메뉴 건너뛰기




Volumn 42, Issue 5, 2014, Pages 1447-1452

Deciphering non-alcoholic fatty liver disease through metabolomics

Author keywords

Membrane; Metabolomics; Non alcoholic fatty liver disease (NAFLD); Phosphatidylcholine; Phosphatidylethanolamine; Steatohepatitis.

Indexed keywords

ALANINE AMINOTRANSFERASE; ARACHIDONIC ACID; BIOLOGICAL MARKER; CHOLINE; DOCOSAHEXAENOIC ACID; FAT DROPLET; GLYCINE METHYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; S ADENOSYLMETHIONINE; SATURATED FATTY ACID; SPHINGOMYELIN; VERY LOW DENSITY LIPOPROTEIN;

EID: 84907188407     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140138     Document Type: Review
Times cited : (25)

References (57)
  • 2
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • CrossRef PubMed
    • Choi, S.S. and Diehl, A.M. (2008) Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr. Opin. Lipidol. 19, 295-300 CrossRef PubMed
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 3
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two 'hits'?
    • CrossRef PubMed
    • Day, C.P. and James, O.F. (1998) Steatohepatitis: a tale of two 'hits'? Gastroenterology 114, 842-845 CrossRef PubMed
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 4
    • 77952576769 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease
    • CrossRef PubMed
    • Bellentani, S., Scaglioni, F., Marino, M. and Bedogni, G. (2010) Epidemiology of non-alcoholic fatty liver disease. Dig. Dis. 28, 155-161 CrossRef PubMed
    • (2010) Dig. Dis. , vol.28 , pp. 155-161
    • Bellentani, S.1    Scaglioni, F.2    Marino, M.3    Bedogni, G.4
  • 5
    • 84894257853 scopus 로고    scopus 로고
    • Clinical approaches to non-alcoholic fatty liver disease
    • CrossRef PubMed
    • Schwenger, K.J. and Allard, J.P. (2014) Clinical approaches to non-alcoholic fatty liver disease. World J. Gastroenterol. 20, 1712-1723 CrossRef PubMed
    • (2014) World J. Gastroenterol. , vol.20 , pp. 1712-1723
    • Schwenger, K.J.1    Allard, J.P.2
  • 6
    • 66349110860 scopus 로고    scopus 로고
    • Physiological consequences of disruption of mammalian phospholipid biosynthetic genes
    • CrossRef PubMed
    • Vance, D.E. and Vance, J.E. (2009) Physiological consequences of disruption of mammalian phospholipid biosynthetic genes. J. Lipid. Res. 50 (suppl), S132-S137 CrossRef PubMed
    • (2009) J. Lipid. Res. , vol.50 , pp. S132-S137
    • Vance, D.E.1    Vance, J.E.2
  • 7
    • 38549173564 scopus 로고    scopus 로고
    • Membrane lipids: Where they are and how they behave
    • CrossRef PubMed
    • van Meer, G., Voelker, D.R. and Feigenson, G.W. (2008) Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 9, 112-124 CrossRef PubMed
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 112-124
    • Van Meer, G.1    Voelker, D.R.2    Feigenson, G.W.3
  • 8
    • 78651095014 scopus 로고    scopus 로고
    • Lipid map of the mammalian cell
    • CrossRef PubMed
    • van Meer, G. and de Kroon, A.I. (2011) Lipid map of the mammalian cell. J. Cell. Sci. 124, 5-8 CrossRef PubMed
    • (2011) J. Cell. Sci. , vol.124 , pp. 5-8
    • Van Meer, G.1    De Kroon, A.I.2
  • 10
    • 84896723424 scopus 로고    scopus 로고
    • Role of lipids in the formation and maintenance of the cutaneous permeability barrier
    • CrossRef PubMed
    • Feingold, K.R. and Elias, P.M. (2014) Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochim. Biophys. Acta 1841, 280-294 CrossRef PubMed
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 280-294
    • Feingold, K.R.1    Elias, P.M.2
  • 11
