메뉴 건너뛰기




Volumn 19, Issue 9, 2014, Pages 937-950

Advanced pancreatic cancer: Flourishing novel approaches in the era of biological therapy

Author keywords

Advanced pancreatic cancer; Biological therapy; Gemcitabine; Targeted therapy

Indexed keywords

AFLIBERCEPT; AXITINIB; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CLIVATUZUMAB TETRAXETAN Y 90; ERLOTINIB; EVOFOSFAMIDE; FLUOROURACIL; FOLINIC ACID; GANITUMAB; GEMCITABINE; IRINOTECAN; LONAFARNIB; MASITINIB; N (6, 7 DIHYDRO 6 OXO 5H DIBENZ [B, D] AZEPIN 7 YL) 2, 2 DIMETHYL N' (2, 2, 3, 3, 3 PENTAFLUOROPROPYL) PROPANEDIAMIDE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; PELAREOREP; PIMASERTIB; REFAMETINIB; RIGOSERTIB; SELUMETINIB; SORAFENIB; TERTOMOTIDE; TIPIFARNIB; TRAMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELIPARIB; DEOXYCYTIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TUMOR MARKER;

EID: 84906976007     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2012-0131     Document Type: Article
Times cited : (12)

References (123)
  • 1
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 1997;15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 2
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364:1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 3
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • Von Hoff DD, Ervin T, Arena FP et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013;369:1691-1703.
    • (2013) N Engl J Med , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3
  • 4
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25: 1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 5
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 6
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 7
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adeno-carcinoma
    • Hezel AF, Kimmelman AC, Stanger BZ et al. Genetics and biology of pancreatic ductal adeno-carcinoma. Genes Dev 2006;20:1218-1249.
    • (2006) Genes Dev , vol.20 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 8
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreaticcarcinomas
    • Schutte M, Hruban RH, Geradts J et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreaticcarcinomas. Cancer Res1997; 57:3126-3130.
    • (1997) Cancer Res , vol.57 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3
  • 9
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreaticadenocarcinoma
    • Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreaticadenocarcinoma. Nat Genet 1994;8:27-32.
    • (1994) Nat Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 10
    • 12644253827 scopus 로고    scopus 로고
    • Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Schutte M, Lu J et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996; 56:5360-5364.
    • (1996) Cancer Res , vol.56 , pp. 5360-5364
    • Goggins, M.1    Schutte, M.2    Lu, J.3
  • 11
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development. J Clin Oncol 1999;17:3631-3652.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 12
    • 0038413837 scopus 로고    scopus 로고
    • Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarci-noma
    • Cohen SJ, Ho L, Ranganathan S et al. Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarci-noma. J Clin Oncol 2003;21:1301-1306.
    • (2003) J Clin Oncol , vol.21 , pp. 1301-1306
    • Cohen, S.J.1    Ho, L.2    Ranganathan, S.3
  • 13
    • 23844517889 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study
    • Macdonald JS, McCoy S, Whitehead RP et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest Oncology Group (SWOG 9924) study. Invest New Drugs 2005;23:485-487.
    • (2005) Invest New Drugs , vol.23 , pp. 485-487
    • Macdonald, J.S.1    McCoy, S.2    Whitehead, R.P.3
  • 14
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, Van de Velde H, Karasek P et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol 2004;22: 1430-1438.
    • (2004) J Clin Oncol , vol.22 , pp. 1430-1438
    • Van Cutsem, E.1    Van De Velde, H.2    Karasek, P.3
  • 15
    • 0002989445 scopus 로고    scopus 로고
    • Randomized phase II study of sch 66336 and gemcitabine in the treatment of metastatic adeno-carcinoma of the pancreas
    • Lersch C, van Cutsem E, Amado R et al. Randomized phase II study of sch 66336 and gemcitabine in the treatment of metastatic adeno-carcinoma of the pancreas. Proc Am Soc Clin Oncol 2001;20:608a.
    • (2001) Proc am Soc Clin Oncol , vol.20
    • Lersch, C.1    Van Cutsem, E.2    Amado, R.3
  • 16
    • 17644410025 scopus 로고    scopus 로고
    • Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene
    • Morioka CY, Machado MC, Saito S et al. Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene. In Vivo 2005;19: 535-538.
    • (2005) In Vivo , vol.19 , pp. 535-538
    • Morioka, C.Y.1    Machado, M.C.2    Saito, S.3
  • 17
    • 34249885111 scopus 로고    scopus 로고
    • K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment
    • Réjiba S, Wack S, Aprahamian M et al. K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment. Cancer Sci 2007; 98:1128-1136.
    • (2007) Cancer Sci , vol.98 , pp. 1128-1136
    • Réjiba, S.1    Wack, S.2    Aprahamian, M.3
  • 18
    • 84864346162 scopus 로고    scopus 로고
    • A phase II open-label randomized studyto assessthe efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy
    • Bodoky G, Timcheva C, Spigel DR et al. A phase II open-label randomized studyto assessthe efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy. Invest New Drugs 2012; 30:1216-1223.
