-
1
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 1997;15:2403-2413.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
2
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364:1817-1825.
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
3
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff DD, Ervin T, Arena FP et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013;369:1691-1703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
-
4
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25: 1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
5
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
6
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoguera C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-554.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
-
7
-
-
33646577163
-
Genetics and biology of pancreatic ductal adeno-carcinoma
-
Hezel AF, Kimmelman AC, Stanger BZ et al. Genetics and biology of pancreatic ductal adeno-carcinoma. Genes Dev 2006;20:1218-1249.
-
(2006)
Genes Dev
, vol.20
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
-
8
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreaticcarcinomas
-
Schutte M, Hruban RH, Geradts J et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreaticcarcinomas. Cancer Res1997; 57:3126-3130.
-
(1997)
Cancer Res
, vol.57
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
-
9
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreaticadenocarcinoma
-
Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreaticadenocarcinoma. Nat Genet 1994;8:27-32.
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
-
10
-
-
12644253827
-
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
-
Goggins M, Schutte M, Lu J et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996; 56:5360-5364.
-
(1996)
Cancer Res
, vol.56
, pp. 5360-5364
-
-
Goggins, M.1
Schutte, M.2
Lu, J.3
-
11
-
-
0032704708
-
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
-
Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. J Clin Oncol 1999;17:3631-3652.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3631-3652
-
-
Rowinsky, E.K.1
Windle, J.J.2
Von Hoff, D.D.3
-
12
-
-
0038413837
-
Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarci-noma
-
Cohen SJ, Ho L, Ranganathan S et al. Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarci-noma. J Clin Oncol 2003;21:1301-1306.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1301-1306
-
-
Cohen, S.J.1
Ho, L.2
Ranganathan, S.3
-
13
-
-
23844517889
-
A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study
-
Macdonald JS, McCoy S, Whitehead RP et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study. Invest New Drugs 2005;23:485-487.
-
(2005)
Invest New Drugs
, vol.23
, pp. 485-487
-
-
Macdonald, J.S.1
McCoy, S.2
Whitehead, R.P.3
-
14
-
-
2342645506
-
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
-
Van Cutsem E, Van de Velde H, Karasek P et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004;22: 1430-1438.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1430-1438
-
-
Van Cutsem, E.1
Van De Velde, H.2
Karasek, P.3
-
15
-
-
0002989445
-
Randomized phase II study of sch 66336 and gemcitabine in the treatment of metastatic adeno-carcinoma of the pancreas
-
Lersch C, van Cutsem E, Amado R et al. Randomized phase II study of sch 66336 and gemcitabine in the treatment of metastatic adeno-carcinoma of the pancreas. Proc Am Soc Clin Oncol 2001;20:608a.
-
(2001)
Proc am Soc Clin Oncol
, vol.20
-
-
Lersch, C.1
Van Cutsem, E.2
Amado, R.3
-
16
-
-
17644410025
-
Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene
-
Morioka CY, Machado MC, Saito S et al. Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene. In Vivo 2005;19: 535-538.
-
(2005)
In Vivo
, vol.19
, pp. 535-538
-
-
Morioka, C.Y.1
Machado, M.C.2
Saito, S.3
-
17
-
-
34249885111
-
K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment
-
Réjiba S, Wack S, Aprahamian M et al. K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment. Cancer Sci 2007; 98:1128-1136.
-
(2007)
Cancer Sci
, vol.98
, pp. 1128-1136
-
-
Réjiba, S.1
Wack, S.2
Aprahamian, M.3
-
18
-
-
84864346162
-
A phase II open-label randomized studyto assessthe efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy
-
Bodoky G, Timcheva C, Spigel DR et al. A phase II open-label randomized studyto assessthe efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy. Invest New Drugs 2012; 30:1216-1223.
-
(2012)
Invest New Drugs
, vol.30
, pp. 1216-1223
-
-
Bodoky, G.1
Timcheva, C.2
Spigel, D.R.3
-
19
-
-
84880053768
-
Dual mek/egfr inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (azd6244; arry-142886) plus erlotinib
-
Ko AH, Tempero MA, Bekaii-Saab TB et al. Dual mek/egfr inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (azd6244; arry-142886) plus erlotinib. J Clin Oncol 2013;31(suppl):4014a.
-
(2013)
J Clin Oncol
, vol.31
-
-
Ko, A.H.1
Tempero, M.A.2
Bekaii-Saab, T.B.3
-
20
-
-
79952787575
-
A phase ib study of the mek inhibitor gsk1120212 combined with gemcitabine in patients with solid tumors: Interim results
-
Tolcher AW, Bendell JC, Patnaik A et al. A phase ib study of the mek inhibitor gsk1120212 combined with gemcitabine in patients with solid tumors: Interim results. J Clin Oncol 2011;29:278a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Tolcher, A.W.1
Bendell, J.C.2
Patnaik, A.3
-
21
-
-
84875046931
-
A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
-
Infante JR, Somer BG, Park JO et al. A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. J Clin Oncol 2013; 31(Suppl 4):291a.
