticles
    • Nieto A, Hou H, Sailor MJ, et al. Ocular silicon distribution and clearance following intravitreal injection of porous silicon microparticles. Exp Eye Res 2013;116:161-8
    • (2013) Exp Eye Res , vol.116 , pp. 161-168
    • Nieto, A.1    Hou, H.2    Sailor, M.J.3
  • 43
    • 84856594715 scopus 로고    scopus 로고
    • A pharmacokinetic study of a combination of beta adrenoreceptor antagonists-In the isolated perfused ovine eye
    • Mains J, Tan LE, Wilson C, Urquhart A. A pharmacokinetic study of a combination of beta adrenoreceptor antagonists-In the isolated perfused ovine eye. Eur J Pharm Biopharm 2012;80(2):393-401
    • (2012) Eur J Pharm Biopharm , vol.80 , Issue.2 , pp. 393-401
    • Mains, J.1    Tan, L.E.2    Wilson, C.3    Urquhart, A.4
  • 45
    • 13944264268 scopus 로고    scopus 로고
    • Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity
    • Pitkänen L, Ranta V-P, Moilanen H, Urtti A. Permeability of retinal pigment epithelium: Effects of permeant molecular weight and lipophilicity. Invest Ophthalmol Vis Sci 2005;46(2):641-6
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , Issue.2 , pp. 641-646
    • Pitkänen, L.1    Ranta, V.-P.2    Moilanen, H.3    Urtti, A.4
  • 46
    • 84867099927 scopus 로고    scopus 로고
    • Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema
    • Campochiaro PA, Brown DM, Pearson A, et al. Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema. Ophthalmology 2012;119(10):2125-32
    • (2012) Ophthalmology , vol.119 , Issue.10 , pp. 2125-2132
    • Campochiaro, P.A.1    Brown, D.M.2    Pearson, A.3
  • 47
    • 77952882990 scopus 로고    scopus 로고
    • Randomized sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion
    • e3
    • Haller JA, Bandello F, Belfort R Jr, et al. Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 2010;117(6):1134-46; e3
    • (2010) Ophthalmology , vol.117 , Issue.6 , pp. 1134-1146
    • Haller, J.A.1    Bandello, F.2    Belfort, R.3
  • 48
    • 33646925637 scopus 로고    scopus 로고
    • Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: Thirtyfour-week results of a multicenter randomized clinical study
    • Jaffe GJ, Martin D, Callanan D, et al. Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: Thirtyfour-week results of a multicenter randomized clinical study. Ophthalmology 2006;113(6):1020-7
    • (2006) Ophthalmology , vol.113 , Issue.6 , pp. 1020-1027
    • Jaffe, G.J.1    Martin, D.2    Callanan, D.3
  • 49
    • 77951282109 scopus 로고    scopus 로고
    • A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases
    • Choonara YE, Pillay V, Danckwerts MP, et al. A review of implantable intravitreal drug delivery technologies for the treatment of posterior segment eye diseases. J Pharm Sci 2010;99(5):2219-39
    • (2010) J Pharm Sci , vol.99 , Issue.5 , pp. 2219-2239
    • Choonara, Y.E.1    Pillay, V.2    Danckwerts, M.P.3
  • 50
    • 84855324053 scopus 로고    scopus 로고
    • Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: Thirty-six-month results
    • Jain N, Stinnett SS, Jaffe GJ. Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: Thirty-six-month results. Ophthalmology 2012;119(1):132-7
    • (2012) Ophthalmology , vol.119 , Issue.1 , pp. 132-137
    • Jain, N.1    Stinnett, S.S.2    Jaffe, G.J.3
  • 53
    • 84864423998 scopus 로고    scopus 로고
    • Fractured Ozurdex-implant in the vitreous cavity
    • Rishi P, Mathur G, Rishi E. Fractured Ozurdex-implant in the vitreous cavity. Indian J Ophthalmol 2012;60(4):337-8
    • (2012) Indian J Ophthalmol , vol.60 , Issue.4 , pp. 337-338
    • Rishi, P.1    Mathur, G.2    Rishi, E.3
  • 54
    • 54049091605 scopus 로고    scopus 로고
    • Iluvien: A new sustained delivery technology for posterior eye disease
