Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Wang, Qingshan ^a   Zhou, Hui ^a   Gao, Huiming ^a   Chen, Shih Heng ^a   Chu, Chun Hsien ^a   Wilson, Belinda ^a   Hong, Jau Shyong ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Binding; Microglia; NADPH oxidase; Neuroinflammation; Opioid receptor

Indexed keywords

CELL PROTEIN; CYTOCHROME C; LIPOPOLYSACCHARIDE; NALOXONE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P47PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; SUPEROXIDE DISMUTASE; TETRAZOLIUM; UNCLASSIFIED DRUG; 2 (4 IODOPHENYL) 3 (4 NITROPHENYL) 5 (2,4 DISULFOPHENYL) 2H TETRAZOLIUM; 2-(4-IODOPHENYL)-3-(4-NITROPHENYL)-5-(2,4-DISULFOPHENYL)-2H-TETRAZOLIUM; BIPHENYL DERIVATIVE; CATION; CYBB PROTEIN, MOUSE; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRITIUM; XANTHINE OXIDASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING COMPETITION; CELL MEMBRANE; CELL STIMULATION; CELL STRAIN COS7; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOSOL; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INACTIVATION; GENETIC TRANSFECTION; GLIA CELL; HUMAN; HUMAN CELL; IC 50; IMMUNOCOMPETENT CELL; IMMUNOPRECIPITATION; LIGAND BINDING; MESENCEPHALON; METABOLIC INHIBITION; MICROGLIA; MOLECULAR INTERACTION; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN TRANSPORT; WESTERN BLOTTING; WILD TYPE; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; CELL CULTURE; CERCOPITHECUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; GENETICS; GLIA; METABOLISM; METHODOLOGY; MOUSE MUTANT; NERVE CELL; THYROID FUNCTION TEST;

ANALYSIS OF VARIANCE; ANIMALS; BIPHENYL COMPOUNDS; CELL MEMBRANE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; IMMUNOPRECIPITATION; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; NALOXONE; NEUROGLIA; NEURONS; NEUTROPHILS; ONIUM COMPOUNDS; SUPEROXIDE DISMUTASE; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; TETRAZOLIUM SALTS; THYROID FUNCTION TESTS; TRANSFECTION; TRITIUM; XANTHINE OXIDASE;

EID: 84858159054     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-32     Document Type: Article

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