-
(2013)
J Clin Oncol
, vol.31
-
-
Infante, J.R.1
Somer, B.G.2
Park, J.O.3
-
22
-
-
84863012865
-
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
-
Collins MA, Bednar F, Zhang Y et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 2012; 122:639-653.
-
(2012)
J Clin Invest
, vol.122
, pp. 639-653
-
-
Collins, M.A.1
Bednar, F.2
Zhang, Y.3
-
23
-
-
0034793404
-
Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
-
Safran H, Steinhoff M, Mangray S et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol 2001;24:496-499.
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 496-499
-
-
Safran, H.1
Steinhoff, M.2
Mangray, S.3
-
24
-
-
0026595557
-
The epidermal growth factor receptor in human pancreatic cancer
-
Lemoine NR, Hughes CM, Barton CM et al. The epidermal growth factor receptor in human pancreatic cancer. J Pathol 1992;166:7-12.
-
(1992)
J Pathol
, vol.166
, pp. 7-12
-
-
Lemoine, N.R.1
Hughes, C.M.2
Barton, C.M.3
-
25
-
-
0027293748
-
Coex-pression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
-
Yamanaka Y, Friess H, Kobrin MS et al. Coex-pression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993;13:565-569.
-
(1993)
Anticancer Res
, vol.13
, pp. 565-569
-
-
Yamanaka, Y.1
Friess, H.2
Kobrin, M.S.3
-
26
-
-
0032423809
-
Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer
-
Dong M, Nio Y, Guo KJ et al. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1998;18(6B):4613-4619.
-
(1998)
Anticancer Res
, vol.18
, Issue.6B
, pp. 4613-4619
-
-
Dong, M.1
Nio, Y.2
Guo, K.J.3
-
27
-
-
4143128359
-
Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis
-
Tobita K, Kijima H, Dowaki S et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med 2003;11:305-309.
-
(2003)
Int J Mol Med
, vol.11
, pp. 305-309
-
-
Tobita, K.1
Kijima, H.2
Dowaki, S.3
-
28
-
-
78650095716
-
Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3
-
da Cunha Santos G, Dhani N, Tu D et al. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3. Cancer 2010;116:5599-5607.
-
(2010)
Cancer
, vol.116
, pp. 5599-5607
-
-
Da Cunha Santos, G.1
Dhani, N.2
Tu, D.3
-
29
-
-
36048940287
-
Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer
-
Kulke MH, Blaszkowsky LS, Ryan DP et al. Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer. J Clin Oncol 2007;25: 4787-4792.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4787-4792
-
-
Kulke, M.H.1
Blaszkowsky, L.S.2
Ryan, D.P.3
-
30
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
Xiong HQ, Rosenberg A, LoBuglio A et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial. J Clin Oncol 2004;22: 2610-2616.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
Lobuglio, A.3
-
31
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
-
Philip PA, Benedetti J, Corless CL et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010;28:3605-3610.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
-
32
-
-
79960227365
-
Randomized phase II trial of panitumumab, erlotinib, and gemcitabine (PGE) versus erlotinib-gemcitabine (GE) in patients with untreated, metastatic pancreatic adenocarcinoma
-
Kim GP, Foster NR, Salim M et al. Randomized phase II trial of panitumumab, erlotinib, and gemcitabine (PGE) versus erlotinib-gemcitabine (GE) in patients with untreated, metastatic pancreatic adenocarcinoma. J Clin Oncol 2011;29 (suppl):4030a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Kim, G.P.1
Foster, N.R.2
Salim, M.3
-
33
-
-
19944429073
-
Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu
-
Safran H, Iannitti D, Ramanathan R et al. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu. Cancer Invest 2004;22:706-712.
-
(2004)
Cancer Invest
, vol.22
, pp. 706-712
-
-
Safran, H.1
Iannitti, D.2
Ramanathan, R.3
-
34
-
-
0034657029
-
High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
-
Seo Y, Baba H, Fukuda T et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000;88:2239-2245.
-
(2000)
Cancer
, vol.88
, pp. 2239-2245
-
-
Seo, Y.1
Baba, H.2
Fukuda, T.3
-
35
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler HL, Niedzwiecki D, Hollis D et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28:3617-3622.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
-
36
-
-
65549150854
-
Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
-
Van Cutsem E, Vervenne WL, Bennouna J et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27:2231-2237.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2231-2237
-
-
Van Cutsem, E.1
Vervenne, W.L.2
Bennouna, J.3
-
37
-
-
45449090215
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
Spano JP, Chodkiewicz C, Maurel J et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study. Lancet 2008;371:2101-2108.
