Inhibition of the NGF and IL-1β-induced expression of Alzheimer's amyloid precursor protein by antisense oligonucleotides

Journal of Molecular Neuroscience

Volumn 12, Issue 1, 1999, Pages 69-74

  Chang, Keun A ^a   Kim, Seong Hun ^a   Y Sasaki, ^b   Kim, Hye Sun ^a   Park, Chan Woong ^a   Suh, Yoo Hun ^a  

^a Seoul National University   (South Korea)

^b NONE

Author keywords

Alzheimer's disease; Amyloid precursor protein; Antisense oligonucleotides; Down syndrome; Interleukin 1 ; Nerve growth factor

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGONUCLEOTIDE; INTERLEUKIN 1BETA; NERVE GROWTH FACTOR; PHOSPHOROTHIOIC ACID DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN BLOOD VESSEL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN SYNDROME; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTEIN EXPRESSION; RAT; SENILE PLAQUE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1; NERVE GROWTH FACTORS; NEUROBLASTOMA; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PC12 CELLS; RATS; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032873916     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:12:1:69     Document Type: Article

References (20)

1. Allinquant B., Hantraye P., Mailleux P., Moya K., Bouillot C., and Prochiantz A. (1995) Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro. J. Cell Biol. 128(5), 919-927.
2. Beyruther K., Pollpwein N. P., Multhaup U., Konig G., Dyrks T., Schubert W., et al. (1993) Regulation and expression of the Alzheimer β/A4 amyloid protein precursor in health, disease, and Down's syndrome. Ann. NY Acad. Sci. 695, 91-102.
3. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. Cosgaya J. M., Latasa M.J., and Pascual A. (1996) Nerve growth factor and ras regulate beta-amyloid precursorprotein gene expression in PC12 cells. J. Neurochem. 67(1), 98-104.
5. Games D., Adams D., Alessandrini R., Barbour R., Berthelete P., Blackwell C., et al. (1995) Alzheimertype neuropathology in transgenic mice overexpressing V717Fβ-amyoid precursor protein. Nature 373, 523-527.
6. Goldgaber D., Harris H. W., Hla T., Maclag T., Donnerlly R. J., Jacobsen J. S., et al. (1989) Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad. Sci. USA 86, 7606-7610.
7. Griffin W. S., Stanley L. C., Ling C., White L., Macleodo V., Perrot L. J., et al. (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 186, 7611-7615.
8. Grilli M., Goffi F., Memo M., and Spano P. (1996) Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J. Biol. Chem. 271(25), 15,002-15,007.
9. Johnson S. A., Pasinetti G. M., May P. C., Ponte P. A., Cordell B., and Finch C. E. (1988) Selective reduction of mRNA for the β-amyloid precursor protein that lacks a Kunity-type protease inhibitor motif in cortex from Alzheimer brain. Exp. Neurol. 102, 264-268.
10. Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
11. Lai F. and Willians R. S. (1989) A prospective study of Alzheimer disease in Down syndrome. Arch. Neurol. 46, 849-853.
12. LeBlanc A. C., Kovacs D. M., Chen H. Y., Villare F., Tykocinski M., Autilio-Gambetti L., et al. (1992) Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J. Neurosci. Res. 31, 635-645.
13. Muller U., Cristina N., Li Z.-W., Wolfer D. P., Lipp H.-P., Rulicke T., et al. (1994) Behavioral and anatom-ical deficits in mice homozygous for a modified b-amyloid precursor protein gene. Cell 79, 755-765.
14. Neve R. L., Finch E. A., and Dawes L. R. (1988) Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1, 669-677.
15. Rumble B., Retallack R., Hilbich C., Simms G., Multhaup G., Martins R., et al. (1989) Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N. Engl. J. Med. 320, 1446-1452.
16. Selkoe D. J. (1994) Cell biology of the β-amyloid protein precursor and the mechanism of Alzheimer disease. Annu. Rev. Cell. Biol. 10, 373-403.
17. Tanaka S., Liu L., Kimura J., Schiojiri S., Takashi Y., Kitaguchi N., et al. (1992) Age-related changes in the proportion of APP mKN As in Alzheimer's disease and other neurological disorders. Brain Res. Mol. Brain Res. 15, 303-310.
18. Wahlestedt C. (1994) Antisense oligonucleotide strategies in neuropharmacology Trends Phrmacol. Sci. 15, 42-46.
19. Wisniewski K. E., Wisniewski H. M., and Wen G. Y. (1985) Occurrecnce of neuropathological changes and dementia of Alzheimer's disease and Down's syndrome. Ann. Neurol. 17, 278-282.
20. Zheng H., Jiang M., Trumbauer M. E., Sirinathsinghji D. J. S., Hopkins R., Smith D. W., et al. (1995) β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81, 525-531.