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Volumn 25, Issue 30, 2007, Pages 4787-4792

Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

CA 19-9 ANTIGEN; CAPECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEMCITABINE; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE; DRUG DERIVATIVE; FLUOROURACIL; QUINAZOLINE DERIVATIVE;

EID: 36048940287     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2007.11.8521     Document Type: Article
Times cited : (161)

References (40)
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris H, Moore M, Andersen J, et al: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15:2403-2413, 1997
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.1    Moore, M.2    Andersen, J.3
  • 3
    • 0033012340 scopus 로고    scopus 로고
    • Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
    • Hidalgo M, Castellano D, Paz-Ares L: Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. J Clin Oncol 17:585-592, 1999
    • (1999) J Clin Oncol , vol.17 , pp. 585-592
    • Hidalgo, M.1    Castellano, D.2    Paz-Ares, L.3
  • 4
    • 0036498787 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer
    • Rocha Lima C, Savarese D, Bruckner H, et al: Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer. J Clin Oncol 20:1182-1191, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1182-1191
    • Rocha Lima, C.1    Savarese, D.2    Bruckner, H.3
  • 5
    • 0033635935 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
    • Heinemann V, Wilke H, Mergenthaler HG, et al: Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann Oncol 11:1399-1403, 2000
    • (2000) Ann Oncol , vol.11 , pp. 1399-1403
    • Heinemann, V.1    Wilke, H.2    Mergenthaler, H.G.3
  • 6
    • 0037087787 scopus 로고    scopus 로고
    • Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma: Final results of a GERCOR multicenter phase II study
    • Louvet C, Andre T, Lledo G, et al: Gemcitabine combined with oxaliplatin in advanced pancreatic adenocarcinoma: Final results of a GERCOR multicenter phase II study. J Clin Oncol 20:1512-1518, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 1512-1518
    • Louvet, C.1    Andre, T.2    Lledo, G.3
  • 7
    • 0036682041 scopus 로고    scopus 로고
    • A phase III study of gemcitabine in combination with 5-FU versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin J, Catalano P, Thomas J, et al: A phase III study of gemcitabine in combination with 5-FU versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20:3270-3275, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.1    Catalano, P.2    Thomas, J.3
  • 8
    • 1542358227 scopus 로고    scopus 로고
    • A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma
    • abstr 1003
    • Heinemann V, Quietzsch D, Gieseler F, et al: A phase III trial comparing gemcitabine plus cisplatin vs. gemcitabine alone in advanced pancreatic carcinoma. Proc Am Soc Clin Oncol 22:250, 2003 (abstr 1003)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 250
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 9
    • 1642323465 scopus 로고    scopus 로고
    • A randomized phase 3 study comparing efficacy and safety of gemcitabine and irinotecan to gemcitabine alone in patients with locally advanced or metastatic pancreatic cancer who have not received prior systemic therapy
    • abstr 1005
    • Rocha Lima C, Rotche R, Jeffery M, et al: A randomized phase 3 study comparing efficacy and safety of gemcitabine and irinotecan to gemcitabine alone in patients with locally advanced or metastatic pancreatic cancer who have not received prior systemic therapy. Proc Am Soc Clin Oncol 22:251, 2003 (abstr 1005)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 251
    • Rocha Lima, C.1    Rotche, R.2    Jeffery, M.3
  • 10
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P, et al: Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial. J Clin Oncol 23:3509-3516, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 11
    • 0036137690 scopus 로고    scopus 로고
    • Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer
    • Cartwright T, Cohn A, Varkey J, et al: Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer. J Clin Oncol 20: 160-164, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 160-164
    • Cartwright, T.1    Cohn, A.2    Varkey, J.3
  • 12
    • 0037208590 scopus 로고    scopus 로고
    • Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: A phase I/II trial
    • Hess V, Salzberg M, Borner M, et al: Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: A phase I/II trial. J Clin Oncol 21:66-68, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 66-68
    • Hess, V.1    Salzberg, M.2    Borner, M.3
  • 13
    • 12244296736 scopus 로고    scopus 로고
    • Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: A randomized phase II trial
