Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Pharmacology and Therapeutics

Volumn 144, Issue 1, 2014, Pages 28-40

  Matsumoto, Rae R ^a,b   Seminerio, Michael J ^a,c   Turner, Ryan C ^b   Robson, Matthew J ^a,d   Nguyen, Linda ^a,b   Miller, Diane B ^e   O'Callaghan, James P ^e  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Autonomic nervous system; Hyperthermia; Methamphetamine; Reactive oxygen species; Thermoregulation; Toxicity

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 5,10,15,20 TETRAKIS(N METHYL 4' PYRIDYL)PORPHYRINATO IRON III; 7 NITROINDAZOLE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; AC 927; ALPHA TOCOPHEROL; AZ 66; CALCITRIOL; CARNOSINE; CM 156; DEFEROXAMINE; ETICLOPRIDE; FENCLONINE; FENFLURAMINE; HALOPERIDOL; MELATONIN; METHAMPHETAMINE; METIROSINE; MITHRAMYCIN; NORADRENALIN; OPIATE ANTAGONIST; PEROXYNITRITE; PHENYTOIN; REACTIVE OXYGEN METABOLITE; RESERPINE; RISPERIDONE; ROTTLERIN; SN 79; SULPIRIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; CENTRAL STIMULANT AGENT; DOPAMINE;

CENTRAL NERVOUS SYSTEM; DOPAMINERGIC SYSTEM; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; HUMAN; HYPERTHERMIA; IMMUNE SYSTEM; LIVER TOXICITY; MOLECULAR BIOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SEROTONINERGIC SYSTEM; THERMOREGULATION; ANIMAL; BODY TEMPERATURE; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG OVERDOSE; FEVER;

ANIMALS; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; CENTRAL NERVOUS SYSTEM STIMULANTS; DOPAMINE; DRUG OVERDOSE; FEVER; HUMANS; METHAMPHETAMINE;

EID: 84906939396     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.05.001     Document Type: Review

References (154)

1. Y. Ago, S. Nakamura, M. Uda, Y. Kajii, M. Abe, and A. Baba et al. Attenuation of the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice Neuropharmacology 51 2006 914 922
2. D.S. Albers, and P.K. Sonsalla Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents J Pharmacol Exp Ther 275 1995 1104 1114
3. T.E. Albertson, R.W. Derlet, and B.E. Van Hoozen Methamphetamine and the expanding complications of amphetamines West J Med 170 1999 214 219
4. 1 receptor deletion strongly reduces neurotoxic effects of methamphetamine Neurobiol Dis 45 2012 810 820
5. A.J. Azzaro, and C.O. Rutledge Selectivity of release of norepinephrine, dopamine, and 5-hydroxytryptamine by amphetamine in various regions of rat brain Biochem Pharmacol 22 1973 2801 2813
6. C.E. Bandtlow, M. Meyer, D. Lindholm, M. Spranger, R. Heumann, and H. Thoenen Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: Possible relationship to the regulation of nerve growth factor synthesis J Cell Biol 111 1990 1701 1711
7. G. Beavais, K. Atwell, S. Jaynathi, B. Ladenheim, and J.L. Cadet Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways PLoS One 6 2011 e28946
8. J.F. Bowyer, and R.R. Holson Methamphetamine and amphetamine neurotoxicity L.W. Chang, R.S. Dyer, Handbook of Neurotoxicology 1995 Marcel Dekker, Inc. New York 845 870
9. J.F. Bowyer, A.W. Tank, G.D. Newport, W. Slikker Jr.; S.F. Ali, and R.R. Holson The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum J Pharmacol Exp Ther 260 1992 817 824
10. J.F. Bowyer, D.L. Davies, L. Schmued, H.W. Broening, G.D. Newport, and W. Slikker Jr. et al. Further studies of the role of hyperthermia in methamphetamine neurotoxicity J Pharmacol Exp Ther 268 1994 1571 1580