    • (2012) Invest New Drugs , vol.30 , pp. 1216-1223
    • Bodoky, G.1    Timcheva, C.2    Spigel, D.R.3
  • 19
    • 84880053768 scopus 로고    scopus 로고
    • Dual mek/egfr inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (azd6244; arry-142886) plus erlotinib
    • Ko AH, Tempero MA, Bekaii-Saab TB et al. Dual mek/egfr inhibition for advanced, chemotherapy-refractory pancreatic cancer: A multicenter phase II trial of selumetinib (azd6244; arry-142886) plus erlotinib. J Clin Oncol 2013;31(suppl):4014a.
    • (2013) J Clin Oncol , vol.31
    • Ko, A.H.1    Tempero, M.A.2    Bekaii-Saab, T.B.3
  • 20
    • 79952787575 scopus 로고    scopus 로고
    • A phase ib study of the mek inhibitor gsk1120212 combined with gemcitabine in patients with solid tumors: Interim results
    • Tolcher AW, Bendell JC, Patnaik A et al. A phase ib study of the mek inhibitor gsk1120212 combined with gemcitabine in patients with solid tumors: Interim results. J Clin Oncol 2011;29:278a.
    • (2011) J Clin Oncol , vol.29
    • Tolcher, A.W.1    Bendell, J.C.2    Patnaik, A.3
  • 21
    • 84875046931 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
    • Infante JR, Somer BG, Park JO et al. A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. J Clin Oncol 2013; 31(Suppl 4):291a.
    • (2013) J Clin Oncol , vol.31
    • Infante, J.R.1    Somer, B.G.2    Park, J.O.3
  • 22
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA, Bednar F, Zhang Y et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 2012; 122:639-653.
    • (2012) J Clin Invest , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3
  • 23
    • 0034793404 scopus 로고    scopus 로고
    • Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
    • Safran H, Steinhoff M, Mangray S et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol 2001;24:496-499.
    • (2001) Am J Clin Oncol , vol.24 , pp. 496-499
    • Safran, H.1    Steinhoff, M.2    Mangray, S.3
  • 24
    • 0026595557 scopus 로고
    • The epidermal growth factor receptor in human pancreatic cancer
    • Lemoine NR, Hughes CM, Barton CM et al. The epidermal growth factor receptor in human pancreatic cancer. J Pathol 1992;166:7-12.
    • (1992) J Pathol , vol.166 , pp. 7-12
    • Lemoine, N.R.1    Hughes, C.M.2    Barton, C.M.3
  • 25
    • 0027293748 scopus 로고
    • Coex-pression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • Yamanaka Y, Friess H, Kobrin MS et al. Coex-pression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993;13:565-569.
    • (1993) Anticancer Res , vol.13 , pp. 565-569
    • Yamanaka, Y.1    Friess, H.2    Kobrin, M.S.3
  • 26
    • 0032423809 scopus 로고    scopus 로고
    • Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer
    • Dong M, Nio Y, Guo KJ et al. Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer. Anticancer Res 1998;18(6B):4613-4619.
    • (1998) Anticancer Res , vol.18 , Issue.6B , pp. 4613-4619
    • Dong, M.1    Nio, Y.2    Guo, K.J.3
  • 27
    • 4143128359 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis
    • Tobita K, Kijima H, Dowaki S et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med 2003;11:305-309.
    • (2003) Int J Mol Med , vol.11 , pp. 305-309
    • Tobita, K.1    Kijima, H.2    Dowaki, S.3
  • 28
    • 78650095716 scopus 로고    scopus 로고
    • Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3
    • da Cunha Santos G, Dhani N, Tu D et al. Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3. Cancer 2010;116:5599-5607.
    • (2010) Cancer , vol.116 , pp. 5599-5607
    • Da Cunha Santos, G.1    Dhani, N.2    Tu, D.3
  • 29
    • 36048940287 scopus 로고    scopus 로고
    • Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer
    • Kulke MH, Blaszkowsky LS, Ryan DP et al. Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer. J Clin Oncol 2007;25: 4787-4792.
    • (2007) J Clin Oncol , vol.25 , pp. 4787-4792
    • Kulke, M.H.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 30
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial. J Clin Oncol 2004;22: 2610-2616.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3
  • 31
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • Philip PA, Benedetti J, Corless CL et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010;28:3605-3610.
    • (2010) J Clin Oncol , vol.28 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 32
    • 79960227365 scopus 로고    scopus 로고
    • Randomized phase II trial of panitumumab, erlotinib, and gemcitabine (PGE) versus erlotinib-gemcitabine (GE) in patients with untreated, metastatic pancreatic adenocarcinoma
    • Kim GP, Foster NR, Salim M et al. Randomized phase II trial of panitumumab, erlotinib, and gemcitabine (PGE) versus erlotinib-gemcitabine (GE) in patients with untreated, metastatic pancreatic adenocarcinoma. J Clin Oncol 2011;29 (suppl):4030a.
    • (2011) J Clin Oncol , vol.29
    • Kim, G.P.1    Foster, N.R.2    Salim, M.3
  • 33
    • 19944429073 scopus 로고    scopus 로고
    • Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu
    • Safran H, Iannitti D, Ramanathan R et al. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress HER-2/neu. Cancer Invest 2004;22:706-712.