    • Scheithauer W, Schull B, Ulrich-Pur H, et al: Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: A randomized phase II trial. Ann Oncol 14:97-104, 2003
    • (2003) Ann Oncol , vol.14 , pp. 97-104
    • Scheithauer, W.1    Schull, B.2    Ulrich-Pur, H.3
  • 14
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
    • Herrmann R, Bodoky G, Ruhstaller T, et al: Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 25:2212-2217, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3
  • 15
    • 29344476191 scopus 로고    scopus 로고
    • Phase III randomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • suppl
    • Cunningham D, Chau I, Stocken D, et al: Phase III randomised comparison of gemcitabine with gemcitabine plus capecitabine in patients with advanced pancreatic cancer. Eur J Cancer 3:4, 2005 (suppl)
    • (2005) Eur J Cancer , vol.3 , pp. 4
    • Cunningham, D.1    Chau, I.2    Stocken, D.3
  • 16
    • 0030774045 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
    • Moyer JD, Barbacci EG, Iwata KK, et al: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 57:4838-4848, 1997
    • (1997) Cancer Res , vol.57 , pp. 4838-4848
    • Moyer, J.D.1    Barbacci, E.G.2    Iwata, K.K.3
  • 17
    • 25144488564 scopus 로고    scopus 로고
    • Approval summary for erlotinib for treatment of patients with locally advanced or metastatic nonsmall cell lung cancer after failure of at least one prior chemotherapy regimen
    • Johnson JR, Cohen M, Sridhara R, et al: Approval summary for erlotinib for treatment of patients with locally advanced or metastatic nonsmall cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res 11: 6414-6421, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 6414-6421
    • Johnson, J.R.1    Cohen, M.2    Sridhara, R.3
  • 18
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, et al: Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 22:77-85, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3
  • 19
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu L, Nemunaitis J: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19:3267-3279, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.2    Nemunaitis, J.3
  • 20
    • 33750618860 scopus 로고    scopus 로고
    • Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127
    • Dragovich T, McCoy S, Fenoglio-Preiser CM, et al: Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J Clin Oncol 24:4922-4927, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 4922-4927
    • Dragovich, T.1    McCoy, S.2    Fenoglio-Preiser, C.M.3
  • 21
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 22
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 23
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al: Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1960-1966, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 24
    • 33646361363 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer
    • Meyerhardt JA, Zhu AX, Enzinger PC, et al: Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer. J Clin Oncol 24:1892-1897, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 1892-1897
    • Meyerhardt, J.A.1    Zhu, A.X.2    Enzinger, P.C.3
  • 25
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205-216, 2000
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 26
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak EL, Jankowski J, Thayer SP, et al: Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 12:4283-4287, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 27
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • Immervoll H, Hoem D, Kugarajh K, et al: Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes. Virchows Arch 448:788-796, 2006
    • (2006) Virchows Arch , vol.448 , pp. 788-796
    • Immervoll, H.1    Hoem, D.2    Kugarajh, K.3
  • 28
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard D, Johnson B, Amler L, et al: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23:5900-5909, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.1    Johnson, B.2    Amler, L.3
  • 29
    • 22044446497 scopus 로고    scopus 로고
    • Responsiveness to cetuximab without mutations in EGFR
    • Tsuchihashi Z, Khambata-Ford S, Hanna N, et al: Responsiveness to cetuximab without mutations in EGFR. N Engl J Med 353:208-209, 2005
    • (2005) N Engl J Med , vol.353 , pp. 208-209
    • Tsuchihashi, Z.1    Khambata-Ford, S.2    Hanna, N.3
  • 30
    • 36549083856 scopus 로고    scopus 로고
    • Phase III study of gemcitabine plus cetuximab versus gemcitabine in patients with locally advanced or metastatic pancreatic adenocarcinoma: SWOG S0205 study
    • suppl; abstr LBA4509, 199s
    • Philip P, Benedetti J, Fenoglio-Preiser C, et al: Phase III study of gemcitabine plus cetuximab versus gemcitabine in patients with locally advanced or metastatic pancreatic adenocarcinoma: SWOG S0205 study. J Clin Oncol 25:199s, 2007 (suppl; abstr LBA4509)