11. J.F. Bowyer, T.A. Patterson, U.T. Saini, J.P. Hanig, M. Thomas, and L. Camacho et al. Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity BMC Genomics 14 2013 147
12. 1A receptor Eur J Pharmacol 204 1991 21 28
13. 2 receptor antagonists with D-methamphetamine- induced hyperthermia and striatal dopamine and serotonin reductions Synapse 56 2005 84 93
14. P.L. Brown, and E.A. Kiyatkin Fatal intra-brain heat accumulation induced by methamphetamine at normothermic conditions in rats Int J Neuroprot Neuroregener 1 2005 86 90
15. P.L. Brown, R.A. Wise, and E.A. Kiyatkin Brain hyperthermia is induced by methamphetamine and exacerbated by social interaction J Neurosci 23 2003 3924 3929
16. G.D. Bynum, K.B. Pandolf, W.H. Schuette, R.F. Goldman, D.E. Lees, and J. Whang-Peng et al. Induced hyperthermia in sedated humans and the concept of critical thermal maximum Am J Physiol Regul Integr Comp Physiol 235 1978 R228 R236
17. B.T. Callahan, and G.A. Ricaurte Effect of 7-nitroindazole on body temperature and methamphetamine-induced dopamine toxicity NeuroReport 9 1998 2691 2695
18. B. Cannon, and J. Nedergaard Brown adipose tissue: Function and physiological significance Physiol Rev 84 2004 277 359
19. W.A. Cass, M.P. Smith, and L.E. Peters Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine Ann N Y Acad Sci 1074 2006 261 271
20. Centers for Disease Control and Prevention (CDC) Heat-related deaths - United States 1999-2003 MMWR Morb Mortal Wkly Rep 55 2006 796 798
21. N. Charkoudian Skin blood flow in adult human thermogenesis: How it works, when it does not, and why Mayo Clin Proc 78 2003 603 612
22. C. Chipana, I. Torres, J. Camarasa, D. Pubill, and E. Escubedo Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents Neuropharmacology 54 2008 1254 1263
23. K.H. Clark, C.A. Wiley, and C.W. Bradberry Psychostimulant abuse and neuroinflammation: Emerging evidence of their interconnection Neurotox Res 23 2013 174 188
24. L.J. Cohen Risperidone Pharmacotherapy 14 1994 253 265
25. R.D. Crean, S.A. Davis, S.N. Von Huben, C.C. Lay, S.N. Katner, and M.A. Taffe Effects of (+/-)3,4-methylenedioxymethamphetamine, (+/-)3,4- methylenedioxyamphetamine and methamphetamine on temperature and activity in rhesus macaques Neuroscience 142 2006 515 525
26. R.D. Crean, S.A. Davis, and M.A. Taffe Oral administration of (+/-)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques Pharmacol Biochem Behav 87 2007 11 19
27. C.C. Cruickshank, and K.R. Dyer A review of the clinical pharmacology of methamphetamine Addiction 104 2009 1085 1099
28. D.D. da Silva, E. Silva, and H. Carmo Combination effects of amphetamines under hyperthermia - The role played by oxidative stress J Appl Toxicol 34 2014 637 650
29. C. Davidson, A.J. Gow, T.H. Lee, and E.H. Ellinwood Methamphetamine neurotoxicity: Necrotic and apoptotic mechanisms and relevance to human abuse and treatment Brain Res Brain Res Rev 36 2001 1 22
30. S. Davis, D.J. Heal, and S.C. Stanford Long-lasting effects of an acute stress on the neurochemistry and function of 5-hydroxytryptaminergic neurons in the mouse brain Psychopharmacology 118 1995 267 272
31. M. Del Rios, M. Lanigan, and V. Zayas Drugs of abuse: Providing the best in evidence-based care to "self-medicated" patients Emerg Med Prac 7 2005 1 24
32. J.R. Docherty, and A.R. Green The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymehtamphetamine (MDMA, ecstasy) and its derivatives Br J Pharmacol 160 2010 1029 1044