    • (2004) Cancer Invest , vol.22 , pp. 706-712
    • Safran, H.1    Iannitti, D.2    Ramanathan, R.3
  • 34
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000;88:2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3
  • 35
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • Kindler HL, Niedzwiecki D, Hollis D et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28:3617-3622.
    • (2010) J Clin Oncol , vol.28 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 36
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27:2231-2237.
    • (2009) J Clin Oncol , vol.27 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 37
    • 45449090215 scopus 로고    scopus 로고
    • Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
    • Spano JP, Chodkiewicz C, Maurel J et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study. Lancet 2008;371:2101-2108.
    • (2008) Lancet , vol.371 , pp. 2101-2108
    • Spano, J.P.1    Chodkiewicz, C.2    Maurel, J.3
  • 38
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
    • Kindler HL, Ioka T, Richel DJ et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study. Lancet Oncol 2011;12:256-262.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3
  • 39
    • 84879952361 scopus 로고    scopus 로고
    • Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
    • Rougier P, Riess H, Manges R et al. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer 2013;49:2633-2642.
    • (2013) Eur J Cancer , vol.49 , pp. 2633-2642
    • Rougier, P.1    Riess, H.2    Manges, R.3
  • 40
    • 84868107516 scopus 로고    scopus 로고
    • Baypan study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer
    • Goncalves A, Gilabert M, Francois E et al. Baypan study: A double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer. Ann Oncol 2012;23: 2799-2805.
    • (2012) Ann Oncol , vol.23 , pp. 2799-2805
    • Goncalves, A.1    Gilabert, M.2    Francois, E.3
  • 41
    • 84929321103 scopus 로고    scopus 로고
    • Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial
    • Deplanque G, Demarchi M, Hebbar M et al. Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2012;31(suppl 4):158a.
    • (2012) J Clin Oncol , vol.31
    • Deplanque, G.1    Demarchi, M.2    Hebbar, M.3
  • 42
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents
    • Tabernero J. The role of VEGF and EGFR inhibition: Implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007;5: 203-220.
    • (2007) Mol Cancer Res , vol.5 , pp. 203-220
    • Tabernero, J.1
  • 43
    • 51749083205 scopus 로고    scopus 로고
    • Final analysis of a randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer
    • Kindler HL, Gangadhar T, Karrison T et al. Final analysis of a randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer. J Clin Oncol 2008;26(suppl):4502a.
    • (2008) J Clin Oncol , vol.26
    • Kindler, H.L.1    Gangadhar, T.2    Karrison, T.3
  • 44
    • 73949102694 scopus 로고    scopus 로고
    • Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer
    • Starling N, Watkins D, Cunningham D et al. Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer. J Clin Oncol 2009;27:5499-5505.
    • (2009) J Clin Oncol , vol.27 , pp. 5499-5505
    • Starling, N.1    Watkins, D.2    Cunningham, D.3
  • 45
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M, Allen E, Hudock J et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-231.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 47
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann U, Funatomi H, Yokoyama M et al. Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles. Cancer Res 1995;55:2007-2011.
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3
  • 48
    • 0028793568 scopus 로고
    • Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor
    • Freeman JW, Mattingly CA, Strodel WE. Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor. J Cell Physiol 1995;165:155-163.
    • (1995) J Cell Physiol , vol.165 , pp. 155-163
    • Freeman, J.W.1    Mattingly, C.A.2    Strodel, W.E.3
  • 49
    • 77951708711 scopus 로고    scopus 로고
    • Crosstalk between insulin/insulin-like growth factor-1 receptors and g protein-coupled receptor signaling systems: A novel target for the antidiabetic drug metformin in pancreatic cancer
    • Rozengurt E, Sinnett-Smith J, Kisfalvi K. Crosstalk between insulin/insulin-like growth factor-1 receptors and g protein-coupled receptor signaling systems: A novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res 2010;16:2505-2511.
    • (2010) Clin Cancer Res , vol.16 , pp. 2505-2511
    • Rozengurt, E.1    Sinnett-Smith, J.2    Kisfalvi, K.3
  • 50
    • 77954777571 scopus 로고    scopus 로고
    • Novel agents for the treatment of pancreatic adenocarcinoma: Any light at the end of the tunnel?
    • Highlights from the "2010 ASCO Annual Meeting, Chicago, IL, USA, June 4-8, 2010
    • Dimou AT, Syrigos KN, Saif MW. Novel agents for the treatment of pancreatic adenocarcinoma: Any light at the end of the tunnel? Highlights from the "2010 ASCO Annual Meeting, Chicago, IL, USA, June 4-8, 2010. J Pancreas 2010;11:324-327.
    • (2010) J Pancreas , vol.11 , pp. 324-327
    • Dimou, A.T.1    Syrigos, K.N.2    Saif, M.W.3
  • 51
    • 79958151669 scopus 로고    scopus 로고
    • SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer
    • Philip PA, Goldman BH, Ramanathan RK et al. SWOG S0727: A randomized phase II trial of combination gemcitabine plus erlotinib plus IMC-A12 (cixutumumab) versus gemcitabine plus erlotinib as first-line treatment in patients (pts) with metastatic pancreatic cancer. J Clin Oncol 2010;28 (suppl 15):TPS223a.