    • Kane FE, Burdan J, Cutino A, Green KE. Iluvien-: A new sustained delivery technology for posterior eye disease. Expert Opin Drug Deliv 2008;5(9):1039-46
    • (2008) Expert Opin Drug Deliv , vol.5 , Issue.9 , pp. 1039-1046
    • Kane, F.E.1    Burdan, J.2    Cutino, A.3    Green, K.E.4
  • 55
    • 0035211330 scopus 로고    scopus 로고
    • Effect of particle size of polymeric nanospheres on intravitreal kinetics
    • Sakurai E, Ozeki H, Kunou N, Ogura Y. Effect of particle size of polymeric nanospheres on intravitreal kinetics. Ophthalmic Res 2000;33(1):31-6
    • (2000) Ophthalmic Res , vol.33 , Issue.1 , pp. 31-36
    • Sakurai, E.1    Ozeki, H.2    Kunou, N.3    Ogura, Y.4
  • 56
    • 66349109049 scopus 로고    scopus 로고
    • Preparation, characterization, and in vivo evaluation of nanoliposomesencapsulated bevacizumab (avastin) for intravitreal administration
    • Abrishami M, Ganavati SZ, Soroush D, et al. Preparation, characterization, and in vivo evaluation of nanoliposomesencapsulated bevacizumab (avastin) for intravitreal administration. Retina 2009;29(5):699-703
    • (2009) Retina , vol.29 , Issue.5 , pp. 699-703
    • Abrishami, M.1    Ganavati, S.Z.2    Soroush, D.3
  • 57
    • 34548057327 scopus 로고    scopus 로고
    • Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal peptide encapsulated in liposomes
    • Lajavardi L, Bochot A, Camelo S, et al. Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal peptide encapsulated in liposomes. Invest Ophthalmol Vis Sci 2007;48(7):3230-8
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.7 , pp. 3230-3238
    • Lajavardi, L.1    Bochot, A.2    Camelo, S.3
  • 58
    • 84860198170 scopus 로고    scopus 로고
    • Gantrez AN nanoparticles for ocular delivery of memantine: In vitro release evaluation in albino rabbits
    • Prieto E, Puente B, Uixera A, et al. Gantrez AN nanoparticles for ocular delivery of memantine: In vitro release evaluation in albino rabbits. Ophthalmic Res 2012;48(3):109-17
    • (2012) Ophthalmic Res , vol.48 , Issue.3 , pp. 109-117
    • Prieto, E.1    Puente, B.2    Uixera, A.3
  • 59
    • 77956272682 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerance study of intravitreal injection of dexamethasoneloaded nanoparticles in rabbits
    • Zhang L, Li Y, Zhang C, et al. Pharmacokinetics and tolerance study of intravitreal injection of dexamethasoneloaded nanoparticles in rabbits. Int J Nanomedicine 2009;4:175-83
    • (2009) Int J Nanomedicine , vol.4 , pp. 175-183
    • Zhang, L.1    Li, Y.2    Zhang, C.3
  • 60
    • 80855130893 scopus 로고    scopus 로고
    • Retinal ganglion cells survival in a glaucoma model by GDNF/Vit e PLGA microspheres prepared according to a novel microencapsulation procedure
    • Checa-Casalengua P, Jiang C, Bravo-Osuna I, et al. Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure. J Control Release 2011;156(1):92-100
    • (2011) J Control Release , vol.156 , Issue.1 , pp. 92-100
    • Checa-Casalengua, P.1    Jiang, C.2    Bravo-Osuna, I.3
  • 61
    • 84889255994 scopus 로고    scopus 로고
    • Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab
    • Yandrapu SK, Upadhyay AK, Petrash JM, Kompella UB. Nanoparticles in porous microparticles prepared by supercritical infusion and pressure quench technology for sustained delivery of bevacizumab. Mol Pharm 2013;10(12):4676-86
    • (2013) Mol Pharm , vol.10 , Issue.12 , pp. 4676-4686
    • Yandrapu, S.K.1    Upadhyay, A.K.2    Petrash, J.M.3    Kompella, U.B.4
  • 62
    • 0020582598 scopus 로고
    • Turnover of hyaluronate in the aqueous humour and vitreous body of the rabbit
    • Laurent UB, Fraser J. Turnover of hyaluronate in the aqueous humour and vitreous body of the rabbit. Exp Eye Res 1983;36(4):493-503
    • (1983) Exp Eye Res , vol.36 , Issue.4 , pp. 493-503
    • Laurent, U.B.1    Fraser, J.2