    • 84859768059 scopus 로고    scopus 로고
    • Lipophagy: Connecting autophagy and lipid metabolism
    • CrossRef PubMed
    • Singh, R. and Cuervo, A.M. (2012) Lipophagy: connecting autophagy and lipid metabolism. Int. J. Cell. Biol. 2012, 282041 CrossRef PubMed
    • (2012) Int. J. Cell. Biol. , vol.2012 , pp. 282041
    • Singh, R.1    Cuervo, A.M.2
  • 12
    • 28844459409 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: From cell biology to clinical practice
    • CrossRef PubMed
    • Cortez-Pinto, H., de Moura, M.C. and Day, C.P. (2006) Non-alcoholic steatohepatitis: from cell biology to clinical practice. J. Hepatol. 44, 197-208 CrossRef PubMed
    • (2006) J. Hepatol. , vol.44 , pp. 197-208
    • Cortez-Pinto, H.1    De Moura, M.C.2    Day, C.P.3
  • 13
    • 33646121972 scopus 로고    scopus 로고
    • The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
    • CrossRef PubMed
    • Li, Z., Agellon, L.B., Allen, T.M., Umeda, M., Jewell, L., Mason, A. and Vance, D.E. (2006) The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 3, 321-331 CrossRef PubMed
    • (2006) Cell Metab. , vol.3 , pp. 321-331
    • Li, Z.1    Agellon, L.B.2    Allen, T.M.3    Umeda, M.4    Jewell, L.5    Mason, A.6    Vance, D.E.7
  • 14
    • 0038159461 scopus 로고    scopus 로고
    • A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice
    • CrossRef PubMed
    • Noga, A.A. and Vance, D.E. (2003) A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J. Biol. Chem. 278, 21851-21859 CrossRef PubMed
    • (2003) J. Biol. Chem. , vol.278 , pp. 21851-21859
    • Noga, A.A.1    Vance, D.E.2
  • 15
    • 0035083842 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Definition and pathology
    • CrossRef PubMed
    • Brunt, E.M. (2001) Nonalcoholic steatohepatitis: definition and pathology. Semin. Liver Dis. 21, 3-16 CrossRef PubMed
    • (2001) Semin. Liver Dis. , vol.21 , pp. 3-16
    • Brunt, E.M.1
  • 16
    • 84859165083 scopus 로고    scopus 로고
    • Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice
    • CrossRef PubMed
    • Ling, J., Chaba, T., Zhu, L.F., Jacobs, R.L. and Vance, D.E. (2012) Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. Hepatology 55, 1094-1102 CrossRef PubMed
    • (2012) Hepatology , vol.55 , pp. 1094-1102
    • Ling, J.1    Chaba, T.2    Zhu, L.F.3    Jacobs, R.L.4    Vance, D.E.5
  • 17
    • 0037203313 scopus 로고    scopus 로고
    • Phosphatidylcholine and cell death
    • CrossRef PubMed
    • Cui, Z. and Houweling, M. (2002) Phosphatidylcholine and cell death. Biochim. Biophys. Acta 1585, 87-96 CrossRef PubMed
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 87-96
    • Cui, Z.1    Houweling, M.2
  • 18
    • 84869040414 scopus 로고    scopus 로고
    • Curvature, lipid packing, and electrostatics of membrane organelles: Defining cellular territories in determining specificity
    • CrossRef PubMed
    • Bigay, J. and Antonny, B. (2012) Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity. Dev. Cell 23, 886-895 CrossRef PubMed
    • (2012) Dev. Cell , vol.23 , pp. 886-895
    • Bigay, J.1    Antonny, B.2
  • 19
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • CrossRef PubMed
    • Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., Lin, X., Watkins, S.M., Ivanov, A.R. and Hotamisligil, G.S. (2011) Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473, 528-531 CrossRef PubMed
    • (2011) Nature , vol.473 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3    Hofmann, O.4    Dicker, L.5    Hide, W.6    Lin, X.7    Watkins, S.M.8    Ivanov, A.R.9    Hotamisligil, G.S.10