    • (2010) J Clin Oncol , vol.28
    • Philip, P.A.1    Goldman, B.H.2    Ramanathan, R.K.3
  • 52
    • 78349242693 scopus 로고    scopus 로고
    • A placebo-controlled, randomized phase II study of conatumumab (c) or amg 479 (a) or placebo (p) plus gemcitabine (g) in patients (pts) with metastatic pancreatic cancer (mpc)
    • Kindler HL, Richards DA, Stephenson J et al. A placebo-controlled, randomized phase II study of conatumumab (c) or amg 479 (a) or placebo (p) plus gemcitabine (g) in patients (pts) with metastatic pancreatic cancer (mpc). J Clin Oncol 2010;28: 4035a.
    • (2010) J Clin Oncol
    • Kindler, H.L.1    Richards, D.A.2    Stephenson, J.3
  • 53
    • 84906974585 scopus 로고    scopus 로고
    • A phase III, multicenter, randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine (g) as first-line therapy for metastatic adenocarcinoma of the pancreas: The gamma trial
    • Fuchs CS, Azevedo SJ, Carrato A et al. A phase III, multicenter, randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine (g) as first-line therapy for metastatic adenocarcinoma of the pancreas: The gamma trial. J Clin Oncol 2012;30:TPS4135a.
    • (2012) J Clin Oncol , vol.30
    • Fuchs, C.S.1    Azevedo, S.J.2    Carrato, A.3
  • 55
    • 78349267741 scopus 로고    scopus 로고
    • Phase I/II study of mk-0646, the humanized monoclonal igf-1 antibody in combination with gemcitabine or gemcitabine plus erlotinib for advanced pancreatic cancer
    • Javle MM, Varadhachary GR, Shroff RT et al. Phase I/II study of mk-0646, the humanized monoclonal igf-1 antibody in combination with gemcitabine or gemcitabine plus erlotinib for advanced pancreatic cancer. J Clin Oncol 2010;18(supp): 4039a.
    • (2010) J Clin Oncol , vol.18
    • Javle, M.M.1    Varadhachary, G.R.2    Shroff, R.T.3
  • 56
    • 79960219919 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine (g) plusanti-igf-1rantibodymk-0646, gpluserlotinib(e) plus mk-0646 and g plus e for advanced pancreatic cancer
    • Javle MM, Varadhachary GR, Fogelman DR et al. Randomized phase II study of gemcitabine (g) plusanti-igf-1rantibodymk-0646, gpluserlotinib(e) plus mk-0646 and g plus e for advanced pancreatic cancer. J Clin Oncol 2011;29:4026a.
    • (2011) J Clin Oncol , vol.29
    • Javle, M.M.1    Varadhachary, G.R.2    Fogelman, D.R.3
  • 57
    • 84871377778 scopus 로고    scopus 로고
    • Effect of the loss of the type III TGFb receptorduringtumor progression on tumor microenvironment: Preclinical development of TGFb inhibition and TGFb-related biomarkers to enhance immunotherapy efficacy
    • Hanks BA, Holtzhausen A, Gimpel P et al. Effect of the loss of the type III TGFb receptorduringtumor progression on tumor microenvironment: Preclinical development of TGFb inhibition and TGFb-related biomarkers to enhance immunotherapy efficacy. J Clin Oncol 2012;30:10563a.
    • (2012) J Clin Oncol , vol.30
    • Hanks, B.A.1    Holtzhausen, A.2    Gimpel, P.3
  • 58
    • 77952896646 scopus 로고    scopus 로고
    • TGF beta signalling: A complex web in cancer progression
    • Ikushima H, Miyazono K. TGF beta signalling: A complex web in cancer progression. Nat Rev Cancer 2010;10:415-424.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 59
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 60
    • 76749088993 scopus 로고    scopus 로고
    • TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells
    • Chow JY, Ban M, Wu HL et al. TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol 2010;298:G275-G282.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G275-G282
    • Chow, J.Y.1    Ban, M.2    Wu, H.L.3
  • 61
    • 84862968354 scopus 로고    scopus 로고
    • High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer
    • Feng C, Yao R, Huang F et al. High level of PTEN expression is associated with low-grade liver metastasis and satisfactory patient survival in pancreatic cancer. Arch Med Res 2011;42:584-588.
    • (2011) Arch Med Res , vol.42 , pp. 584-588
    • Feng, C.1    Yao, R.2    Huang, F.3
  • 62
    • 84864528071 scopus 로고    scopus 로고
    • Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen
    • Oettle H, Seufferiein T, Luger T et al. Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen. J Clin Oncol 2012;30(supp):4034a.
    • (2012) J Clin Oncol , vol.30
    • Oettle, H.1    Seufferiein, T.2    Luger, T.3
  • 63
    • 15744372725 scopus 로고    scopus 로고
    • Role of transforming growth factor Beta in human cancer
    • Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005;23:2078-2093.
    • (2005) J Clin Oncol , vol.23 , pp. 2078-2093
    • Elliott, R.L.1    Blobe, G.C.2
  • 64
    • 58249085318 scopus 로고    scopus 로고
    • Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer
    • Wolpin BM, Hezel AF, Abrams T et al. Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer. J Clin Oncol 2009;27:193-198.