  • 63
    • 79951577891 scopus 로고    scopus 로고
    • Anti-Flt1 peptide-Hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy
    • Oh EJ, Choi J-S, Kim H, et al. Anti-Flt1 peptide-Hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy. Biomaterials 2011;32(11):3115-23
    • (2011) Biomaterials , vol.32 , Issue.11 , pp. 3115-3123
    • Oh, E.J.1    Choi, J.-S.2    Kim, H.3
  • 64
    • 85027944784 scopus 로고    scopus 로고
    • Inflammatory response to intravitreal injection of gold nanorods
    • Sandrian MG, Wollstein G, Schuman JS, et al. Inflammatory response to intravitreal injection of gold nanorods. Br J Ophthalmol 2012;96(12):1522-9
    • (2012) Br J Ophthalmol , vol.96 , Issue.12 , pp. 1522-1529
    • Sandrian, M.G.1    Wollstein, G.2    Schuman, J.S.3
  • 66
    • 81155152766 scopus 로고    scopus 로고
    • Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
    • Iezzi R, Guru BR, Glybina IV, et al. Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012;33(3):979-88
    • (2012) Biomaterials , vol.33 , Issue.3 , pp. 979-988
    • Iezzi, R.1    Guru, B.R.2    Glybina, I.V.3
  • 67
    • 27544499791 scopus 로고    scopus 로고
    • Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-Term study into inhibition of laser-induced CNV, distribution, uptake and toxicity
    • Marano R, Toth I, Wimmer N, et al. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-Term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther 2005;12(21):1544-50
    • (2005) Gene Ther , vol.12 , Issue.21 , pp. 1544-1550
    • Marano, R.1    Toth, I.2    Wimmer, N.3
  • 68
    • 33646809712 scopus 로고    scopus 로고
    • Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
    • Parekh HS, Marano RJ, Rakoczy EP, et al. Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorgan Med Chem 2006;14(14):4775-80
    • (2006) Bioorgan Med Chem , vol.14 , Issue.14 , pp. 4775-4780
    • Parekh, H.S.1    Marano, R.J.2    Rakoczy, E.P.3
  • 69
    • 84862782522 scopus 로고    scopus 로고
    • The movement of self-Assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection
    • Koo H, Moon H, Han H, et al. The movement of self-Assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection. Biomaterials 2012;33(12):3485-93
    • (2012) Biomaterials , vol.33 , Issue.12 , pp. 3485-3493
    • Koo, H.1    Moon, H.2    Han, H.3
  • 70
    • 0042844771 scopus 로고    scopus 로고
    • Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles
    • Bourges JL, Gautier SE, Delie F, et al. Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Invest Ophthalmol Vis Sci 2003;44(8):3562-9
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.8 , pp. 3562-3569
    • Bourges, J.L.1    Gautier, S.E.2    Delie, F.3
  • 71
    • 84874852947 scopus 로고    scopus 로고
    • Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection
    • Wong LL, Hirst SM, Pye QN, et al. Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection. PLoS One 2013;8(3):e58431
    • (2013) PLoS One , vol.8 , Issue.3 , pp. e58431
    • Wong, L.L.1    Hirst, S.M.2    Pye, Q.N.3
  • 72
    • 84887025605 scopus 로고    scopus 로고
    • Sustained inhibition of neovascularization in vldlr (-/-) mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-kappaB pathway
    • Cai X, Seal S, McGinnis J. Sustained inhibition of neovascularization in vldlr (-/-) mice following intravitreal injection of cerium oxide nanoparticles and the role of the ASK1-P38/JNK-NF-kappaB pathway. Biomaterials 2014;35(1):249-58
    • (2014) Biomaterials , vol.35 , Issue.1 , pp. 249-258
    • Cai, X.1    Seal, S.2    McGinnis, J.3
  • 73
    • 76749087849 scopus 로고    scopus 로고
    • Nanoparticle-integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats
    • Kim H, Csaky KG. Nanoparticle-integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats. J Control Release 2010;142(2):286-93