    • (2007) J Clin Oncol , vol.25
    • Philip, P.1    Benedetti, J.2    Fenoglio-Preiser, C.3
  • 31
    • 34047101956 scopus 로고    scopus 로고
    • Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: A multicenter phase II trial
    • Boeck S, Weigang-Kohler K, Fuchs M, et al: Second-line chemotherapy with pemetrexed after gemcitabine failure in patients with advanced pancreatic cancer: A multicenter phase II trial. Ann Oncol 18:745-751, 2007
    • (2007) Ann Oncol , vol.18 , pp. 745-751
    • Boeck, S.1    Weigang-Kohler, K.2    Fuchs, M.3
  • 32
    • 33344468699 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin (GEMOX) in gemcitabine refractory advanced pancreatic adenocarcinoma: A phase II study
    • Demols A, Peeters M, Polus M, et al: Gemcitabine and oxaliplatin (GEMOX) in gemcitabine refractory advanced pancreatic adenocarcinoma: A phase II study. Br J Cancer 94:481-485, 2006
    • (2006) Br J Cancer , vol.94 , pp. 481-485
    • Demols, A.1    Peeters, M.2    Polus, M.3
  • 33
    • 33645277368 scopus 로고    scopus 로고
    • Raltitrexedeloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer
    • Reni M, Pasetto L, Aprile G, et al: Raltitrexedeloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer. Br J Cancer 94:785-791, 2006
    • (2006) Br J Cancer , vol.94 , pp. 785-791
    • Reni, M.1    Pasetto, L.2    Aprile, G.3
  • 34
    • 22144433634 scopus 로고    scopus 로고
    • Second-line treatment with oxaliplatin, leucovorin and 5-fluorouracil in gemcitabine-pretreated advanced pancreatic cancer: A phase II study
    • Tsavaris N, Kosmas C, Skopelitis H, et al: Second-line treatment with oxaliplatin, leucovorin and 5-fluorouracil in gemcitabine-pretreated advanced pancreatic cancer: A phase II study. Invest New Drugs 23:369-375, 2005
    • (2005) Invest New Drugs , vol.23 , pp. 369-375
    • Tsavaris, N.1    Kosmas, C.2    Skopelitis, H.3
  • 35
    • 29444457229 scopus 로고    scopus 로고
    • A randomized phase III study of rubitican vs best choice in 409 patients with refractory pancreatic cancer report from a North-American multi-center study
    • suppl; abstr 4013, 316s
    • Jacobs A, Burris H, Rivkin S, et al: A randomized phase III study of rubitican vs best choice in 409 patients with refractory pancreatic cancer report from a North-American multi-center study. J Clin Oncol 22:316s, 2004 (suppl; abstr 4013)
    • (2004) J Clin Oncol , vol.22
    • Jacobs, A.1    Burris, H.2    Rivkin, S.3
  • 36
    • 8344288331 scopus 로고    scopus 로고
    • Combined irinotecan and oxaliplatin in patients with advanced pre-treated pancreatic cancer
    • Cantore M, Rabbi C, Fiorentini G, et al: Combined irinotecan and oxaliplatin in patients with advanced pre-treated pancreatic cancer. Oncology 67:93-97, 2004
    • (2004) Oncology , vol.67 , pp. 93-97
    • Cantore, M.1    Rabbi, C.2    Fiorentini, G.3
  • 37
    • 3042524200 scopus 로고    scopus 로고
    • Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma
    • Milella M, Gelibter A, Di Cosimo S, et al: Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma. Cancer 101:133-138, 2004
    • (2004) Cancer , vol.101 , pp. 133-138
    • Milella, M.1    Gelibter, A.2    Di Cosimo, S.3
  • 38
    • 0038823799 scopus 로고    scopus 로고
    • Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated advanced pancreatic adenocarcinoma
    • Ulrich-Pur H, Raderer M, Verena Kornek G, et al: Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated advanced pancreatic adenocarcinoma. Br J Cancer 88:1180-1184, 2003
    • (2003) Br J Cancer , vol.88 , pp. 1180-1184
    • Ulrich-Pur, H.1    Raderer, M.2    Verena Kornek, G.3
  • 39
    • 18044362891 scopus 로고    scopus 로고
    • Irinotecan combined with gemcitabine, 5-fluorouracil, leucovorin, and cisplatin (G-FLIP) is an effective and noncross-resistant treatment for chemotherapy refractory metastatic pancreatic cancer
    • Kozuch P, Grossbard M, Barzdins A, et al: Irinotecan combined with gemcitabine, 5-fluorouracil, leucovorin, and cisplatin (G-FLIP) is an effective and noncross-resistant treatment for chemotherapy refractory metastatic pancreatic cancer. Oncologist 6:488-495, 2001
    • (2001) Oncologist , vol.6 , pp. 488-495
    • Kozuch, P.1    Grossbard, M.2    Barzdins, A.3
  • 40
    • 0033783410 scopus 로고    scopus 로고
    • Paclitaxel as weekly second-line therapy in patients with advanced pancreatic carcinoma
    • Oettle H, Arnold D, Esser M, et al: Paclitaxel as weekly second-line therapy in patients with advanced pancreatic carcinoma. Anticancer Drugs 11:635-638, 2000
    • (2000) Anticancer Drugs , vol.11 , pp. 635-638
    • Oettle, H.1    Arnold, D.2    Esser, M.3


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