Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity

Neuropsychopharmacology

Volumn 39, Issue 4, 2014, Pages 1031-1038

  Halpin, Laura E ^a   Northrop, Nicole A ^a   Yamamoto, Bryan K ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

ammonia; excitotoxicity; glutamate; glutamate transporter; methamphetamine

Indexed keywords

AMMONIA; ANIMALS; ASPARTIC ACID; BODY TEMPERATURE; BRAIN; CALPAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; LACTULOSE; MALE; METHAMPHETAMINE; MOLECULAR WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; SPECTRIN; TIME FACTORS;

EID: 84894033098     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.306     Document Type: Article

References (65)

1. Abekawa T, Ohmori T, Koyama T (1994). Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens. Brain Res 643: 276-281.
2. Al Sibae MR, McGuire BM (2009). Current trends in the treatment of hepatic encephalopathy. Therap Clin Risk Manag 5: 617-626.
3. Albers DS, Sonsalla PK (1995). Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents. J Pharmacol Exp Therap 275: 1104-1114.
4. Barbour B, Brew H, Attwell D (1988). Electrogenic glutamate uptake in glial cells is activated by intracellular potassium. Nature 335: 433-435.
5. Benjamin AM, Quastel JH (1975). Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: a possible role of ammonia in brain function. J Neurochem 25: 197-206.
6. Betarbet R, Greenamyre JT (1999). Differential expression of glutamate receptors by the dopaminergic neurons of the primate striatum. Exp Neurol 159: 401-408.
7. Bowyer JF, Davies DL, Schmued L, Broening HW, Newport GD, Slikker W Jr et al (1994). Further studies of the role of hyperthermia in methamphetamine neurotoxicity. J Pharmacol Exp Ther 268: 1571-1580.
8. Bowyer JF, Tank AW, Newport GD, Slikker W Jr., Ali SF, Holson RR (1992). The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum. J Pharmacol Exp Ther 260: 817-824.
9. Cauli O, Rodrigo R, Piedrafita B, Boix J, Felipo V (2007). Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology 46: 514-519.
10. Chan H, Butterworth RF (1999). Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy. Neurochem Res 24: 1397-1401.
11. Chan H, Hazell AS, Desjardins P, Butterworth RF (2000). Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes. Neurochem Int 37: 243-248.
12. Choi DW (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634.
13. Clark L, Robbins TW, Ersche KD, Sahakian BJ (2006). Reflection impulsivity in current and former substance users. Biol Psychiatry 60: 515-522.
14. Cruickshank CC, Dyer KR (2009). A review of the clinical pharmacology of methamphetamine. Addiction 104: 1085-1099.
15. Danbolt NC (2001). Glutamate uptake. Prog Neurobiol 65: 1-105.
16. Donzanti BA, Yamamoto BK (1988). An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates. Life Sci 43: 913-922.
17. Farfel GM, Vosmer GL, Seiden LS (1992). The N-methyl-Daspartate antagonist MK-801 protects against serotonin depletions induced by methamphetamine, 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. Brain Res 595: 121-127.
18. Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG et al (2009). Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem 110: 990-1004.
19. Goll DE, Thompson VF, Li H, Wei W, Cong J (2003). The calpain system. Physiol Rev 83: 731-801.
20. Gorg B, Morwinsky A, Keitel V, Qvartskhava N, Schror K, Haussinger D (2010). Ammonia triggers exocytotic release of L-glutamate from cultured rat astrocytes. Glia 58: 691-705.
21. Gorg B, Qvartskhava N, Voss P, Grune T, Haussinger D, Schliess F (2007). Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration. FEBS Lett 581: 84-90.
22. Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T (2008). Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life 60: 609-619.
23. Halpin LE, Yamamoto BK (2012). Peripheral ammonia as a mediator of methamphetamine neurotoxicity. J Neurosci 32: 13155-13163.
24. Harris AS, Morrow JS (1988). Proteolytic processing of human brain alpha spectrin (fodrin): identification of a hypersensitive site. J Neurosci 8: 2640-2651.
25. Haskew-Layton RE, Rudkouskaya A, Jin Y, Feustel PJ, Kimelberg HK, Mongin AA (2008). Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo. PLoS One 3: e3543.
26. Haughey HM, Fleckenstein AE, Metzger RR, Hanson GR (2000). The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. J Neurochem 75: 1608-1617.
27. Hawkins RA, Miller AL, Nielsen RC, Veech RL (1973). The acute action of ammonia on rat brain metabolism in vivo. Biochem J 134: 1001-1008.
28. Hernandez LF, Segovia G, Mora F (2003). Effects of activation of NMDA and AMPA glutamate receptors on the extracellular concentrations of dopamine, acetylcholine, and GABA in striatum of the awake rat: a microdialysis study. Neurochem Res 28: 1819-1827.
29. Jia L, Zhang MH (2005). Comparison of probiotics and lactulose in the treatment of minimal hepatic encephalopathy in rats. World J Gastroenterol 11: 908-911.
30. Johanson CE, Frey KA, Lundahl LH, Keenan P, Lockhart N, Roll J et al (2006). Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers. Psychopharmacology (Berl) 185: 327-338.