33. J.R. Doyle, and B.K. Yamamoto Serotonin 2 receptor modulation of hyperthermia, corticosterone, and hippocampal serotonin depletion following serial exposure to chronic stress and methamphetamine Psychoneuroendocrinology 35 2010 629 633
34. ++ influx and beating rate in cultured cardiac myocytes J Pharmacol Exp Ther 269 1994 1300 1309
35. E. Escubedo, C. Chipana, M. Perez-Sanchez, J. Camarasa, and D. Pubill Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors J Pharmacol Exp Ther 315 2005 658 667
36. M.R. Eskandari, M. Rahmati, A.R. Khajeamiri, F. Kobarfard, M. Noubarani, and H. Heidari A new approach on methamphetamine-induced hepatotoxicity: involvement of mitochondrial dysfunction Xenobiotica 44 2014 70 76
37. C.J. Estler Dependence on age of methamphetamine-produced changes in thermoregulation and metabolism Experientia 31 1975 1436 1437
38. F. Eyer, and T. Zilker Bench-to-bedside review: Mechanisms and management of hyperthermia due to toxicity Crit Care 11 2007 236
39. M. Fukumura, G.D. Cappon, H.W. Broening, and C.V. Vorhees Methamphetamine-induced dopamine and serotonin reductions in neostriatum are not gender specific n rats with comparable hyperthermic responses Neurotoxicol Teratol 20 1998 441 448
40. M. Funahashi, H. Kohda, O. Hori, H. Hayashida, and H. Kimura Potentiating effect of morphine upon d-methamphetamine-induced hyperthermia in mice. Effects of naloxone and haloperidol Pharmacol Biochem Behav 36 1990 345 350
41. N.L. Gerber, and A.D. Steinberg Clinical use of immunosuppressive drugs: Part II Drugs 11 1976 90 112
42. O.T. Ginawi, A.A. Al-Majed, and A.K. Al-Suwailem NAN-190, a possible specific antagonist for methamphetamine Regul Toxicol Pharmacol 42 2005 122 127
43. C.J. Gordon A review of terms and proposed nomenclature for regulated vs. forced changes in body temperature Life Sci 32 1983 1285 1295
44. C.J. Gordon Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach 2005 CRC Press Boca Raton, FL
45. C.J. Gordon Thermophysiological responses to hyperthermia drugs: Extrapolating from rodent to human Prog Brain Res 162 2007 63 79
46. C.G. Gordon, W.P. Watkinson, J.P. O'Callahan, and D.B. Miller Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory response of the rat Pharmacol Biochem Behav 38 1991 339 344
47. 2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA Neurobiol Dis 42 2011 391 403
48. A.R. Green, E. O'Shea, and M.R. Colado A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response Eur J Pharmacol 500 2004 3 13
49. E.N. Greenblatt, and A.C. Osterberg Correlations of activating and lethal effects of excitatory drugs in grouped and isolated mice J Pharmacol Exp Ther 131 1961 115 119
50. L.J. Grimm, J.A. Blendy, K.J. Kellar, and D.C. Perry Chronic reserpine administration selectively up-regulates beta 1- and alpha 1b-adrenergic receptors in rat brain: An autoradiographic study Neuroscience 47 1992 77 86
51. H. Hagiwara, M. Iyo, and K. Hashimoto Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine Brain Res 1301 2009 189 196
52. L.E. Halpin, and B.K. Yamamoto Peripheral ammonia as a mediator of methamphetamine neurotoxicity J Neurosci 32 2012 13155 13163
53. L.E. Halpin, N.A. Northrop, and B.K. Yamamoto Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity Neuropsychopharmacology 39 2014 1031 1038