  • 20
    • 43249108174 scopus 로고    scopus 로고
    • Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis
    • CrossRef PubMed
    • Vance, D.E. (2008) Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis. Curr. Opin. Lipidol. 19, 229-234 CrossRef PubMed
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 229-234
    • Vance, D.E.1
  • 21
    • 1442285086 scopus 로고    scopus 로고
    • Synthesis and function of hepatic very-low-density lipoprotein
    • CrossRef PubMed
    • Gibbons, G.F., Wiggins, D., Brown, A.M. and Hebbachi, A.M. (2004) Synthesis and function of hepatic very-low-density lipoprotein. Biochem. Soc. Trans. 32, 59-64 CrossRef PubMed
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 59-64
    • Gibbons, G.F.1    Wiggins, D.2    Brown, A.M.3    Hebbachi, A.M.4
  • 22
    • 70350169763 scopus 로고    scopus 로고
    • Fat on the move: Intracellular motion of lipid droplets
    • CrossRef PubMed
    • Welte, M.A. (2009) Fat on the move: intracellular motion of lipid droplets. Biochem. Soc. Trans. 37, 991-996 CrossRef PubMed
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 991-996
    • Welte, M.A.1
  • 23
    • 79955750296 scopus 로고    scopus 로고
    • Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo
    • CrossRef PubMed
    • Horl, G., Wagner, A., Cole, L.K., Malli, R., Reicher, H., Kotzbeck, P., Kofeler, H., Hofler, G., Frank, S., Bogner-Strauss, J.G., Sattler, W. et al. (2011) Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J. Biol. Chem. 286, 17338-17350 CrossRef PubMed
    • (2011) J. Biol. Chem. , vol.286 , pp. 17338-17350
    • Horl, G.1    Wagner, A.2    Cole, L.K.3    Malli, R.4    Reicher, H.5    Kotzbeck, P.6    Kofeler, H.7    Hofler, G.8    Frank, S.9    Bogner-Strauss, J.G.10    Sattler, W.11
  • 24
    • 34248653254 scopus 로고    scopus 로고
    • Role of S-adenosyl-l-methionine in liver health and injury
    • CrossRef PubMed
    • Mato, J.M. and Lu, S.C. (2007) Role of S-adenosyl-l-methionine in liver health and injury. Hepatology 45, 1306-1312 CrossRef PubMed
    • (2007) Hepatology , vol.45 , pp. 1306-1312
    • Mato, J.M.1    Lu, S.C.2
  • 25
    • 84867573089 scopus 로고    scopus 로고
    • S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility
    • CrossRef PubMed
    • Anstee, Q.M. and Day, C.P. (2012) S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. J. Hepatol. 57, 1097-1109 CrossRef PubMed
    • (2012) J. Hepatol. , vol.57 , pp. 1097-1109
    • Anstee, Q.M.1    Day, C.P.2
  • 29
    • 84884981455 scopus 로고    scopus 로고
    • Finding the balance: The role of S-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease
    • CrossRef PubMed
    • Jacobs, R.L., van der Veen, J.N. and Vance, D.E. (2013) Finding the balance: the role of S-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease. Hepatology 58, 1207-1209 CrossRef PubMed
    • (2013) Hepatology , vol.58 , pp. 1207-1209
    • Jacobs, R.L.1    Van Der Veen, J.N.2    Vance, D.E.3
  • 30
    • 0000466478 scopus 로고
    • Activation of methionine for transmethylation
    • PubMed
    • Cantoni, G.L. (1951) Activation of methionine for transmethylation. J. Biol. Chem. 189, 745-754 PubMed
    • (1951) J. Biol. Chem. , vol.189 , pp. 745-754
    • Cantoni, G.L.1
  • 32
    • 0023902956 scopus 로고
    • S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis
    • CrossRef PubMed
    • Duce, A.M., Ortiz, P., Cabrero, C. and Mato, J.M. (1988) S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 8, 65-68 CrossRef PubMed
    • (1988) Hepatology , vol.8 , pp. 65-68