-
(2008)
Lancet
, vol.371
, pp. 2101-2108
-
-
Spano, J.P.1
Chodkiewicz, C.2
Maurel, J.3
-
38
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study. Lancet Oncol 2011;12:256-262.
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
-
39
-
-
84879952361
-
Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
-
Rougier P, Riess H, Manges R et al. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer 2013;49:2633-2642.
-
(2013)
Eur J Cancer
, vol.49
, pp. 2633-2642
-
-
Rougier, P.1
Riess, H.2
Manges, R.3
-
40
-
-
84868107516
-
Baypan study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
-
Goncalves A, Gilabert M, Francois E et al. Baypan study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann Oncol 2012;23: 2799-2805.
-
(2012)
Ann Oncol
, vol.23
, pp. 2799-2805
-
-
Goncalves, A.1
Gilabert, M.2
Francois, E.3
-
41
-
-
84929321103
-
Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial
-
Deplanque G, Demarchi M, Hebbar M et al. Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2012;31(suppl 4):158a.
-
(2012)
J Clin Oncol
, vol.31
-
-
Deplanque, G.1
Demarchi, M.2
Hebbar, M.3
-
42
-
-
34147130694
-
The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
-
Tabernero J. The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007;5: 203-220.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 203-220
-
-
Tabernero, J.1
-
43
-
-
51749083205
-
Final analysis of a randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer
-
Kindler HL, Gangadhar T, Karrison T et al. Final analysis of a randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer. J Clin Oncol 2008;26(suppl):4502a.
-
(2008)
J Clin Oncol
, vol.26
-
-
Kindler, H.L.1
Gangadhar, T.2
Karrison, T.3
-
44
-
-
73949102694
-
Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer
-
Starling N, Watkins D, Cunningham D et al. Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer. J Clin Oncol 2009;27:5499-5505.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5499-5505
-
-
Starling, N.1
Watkins, D.2
Cunningham, D.3
-
45
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Pàez-Ribes M, Allen E, Hudock J et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Pàez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
47
-
-
0028997487
-
Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
-
Bergmann U, Funatomi H, Yokoyama M et al. Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles. Cancer Res 1995;55:2007-2011.
-
(1995)
Cancer Res
, vol.55
, pp. 2007-2011
-
-
Bergmann, U.1
Funatomi, H.2
Yokoyama, M.3
-
48
-
-
0028793568
-
Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor
-
Freeman JW, Mattingly CA, Strodel WE. Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor. J Cell Physiol 1995;165:155-163.
-
(1995)
J Cell Physiol
, vol.165
, pp. 155-163
-
-
Freeman, J.W.1
Mattingly, C.A.2
Strodel, W.E.3
-
49
-
-
77951708711
-
Crosstalk between insulin/insulin-like growth factor-1 receptors and g protein-coupled receptor signaling systems: A novel target for the antidiabetic drug metformin in pancreatic cancer
-
Rozengurt E, Sinnett-Smith J, Kisfalvi K. Crosstalk between insulin/insulin-like growth factor-1 receptors and g protein-coupled receptor signaling systems: A novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res 2010;16:2505-2511.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2505-2511
-
-
Rozengurt, E.1
Sinnett-Smith, J.2
Kisfalvi, K.3
-
50
-
-
77954777571
-
Novel agents for the treatment of pancreatic adenocarcinoma: Any light at the end of the tunnel?
-
Highlights from the "2010 ASCO Annual Meeting, Chicago, IL, USA, June 4-8, 2010
-
Dimou AT, Syrigos KN, Saif MW. Novel agents for the treatment of pancreatic adenocarcinoma: Any light at the end of the tunnel? Highlights from the "2010 ASCO Annual Meeting, Chicago, IL, USA, June 4-8, 2010. J Pancreas 2010;11:324-327.
-
(2010)
J Pancreas
, vol.11
, pp. 324-327
-
-
Dimou, A.T.1
Syrigos, K.N.2
Saif, M.W.3
-
51
-
-
79958151669
-
SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer
-
Philip PA, Goldman BH, Ramanathan RK et al. SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer. J Clin Oncol 2010;28 (suppl 15):TPS223a.
-
(2010)
J Clin Oncol
, vol.28
-
-
Philip, P.A.1
Goldman, B.H.2
Ramanathan, R.K.3
-
52
-
-
78349242693
-
A placebo-controlled, randomized phase II study of conatumumab (c) or amg 479 (a) or placebo (p) plus gemcitabine (g) in patients (pts) with metastatic pancreatic cancer (mpc)
-
Kindler HL, Richards DA, Stephenson J et al. A placebo-controlled, randomized phase II study of conatumumab (c) or amg 479 (a) or placebo (p) plus gemcitabine (g) in patients (pts) with metastatic pancreatic cancer (mpc). J Clin Oncol 2010;28: 4035a.