    • (2009) J Clin Oncol , vol.27 , pp. 193-198
    • Wolpin, B.M.1    Hezel, A.F.2    Abrams, T.3
  • 65
    • 77954478305 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: Results of two phase II studies
    • Javle MM, Shroff RT, Xiong H et al. Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: Results of two phase II studies. BMC Cancer 2010;10:368.
    • (2010) Bmc Cancer , vol.10 , pp. 368
    • Javle, M.M.1    Shroff, R.T.2    Xiong, H.3
  • 66
    • 84906976722 scopus 로고    scopus 로고
    • Final resultsof aphasei studyof thecombinationof anovel cell cycle inhibitor on 01910.Na with gemcitabine in patients with advanced pancreatic and other solid tumors
    • Ma WW, Messersmith WA, Dy GK et al. Final resultsof aphasei studyof thecombinationof anovel cell cycle inhibitor on 01910.Na with gemcitabine in patients with advanced pancreatic and other solid tumors. J Clin Oncol 2011;29(suppl):3101a.
    • (2011) J Clin Oncol , vol.29
    • Ma, W.W.1    Messersmith, W.A.2    Dy, G.K.3
  • 68
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: The core pathway and its posttranslational regulation
    • Fortini ME. Notch signaling: The core pathway and its posttranslational regulation. Dev Cell 2009; 16:633-647.
    • (2009) Dev Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 69
    • 84938081971 scopus 로고    scopus 로고
    • Phase 1b of anticancer stem cell antibody omp-59r5 (anti-notch 2/3) in combination with nab-paclitaxel and gemcitabine in patients with untreated metastatic pancreatic cancer
    • O'Reilly EM, Smith LS, Bendell JC et al. Phase 1b of anticancer stem cell antibody omp-59r5 (anti-notch 2/3) in combination with nab-paclitaxel and gemcitabine in patients with untreated metastatic pancreatic cancer. J Clin Oncol 2014;32(suppl 3): 220a
    • (2014) J Clin Oncol , vol.32
    • O'reilly, E.M.1    Smith, L.S.2    Bendell, J.C.3
  • 70
    • 84906980611 scopus 로고    scopus 로고
    • A phase 1b study of the anticancer stem cell agent demcizumab and gemcitabine with or without paclitaxel protein bound particles in patients with pancreatic cancer
    • Gracian AC, Jameson MB, Grande E et al. A phase 1b study of the anticancer stem cell agent demcizumab and gemcitabine with or without paclitaxel protein bound particles in patients with pancreatic cancer. J Clin Oncol 2014;32(suppl 3): 279a.
    • (2014) J Clin Oncol , vol.32
    • Gracian, A.C.1    Jameson, M.B.2    Grande, E.3
  • 71
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997;89:1260-1270.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 72
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002; 87:161-167.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 73
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003;21: 3296-3302.
    • (2003) J Clin Oncol , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 74
    • 44749090941 scopus 로고    scopus 로고
    • A constitutive regulator of chemoresistance and malignancy in cancer cells
    • Toole BP, Slomiany MG. Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells. Semin Cancer Biol 2008;18:244-250.
    • (2008) Semin Cancer Biol , vol.18 , pp. 244-250
    • Toole, B.P.1    Hyaluronan, M.G.2
  • 75
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • Jacobetz MA, Chan DS, Neesse A et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013;62:112-120.
    • (2013) Gut , vol.62 , pp. 112-120
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3
  • 76
    • 84890936723 scopus 로고    scopus 로고
    • A phase 1b study of gemcitabine plus pegph20 (pegylated recombinant human hyaluronidase) in patients with stage iv previously untreated pancreatic cancer
    • Hingorani SR, Harris WP, Beck JT et al. A phase 1b study of gemcitabine plus pegph20 (pegylated recombinant human hyaluronidase) in patients with stage iv previously untreated pancreatic cancer. J Clin Oncol 2013;31(suppl):4010a.
    • (2013) J Clin Oncol , vol.31
    • Hingorani, S.R.1    Harris, W.P.2    Beck, J.T.3
  • 77
    • 0025341692 scopus 로고
    • Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells
    • Snow AD, Bolender RP, Wight TN et al. Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells. Am J Pathol 1990;137:313-330.
    • (1990) Am J Pathol , vol.137 , pp. 313-330
    • Snow, A.D.1    Bolender, R.P.2    Wight, T.N.3
  • 78
    • 0031046646 scopus 로고    scopus 로고
    • Growth factors in the extracellular matrix
    • Taipale J, Keski-Oja J. Growth factors in the extracellular matrix. FASEB J 1997;11:51-59.
    • (1997) Faseb J , vol.11 , pp. 51-59
    • Taipale, J.1    Keski-Oja, J.2
  • 79
    • 84862316521 scopus 로고    scopus 로고
    • Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model
    • Sudha T, Phillips P, Kanaan C et al. Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model. Clin Exp Metastasis 2012;29:431-439.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 431-439
    • Sudha, T.1    Phillips, P.2    Kanaan, C.3
  • 80
    • 70449122133 scopus 로고    scopus 로고
    • Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells
    • Lee DY, Lee SW, Kim SK et al. Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells. Pharm Res 2009;26: 2667-2676.