    • (2010) J Control Release , vol.142 , Issue.2 , pp. 286-293
    • Kim, H.1    Csaky, K.G.2
  • 74
    • 80051513044 scopus 로고    scopus 로고
    • Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor
    • Jin J, Zhou KK, Park K, et al. Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor. Invest Ophthalmol Vis Sci 2011;52(9):6230-7
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.9 , pp. 6230-6237
    • Jin, J.1    Zhou, K.K.2    Park, K.3
  • 75
    • 79955471838 scopus 로고    scopus 로고
    • Suppression of phagocytic cells in retinal disorders using amphiphilic poly (gamma-glutamic acid) nanoparticles containing dexamethasone
    • Ryu M, Nakazawa T, Akagi T, et al. Suppression of phagocytic cells in retinal disorders using amphiphilic poly (gamma-glutamic acid) nanoparticles containing dexamethasone. J Control Release 2011;151(1):65-73
    • (2011) J Control Release , vol.151 , Issue.1 , pp. 65-73
    • Ryu, M.1    Nakazawa, T.2    Akagi, T.3
  • 76
    • 77955537470 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune uveoretinitis with intravitreal injection of tacrolimus (fk506) encapsulated in liposomes
    • Zhang R, He R, Qian JA, et al. Treatment of experimental autoimmune uveoretinitis with intravitreal injection of tacrolimus (fk506) encapsulated in liposomes. Invest Ophthalmol Vis Sci 2010;51(7):3575-82
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.7 , pp. 3575-3582
    • Zhang, R.1    He, R.2    Qian, J.A.3
  • 77
    • 80052386408 scopus 로고    scopus 로고
    • A Lipid nanoparticle system improves siRNA efficacy in RPE cells and a laserinduced murine CNV model
    • Liu H, Liu Y, Ma Z, et al. A Lipid nanoparticle system improves siRNA efficacy in RPE cells and a laserinduced murine CNV model. Invest Ophthalmol Vis Sci 2011;52(7):4789-94
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.7 , pp. 4789-4794
    • Liu, H.1    Liu, Y.2    Ma, Z.3
  • 78
    • 42449150066 scopus 로고    scopus 로고
    • Drainage of fluorescent liposomes from the vitreous to cervical lymph nodes via conjunctival lymphatics
    • Camelo S, Lajavardi L, Bochot A, et al. Drainage of fluorescent liposomes from the vitreous to cervical lymph nodes via conjunctival lymphatics. Ophthalmic Res 2008;40(3-4):145-50
    • (2008) Ophthalmic Res , vol.40 , Issue.3-4 , pp. 145-150
    • Camelo, S.1    Lajavardi, L.2    Bochot, A.3
  • 79
    • 84872016241 scopus 로고    scopus 로고
    • EphA2 targeted doxorubicin stealth liposomes as a therapy system for choroidal neovascularization in rats
    • Wang J, Liu Y, Li Y, et al. EphA2 targeted doxorubicin stealth liposomes as a therapy system for choroidal neovascularization in rats. Invest Ophthalmol Vis Sci 2012;53(11):7348-57
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , Issue.11 , pp. 7348-7357
    • Wang, J.1    Liu, Y.2    Li, Y.3
  • 80
    • 79952605798 scopus 로고    scopus 로고
    • Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416
    • Honda M, Asai T, Umemoto T, et al. Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416. Arch Ophthalmol 2011;129(3):317-21
    • (2011) Arch Ophthalmol , vol.129 , Issue.3 , pp. 317-321
    • Honda, M.1    Asai, T.2    Umemoto, T.3
  • 81
    • 66249146393 scopus 로고    scopus 로고
    • Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4
    • Ma L, Liu YL, Ma ZZ, et al. Targeted treatment of choroidal neovascularization using integrin-mediated sterically stabilized liposomes loaded with combretastatin A4. J Ocul Pharmacol Ther 2009;25(3):195-200
    • (2009) J Ocul Pharmacol Ther , vol.25 , Issue.3 , pp. 195-200
    • Ma, L.1    Liu, Y.L.2    Ma, Z.Z.3
  • 82
    • 84873376827 scopus 로고    scopus 로고
    • Targeting therapy of choroidal neovascularization by use of polypeptide-And PEDF-loaded immunoliposomes under ultrasound exposure