-
(2010)
J Clin Oncol
-
-
Kindler, H.L.1
Richards, D.A.2
Stephenson, J.3
-
53
-
-
84906974585
-
A phase III, multicenter, randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine (g) as first-line therapy for metastatic adenocarcinoma of the pancreas: The gamma trial
-
Fuchs CS, Azevedo SJ, Carrato A et al. A phase III, multicenter, randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine (g) as first-line therapy for metastatic adenocarcinoma of the pancreas: The gamma trial. J Clin Oncol 2012;30:TPS4135a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Fuchs, C.S.1
Azevedo, S.J.2
Carrato, A.3
-
55
-
-
78349267741
-
Phase I/II study of mk-0646, the humanized monoclonal igf-1 antibody in combination with gemcitabine or gemcitabine plus erlotinib for advanced pancreatic cancer
-
Javle MM, Varadhachary GR, Shroff RT et al. Phase I/II study of mk-0646, the humanized monoclonal igf-1 antibody in combination with gemcitabine or gemcitabine plus erlotinib for advanced pancreatic cancer. J Clin Oncol 2010;18(supp): 4039a.
-
(2010)
J Clin Oncol
, vol.18
-
-
Javle, M.M.1
Varadhachary, G.R.2
Shroff, R.T.3
-
56
-
-
79960219919
-
Randomized phase II study of gemcitabine (g) plusanti-igf-1rantibodymk-0646, gpluserlotinib(e) plus mk-0646 and g plus e for advanced pancreatic cancer
-
Javle MM, Varadhachary GR, Fogelman DR et al. Randomized phase II study of gemcitabine (g) plusanti-igf-1rantibodymk-0646, gpluserlotinib(e) plus mk-0646 and g plus e for advanced pancreatic cancer. J Clin Oncol 2011;29:4026a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Javle, M.M.1
Varadhachary, G.R.2
Fogelman, D.R.3
-
57
-
-
84871377778
-
Effect of the loss of the type III TGFb receptorduringtumor progression on tumor microenvironment: Preclinical development of TGFb inhibition and TGFb-related biomarkers to enhance immunotherapy efficacy
-
Hanks BA, Holtzhausen A, Gimpel P et al. Effect of the loss of the type III TGFb receptorduringtumor progression on tumor microenvironment: Preclinical development of TGFb inhibition and TGFb-related biomarkers to enhance immunotherapy efficacy. J Clin Oncol 2012;30:10563a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Hanks, B.A.1
Holtzhausen, A.2
Gimpel, P.3
-
58
-
-
77952896646
-
TGF beta signalling: A complex web in cancer progression
-
Ikushima H, Miyazono K. TGF beta signalling: A complex web in cancer progression. Nat Rev Cancer 2010;10:415-424.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 415-424
-
-
Ikushima, H.1
Miyazono, K.2
-
59
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
-
60
-
-
76749088993
-
TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells
-
Chow JY, Ban M, Wu HL et al. TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol 2010;298:G275-G282.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. G275-G282
-
-
Chow, J.Y.1
Ban, M.2
Wu, H.L.3
-
61
-
-
84862968354
-
High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer
-
Feng C, Yao R, Huang F et al. High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. Arch Med Res 2011;42:584-588.
-
(2011)
Arch Med Res
, vol.42
, pp. 584-588
-
-
Feng, C.1
Yao, R.2
Huang, F.3
-
62
-
-
84864528071
-
Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen
-
Oettle H, Seufferiein T, Luger T et al. Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen. J Clin Oncol 2012;30(supp):4034a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Oettle, H.1
Seufferiein, T.2
Luger, T.3
-
63
-
-
15744372725
-
Role of transforming growth factor Beta in human cancer
-
Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005;23:2078-2093.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2078-2093
-
-
Elliott, R.L.1
Blobe, G.C.2
-
64
-
-
58249085318
-
Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
-
Wolpin BM, Hezel AF, Abrams T et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol 2009;27:193-198.
-
(2009)
J Clin Oncol
, vol.27
, pp. 193-198
-
-
Wolpin, B.M.1
Hezel, A.F.2
Abrams, T.3
-
65
-
-
77954478305
-
Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: Results of two phase II studies
-
Javle MM, Shroff RT, Xiong H et al. Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: Results of two phase II studies. BMC Cancer 2010;10:368.