    • (2009) Pharm Res , vol.26 , pp. 2667-2676
    • Lee, D.Y.1    Lee, S.W.2    Kim, S.K.3
  • 81
    • 70949096151 scopus 로고    scopus 로고
    • The hedgehog pathway and pancreatic cancer
    • Hidalgo M, Maitra A. The hedgehog pathway and pancreatic cancer. N Engl J Med 2009;361: 2094-2096.
    • (2009) N Engl J Med , vol.361 , pp. 2094-2096
    • Hidalgo, M.1    Maitra, A.2
  • 82
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog isan early andlatemediator of pancreatic cancer tumorigenesis
    • Thayer SP, di Magliano MP, Heiser PW et al. Hedgehog isan early andlatemediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-856.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    Di Magliano, M.P.2    Heiser, P.W.3
  • 83
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324:1457-1461.
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 84
    • 84858640430 scopus 로고    scopus 로고
    • A phase Ib trial of ipi-926, a hedgehog pathway inhibitor, plus gemcitabine in patients with metastatic pancreatic cancer
    • Richards DA, Stephenson J, Wolpin BM et al. A phase Ib trial of ipi-926, a hedgehog pathway inhibitor, plus gemcitabine in patients with metastatic pancreatic cancer. J Clin Oncol 2012;30(Suppl 4):213a.
    • (2012) J Clin Oncol , vol.30
    • Richards, D.A.1    Stephenson, J.2    Wolpin, B.M.3
  • 86
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009;9: 239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 87
    • 84906985912 scopus 로고    scopus 로고
    • Th-302 plus gemcitabine versus gemcitabine in patients with previously untreated advanced pancreatic cancer
    • Ryan DP, Reddy SG, Bahary N et al. Th-302 plus gemcitabine versus gemcitabine in patients with previously untreated advanced pancreatic cancer. J Clin Oncol 2012;31(suppl 4):325a.
    • (2012) J Clin Oncol , vol.31
    • Ryan, D.P.1    Reddy, S.G.2    Bahary, N.3
  • 88
    • 84876159000 scopus 로고    scopus 로고
    • A phase II trial of nab-paclitaxel as second-line therapy in patients with advanced pancreatic cancer
    • Hosein PJ, de Lima Lopes GJr., Pastorini VH et al. A phase II trial of nab-paclitaxel as second-line therapy in patients with advanced pancreatic cancer. Am J Clin Oncol 2013;36:151-156.
    • (2013) Am J Clin Oncol , vol.36 , pp. 151-156
    • Hosein, P.J.1    De Lima Lopes, G.2    Pastorini, V.H.3
  • 89
    • 34347263711 scopus 로고    scopus 로고
    • Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models
    • Xie X, Xia W, Li Z et al. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell 2007;12:52-65.
    • (2007) Cancer Cell , vol.12 , pp. 52-65
    • Xie, X.1    Xia, W.2    Li, Z.3
  • 90
    • 66349096607 scopus 로고    scopus 로고
    • PALB2 is an integral component of the BRCA complex required for homologous recombination repair
    • Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci USA 2009;106:7155-7160.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7155-7160
    • Sy, S.M.1    Huen, M.S.2    Chen, J.3
  • 91
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE et al. Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 2010;376:235-244.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 92
    • 3442883904 scopus 로고    scopus 로고
    • Mutation-selective tumor remission with Rastargeted, whole yeast-based immunotherapy
    • Lu Y, Bellgrau D, Dwyer-Nield LD et al. Mutation-selective tumor remission with Rastargeted, whole yeast-based immunotherapy. Cancer Res 2004;64:5084-5088.
    • (2004) Cancer Res , vol.64 , pp. 5084-5088
    • Lu, Y.1    Bellgrau, D.2    Dwyer-Nield, L.D.3
  • 93
    • 84892429361 scopus 로고    scopus 로고
    • Immunogenicity of GI-4000 vaccine in adjuvant consolidation therapy following definitive treatment in patients with stage I-III adenocarcinoma of the lung with g12c, g12d, or g12v kras mutations
    • D'Angelo S, Park B, Krug L et al. Immunogenicity of GI-4000 vaccine in adjuvant consolidation therapy following definitive treatment in patients with stage I-III adenocarcinoma of the lung with g12c, g12d, or g12v kras mutations. J Clin Oncol 2011;29:7070a.
    • (2011) J Clin Oncol , vol.29
    • D'angelo, S.1    Park, B.2    Krug, L.3
  • 94
    • 85042902284 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double blind, multicenter phase II adjuvant trial of the efficacy, immunogenicity, and safety of GI-4000 plus gem versus gem alone in patients with resected pancreas cancer with activating ras mutations/survival and immunology analysis of the r1subgroup
    • Muscarella P, Wilfong LS, Ross SB et al. A randomized, placebo-controlled, double blind, multicenter phase II adjuvant trial of the efficacy, immunogenicity, and safety of GI-4000 plus gem versus gem alone in patients with resected pancreas cancer with activating ras mutations/survival and immunology analysis of the r1subgroup. J Clin Oncol 2012;30(suppl):e14501.