54. W. Haning, and D. Goebert Electrocardiographic abnormalities in methamphetamine abusers Addiction 102 Suppl. 1 2007 70 75
55. J. He, H. Xu, Y. Yang, X. Zhang, and X.M. Li Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats Brain Res 1018 2004 186 192
56. R.G. Hendrickson, B.Z. Horowitz, R.L. Norton, and H. Notenboom "Parachuting" meth: A novel delivery method for methamphetamine and delayed-onset toxicity from "body stuffing" Clin Toxicol 44 2006 379 382
57. H. Hozumi, M. Asanuma, I. Miyazaki, S. Fukuoka, Y. Kikkawa, and N. Kimoto et al. Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity Toxicol Lett 177 2008 123 129
58. C.M. Hysek, Y. Schmid, A. Rickli, and M.E. Liechti Carvedilol inhibits cardiostimulant and thermogenic effects of MDMA in humans: Lost in translation Br J Pharmacol 170 2013 1273 1275
59. S.Z. Imam, and S.F. Ali Aging increases susceptibility tomethamphetamine-induced dopaminergic neurotoxicity in rats: Correlation with peroxynitrite production and hyperthermia J Neurochem 78 2001 952 959
60. S.Z. Imam, J.P. Crow, G.D. Newport, F. Islam, W. Slikker Jr.; and S.F. Ali Methamphetamine generates peroxynitrite and produced dopaminergic neurotoxicity in mice: Protective effects of peroxynitrite decomposition catalyst Brain Res 837 1999 15 21
61. M. Ito, Y. Numachi, A. Ohara, and I. Sora Hyperthermic and lethal effects of methamphetamine: Roles of dopamine D1 and D2 receptors Neurosci Lett 438 2008 327 329
62. Y. Itzhak, and S.F. Ali The neuronal nitric oxide synthase inhibitor, 7-nitroindazole, protects against methamphetamine-induced neurotoxicity in vivo J Neurochem 67 1996 1770 1773
63. Y. Itzhak, C. Gandia, P.L. Huang, and S.F. Ali Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity J Pharmacol Exp Ther 284 1998 1040 1047
64. Y. Itzhak, J.L. Martin, M.D. Black, and S.F. Ali Effect of melatonin on methamphetamine- and i-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization Neuropharmacology 37 1998 781 791
65. Y. Itzhak, J.L. Martin, and S.F. Ali nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice NeuroReport 11 2000 2943 2946
66. Y. Kamijo, K. Soma, M. Nishida, A. Namera, and T. Ohwada Acute liver failure following intravenous methamphetamine Vet Hum Toxicol 44 2002 216 217
67. J. Kashani, and A.M. Ruha Methamphetamine toxicity secondary to inavaginal body stuffing J Toxicol Clin Toxicol 42 2004 987 989
68. N. Kaushal, M.J. Seminerio, J. Shaikh, M.A. Medina, C. Mesangeau, and L.L. Wilson et al. CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice Neuropharmacology 61 2011 992 1000
69. N. Kaushal, M.J. Seminerio, M.J. Robson, C.R. McCurdy, and R.R. Matsumoto Pharmacological evaluation of SN79, and sigma (σ) receptor ligand, against methamphetamine-induced neurotoxcity in vivo Eur Neuropsychopharmacol 23 2013 960 971
70. T. Kawasaki, K. Ishihara, Y. Ago, S. Nakamura, S. Itoh, and A. Baba et al. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum Eur J Pharmacol 542 2006 92 99
71. J.J. Ke, H.I. Chen, C.J. Jen, Y.M. Kuo, C.G. Cherng, and Y.P. Tsai et al. Mutual enhancement of central neurotoxicity induced by ketamine followed by methamphetamine Toxicol Appl Pharmacol 227 2008 239 247
72. E.A. Kiyatkin Brain temperature fluctuations during physiological and pathological conditions Eur J Appl Physiol 101 2007 3 17
73. E.A. Kiyatkin, and H.S. Sharma Acute methamphetamine intoxication: Brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities Int Rev Neurobiol 88 2009 65 100