-
(2010)
Bmc Cancer
, vol.10
, pp. 368
-
-
Javle, M.M.1
Shroff, R.T.2
Xiong, H.3
-
66
-
-
84906976722
-
Final resultsof aphasei studyof thecombinationof anovel cell cycle inhibitor on 01910.Na with gemcitabine in patients with advanced pancreatic and other solid tumors
-
Ma WW, Messersmith WA, Dy GK et al. Final resultsof aphasei studyof thecombinationof anovel cell cycle inhibitor on 01910.Na with gemcitabine in patients with advanced pancreatic and other solid tumors. J Clin Oncol 2011;29(suppl):3101a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Ma, W.W.1
Messersmith, W.A.2
Dy, G.K.3
-
68
-
-
65549121943
-
Notch signaling: The core pathway and its posttranslational regulation
-
Fortini ME. Notch signaling: The core pathway and its posttranslational regulation. Dev Cell 2009; 16:633-647.
-
(2009)
Dev Cell
, vol.16
, pp. 633-647
-
-
Fortini, M.E.1
-
69
-
-
84938081971
-
Phase 1b of anticancer stem cell antibody omp-59r5 (anti-notch 2/3) in combination with nab-paclitaxel and gemcitabine in patients with untreated metastatic pancreatic cancer
-
O'Reilly EM, Smith LS, Bendell JC et al. Phase 1b of anticancer stem cell antibody omp-59r5 (anti-notch 2/3) in combination with nab-paclitaxel and gemcitabine in patients with untreated metastatic pancreatic cancer. J Clin Oncol 2014;32(suppl 3): 220a
-
(2014)
J Clin Oncol
, vol.32
-
-
O'reilly, E.M.1
Smith, L.S.2
Bendell, J.C.3
-
70
-
-
84906980611
-
A phase 1b study of the anticancer stem cell agent demcizumab and gemcitabine with or without paclitaxel protein bound particles in patients with pancreatic cancer
-
Gracian AC, Jameson MB, Grande E et al. A phase 1b study of the anticancer stem cell agent demcizumab and gemcitabine with or without paclitaxel protein bound particles in patients with pancreatic cancer. J Clin Oncol 2014;32(suppl 3): 279a.
-
(2014)
J Clin Oncol
, vol.32
-
-
Gracian, A.C.1
Jameson, M.B.2
Grande, E.3
-
71
-
-
0030806173
-
Changing views of the role of matrix metalloproteinases in metastasis
-
Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997;89:1260-1270.
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 1260-1270
-
-
Chambers, A.F.1
Matrisian, L.M.2
-
72
-
-
0037100983
-
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
-
Bramhall SR, Schulz J, Nemunaitis J et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002; 87:161-167.
-
(2002)
Br J Cancer
, vol.87
, pp. 161-167
-
-
Bramhall, S.R.1
Schulz, J.2
Nemunaitis, J.3
-
73
-
-
0141688333
-
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Hamm J, Dancey J et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003;21: 3296-3302.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3296-3302
-
-
Moore, M.J.1
Hamm, J.2
Dancey, J.3
-
74
-
-
44749090941
-
A constitutive regulator of chemoresistance and malignancy in cancer cells
-
Toole BP, Slomiany MG. Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells. Semin Cancer Biol 2008;18:244-250.
-
(2008)
Semin Cancer Biol
, vol.18
, pp. 244-250
-
-
Toole, B.P.1
Hyaluronan, M.G.2
-
75
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Jacobetz MA, Chan DS, Neesse A et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013;62:112-120.
-
(2013)
Gut
, vol.62
, pp. 112-120
-
-
Jacobetz, M.A.1
Chan, D.S.2
Neesse, A.3
-
76
-
-
84890936723
-
A phase 1b study of gemcitabine plus pegph20 (pegylated recombinant human hyaluronidase) in patients with stage iv previously untreated pancreatic cancer
-
Hingorani SR, Harris WP, Beck JT et al. A phase 1b study of gemcitabine plus pegph20 (pegylated recombinant human hyaluronidase) in patients with stage iv previously untreated pancreatic cancer. J Clin Oncol 2013;31(suppl):4010a.
-
(2013)
J Clin Oncol
, vol.31
-
-
Hingorani, S.R.1
Harris, W.P.2
Beck, J.T.3
-
77
-
-
0025341692
-
Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells
-
Snow AD, Bolender RP, Wight TN et al. Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells. Am J Pathol 1990;137:313-330.
-
(1990)
Am J Pathol
, vol.137
, pp. 313-330
-
-
Snow, A.D.1
Bolender, R.P.2
Wight, T.N.3
-
78
-
-
0031046646
-
Growth factors in the extracellular matrix
-
Taipale J, Keski-Oja J. Growth factors in the extracellular matrix. FASEB J 1997;11:51-59.
-
(1997)
Faseb J
, vol.11
, pp. 51-59
-
-
Taipale, J.1
Keski-Oja, J.2
-
79
-
-
84862316521
-
Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model
-
Sudha T, Phillips P, Kanaan C et al. Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model. Clin Exp Metastasis 2012;29:431-439.