    • Duce, A.M.1    Ortiz, P.2    Cabrero, C.3    Mato, J.M.4
  • 34
    • 27244449894 scopus 로고    scopus 로고
    • Endotoxin promotes preferential periportal upregulation of VLDL secretion in the rat liver
    • CrossRef PubMed
    • Aspichueta, P., Perez, S., Ochoa, B. and Fresnedo, O. (2005) Endotoxin promotes preferential periportal upregulation of VLDL secretion in the rat liver. J. Lipid Res. 46, 1017-1026 CrossRef PubMed
    • (2005) J. Lipid Res. , vol.46 , pp. 1017-1026
    • Aspichueta, P.1    Perez, S.2    Ochoa, B.3    Fresnedo, O.4
  • 35
  • 36
    • 0023744186 scopus 로고
    • Kinetic mechanism of phosphatidylethanolamine N-methyltransferase
    • PubMed
    • Ridgway, N.D. and Vance, D.E. (1988) Kinetic mechanism of phosphatidylethanolamine N-methyltransferase. J. Biol. Chem. 263, 16864-16871 PubMed
    • (1988) J. Biol. Chem. , vol.263 , pp. 16864-16871
    • Ridgway, N.D.1    Vance, D.E.2
  • 37
    • 0033569752 scopus 로고    scopus 로고
    • Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
    • CrossRef PubMed
    • DeLong, C.J., Shen, Y.J., Thomas, M.J. and Cui, Z. (1999) Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J. Biol. Chem. 274, 29683-29688 CrossRef PubMed
    • (1999) J. Biol. Chem. , vol.274 , pp. 29683-29688
    • DeLong, C.J.1    Shen, Y.J.2    Thomas, M.J.3    Cui, Z.4
  • 38
    • 79955371821 scopus 로고    scopus 로고
    • Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans
    • CrossRef PubMed
    • da Costa, K.A., Sanders, L.M., Fischer, L.M. and Zeisel, S.H. (2011) Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. Am. J. Clin. Nutr. 93, 968-974 CrossRef PubMed
    • (2011) Am. J. Clin. Nutr. , vol.93 , pp. 968-974
    • Da Costa, K.A.1    Sanders, L.M.2    Fischer, L.M.3    Zeisel, S.H.4
  • 39
    • 84856977834 scopus 로고    scopus 로고
    • Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat
    • CrossRef PubMed
    • Williams, K.T. and Schalinske, K.L. (2012) Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat. Diabetes Metab. Res. Rev. 28, 123-131 CrossRef PubMed
    • (2012) Diabetes Metab. Res. Rev. , vol.28 , pp. 123-131
    • Williams, K.T.1    Schalinske, K.L.2
  • 40
    • 77950612089 scopus 로고    scopus 로고
    • A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
    • CrossRef PubMed
    • Buque, X., Martinez, M.J., Cano, A., Miquilena-Colina, M.E., Garcia-Monzon, C., Aspichueta, P. and Ochoa, B. (2010) A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. J. Lipid Res. 51, 500-513 CrossRef PubMed
    • (2010) J. Lipid Res. , vol.51 , pp. 500-513
    • Buque, X.1    Martinez, M.J.2    Cano, A.3    Miquilena-Colina, M.E.4    Garcia-Monzon, C.5    Aspichueta, P.6    Ochoa, B.7
  • 41
    • 84884841675 scopus 로고    scopus 로고
    • Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition
    • CrossRef PubMed
    • Hellmuth, C., Demmelmair, H., Schmitt, I., Peissner, W., Bluher, M. and Koletzko, B. (2013) Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition. PLoS ONE 8, e74927 CrossRef PubMed
    • (2013) PLoS ONE , vol.8 , pp. e74927
    • Hellmuth, C.1    Demmelmair, H.2    Schmitt, I.3    Peissner, W.4    Bluher, M.5    Koletzko, B.6
  • 42
    • 77951665499 scopus 로고    scopus 로고
    • Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
    • CrossRef PubMed
    • Kotronen, A., Seppanen-Laakso, T., Westerbacka, J., Kiviluoto, T., Arola, J., Ruskeepaa, A.L., Yki-Jarvinen, H. and Oresic, M. (2010) Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum. Obesity 18, 937-944 CrossRef PubMed
    • (2010) Obesity , vol.18 , pp. 937-944