74. E.A. Kiyatkin, and H.S. Sharma Expression of heat shock protein (HSP 72 kDa) during acute methamphetamine intoxication depends on brain hyperthermia: Neurotoxicity or neuroprotection? J Neural Transm 118 2011 47 60
75. E.A. Kiyatkin, and H.S. Sharma Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse Int Rev Neurobiol 102 2012 147 171
76. E.A. Kiyatkin, P.L. Brown, and R.A. Wise Brain temperature fluctuation: A reflection of functional neural activation Eur J Neurosci 17 2002 1 5
77. M.J. Kluger Fever: Role of pyrogens and cryogens Physiol Rev 71 1991 93 127
78. I.N. Krasnova, and J.L. Cadet Methamphetamine toxicity and messengers of death Brain Res Rev 60 2009 379 407
79. R. Kuczenski, D.S. Segal, A.K. Cho, and W. Melega Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine J Neurosci 15 1995 1308 1317
80. B. Ladenheim, I.N. Krasnova, X. Deng, J.M. Oyler, A. Polettini, and T.H. Moran et al. Methamphetamine-induced neurotoxicity is attenuated in transgenic mice with a null mutation for interleukin-6 Mol Pharmacol 58 2000 1247 1256
81. M.J. LaVoie, and T.G. Hastings Dopamine quinine formation and protein modification associated with the striatal neurotoxicity of methamphetamine: Evidence against a role for extracellular dopamine J Neurosci 19 1999 1484 1491
82. L.R. Leon Cytokine regulation of fever: Studies using gene knockout mice J Appl Physiol 92 2002 2648 2655
83. K.P. Lesch, B.L. Wolozin, D.L. Murphy, and P. Reiderer Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter J Neurochem 60 1993 2319 2322
84. M.S. Levi, B. Divine, J.P. Hanig, D.R. Doerge, M.M. Vanlandingham, and N.I. George et al. A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the waking (lights off) cycle Neurotoxicol Teratol 34 2012 253 262
85. M.T. Lin, A. Chandra, B.L. Tsay, and Y.F. Chern Hypothalamic and striatal dopamine activation inhibits heat production in the rat Am J Physiol Regul Integr Comp Physiol 242 1982 R471 R481
86. M.T. Lin, J.J. Wu, and B.L. Tsay Serotonergic mechanisms in the hypothalamus mediate thermoregulatory responses in rats Naunyn Schmiedebergs Arch Pharmacol 322 1983 271 278
87. W. Loscher, U. Witte, G. Fredow, M. Ganter, and K. Bickhardt Phamacodynamic effects of serotonin (5-HT) receptor ligands in pigs: Stimulation of 5-HT2 receptors induces malignant hyperthermia Naunyn Schmiedebergs Arch Pharmacol 341 1990 483 493
88. T. Makisumi, K. Yoshida, T. Watanabe, N. Tan, N. Murakami, and A. Morimoto Sympatho-adrenal involvement in methamphetamine-indced hyperthermia through skeletal muscle hypermetabolism Eur J Pharmacol 363 1998 107 112
89. B.N. Mallick, S.K. Jha, and F. Islam Presence of alpha-1 adrenoceptors on thermosensitive neurons in the medial preoptico-anterior hypothalamic area in rats Neuropharmacology 42 2002 697 705
90. Z. Marinova, M. Ren, J.R. Wendland, Y. Leng, M.H. Liang, and S. Yasuda et al. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of SP1 acetylation J Neurochem 111 2009 976 987
91. J.F. Marshall, and S.J. O'Dell Methamphetamine influences on brain and behavior: Unsafe at any speed? Trends Neurosci 35 2012 536 545
92. R.R. Matsumoto, J. Shaikh, L.L. Wilson, S. Vedam, and A. Coop Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies Eur Neuropsychopharmacol 18 2008 871 881
