Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells

Anti-Cancer Agents in Medicinal Chemistry

Volumn 14, Issue 8, 2014, Pages 1146-1153

  Guo, Jiajie ^a   Zhao, Wenwen ^a   Hao, Wenhui ^a   Ren, Guowen ^a   Lu, Jinjian ^a   Chen, Xiuping ^a  

^a University of Macau   (Macao)

Author keywords

Apoptosis; Cancer; Cucurbitacin B; DNA damage; G2 M arrest; ROS

Indexed keywords

CUCURBITACIN; CUCURBITACIN B; HISTONE H2AX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CALCIUM; H2AFX PROTEIN, HUMAN; HISTONE; SCAVENGER; TRITERPENE;

APOPTOSIS; ARTICLE; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PROTEIN EXPRESSION; WESTERN BLOTTING; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; K562 CELL LINE; METABOLISM;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; FREE RADICAL SCAVENGERS; G2 PHASE CELL CYCLE CHECKPOINTS; HISTONES; HUMANS; K562 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 84907171833     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520614666140601220915     Document Type: Article

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