Enhanced responsivity of 5-HT2A receptors at warm ambient temperatures is responsible for the augmentation of the 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced hyperthermia

Neuroscience Letters

Volumn 490, Issue 1, 2011, Pages 68-71

  Zhang, Gongliang ^a,b   Tao, Rui ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

5 HT2A receptor; Ambient temperature; Hyperthermia; MDMA; Serotonin

Indexed keywords

1 (2,5 DIMETHOXY 4 IODOPHENYL)2 AMINOPROPANE; KETANSERIN TARTRATE; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE MEASUREMENT; CENTRAL NERVOUS SYSTEM; COLD; CONTROLLED STUDY; CORE TEMPERATURE; DOSE RESPONSE; DRUG ANTAGONISM; ENVIRONMENTAL TEMPERATURE; HYPERTHERMIA; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMPHETAMINES; ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG SYNERGISM; FEVER; KETANSERIN; MALE; METHAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS; TEMPERATURE; TIME FACTORS;

EID: 78751701469     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.12.028     Document Type: Article

References (17)

1. Ali S.F., Newport G.D., Holson R.R., Slikker J., Bowyer F. Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice. Brain Res. 1994, 658:33-38.
2. Baumann M.H., Clark R.D., Franken F.H., Rutter J.J., Rothman R.B. Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges. Neuroscience 2008, 152:773-784.
3. Bowyer J.F., Davies D.L., Schmued L., Broening H.W., Newport G.D., Slikker W., Holson R.R. Further studies of the role of hyperthermia in methamphetamine neurotoxicity. J. Pharmacol. Exp. Ther. 1994, 268:1571-1580.
4. Chio C.C., Tsai S.M., Wang J.J., Lin M.T. 5-HT2A-μ opioid receptor mechanisms in the hypothalamus mediate interleukin-1β fever in rats. Neurosci. Lett. 2005, 381:6-11.
5. Dalpiaz A., Gessi S., Borea P.A., Gilli G. Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5-HT2A and 5-HT3 receptors. Life Sci. 1995, 57:PL141-146.
6. Gordon C.J. Relationship between preferred ambient temperature and autonomic thermoregulatory function in rat. Am. J. Physiol. 1987, 252:R1130-R1137.
7. Kankaanpaa A., Meririnne E., Lillsunde P., Seppala T. The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens. Pharmacol. Biochem. Behav. 1998, 59:1003-1009.
8. Krishnamoorthy S., Ma Z., Zhang G., Wei J., Auerbach S.B., Tao R. Involvement of 5-HT2A receptors in the serotonin (5-HT) syndrome caused by excessive 5-HT efflux in rat brain. Basic Clin. Pharmacol. Toxicol. 2010, 107:830-841.
9. Lin M.T., Tsay H.J., Su W.H., Chueh F.Y. Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function. Am. J. Physiol. 1998, 274:R1260-1267.
10. Ma Z., Zhang G., Jenney C., Krishnamoorthy S., Tao R. Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats. Eur. J. Pharmacol. 2008, 588:198-206.
11. Malberg J.E., Seiden L.S. Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J. Neurosci. 1998, 18:5086-5094.
12. Marzuk P.M., Tardiff K., Leon A.C., Hirsch C.S., Portera L., Iqbal M.I., Nock M.K., Hartwell N. Ambient temperature and mortality from unintentional cocaine overdose. JAMA 1998, 279:1795-1800.
13. Mazzola-Pomietto P., Aulakh C.S., Tolliver T., Murphy D.L. Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists. Psychopharmacology (Berl.) 1997, 130:144-151.
14. Miller D.B., O'Callaghan J.P. Elevated environmental temperature and methamphetamine neurotoxicity. Environ. Res. 2003, 92:48-53.
15. Nash J.F., Meltzer H.Y., Gudelsky G.A. Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. Eur. J. Pharmacol. 1988, 151:463-469.
16. Nisijima K., Yoshino T., Yui K., Katoh S. Potent serotonin (5-HT2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain Res. 2001, 890:23-31.
17. Rusyniak D.E., Ootsuka Y., Blessing W.W. When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists. Neuroscience 2008, 154:1619-1626.