93. L. Matuszewich, and B.K. Yamamoto Long-lasting effects of chronic stress on DOI-induced hyperthermia in male rats Psychopharmacology 169 2003 169 175
94. E. Mauer-Spurej Circulating serotonin in vertebrates Cell Mol Life Sci 62 2005 1881 1889
95. K.J. McAllen, and D.R. Schwartz Adverser drug reactions resulting in hyperthermia in the intensive care unit Crit Care Med 38 2010 S244 S252
96. S. McLean, and E. Weber Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain Neuroscience 25 1988 259 269
97. R.R. Metzger, H.M. Haughey, D.G. Wilkins, J.W. Gibb, G.R. Hanson, and A.E. Fleckenstein Methamphetamine-induced rapid decrease in dopamine transporter function: Role of dopamine and hyperthermia J Pharmacol Exp Ther 295 2000 1077 1085
98. D.B. Miller, and J.P. O'Callaghan Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6 J mouse J Pharmacol Exp Ther 270 1994 752 760
99. D.B. Miller, and J.P. O'Callaghan Elevated environmental temperature and methamphetamine neurotoxicity Environ Res 92 2003 48 53
100. S.F. Morrison, and K. Nakamura Central neural pathways fro thermoregulation Front Biosci 16 2011 74 104
101. T. Nakayama, J.S. Eisenman, and J.D. Hardy Single unit activity of anterior hypothalamus during local heating Science 134 1961 560 561
102. E.C. Nguyen, K.A. McCracken, B. Pouw, and R.R. Matsumoto Involvement of sigma receptors in the actions of methamphetamine: Receptor binding and behavioral studies Neuropharmacology 49 2005 638 645
103. NIDA Drug-related hospital emergency room visits NIDA Info Facts 2011
104. Y. Numachi, A. Ohara, M. Yamashita, S. Fukushima, H. Kobayashi, and H. Hata et al. Methamphetamine-induced hyperthermia and lethal toxicity: Role of the dopamine and serotonin transporters Eur J Pharmacol 572 2007 120 128
105. L. Nybo Brain temperature and exercise performance Exp Physiol 97 2012 333 339
106. J.P. O'Callaghan, and D.B. Miller Neurotoxic effects of substituted amphetamines in rats and mice: Challenges to the current dogma E.J. Massaro, Handbook of Neurotoxicity Vol. 2 2002 Humana Press Totowa, NJ 269 301
107. J.P. O'Callaghan, and D.B. Miller Neurotoxicity profiles of substituted amphetamines in the C57BL/6 J mouse J Pharmacol Exp Ther 270 1994 741 751
108. G. Ossowska, G. Nowa, R. Kata, B. Klenk-Majewska, Z. Danilczuk, and I. Zebrowska-Lupina Brain monoamine receptors in a chronic unpredictable stress model in rats J Neural Transm 108 2001 311 319
109. M.J. Park, S.K. Lee, M.A. Lim, H.S. Chung, S.I. Cho, and C.G. Jang et al. Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity Brain Res 1109 2006 176 182
110. P.K. Phillips, and J.E. Heath Dependency of surface temperature regulation on body size in terrestrial mammals J Therm Biol 20 1995 281 289
111. D. Pubill, E. Verdaguer, F.X. Sureda, A. Camins, M. Pallas, and J. Camarasa et al. Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats Eur J Pharmacol 448 2002 165 168
112. R. Ray, R.C. Snyder, S. Thomas, C.A. Koller, and D.M. Miller Mithramycin blocks protein binding and function of the SV40 early promoter J Clin Invest 83 1989 2003 2007
113. G.A. Reznikoff, S. Manker, C.H. Rhodes, A. Winokur, and T.C. Rainbow Localization and quantification of beta-adrenergic receptors in human brain Neurology 36 1986 1067 1073
114. M.J. Robson, M.J. Seminerio, C.R. McCurdy, A. Coop, and R.R. Matsumoto σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation Pharmacol Rep 65 2013 343 349
