Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone

Journal of Controlled Release

Volumn 151, Issue 1, 2011, Pages 65-73

  Ryu, Morin ^a   Nakazawa, Toru ^a   Akagi, Takami ^b,c   Tanaka, Tatsuhide ^d   Watanabe, Ryou ^a   Yasuda, Masayuki ^a   Himori, Noriko ^a   Maruyama, Kazuichi ^e   Yamashita, Toshihide ^e   Abe, Toshiaki ^a   Akashi, Mitsuru ^b,c   Nishida, Kohji ^a,f  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^f OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Cytokines; Drug delivery; Microglia; Monocyte recruitment; Nanoparticles; Neuroprotection

Indexed keywords

AMPHIPHILICS; ANTI-INFLAMMATORY EFFECTS; CYTOKINES; DEXAMETHASONES; EXCITOTOXICITY; GLUTAMIC ACID; IN-VITRO; INFLAMMATORY CELLS; L-PHENYLALANINE; MICROGLIA; MONOCYTE RECRUITMENT; NEUROPROTECTION; PATHOLOGICAL CONDITIONS; PHAGOCYTIC CELLS; Q-RT-PCR; RETINAL DISEASE; RETINAL GANGLION CELLS;

AMINO ACIDS; BODY FLUIDS; CYTOLOGY; DRUG DELIVERY; MACROPHAGES; OPHTHALMOLOGY; VISION;

NANOPARTICLES;

AMPHOPHILE; CHEMOKINE; CYTOKINE; DEXAMETHASONE; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOPARTICLE; PHENYLALANINE; POLY(GAMMA GLUTAMIC ACID); POLYGLUTAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONJUGATION; EXCITOTOXICITY; FEMALE; MACROPHAGE; MALE; MICROGLIA; NONHUMAN; PHAGOCYTOSIS; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA DETACHMENT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; DRUG CARRIERS; HUMANS; INFLAMMATION; MALE; NANOPARTICLES; PHAGOCYTES; POLYGLUTAMIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DISEASES;

EID: 79955471838     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.11.029     Document Type: Article

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