Hydraulic flow and vascular clearance influences on intravitreal drug delivery

Pharmaceutical Research

Volumn 19, Issue 11, 2002, Pages 1636-1647

  Missel, Paul J ^a  

^a ALCON RESEARCH LTD   (United States)

Author keywords

Darcy's law; Hydraulic flow; Intravitreal drug delivery; Vascular clearance

Indexed keywords

DEXTRAN; FLUORESCEIN;

ANTERIOR EYE CHAMBER; AQUEOUS HUMOR; ARTICLE; DIFFUSION COEFFICIENT; DRUG CLEARANCE; FINITE ELEMENT ANALYSIS; FLOW RATE; HYDRAULIC PERMEABILITY; INTRAOCULAR PRESSURE; MOLECULAR WEIGHT; OCULAR BLOOD VESSEL; PRIORITY JOURNAL; RABBIT; SCLERA; THERMODYNAMICS; VITREOUS BODY;

BLOOD FLOW VELOCITY; DRUG DELIVERY SYSTEMS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; VITREOUS BODY;

EID: 0036845775     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020940927675     Document Type: Article

References (26)

1. J. Xu, J. J. Heys, V. H. Barocas, and T. W. Randolph. Permeability and diffusion in vitreous humor: Implications for drug delivery. Pharm. Res. 17:664-669 (2000).
2. S. Friedrich, Y.-L. Cheng, and B. Saville. Finite element modeling of drug distribution in the vitreous humor of the rabbit eye. Ann. Biomed. Eng. 25:303-314 (1997).
3. S. W. Friedrich, B. A. Saville, and Y.-L. Cheng. Finite element modeling of drug distribution in the vitreous humor of the eye. Invest. Ophthalmol. Vis. Sci. 37:S582 (1996).
4. P. M. Pinksy, D. M. Maurice, and D. V. Datye. Finite element modeling of intravitreous drug kinetics. Invest. Ophthalmol. Vis. Sci. 37:S700 (1996).
5. D. M. Maurice. Review: Practical issues in intravitreal drug delivery. J. Ocular Pharm. Ther. 17:393-401 (2001).
6. rd ed., Revised and Expanded, Marcel Dekker, New York, 2002, pp. 415-478.
7. The Anecortave Acetate Clinical Study Group. Anecortave Acetate as Monotherapy for the Treatment of Subfoveal Lesions in Patients with Exudative Age-Related Macular Degeneration (AMD): Interim (Month 6) Analysis of Clinical Safety and Efficacy. Retina (accepted).
8. P. J. Missel. Finite and infinitesimal representations of the vasculature: Ocular drug clearance by vascular and hydraulic effects. Ann. Biomed. Eng. 30: (2002).
9. P. J. Missel. Finite element modeling of diffusion and partitioning in biological systems: The infinite composite medium problem. Ann. Biomed. Eng. 28:1307-1317 (2000).
10. T. E. Faber. Fluid Dynamics for Physicists, Cambridge University Press, Cambridge, 1995, p. 238.
11. D. J. Tritton. Physical Fluid Dynamics, Oxford University Press, Oxford, 1988, pp. 52-53.
12. B. Dhillon, A. Kamal, and C. Leen. Intravitreal sustained-release ganciclovir implantation to control cytomegalovirus retinitis in aids. Int. J. STD & AIDS 9:227-230 (1998).
13. M. Araie and D. M. Maurice. The Loss of fluorescein, fluorescein glucoronide (FG) and fluorescein isothiocyanate dextran (FD) from the vitreous by the anterior and retinal pathways. Exp. Eye Res. 52:27-39 (1991).
14. F. Johnson and D. Maurice. A simple method of measuring aqueous humor flow with intravitreal fluoresceinated dextrans. Exp. Eye Res. 39:791-805 (1984).
15. M. R. Prausnitz and J. S. Noonan. Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye. J. Pharm. Sci. 87:1479-1488 (1998).
16. T. W. Olsen, H. F. Edelhauser, J. I. Lim, and D. H. Geroski. Human scleral permeability: Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Invest. Ophthalmol. Vis. Sci. 36:1893-1903 (1995).
17. T. Krupin, L. F. Rosenberg, A. L. Sandridge, C. J. Bock, A. Berman, and J. M. Ruderman. Effects of topical k-strophanthin on aqueous humor and corneal dynamics. J. Glaucoma 4:327-333 (1995).
18. R. H. Funk, J. Gehr, and J. W. Rohen. Short-term hemodynamic changes in episcleral arteriovenous anastomoses correlate with venous pressure and IOP changes in the albino rabbit. Curr. Eye Res. 15:87-93 (1996).
19. P. Blondeau, J. P. Tetrault, and C. Papamarkakis. Diurnal variation of episcleral venous pressure in healthy patients: A pilot study. J. Glaucoma 10:18-24 (2001).
20. A. Bill. Uveoscleral drainage of aqueous humour in human eyes. Exp. Eye Res. 12:275-281 (1971).
21. J. Cunha-Vaz and D. Maurice. Fluorescein dynamics in the eye. Documenta Ophthalmol 26:61-72 (1969).
22. G. Backstrom. Fluid Dynamics by Finite Element Analysis, Studentlitteratur, Lund,1999; see for example Chapter 9, Viscous Flow in Channels.
23. M. Kaviany. Principles of Heat Transfer in Porous Media, Springer Verlag, New York, 1991, chapter 2.
24. D. M. Maurice. Flow of water between aqueous and vitreous compartments in the rabbit eye. Am. J. Physiol. 252:F104-F108 (1987).
25. J. G. Cunha-Vaz and D. M. Maurice. The Active transport of fluorescein by the retinal vessels and the retina. J. Physiol. 191:467-486 (1967).
26. I. Fatt and B. Hedbys. Flow of water in the sclera. Exp. Eye Res. 10:243-249 (1970).