    • (2012) J Clin Oncol , vol.30
    • Muscarella, P.1    Wilfong, L.S.2    Ross, S.B.3
  • 95
    • 0032526693 scopus 로고    scopus 로고
    • The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus
    • Strong JE, Coffey MC, Tang D et al. The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus. EMBO J 1998; 17:3351-3362.
    • (1998) Embo J , vol.17 , pp. 3351-3362
    • Strong, J.E.1    Coffey, M.C.2    Tang, D.3
  • 96
    • 67649997035 scopus 로고    scopus 로고
    • Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in an immunocompetent animal model
    • Hirano S, Etoh T, Okunaga R et al. Reovirus inhibits the peritoneal dissemination of pancreatic cancer cells in an immunocompetent animal model. Oncol Rep 2009;21:1381-1384.
    • (2009) Oncol Rep , vol.21 , pp. 1381-1384
    • Hirano, S.1    Etoh, T.2    Okunaga, R.3
  • 97
    • 84862550301 scopus 로고    scopus 로고
    • Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients
    • 138ra177
    • Adair RA, Roulstone V, Scott KJ et al. Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients. Sci Transl Med 2012;4:138ra177.
    • (2012) Sci Transl Med , vol.4
    • Adair, R.A.1    Roulstone, V.2    Scott, K.J.3
  • 98
    • 0033493173 scopus 로고    scopus 로고
    • Telomerase activity in human solid tumors. Diagnosticutility and clinical applications
    • Vasef MA, Ross JS, Cohen MB. Telomerase activity in human solid tumors. Diagnosticutility and clinical applications. Am J Clin Pathol 1999;112 (Suppl 1):S68-S75.
    • (1999) Am J Clin Pathol , vol.112 , pp. S68-S75
    • Vasef, M.A.1    Ross, J.S.2    Cohen, M.B.3
  • 99
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study
    • Bernhardt SL, Gjertsen MK, Trachsel S et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer 2006;95:1474-1482.
    • (2006) Br J Cancer , vol.95 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3
  • 100
    • 84880052883 scopus 로고    scopus 로고
    • A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer
    • LBA4004a
    • Middleton GW, Valle JW, Wedsley J et al. A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer. J Clin Oncol 2013;31(suppl): LBA4004a.
    • (2013) J Clin Oncol , vol.31
    • Middleton, G.W.1    Valle, J.W.2    Wedsley, J.3
  • 101
    • 84906980097 scopus 로고    scopus 로고
    • Safety, efficacy, and immune analyses of a phase 2, randomized study of gvax pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer
    • Le D, Gilliam AW, Picozzi V et al. Safety, efficacy, and immune analyses of a phase 2, randomized study of gvax pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer. Eur J Cancer 2013;49(suppl 2):S616.
    • (2013) Eur J Cancer , vol.49 , pp. S616
    • Le, D.1    Gilliam, A.W.2    Picozzi, V.3
  • 102
    • 84856519280 scopus 로고    scopus 로고
    • A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction
    • Le DT, Brockstedt DG, Nir-Paz R et al. A liveattenuated Listeria vaccine (ANZ-100) and a liveattenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase I studies of safety and immune induction. Clin Cancer Res 2012; 18:858-868.
    • (2012) Clin Cancer Res , vol.18 , pp. 858-868
    • Le, D.T.1    Brockstedt, D.G.2    Nir-Paz, R.3
  • 103
    • 84883811812 scopus 로고    scopus 로고
    • Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus ags-1c4d4 in patients with previously untreated, metastatic pancreatic cancer
    • Wolpin BM, O'Reilly EM, Ko YJ et al. Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus ags-1c4d4 in patients with previously untreated, metastatic pancreatic cancer. Ann Oncol 2013;24:1792-1801.
    • (2013) Ann Oncol , vol.24 , pp. 1792-1801
    • Wolpin, B.M.1    O'reilly, E.M.2    Ko, Y.J.3
  • 104
    • 84868191187 scopus 로고    scopus 로고
    • Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial
    • Ocean AJ, Pennington KL, Guarino MJ et al. Fractionated radioimmunotherapy with (90) Y-clivatuzumab tetraxetan and low-dose gemcitabine is active in advanced pancreatic cancer: A phase 1 trial. Cancer 2012;118:5497-5506.
    • (2012) Cancer , vol.118 , pp. 5497-5506
    • Ocean, A.J.1    Pennington, K.L.2    Guarino, M.J.3
  • 105
    • 84888086049 scopus 로고    scopus 로고
    • A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • Beatty GL, Torigian DA, Chiorean EG et al. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res 2013;19:6286-6295.
    • (2013) Clin Cancer Res , vol.19 , pp. 6286-6295
    • Beatty, G.L.1    Torigian, D.A.2    Chiorean, E.G.3
  • 106
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011;331:1612-1616.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3
  • 107
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363: 711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'day, S.J.2    McDermott, D.F.3
  • 108
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • Royal RE, Levy C, Turner K et al. Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 2010;33:828-833.