-
(2012)
Clin Exp Metastasis
, vol.29
, pp. 431-439
-
-
Sudha, T.1
Phillips, P.2
Kanaan, C.3
-
80
-
-
70449122133
-
Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells
-
Lee DY, Lee SW, Kim SK et al. Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells. Pharm Res 2009;26: 2667-2676.
-
(2009)
Pharm Res
, vol.26
, pp. 2667-2676
-
-
Lee, D.Y.1
Lee, S.W.2
Kim, S.K.3
-
81
-
-
70949096151
-
The hedgehog pathway and pancreatic cancer
-
Hidalgo M, Maitra A. The hedgehog pathway and pancreatic cancer. N Engl J Med 2009;361: 2094-2096.
-
(2009)
N Engl J Med
, vol.361
, pp. 2094-2096
-
-
Hidalgo, M.1
Maitra, A.2
-
82
-
-
0242270878
-
Hedgehog isan early andlatemediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW et al. Hedgehog isan early andlatemediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
-
83
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
84
-
-
84858640430
-
A phase Ib trial of ipi-926, a hedgehog pathway inhibitor, plus gemcitabine in patients with metastatic pancreatic cancer
-
Richards DA, Stephenson J, Wolpin BM et al. A phase Ib trial of ipi-926, a hedgehog pathway inhibitor, plus gemcitabine in patients with metastatic pancreatic cancer. J Clin Oncol 2012;30(Suppl 4):213a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Richards, D.A.1
Stephenson, J.2
Wolpin, B.M.3
-
86
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009;9: 239-252.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
87
-
-
84906985912
-
Th-302 plus gemcitabine versus gemcitabine in patients with previously untreated advanced pancreatic cancer
-
Ryan DP, Reddy SG, Bahary N et al. Th-302 plus gemcitabine versus gemcitabine in patients with previously untreated advanced pancreatic cancer. J Clin Oncol 2012;31(suppl 4):325a.
-
(2012)
J Clin Oncol
, vol.31
-
-
Ryan, D.P.1
Reddy, S.G.2
Bahary, N.3
-
88
-
-
84876159000
-
A phase II trial of nab-paclitaxel as second-line therapy in patients with advanced pancreatic cancer
-
Hosein PJ, de Lima Lopes GJr., Pastorini VH et al. A phase II trial of nab-paclitaxel as second-line therapy in patients with advanced pancreatic cancer. Am J Clin Oncol 2013;36:151-156.
-
(2013)
Am J Clin Oncol
, vol.36
, pp. 151-156
-
-
Hosein, P.J.1
De Lima Lopes, G.2
Pastorini, V.H.3
-
89
-
-
34347263711
-
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models
-
Xie X, Xia W, Li Z et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell 2007;12:52-65.
-
(2007)
Cancer Cell
, vol.12
, pp. 52-65
-
-
Xie, X.1
Xia, W.2
Li, Z.3
-
90
-
-
66349096607
-
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
-
Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci USA 2009;106:7155-7160.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7155-7160
-
-
Sy, S.M.1
Huen, M.S.2
Chen, J.3
-
91
-
-
77955019276
-
Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 2010;376:235-244.
-
(2010)
Lancet
, vol.376
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
-
92
-
-
3442883904
-
Mutation-selective tumor remission with Rastargeted, whole yeast-based immunotherapy
-
Lu Y, Bellgrau D, Dwyer-Nield LD et al. Mutation-selective tumor remission with Rastargeted, whole yeast-based immunotherapy. Cancer Res 2004;64:5084-5088.
-
(2004)
Cancer Res
, vol.64
, pp. 5084-5088
-
-
Lu, Y.1
Bellgrau, D.2
Dwyer-Nield, L.D.3
-
93
-
-
84892429361
-
Immunogenicity of GI-4000 vaccine in adjuvant consolidation therapy following definitive treatment in patients with stage I-III adenocarcinoma of the lung with g12c, g12d, or g12v kras mutations
-
D'Angelo S, Park B, Krug L et al. Immunogenicity of GI-4000 vaccine in adjuvant consolidation therapy following definitive treatment in patients with stage I-III adenocarcinoma of the lung with g12c, g12d, or g12v kras mutations. J Clin Oncol 2011;29:7070a.
-
(2011)
J Clin Oncol
, vol.29
-
-
D'angelo, S.1
Park, B.2
Krug, L.3
-
94
-
-
85042902284
-
A randomized, placebo-controlled, double blind, multicenter phase II adjuvant trial of the efficacy, immunogenicity, and safety of GI-4000 plus gem versus gem alone in patients with resected pancreas cancer with activating ras mutations/survival and immunology analysis of the r1subgroup
-
Muscarella P, Wilfong LS, Ross SB et al. A randomized, placebo-controlled, double blind, multicenter phase II adjuvant trial of the efficacy, immunogenicity, and safety of GI-4000 plus gem versus gem alone in patients with resected pancreas cancer with activating ras mutations/survival and immunology analysis of the r1subgroup. J Clin Oncol 2012;30(suppl):e14501.
