'Click' assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4523-4528

  Rajaram, Hemalatha ^a   Palanivelu, Manoj Kumar ^a   Arumugam, Thiruma V ^b   Rao, Venkatesan M ^a   Shaw, P Nicholas ^a   McGeary, Ross P ^a   Ross, Benjamin P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Alzheimer's disease; Amyloid beta peptides; Click chemistry; Glycoclusters; Osmolytes

Indexed keywords

ALKYNE; AMYLOID BETA PROTEIN[1-40]; AZIDE; CARBOHYDRATE DERIVATIVE; COPPER; GALACTOSE; GLUCOSE; LACTOSE; NOOTROPIC AGENT; TREHALOSE; AMYLOID BETA PROTEIN; GLYCOCONJUGATE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; CLICK CHEMISTRY; CYCLOADDITION; DRUG ACETYLATION; DRUG POTENCY; DRUG SYNTHESIS; FLUORESCENCE ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILICITY; PH; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN SECONDARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYLOID BETA-PEPTIDES; ANIMALS; CLICK CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GLYCOCONJUGATES; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TREHALOSE;

EID: 84906967202     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.077     Document Type: Article

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