115. R.B. Rothman, R.D. Clark, J.S. Partilla, and M.H. Baumann (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters J Pharmacol Exp Ther 305 2003 1191 1199
116. R.B. Rothman, D. Zolkowska, and M.H. Baumann Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats Ann N Y Acad Sci 1139 2008 268 284
117. N.J. Rothwell CNS regulation of thermogenesis Crit Rev Neurobiol 8 1994 1 10
118. D.E. Rusyniak, and J.E. Sprague Hyperthermic syndromes induced by toxins Clin Lab Med 26 2006 165 184
119. P. Salmi, and S. Ahlenius Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms Pharmacol Toxicol 82 1998 122 127
120. V. Sandoval, G.R. Hanson, and A.E. Fleckenstein Methamphetamine decreases mouse striatal dopamine transporter activity: Roles of hyperthermia and dopamine Eur J Pharmacol 409 2000 265 271
121. L.J. Schep, R.J. Slaughter, and D.M. Beasley The clinical toxicology of metamfetamine Clin Toxicol 48 2010 675 694
122. P.J. Schwartz, T.A. Wehr, N.E. Rosenthal, J.J. Bartko, D.A. Oren, and C. Luetke et al. Serotonin and thermoregulation. Physiologic and pharmacologic aspects of control revealed by intravenous m-CPP in normal human subjects Neuropsychopharmacology 13 1995 105 115
123. M.J. Seminerio, N. Kaushal, J. Shaikh, J.D. Huber, A. Coop, and R.R. Matsumoto Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice Pharmacol Biochem Behav 98 2011 12 20
124. M.J. Seminerio, M.J. Robson, C.R. McCurdy, and R.R. Matsumoto Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus Eur J Pharmacol 691 2012 103 109
125. M.J. Seminerio, R. Hansen, N. Kaushal, H.-T. Zhang, C.R. McCurdy, and R.R. Matsumoto The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice Int J Neuropsychopharmacol 16 2013 1033 1044
126. E.J. Shin, C.X. Dong, T.X. Nguyen, G. Bing, J.H. Bach, and D.H. Park et al. PKCdelta inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment Neurochem Int 59 2011 39 50
127. K. Shioda, K. Nishijima, T. Yoshino, and S. Kato Effect of risperidone on acute methamphetamine-induced hyperthermia in rats Drug Alcohol Depend 11 2010 241 249
128. J.L. Skibba, and E.A. Gwartney Liver hyperthermia and oxidative stress: Role of iron and aldehyde production Int J Hyperthermia 13 1997 215 226
129. J.L. Skibba, R.H. Powers, A. Stadnicka, and J.H. Kalbfleisch Lipid peroxidation caused by hyperthermic perfusion of rat liver Biochem Pharmacol 40 1990 1411 1414
130. J.L. Skibba, R.H. Powers, A. Stadnicka, D.W. Cullinane, U.A. Almagro, and J.H. Kalbfleisch Oxidative stress as a precursor to the irreversible hepatoceullar injury caused by hyperthermia Int J Hyperthermia 7 1991 749 761
131. S.F. Sleiman, B.C. Langley, M. Basso, J. Berlin, L. Xia, and J.B. Payappilly et al. Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration J Neurosci 31 2011 6858 6870
132. D.E. Smith, and C.M. Fischer An analysis of 310 cases of acute high-dose methamphetamine toxicity in Haight-Ashbury Clin Toxicol 3 1970 117 124
133. J.E. Sprague, X. Yang, J. Sommers, T.L. Gilman, and E.M. Mills Roles of norepinephrine, free fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis J Pharmacol Exp Ther 320 2007 274 280
134. J.R. Suchard Recovery from severe hyperthermia (45 °C) and rhabdomyolysis induced by methamphetamine body-stuffing West J Emerg Med 8 2007 93 95