31. Keefe KA, Zigmond MJ, Abercrombie ED (1993). In vivo regulation of extracellular dopamine in the neostriatum: influence of impulse activity and local excitatory amino acids. J Neural Transmission General Sect 91: 223-240.
32. Kiyatkin EA, Sharma HS (2009). Acute methamphetamine intoxication brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities. Int Rev Neurobiol 88: 65-100.
33. Kosenko E, Kaminsky Y, Kaminsky A, Valencia M, Lee L, Hermenegildo C et al (1997). Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic Res 27: 637-644.
34. Kosenko E, Llansola M, Montoliu C, Monfort P, Rodrigo R, Hernandez-Viadel M et al (2003). Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int 43: 493-499.
35. Maravall M, Mainen ZF, Sabatini BL, Svoboda K (2000). Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J 78: 2655-2667.
36. Mark KA, Soghomonian JJ, Yamamoto BK (2004). High-dose methamphetamine acutely activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity. J Neurosci 24: 11449-11456.
37. McCann UD, Wong DF, Yokoi F, Villemagne V, Dannals RF, Ricaurte GA (1998). Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. J Neurosci 18: 8417-8422.
38. McKetin R, McLaren J, Lubman DI, Hides L (2006). The prevalence of psychotic symptoms among methamphetamine users. Addiction 101: 1473-1478.
39. Mortensen PB (1992). The effect of oral-administered lactulose on colonic nitrogen metabolism and excretion. Hepatology 16: 1350-1356.
40. Nash JF, Yamamoto BK (1992). Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine. Brain Res 581: 237-243.
41. Nicaise C, Prozzi D, Viaene E, Moreno C, Gustot T, Quertinmont E et al (2008). Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. Hepatology 48: 1184-1192.
42. Norenberg MD (1987). The role of astrocytes in hepatic encephalopathy. Neurochem Pathol 6: 13-33.
43. O'Callaghan JP, Miller DB (1994). Neurotoxicity profiles of substituted amphetamines in the C57BL/6 J mouse. J Pharmacol Exp Ther 270: 741-751.
44. Panesar PS, Kumari S (2011). Lactulose: production, purification and potential applications. Biotechnol Adv 29: 940-948.
45. Pike BR, Flint J, Dutta S, Johnson E, Wang KK, Hayes RL (2001). Accumulation of non-erythroid alpha II-spectrin and calpaincleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats. J Neurochem 78: 1297-1306.
46. Pu C, Broening HW, Vorhees CV (1996). Effect of methamphetamine on glutamate-positive neurons in the adult and developing rat somatosensory cortex. Synapse 23: 328-334.
47. Ricaurte GA, Guillery RW, Seiden LS, Schuster CR, Moore RY (1982). Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain. Brain Res 235: 93-103.
48. Ricaurte GA, Schuster CR, Seiden LS (1980). Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study. Brain Res 193: 153-163.
49. Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K et al (1999). Dissociable deficits in the decisionmaking cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 20: 322-339.
50. Rose C (2002). Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release? Metabolic Brain Dis 17: 251-261.
51. Saggu SK, Chotaliya HP, Blumbergs PC, Casson RJ (2010). Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study. BMC Neurosci 11: 97.
52. Seiden LS, Commins DL, Vosmer G, Axt K, Marek G (1988). Neurotoxicity in dopamine and 5-hydroxytryptamine terminal fields: a regional analysis in nigrostriatal and mesolimbic projections. Ann N Y Acad Sci 537: 161-172.
53. Siman R, Noszek JC, Kegerise C (1989). Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 9: 1579-1590.
54. Simon SL, Domier CP, Sim T, Richardson K, Rawson RA, Ling W (2002). Cognitive performance of current methamphetamine and cocaine abusers. J Addict Dis 21: 61-74.
55. Sonsalla PK, Riordan DE, Heikkila RE (1991). Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice. J Pharmacol Exp Ther 256: 506-512.
56. Staszewski RD, Yamamoto BK (2006). Methamphetamine-induced spectrin proteolysis in the rat striatum. J Neurochem 96: 1267-1276.
57. Stephans SE, Yamamoto BK (1994). Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux. Synapse 17: 203-209.
58. Szatkowski M, Barbour B, Attwell D (1990). Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348: 443-446.
59. Tata DA, Yamamoto BK (2007). Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction. Addiction 102(Suppl 1): 49-60.
60. Volkow ND, Chang L, Wang GJ, Fowler JS, Leonido-Yee M, Franceschi D et al (2001). Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am J Psychiatry 158: 377-382.
61. Wagner GC, Ricaurte GA, Seiden LS, Schuster CR, Miller RJ, Westley J (1980). Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res 181: 151-160.
62. Wang GJ, Smith L, Volkow ND, Telang F, Logan J, Tomasi D et al (2012). Decreased dopamine activity predicts relapse in methamphetamine abusers. Mol Psychiatry 17: 918-925.
63. Xie T, McCann UD, Kim S, Yuan J, Ricaurte GA (2000). Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: implications for methamphetamine- induced dopaminergic neurotoxicity. J Neurosci 20: 7838-7845.
64. Yamamoto BK, Raudensky J (2008). The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse. J Neuroimmune Pharmacol 3: 203-217.
65. Zhu JP, Xu W, Angulo JA (2005). Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice. Brain Res 1049: 171-181.