Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

Journal of Neuroscience

Volumn 34, Issue 37, 2014, Pages 12490-12503

  Wang, Qingshan ^a   Chu, Chun Hsien ^a   Qian, Li ^a   Chen, Shih Heng ^a   Wilson, Belinda ^a   Oyarzabal, Esteban ^a   Jiang, Lulu ^a   Hong, Jau Shyong ^a   Ali, Syed ^b   Robinson, Bonnie ^b   Kim, Hyoung Chun ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c Kangwon National University   (South Korea)

Author keywords

GPCR independence; NADPH oxidase; Neuroinflammation; Parkinson s disease; Substance P

Indexed keywords

SEROTONIN; DOPAMINE; LIPOPOLYSACCHARIDE; NEUROKININ 1 RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUBSTANCE P;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DENDRITIC CELL; DEPRESSION; EMBRYO; FEMALE; FORCED SWIM TEST; HISTOLOGY; LEARNING; MALE; MEMBRANE STEADY POTENTIAL; MEMORY; MOUSE; NERVE POTENTIAL; NONHUMAN; OPEN FIELD BEHAVIOR; PREFRONTAL CORTEX; PYRAMIDAL NERVE CELL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; KNOCKOUT MOUSE; METABOLISM; MICROGLIA; PARKINSONISM; PATHOLOGY;

ANIMALS; DOPAMINE; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NADPH OXIDASE; PARKINSONIAN DISORDERS; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 84907011084     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2238-14.2014     Document Type: Article

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