135. H. Tagashira, S. Bhuiyan, N. Shioda, H. Hasegawa, H. Kanai, and K. Fukunaga Sigma receptor stimulation with fluvoxamine ameliorates transverse aortic constriction-induced myocardial hypertrophy and dysfunction in mice Am J Physiol Heart Circ Physiol 299 2010 H1535 H1545
136. K. Takao, T. Nagatani, Y. Kitamura, K. Kawasaki, H. Hayakawa, and S. Yamawaki Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the wet-dog shakes they mediate, but not frontal cortical beta-adrenoceptors Eur J Pharmacol 294 1995 721 726
137. D.A. Tata, J. Raudensky, and B.K. Yamamoto Augmentation of methamphetamine-induced toxicity in the rat striatum by unpredictable stress: Contribution of enhanced hyperthermia Eur J Neurosci 26 2007 739 748
138. D.M. Thomas, D.M. Francescutti-Verbeem, and D.M. Kuhn The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity J Neurochem 105 2008 605 616
139. D.M. Thomas, M. Angoa Perez, D.M. Francescutti-Verbeem, M.M. Shah, and D.M. Kuhn The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum J Neurochem 115 2010 595 605
140. T. Tsuji, M. Asanuma, I. Miyazaki, K. Miyoshi, and N. Ogawa Reduction of nuclear peroxisome proliferation-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen Neurochem Res 34 2009 764 774
141. S.D. Turnipseed, J.R. Richards, J.D. Kirk, D.B. Diercks, and E.A. Anderson Frequency of acute coronary syndrome in patients presenting to the emergency department with chest pain after methamphetamine use J Emerg Med 24 2003 369 373
142. 3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss Neurosci Lett 504 2011 209 214
143. D.J. Watts, and L. McCollester Methamphetamine-induced myocardial infarction with elevated troponin I Am J Emerg Med 24 2006 132 134
144. P. Webb The physiology of heat regulation Am J Physiol Regul Integr Comp Physiol 268 1995 R838 R850
145. D. Wendt, L.J.C. van Loon, and W.D. van Marken Lichtenbelt Thermoregulation during exercise in the heat Sports Med 37 2007 669 682
146. P.L. West, N.J. McKeown, and R.G. Hendrickson Methamphetamine body stuffers: An observational case series Ann Emerg Med 55 2010 190 197
147. W. Xu, J.P.Q. Zhu, and J.A. Angulo Induction of striatal pre- and postsynaptic damage by methamphetamine requires the dopamine receptors Synapse 58 2005 110 121
148. T. Yamaguchi, Y. Kuraishi, M. Minami, S. Nakai, Y. Hirai, and M. Satoh Methamphetamine-induced expression of interleukin-1 beta mRNA in the rat hypothalamus Neurosci Lett 128 1991 90 92
149. X. Yu, S.Z. Imam, G.D. Newport, W. Slikker Jr.; and S.F. Ali Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice Brain Res 823 1999 213 216
150. S. Yubera-Lahoz, M.A. Ayestas Jr.; B.E. Blough, J.S. Partilla, R.B. Rothman, and R. de la Torre et al. Effects of MDMA and related analogs on plasma 5-HT: Relevance to 5-HT transporters in blood and brain Eur J Pharmacol 674 2012 337 344
151. H. Zhang, and J. Cuevas Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons J Neurophysiol 87 2002 2867 2879
152. 2A receptors at warm ambient temperatures is responsible for the augmentation of the 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia Neurosci Lett 490 2011 68 71
153. L. Zhang, K. Kitaichi, Y. Fujimoto, H. Nakayama, E. Shimizu, and M. Iyo et al. Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine Prog Neuropsychopharmacol Biol Psychiatry 30 2006 1381 1393
154. D. Zolkowska, R.B. Rothman, and M.H. Baumann Amphetamine analogs increase plasma serotonin: Implications for cardiac and pulmonary disease J Pharmacol Exp Ther 318 2006 604 610