Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine A/-methyltransferase activity in humans

American Journal of Clinical Nutrition

Volumn 93, Issue 5, 2011, Pages 968-974

  Da Costa, Kerry Ann ^a   Sanders, Lisa M ^a   Fischer, Leslie M ^b   Zeisel, Steven H ^a,c,d  

^a University of North Carolina   (United States)

^b KELLOGG COMPANY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d Nutrition Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ESTROGEN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ADULT; AGED; ARTICLE; DIETARY INTAKE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME POLYMORPHISM; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER; MALE; NORMAL HUMAN; PREMENOPAUSE;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CHOLESTEROL, DIETARY; CHOLINE; CHOLINE DEFICIENCY; DOCOSAHEXAENOIC ACIDS; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; LIVER; MALE; MENOPAUSE; MIDDLE AGED; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; POLYMORPHISM, SINGLE NUCLEOTIDE; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; YOUNG ADULT;

MUS;

EID: 79955371821     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.011064     Document Type: Article

References (42)

1. Fischer LM, daCosta K, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr 2007;85:1275-85. (Pubitemid 46740469)
2. da Costa KA, Badea M, Fischer LM, Zeisel SH. Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr 2004;80:163-70. (Pubitemid 41115570)
3. Zeisel SH, Mar MH, Howe JC, Holden JM. Concentrations of choline- containing compounds and betaine in common foods. J Nutr 2003;133: 1302-7. (Pubitemid 36548698)
4. Zeisel SH, Mar M-H, Howe JC, Holden JM. Concentrations of chol- ine-containing compounds and betaine in common foods. J Nutr 2003; 133:2918-9 (erratum).
5. Fischer LM, Scearce JA, Mar MH, et al. Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J Nutr 2005;135:826-9. (Pubitemid 40464112)
6. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr 2006;26:229-50.
7. Vance DE, Walkey CJ, Cui Z. Phosphatidylethanolamine N-methyltransferase from liver. Biochim Biophys Acta 1997;1348:142-50. (Pubitemid 27467087)
8. da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J 2006;20:1336-44. (Pubitemid 44943841)
9. Young DL. Estradiol- and testosterone-induced alterations in phosphatidylcholine and triglyceride synthesis in hepatic endoplasmic reticulum. J Lipid Res 1971;12:590-5.
10. Vigo C, Vance DE. Effect of diethylstilboestrol on phosphatidylcholine biosynthesis in the liver of roosters. Biochem Soc Trans 1981;9:98-9. (Pubitemid 11066213)
11. Resseguie M, Song J, Niculescu MD, da Costa KA, Randall TA, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J 2007;21:2622-32. (Pubitemid 47230690)
12. Resseguie ME, da Costa KA, Galanko JA, Patel M, Davis IJ, Zeisel SH. Aberrant estrogen regulation of PEMT results in choline deficiency- associated liver dysfunction. J Biol Chem 2011;286:1649-58.
13. Fischer LM, da Costa KA, Kwock L, Galanko J, Zeisel SH. Dietary choline requirements of women: effects of estrogen and genetic variation. Am J Clin Nutr 2010;92(5):1113-9.
14. Waite KA, Cabilio NR, Vance DE. Choline deficiency-induced liver damage is reversible in Pemt(-/-) mice. J Nutr 2002;132:68-71. (Pubitemid 34042457)
15. Furtado VC, Takiya CM, Braulio VB. Phosphatidylethanolamine N-methyltransferase activity is increased in rat intestinal brush-border membrane by chronic ethanol ingestion. Alcohol Alcohol 2002;37: 561-5. (Pubitemid 35385889)
16. Nishimaki-Mogami T, Suzuki K, Okochi E, Takahashi A. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta 1996;1304:11-20. (Pubitemid 26388893)
17. Nishimaki-Mogami T, Suzuki T, Takahashi A. The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins. Biochim Biophys Acta 1996;1304:21-31. (Pubitemid 26388894)
18. Hoffman DR, Haning JA, Cornatzer WE. Effects of a methyl-deficient diet on rat liver phosphatidylcholine biosynthesis. Can J Biochem 1981;59:543-50. (Pubitemid 12239126)
19. Cui Z, Vance DE. Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats. J Biol Chem 1996;271:2839-43. (Pubitemid 26047905)
20. Song J, da Costa KA, Fischer LM, et al. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J 2005;19:1266-71. (Pubitemid 41113723)
21. Noga AA, Vance DE. A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem 2003;278:21851-9. (Pubitemid 36792591)
22. Noga AA, Zhao Y, Vance DE. An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem 2002;277:42358-65. (Pubitemid 35257557)
23. Vance JE. Secretion of VLDL, but not HDL, by rat hepatocytes is inhibited by the ethanolamine analogue N-monomethylethanolamine. J Lipid Res 1991;32:1971-82.
24. Lieber CS. Alcoholic liver injury: pathogenesis and therapy in 2001. Pathol Biol (Paris) 2001;49:738-52. (Pubitemid 33091868)
25. DeLong CJ, Shen YJ, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP- choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem 1999; 274:29683-8.
26. Watkins SM, Zhu X, Zeisel SH. Phosphatidylethanolamine-N- methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr 2003;133: 3386-91. (Pubitemid 37409463)
27. Samborski RW, Ridgway ND, Vance DE. Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase. J Lipid Res 1993;34:125-37. (Pubitemid 23016628)
28. Busby MG, Fischer L, Da Costa KA, Thompson D, Mar MH, Zeisel SH. Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria. J Am Diet Assoc 2004;104:1836-45. (Pubitemid 39572871)
29. Institute of Medicine, National Academy of Sciences. Choline. Dietary Reference Intakes for folate, thiamin, riboflavin, niacin, vitamin B12, pantothenic acid, biotin, and choline. Washington DC: National Academy Press, 1998:390-422.
30. Koc H, Mar MH, Ranasinghe A, Swenberg JA, Zeisel SH. Quantitation of choline and its metabolites in tissues and foods by liquid chroma- tography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem 2002;74:4734-40.
31. Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci USA 2005; 102: 16025-30. (Pubitemid 41552861)
32. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-7.
33. Tacconi M, Wurtman RJ. Rat brain phosphatidyl-N,N-dimethyletha- nolamine is rich in polyunsaturated fatty acids. J Neurochem 1985;45: 805-9. (Pubitemid 16238544)
34. Capdevila A, Wagner C. Measurement of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent isoindoles. Anal Biochem 1998;264:180-4. (Pubitemid 28536892)
35. Ridgway ND, Vance DE. Kinetic mechanism of phosphatidylethanolamine N-methyltransferase. J Biol Chem 1988;263:16864-71. (Pubitemid 18268869)
36. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr 2006;83: 5-10. (Pubitemid 44699227)
37. Shields DJ, Altarejos JY, Wang X, Agellon LB, Vance DE. Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase. J Biol Chem 2003;278:35826-36. (Pubitemid 37102361)
38. Kalhan SC, Guo L, Edmison J, et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism 2010;60:404-13.
39. Zeisel SH, Zola T, daCosta K, Pomfret EA. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem J 1989;259:725-9. (Pubitemid 19118838)
40. Spector AA. Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J Mol Neurosci 2001;16: 159-65, discussion 215-21. (Pubitemid 32664775)
41. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified ei- cosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59. (Pubitemid 27366792)
42. Saito S, Iida A, Sekine A, et al. Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population. J Hum Genet 2001;46:529-37. (Pubitemid 32847568)