-
(2012)
J Clin Oncol
, vol.30
-
-
Muscarella, P.1
Wilfong, L.S.2
Ross, S.B.3
-
95
-
-
0032526693
-
The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus
-
Strong JE, Coffey MC, Tang D et al. The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus. EMBO J 1998; 17:3351-3362.
-
(1998)
Embo J
, vol.17
, pp. 3351-3362
-
-
Strong, J.E.1
Coffey, M.C.2
Tang, D.3
-
96
-
-
67649997035
-
Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in an immunocompetent animal model
-
Hirano S, Etoh T, Okunaga R et al. Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in an immunocompetent animal model. Oncol Rep 2009;21:1381-1384.
-
(2009)
Oncol Rep
, vol.21
, pp. 1381-1384
-
-
Hirano, S.1
Etoh, T.2
Okunaga, R.3
-
97
-
-
84862550301
-
Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients
-
138ra177
-
Adair RA, Roulstone V, Scott KJ et al. Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients. Sci Transl Med 2012;4:138ra177.
-
(2012)
Sci Transl Med
, vol.4
-
-
Adair, R.A.1
Roulstone, V.2
Scott, K.J.3
-
98
-
-
0033493173
-
Telomerase activity in human solid tumors. Diagnosticutility and clinical applications
-
Vasef MA, Ross JS, Cohen MB. Telomerase activity in human solid tumors. Diagnosticutility and clinical applications. Am J Clin Pathol 1999;112 (Suppl 1):S68-S75.
-
(1999)
Am J Clin Pathol
, vol.112
, pp. S68-S75
-
-
Vasef, M.A.1
Ross, J.S.2
Cohen, M.B.3
-
99
-
-
33845247353
-
Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study
-
Bernhardt SL, Gjertsen MK, Trachsel S et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer 2006;95:1474-1482.
-
(2006)
Br J Cancer
, vol.95
, pp. 1474-1482
-
-
Bernhardt, S.L.1
Gjertsen, M.K.2
Trachsel, S.3
-
100
-
-
84880052883
-
A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer
-
LBA4004a
-
Middleton GW, Valle JW, Wedsley J et al. A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer. J Clin Oncol 2013;31(suppl): LBA4004a.
-
(2013)
J Clin Oncol
, vol.31
-
-
Middleton, G.W.1
Valle, J.W.2
Wedsley, J.3
-
101
-
-
84906980097
-
Safety, efficacy, and immune analyses of a phase 2, randomized study of gvax pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer
-
Le D, Gilliam AW, Picozzi V et al. Safety, efficacy, and immune analyses of a phase 2, randomized study of gvax pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer. Eur J Cancer 2013;49(suppl 2):S616.
-
(2013)
Eur J Cancer
, vol.49
, pp. S616
-
-
Le, D.1
Gilliam, A.W.2
Picozzi, V.3
-
102
-
-
84856519280
-
A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction
-
Le DT, Brockstedt DG, Nir-Paz R et al. A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction. Clin Cancer Res 2012; 18:858-868.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 858-868
-
-
Le, D.T.1
Brockstedt, D.G.2
Nir-Paz, R.3
-
103
-
-
84883811812
-
Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus ags-1c4d4 in patients with previously untreated, metastatic pancreatic cancer
-
Wolpin BM, O'Reilly EM, Ko YJ et al. Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus ags-1c4d4 in patients with previously untreated, metastatic pancreatic cancer. Ann Oncol 2013;24:1792-1801.
-
(2013)
Ann Oncol
, vol.24
, pp. 1792-1801
-
-
Wolpin, B.M.1
O'reilly, E.M.2
Ko, Y.J.3
-
104
-
-
84868191187
-
Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial
-
Ocean AJ, Pennington KL, Guarino MJ et al. Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial. Cancer 2012;118:5497-5506.
-
(2012)
Cancer
, vol.118
, pp. 5497-5506
-
-
Ocean, A.J.1
Pennington, K.L.2
Guarino, M.J.3
-
105
-
-
84888086049
-
A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
-
Beatty GL, Torigian DA, Chiorean EG et al. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res 2013;19:6286-6295.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6286-6295
-
-
Beatty, G.L.1
Torigian, D.A.2
Chiorean, E.G.3
-
106
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty GL, Chiorean EG, Fishman MP et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011;331:1612-1616.
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
-
107
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363: 711-723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'day, S.J.2
McDermott, D.F.3
-
108
-
-
77958050577
-
Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
Royal RE, Levy C, Turner K et al. Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010;33:828-833.