    • (2010) J Immunother , vol.33 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3
  • 109
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 110
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 anti-body in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 anti-body in cancer. N Engl J Med 2012;366:2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 111
    • 84866653054 scopus 로고    scopus 로고
    • T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice
    • Chmielewski M, Hahn O, Rappl G et al. T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice. Gastroenterology 2012; 143:1095-1107.
    • (2012) Gastroenterology , vol.143 , pp. 1095-1107
    • Chmielewski, M.1    Hahn, O.2    Rappl, G.3
  • 112
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity
    • García-Manteiga J, Molina-Arcas M, Casado FJ et al. Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. Clin Cancer Res 2003;9:5000-5008.
    • (2003) Clin Cancer Res , vol.9 , pp. 5000-5008
    • García-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3
  • 113
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Del Tacca M, Mey V et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006;66:3928-3935.
    • (2006) Cancer Res , vol.66 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3
  • 114
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano Y, Tanno S, Koizumi K et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007; 96:457-463.
    • (2007) Br J Cancer , vol.96 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 115
    • 84894297251 scopus 로고    scopus 로고
    • Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: Including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity
    • Poplin E, Wasan H, Rolfe L et al. Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: Including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity. J Clin Oncol 2013;31:4453-4461.
    • (2013) J Clin Oncol , vol.31 , pp. 4453-4461
    • Poplin, E.1    Wasan, H.2    Rolfe, L.3
  • 116
    • 59849115856 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer
    • Farrell JJ, Elsaleh H, Garcia M et al. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer. Gastroenterology 2009;136:187-195.
    • (2009) Gastroenterology , vol.136 , pp. 187-195
    • Farrell, J.J.1    Elsaleh, H.2    Garcia, M.3
  • 117
    • 84892633020 scopus 로고    scopus 로고
    • Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial
    • djt347
    • Greenhalf W, Ghaneh P, Neoptolemos JP et al. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. J Natl Cancer Inst 2014;106:djt347.
    • (2014) J Natl Cancer Inst , vol.106
    • Greenhalf, W.1    Ghaneh, P.2    Neoptolemos, J.P.3
  • 118
    • 84860830887 scopus 로고    scopus 로고
    • Molecular markers of the egfr pathway in erlotinib-treated patients with advanced pancreatic cancer (apc): Translational analyses of a randomized, cross-over aio phase III trial
    • Boeck SH, Jung A, Laubender RP et al. Molecular markers of the egfr pathway in erlotinib-treated patients with advanced pancreatic cancer (apc): Translational analyses of a randomized, cross-over aio phase III trial. J Clin Oncol 2011;29(suppl):4047a.
    • (2011) J Clin Oncol , vol.29
    • Boeck, S.H.1    Jung, A.2    Laubender, R.P.3
  • 119
    • 84867035475 scopus 로고    scopus 로고
    • Comprehensive analysis of potential predictive biomarkers for insulin-like growth factor type-1 receptor (igf-1r) targeted therapy in pancreatic cancer
    • Shroff RT, Javle MM, Li D et al. Comprehensive analysis of potential predictive biomarkers for insulin-like growth factor type-1 receptor (igf-1r) targeted therapy in pancreatic cancer. J Clin Oncol 2011;29(suppl):4052a.
    • (2011) J Clin Oncol , vol.29
    • Shroff, R.T.1    Javle, M.M.2    Li, D.3
  • 120
    • 84875044556 scopus 로고    scopus 로고
    • Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance
    • Sangar V, Ricigliano M, O'Reilly EM et al. Use of pharmacogenomic modeling in pancreatic cancer for prediction of chemotherapy response and resistance. J Clin Oncol 2012;30(Suppl 34): 142a.
    • (2012) J Clin Oncol , vol.30
    • Sangar, V.1    Ricigliano, M.2    O'reilly, E.M.3
  • 121
    • 79960282940 scopus 로고    scopus 로고
    • BAYPAN study: A double-blind, phase III randomized trial of gemcitabine plus sorafenib versus gemcitabine plus placebo in patients with advanced pancreatic cancer
    • Goncalves A, Viret F, François E et al. BAYPAN study: A double-blind, phase III randomized trial of gemcitabine plus sorafenib versus gemcitabine plus placebo in patients with advanced pancreatic cancer. J Clin Oncol 2011;29(suppl):4028a.
    • (2011) J Clin Oncol , vol.29
    • Goncalves, A.1    Viret, F.2    François, E.3
  • 122
    • 84929321103 scopus 로고    scopus 로고
    • Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial
    • Deplanque G, Demarchi M, Hebbar M et al. Masitinib in nonresectable pancratic cancer: Results of a phase III randomized placebo-controlled trial. J Clin Oncol 2012;30(Suppl 34):158a.
    • (2012) J Clin Oncol , vol.30
    • Deplanque, G.1    Demarchi, M.2    Hebbar, M.3
  • 123
    • 84875046931 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas
    • Infante JR, Somer BG, Park JO et al. A randomized, double-blind, placebo-controlled trial of trametinib, a mek inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas. J Clin Oncol 2012; 30(Suppl 34):291a.
    • (2012) J Clin Oncol , vol.30
    • Infante, J.R.1    Somer, B.G.2    Park, J.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.