    • Li T, Zhang M, Han Y, et al. Targeting therapy of choroidal neovascularization by use of polypeptide-And PEDF-loaded immunoliposomes under ultrasound exposure. J Huazhong Univ Science Technol Med Sci 2010;30(6):798-803
    • (2010) J Huazhong Univ Science Technol Med Sci , vol.30 , Issue.6 , pp. 798-803
    • Li, T.1    Zhang, M.2    Han, Y.3
  • 83
    • 77953251302 scopus 로고    scopus 로고
    • In: Schäfer-Korting M, Editor. Handbook of Experimental Pharmacology: Drug Delivery. Springer; Heidelberg
    • Heilbronn R, Weger S. Viral vectors for gene transfer: Current status of gene therapeutics. In: Schäfer-Korting M, editor. Handbook of experimental pharmacology: Drug delivery. 197. Springer; Heidelberg: 2010. p. 143-70
    • (2010) Viral Vectors for Gene Transfer: Current Status of Gene Therapeutics , vol.197 , pp. 143-170
    • Heilbronn, R.1    Weger, S.2
  • 84
    • 84856950131 scopus 로고    scopus 로고
    • Novel adeno-Associated viral vectors for retinal gene therapy
    • Vandenberghe L, Auricchio A. Novel adeno-Associated viral vectors for retinal gene therapy. Gene Ther 2011;19(2):162-8
    • (2011) Gene Ther , vol.19 , Issue.2 , pp. 162-168
    • Vandenberghe, L.1    Auricchio, A.2
  • 85
    • 70349230977 scopus 로고    scopus 로고
    • RAAV. SFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector
    • Lai C-M, Estcourt MJ, Wikstrom M, et al. rAAV. sFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector. Invest Ophthalmol Vis Sci 2009;50(9):4279-87
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.9 , pp. 4279-4287
    • Lai, C.-M.1    Estcourt, M.J.2    Wikstrom, M.3
  • 86
    • 84880540708 scopus 로고    scopus 로고
    • In vivo-directed evolution of a new adeno-Associated virus for therapeutic outer retinal gene delivery from the vitreous
    • Dalkara D, Byrne LC, Klimczak RR, et al. In vivo-directed evolution of a new adeno-Associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med 2013;5(189):189ra76
    • (2013) Sci Transl Med , vol.5 , Issue.189 , pp. 189-276
    • Dalkara, D.1    Byrne, L.C.2    Klimczak, R.R.3
  • 87
    • 83155177072 scopus 로고    scopus 로고
    • Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey
    • Vandenberghe LH, Bell P, Maguire AM, et al. Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med 2011;3(88):88ra54
    • (2011) Sci Transl Med , vol.3 , Issue.88 , pp. 88-154
    • Vandenberghe, L.H.1    Bell, P.2    Maguire, A.M.3
  • 88
    • 83655192122 scopus 로고    scopus 로고
    • Sonophoresis-mediated permeation and retention of peptide dendrimers across human epidermis
    • Mutalik S, Nayak U, Kalra R, et al. Sonophoresis-mediated permeation and retention of peptide dendrimers across human epidermis. Skin Res Technol 2012;18(1):101-7
    • (2012) Skin Res Technol , vol.18 , Issue.1 , pp. 101-107
    • Mutalik, S.1    Nayak, U.2    Kalra, R.3
  • 89
    • 14944376721 scopus 로고    scopus 로고
    • Healing sound: The use of ultrasound in drug delivery and other therapeutic applications
    • Mitragotri S. Healing sound: The use of ultrasound in drug delivery and other therapeutic applications. Nat Rev Drug Discov 2005;4(3):255-60
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.3 , pp. 255-260
    • Mitragotri, S.1
  • 90
    • 67650069449 scopus 로고    scopus 로고
    • Drug loaded microbubble design for ultrasound triggered delivery
    • Lentacker I, De Smedt SC, Sanders NN. Drug loaded microbubble design for ultrasound triggered delivery. Soft Matter 2009;5(11):2161-70
    • (2009) Soft Matter , vol.5 , Issue.11 , pp. 2161-2170
    • Lentacker, I.1    De Smedt, S.C.2    Sanders, N.N.3
  • 91
    • 53949093002 scopus 로고    scopus 로고
    • Can ultrasound solve the transport barrier of the neural retina?