-
(2010)
J Immunother
, vol.33
, pp. 828-833
-
-
Royal, R.E.1
Levy, C.2
Turner, K.3
-
109
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-2465.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
110
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 anti-body in cancer
-
Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 anti-body in cancer. N Engl J Med 2012;366:2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
111
-
-
84866653054
-
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
-
Chmielewski M, Hahn O, Rappl G et al. T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice. Gastroenterology 2012; 143:1095-1107.
-
(2012)
Gastroenterology
, vol.143
, pp. 1095-1107
-
-
Chmielewski, M.1
Hahn, O.2
Rappl, G.3
-
112
-
-
0142219312
-
Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity
-
García-Manteiga J, Molina-Arcas M, Casado FJ et al. Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. Clin Cancer Res 2003;9:5000-5008.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5000-5008
-
-
García-Manteiga, J.1
Molina-Arcas, M.2
Casado, F.J.3
-
113
-
-
33645731188
-
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
-
Giovannetti E, Del Tacca M, Mey V et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006;66:3928-3935.
-
(2006)
Cancer Res
, vol.66
, pp. 3928-3935
-
-
Giovannetti, E.1
Del Tacca, M.2
Mey, V.3
-
114
-
-
33846816556
-
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
-
Nakano Y, Tanno S, Koizumi K et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007; 96:457-463.
-
(2007)
Br J Cancer
, vol.96
, pp. 457-463
-
-
Nakano, Y.1
Tanno, S.2
Koizumi, K.3
-
115
-
-
84894297251
-
Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: Including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity
-
Poplin E, Wasan H, Rolfe L et al. Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: Including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity. J Clin Oncol 2013;31:4453-4461.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4453-4461
-
-
Poplin, E.1
Wasan, H.2
Rolfe, L.3
-
116
-
-
59849115856
-
Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
-
Farrell JJ, Elsaleh H, Garcia M et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009;136:187-195.
-
(2009)
Gastroenterology
, vol.136
, pp. 187-195
-
-
Farrell, J.J.1
Elsaleh, H.2
Garcia, M.3
-
117
-
-
84892633020
-
Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial
-
djt347
-
Greenhalf W, Ghaneh P, Neoptolemos JP et al. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. J Natl Cancer Inst 2014;106:djt347.
-
(2014)
J Natl Cancer Inst
, vol.106
-
-
Greenhalf, W.1
Ghaneh, P.2
Neoptolemos, J.P.3
-
118
-
-
84860830887
-
Molecular markers of the egfr pathway in erlotinib-treated patients with advanced pancreatic cancer (apc): Translational analyses of a randomized, cross-over aio phase III trial
-
Boeck SH, Jung A, Laubender RP et al. Molecular markers of the egfr pathway in erlotinib-treated patients with advanced pancreatic cancer (apc): Translational analyses of a randomized, cross-over aio phase III trial. J Clin Oncol 2011;29(suppl):4047a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Boeck, S.H.1
Jung, A.2
Laubender, R.P.3
-
119
-
-
84867035475
-
Comprehensive analysis of potential predictive biomarkers for insulin-like growth factor type-1 receptor (igf-1r) targeted therapy in pancreatic cancer
-
Shroff RT, Javle MM, Li D et al. Comprehensive analysis of potential predictive biomarkers for insulin-like growth factor type-1 receptor (igf-1r) targeted therapy in pancreatic cancer. J Clin Oncol 2011;29(suppl):4052a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Shroff, R.T.1
Javle, M.M.2
Li, D.3
-
120
-
-
84875044556
-
Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance
-
Sangar V, Ricigliano M, O'Reilly EM et al. Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance. J Clin Oncol 2012;30(Suppl 34): 142a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Sangar, V.1
Ricigliano, M.2
O'reilly, E.M.3
-
121
-
-
79960282940
-
BAYPAN study: A double-blind, phase III randomized trial of gemcitabine plus sorafenib versus gemcitabine plus placebo in patients with advanced pancreatic cancer
-
Goncalves A, Viret F, François E et al. BAYPAN study: A double-blind, phase III randomized trial of gemcitabine plus sorafenib versus gemcitabine plus placebo in patients with advanced pancreatic cancer. J Clin Oncol 2011;29(suppl):4028a.
-
(2011)
J Clin Oncol
, vol.29
-
-
Goncalves, A.1
Viret, F.2
François, E.3
-
122
-
-
84929321103
-
Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial
-
Deplanque G, Demarchi M, Hebbar M et al. Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2012;30(Suppl 34):158a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Deplanque, G.1
Demarchi, M.2
Hebbar, M.3
-
123
-
-
84875046931
-
A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
-
Infante JR, Somer BG, Park JO et al. A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. J Clin Oncol 2012; 30(Suppl 34):291a.
-
(2012)
J Clin Oncol
, vol.30
-
-
Infante, J.R.1
Somer, B.G.2
Park, J.O.3
|