Suprachoroidal delivery in a rabbit ex vivo eye model: Influence of drug properties, regional differences in delivery, and comparison with intravitreal and intracameral routes

Molecular Vision

Volumn 19, Issue , 2013, Pages 1198-1210

  Kadam, Rajendra S ^a   Williams, Jason ^a   Tyagi, Puneet ^a   Edelhauser, Henry F ^b   Kompella, Uday B ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b EMORY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BETAXOLOL; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; FLUORESCEIN SODIUM; LABETALOL; METOPROLOL TARTRATE; NADOLOL; PINDOLOL; PROPRANOLOL; SOTALOL; TIMOLOL MALEATE;

ANIMAL TISSUE; ARTICLE; CHOROID; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; EX VIVO STUDY; INTRACAMERAL DRUG ADMINISTRATION; INTRAOCULAR DRUG ADMINISTRATION; INTRAVITREAL DRUG ADMINISTRATION; LIPOPHILICITY; MOLECULAR WEIGHT; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; SCLERA; SUPRACHOROIDAL DRUG DELIVERY; TISSUE DISTRIBUTION; VITREOUS BODY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CARBON; CHOROID; DEXTRANS; DRUG ADMINISTRATION ROUTES; DRUG DELIVERY SYSTEMS; FLUORESCEIN; FLUORESCEIN-5-ISOTHIOCYANATE; FLUOROPHOTOMETRY; INTRAVITREAL INJECTIONS; MODELS, ANIMAL; RABBITS; RETINA; TISSUE DISTRIBUTION;