    • Peeters L, Lentacker I, Vandenbroucke RE, et al. Can ultrasound solve the transport barrier of the neural retina? Pharm Res 2008;25(11):2657-65
    • (2008) Pharm Res , vol.25 , Issue.11 , pp. 2657-2665
    • Peeters, L.1    Lentacker, I.2    Vandenbroucke, R.E.3
  • 92
    • 44149127417 scopus 로고    scopus 로고
    • Liposomes in ultrasonic drug and gene delivery
    • Huang SL. Liposomes in ultrasonic drug and gene delivery. Adv Drug Deliv Rev 2008;60(10):1167-76
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.10 , pp. 1167-1176
    • Huang, S.L.1
  • 93
    • 70249149259 scopus 로고    scopus 로고
    • Ultrasound-Targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo
    • Li H, Zheng X, Wang H, et al. Ultrasound-Targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo. Gene Ther 2009;16(9):1146-53
    • (2009) Gene Ther , vol.16 , Issue.9 , pp. 1146-1153
    • Li, H.1    Zheng, X.2    Wang, H.3
  • 94
    • 73449128961 scopus 로고    scopus 로고
    • Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization
    • Zhou X-Y, Liao Q, Pu Y-M, et al. Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization. Chin Med J (Engl Ed) 2009;122(22):2711-17
    • (2009) Chin Med J (Engl Ed) , vol.122 , Issue.22 , pp. 2711-2717
    • Zhou, X.-Y.1    Liao, Q.2    Pu, Y.-M.3
  • 95
    • 84898599400 scopus 로고    scopus 로고
    • Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery
    • Paul S, Nahire R, Mallik S, Sarkar K. Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery. Comput Mech 2014;53(3):413-35
    • (2014) Comput Mech , vol.53 , Issue.3 , pp. 413-435
    • Paul, S.1    Nahire, R.2    Mallik, S.3    Sarkar, K.4
  • 96
    • 78651256000 scopus 로고    scopus 로고
    • Progress in the development of ultrasound-mediated gene delivery systems utilizing nano-And microbubbles
    • Suzuki R, Oda Y, Utoguchi N, Maruyama K. Progress in the development of ultrasound-mediated gene delivery systems utilizing nano-And microbubbles. J Control Release 2011;149(1):36-41
    • (2011) J Control Release , vol.149 , Issue.1 , pp. 36-41
    • Suzuki, R.1    Oda, Y.2    Utoguchi, N.3    Maruyama, K.4
  • 97
    • 84873807954 scopus 로고    scopus 로고
    • Selective gene transfer to the retina using intravitreal ultrasound irradiation
    • 2012:Article ID
    • Sonoda S, Tachibana K, Yamashita T, et al. Selective gene transfer to the retina using intravitreal ultrasound irradiation. J Ophthalmol 2012;2012:Article ID 412752
    • (2012) J Ophthalmol
    • Sonoda, S.1    Tachibana, K.2    Yamashita, T.3
  • 98
    • 77952052297 scopus 로고    scopus 로고
    • Retinal vascular changes after glial disruption in rats
    • Shen W, Li S, Chung SH, Gillies MC. Retinal vascular changes after glial disruption in rats. J Neurosci Res 2010;88(7):1485-99
    • (2010) J Neurosci Res , vol.88 , Issue.7 , pp. 1485-1499
    • Shen, W.1    Li, S.2    Chung, S.H.3    Gillies, M.C.4
  • 99
    • 77953541928 scopus 로고    scopus 로고
    • Filter-cultured ARPE-19 cells as outer blood-retinal barrier model
    • Mannermaa E, Reinisalo M, Ranta V-P, et al. Filter-cultured ARPE-19 cells as outer blood-retinal barrier model. Eur J Pharm Sci 2010;40(4):289-96
    • (2010) Eur J Pharm Sci , vol.40 , Issue.4 , pp. 289-296
    • Mannermaa, E.1    Reinisalo, M.2    Ranta, V.-P.3
  • 100
    • 70349618474 scopus 로고    scopus 로고
    • Immunohistochemical study of pig retinal development
    • Guduric-Fuchs J, Ringland LJ, Gu P, et al. Immunohistochemical study of pig retinal development. Mol Vis 2009;15:1915-28
    • (2009) Mol Vis , vol.15 , pp. 1915-1928
    • Guduric-Fuchs, J.1    Ringland, L.J.2    Gu, P.3
  • 101
    • 41049091678 scopus 로고    scopus 로고
    • Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: Characterisation of an organotypic in vitro model
    • Kobuch K, Herrmann WA, Framme C, et al. Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: Characterisation of an organotypic in vitro model. Exp Eye Res 2008;86(4):661-8
    • (2008) Exp Eye Res , vol.86 , Issue.4 , pp. 661-668
    • Kobuch, K.1    Herrmann, W.A.2    Framme, C.3
  • 102
    • 0035102496 scopus 로고    scopus 로고
    • Amino acids and their transporters in the retina
    • Pow DV. Amino acids and their transporters in the retina. Neurochem Int 2001;38(6):463-84
    • (2001) Neurochem Int , vol.38 , Issue.6 , pp. 463-484
    • Pow, D.V.1


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