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5    Ruskeepaa, A.L.6    Yki-Jarvinen, H.7    Oresic, M.8
  • 43
    • 77956326416 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease
    • CrossRef PubMed
    • Barr, J., Vazquez-Chantada, M., Alonso, C., Perez-Cormenzana, M., Mayo, R., Galan, A., Caballeria, J., Martin-Duce, A., Tran, A., Wagner, C. et al. (2010) Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J. Proteome. Res. 9, 4501-4512 CrossRef PubMed
    • (2010) J. Proteome. Res. , vol.9 , pp. 4501-4512
    • Barr, J.1    Vazquez-Chantada, M.2    Alonso, C.3    Perez-Cormenzana, M.4    Mayo, R.5    Galan, A.6    Caballeria, J.7    Martin-Duce, A.8    Tran, A.9    Wagner, C.10
  • 47
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabonomics
    • CrossRef PubMed
    • Nicholson, J.K. and Lindon, J.C. (2008) Systems biology: metabonomics. Nature 455, 1054-1056 CrossRef PubMed
    • (2008) Nature , vol.455 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 48
    • 84858790233 scopus 로고    scopus 로고
    • Innovation: Metabolomics - The apogee of the omics trilogy
    • CrossRef PubMed
    • Patti, G.J., Yanes, O. and Siuzdak, G. (2012) Innovation: metabolomics - the apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol. 13, 263-269 CrossRef PubMed
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 263-269
    • Patti, G.J.1    Yanes, O.2    Siuzdak, G.3
  • 51
    • 80053926087 scopus 로고    scopus 로고
    • A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations
    • CrossRef PubMed
    • Garcia-Canaveras, J.C., Donato, M.T., Castell, J.V. and Lahoz, A. (2011) A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations. J. Proteome Res. 10, 4825-4834 CrossRef PubMed
    • (2011) J. Proteome Res. , vol.10 , pp. 4825-4834
    • Garcia-Canaveras, J.C.1    Donato, M.T.2    Castell, J.V.3    Lahoz, A.4
  • 53
    • 37849028864 scopus 로고    scopus 로고
    • Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study
    • CrossRef PubMed
    • Allard, J.P., Aghdassi, E., Mohammed, S., Raman, M., Avand, G., Arendt, B.M., Jalali, P., Kandasamy, T., Prayitno, N., Sherman, M. et al. (2008) Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. J. Hepatol. 48, 300-307 CrossRef PubMed
    • (2008) J. Hepatol. , vol.48 , pp. 300-307
    • Allard, J.P.1    Aghdassi, E.2    Mohammed, S.3    Raman, M.4    Avand, G.5    Arendt, B.M.6    Jalali, P.7    Kandasamy, T.8    Prayitno, N.9    Sherman, M.10
  • 56
    • 84907190808 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • (Nicholls, A., Theodoridis, G. and Wilson, I.D., eds) Future Science Ltd
    • Alonso, C. and Mato, J.M. (2014) Nonalcoholic fatty liver disease. In Global Metabolic Profiling: Clinical Applications (Nicholls, A., Theodoridis, G. and Wilson, I.D., eds), pp. 110-122, Future Science Ltd, doi:10.4155/ebo.13.392
    • (2014) Global Metabolic Profiling: Clinical Applications , pp. 110-122
    • Alonso, C.1    Mato, J.M.2
  • 57
    • 84979851098 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine
    • CrossRef PubMed
    • Arendt, B.M., Ma, D.W., Simons, B., Noureldin, S.A., Therapondos, G., Guindi, M., Sherman, M. and Allard, J.P. (2013) Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. Appl. Physiol. Nutr. Metab. 38, 334-340 CrossRef PubMed
    • (2013) Appl. Physiol. Nutr. Metab. , vol.38 , pp. 334-340
    • Arendt, B.M.1    Ma, D.W.2    Simons, B.3    Noureldin, S.A.4    Therapondos, G.5    Guindi, M.6    Sherman, M.7    Allard, J.P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.