EID: 84878631466     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Del Amo EM, Urtti A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov Today 2008; 13:135-43. [PMID: 18275911].
2. Wiener JM, Tilly J. Population ageing in the United States of America: implications for public programmes. Int J Epidemiol 2002; 31:776-81. [PMID: 12177018].
3. United Nations. Current status of the social situation, wellbeing, participation in development and rights of older persons worldwide;August 2010
4. Sunkara G, Kompella UB. Membrane transport processes in the eye. In: Ophthalmic drug Delivery Systems. New York: Marcel Dekker Inc.; 2003.
5. Kompella UB, Kadam RS, Lee VH. Recent advances in ophthalmic drug delivery. Ther Deliv 2010; 1:435-56. [PMID: 21399724].
6. Maurice DM. Drug delivery to the posterior segment from drops. Surv Ophthalmol 2002; 47:Suppl 1S41-52. [PMID: 12204700].
7. Raghava S, Hammond M, Kompella UB. Periocular routes for retinal drug delivery. Expert Opin Drug Deliv 2004; 1:99-114. [PMID: 16296723].
8. Robinson MR, Lee SS, Kim H, Kim S, Lutz RJ, Galban C, Bungay PM, Yuan P, Wang NS, Kim J, Csaky KG. A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide. Exp Eye Res 2006; 82:479-87. [PMID: 16168412].
9. Ambati J, Canakis CS, Miller JW, Gragoudas ES, Edwards A, Weissgold DJ, Kim I, Delori FC, Adamis AP. Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci 2000; 41:1181-5. [PMID: 10752958].
10. Kadam RS, Cheruvu NP, Edelhauser HF, Kompella UB. Sclera-choroid-RPE transport of eight beta-blockers in human, bovine, porcine, rabbit, and rat models. Invest Ophthalmol Vis Sci 2011; 52:5387-99. [PMID: 21282583].
11. Shah CP, Garg SJ, Vander JF, Brown GC, Kaiser RS, Haller JA. Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. Ophthalmology 2011; 118:2028-34. [PMID: 21705087].
12. Einmahl S, Savoldelli M, D'Hermies F, Tabatabay C, Gurny R, Behar-Cohen F. Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye. Invest Ophthalmol Vis Sci 2002; 43:1533-9. [PMID: 11980871].
13. Olsen TW, Feng X, Wabner K, Conston SR, Sierra DH, Folden DV, Smith ME, Cameron JD. Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment. Am J Ophthalmol 2006; 142:777-87. [PMID: 16989764].
14. Olsen TW, Feng X, Wabner K, Csaky K, Pambuccian S, Cameron JD. Pharmacokinetics of pars plana intravitreal injections versus microcannula suprachoroidal injections of bevacizumab in a porcine model. Invest Ophthalmol Vis Sci 2011; 52:4749-56. [PMID: 21447680].
15. Patel SR, Lin AS, Edelhauser HF, Prausnitz MR. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm Res 2011; 28:166-76. [PMID: 20857178].
16. Kim TW, Lindsey JD, Aihara M, Anthony TL, Weinreb RN. Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice. Invest Ophthalmol Vis Sci 2002; 43:1809-16. [PMID: 12036983].
17. Bernd AS, Aihara M, Lindsey JD, Weinreb RN. Influence of molecular weight on intracameral dextran movement to the posterior segment of the mouse eye. Invest Ophthalmol Vis Sci 2004; 45:480-4. [PMID: 14744888].
18. Latendresse JR, Warbrittion AR, Jonassen H, Creasy DM. Fixation of Testes and Eyes Using a Modified Davidson's Fluid: Comparison with Bouin's Fluid and Conventional Davidson's Fluid. Toxicol Pathol 2002; 30:524-33. [PMID: 12187944].
19. Berezovsky DE, Patel SR, McCarey BE, Edelhauser HF. In vivo ocular fluorophotometry: delivery of fluoresceinated dextrans via transscleral diffusion in rabbits. Invest Ophthalmol Vis Sci 2011; 52:7038-45. [PMID: 21791594].
20. Ghate D, Brooks W, McCarey BE, Edelhauser HF. Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometry. Invest Ophthalmol Vis Sci 2007; 48:2230-7. [PMID: 17460284].
21. Kadam RS, Kompella UB. Cassette analysis of eight beta-blockers in bovine eye sclera, choroid-RPE, retina, and vitreous by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:253-60. [PMID: 19117816].
22. Taban M, Sarayba MA, Ignacio TS, Behrens A, McDonnell PJ. Ingress of India ink into the anterior chamber through sutureless clear corneal cataract wounds. Arch Ophthalmol 2005; 123:643-8. [PMID: 15883283].
23. Seiler GS, Salmon JH, Mantuo R, Feingold S, Dayton PA, Gilger BC. Effect and distribution of contrast medium after injection into the anterior suprachoroidal space in ex vivo eyes. Invest Ophthalmol Vis Sci 2011; 52:5730-6. [PMID: 21685338].
24. Kim SH, Galban CJ, Lutz RJ, Dedrick RL, Csaky KG, Lizak MJ, Wang NS, Tansey G, Robinson MR. Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging. Invest Ophthalmol Vis Sci 2007; 48:808-14. [PMID: 17251481].
25. Lin CW, Wang Y, Challa P, Epstein DL, Yuan F. Transscleral diffusion of ethacrynic acid and sodium fluorescein. Mol Vis 2007; 13:243-51. [PMID: 17356511].
26. McCarey BE. Fluorophotometry for Pharmacokinetic Assessment In: Drug Product Development for the Back of the EyeNew York: Springer; 2011.
27. Gray JR, Mosier MA, Ishimoto BM. Optimized protocol for Fluorotron Master. Graefes Arch Clin Exp Ophthalmol 1985; 222:225-9. [PMID: 3979849].
28. Pitkänen L, Ranta VP, Moilanen H, Urtti A. Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity. Invest Ophthalmol Vis Sci 2005; 46:641-6. [PMID: 15671294].
29. Kadam RS, Kompella UB. Influence of lipophilicity on drug partitioning into sclera, choroid-retinal pigment epithelium, retina, trabecular meshwork, and optic nerve. J Pharmacol Exp Ther 2010; 332:1107-20. [PMID: 19926800].
30. Majumdar S, Hingorani T, Srirangam R. Evaluation of active and passive transport processes in corneas extracted from preserved rabbit eyes. J Pharm Sci 2010; 99:1921-30. [PMID: 19890936].
31. Chen Y, Lu Q, Schneeberger EE, Goodenough DA. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell 2000; 11:849-62. [PMID: 10712504].