Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2338-2350

  Zhang, Xue ^a   Zhang, Yun ^a   Tao, Bo ^a   Teng, Li ^a   Li, Yanwei ^a   Cao, Rui ^a   Gui, Qiu ^a   Ye, Madong ^a   Mou, Xiaozhou ^a   Cheng, Hongqiang ^a   Hu, Hu ^a   Zhou, Ren ^a   Wu, Ximei ^a   Xie, Qiangmin ^a   Ning, Wen ^b   Lai, Maode ^a   Shen, Huahao ^a   Feng, Gen Sheng ^c,d   Ke, Yuehai ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANKAI UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Abca3; FGFs; IPF; Surfactant proteins; TTF 1

Indexed keywords

ABC TRANSPORTER; ATP BINDING CASSETTE SUBFAMILY A MEMBER 3; LUNG SURFACTANT; PROTEIN TYROSINE PHOSPHATASE SHP 2; THYROID TRANSCRIPTION FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HOMEOSTASIS; IN VIVO STUDY; KNOCKOUT MOUSE; LAMELLAR BODY; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; FIBROBLAST GROWTH FACTORS; HOMEOSTASIS; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PULMONARY ALVEOLI; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEINS; PULMONARY SURFACTANTS; TRANSCRIPTION FACTORS;

MUS;

EID: 84861786170     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-200139     Document Type: Article

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