Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4646-4657

  Asamitsu, Sefan ^a   Kawamoto, Yusuke ^a   Hashiya, Fumitaka ^a   Hashiya, Kaori ^a   Yamamoto, Makoto ^a   Kizaki, Seiichiro ^a   Bando, Toshikazu ^a   Sugiyama, Hiroshi ^a,b,c  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

CAG CTG repeat sequence; Pyrrole imidazole polyamide; Sequence specific DNA; Transcriptional inhibition

Indexed keywords

4 AMINOBUTYRIC ACID; ADENINE; DNA; GUANINE; POLYAMIDE; PYRROLE DERIVATIVE; PYRROLE IMIDAZOLE POLYAMIDE CHLORAMBUCIL CONJUGATE; RNA POLYMERASE; UNCLASSIFIED DRUG; CHLORAMBUCIL; IMIDAZOLE; IMIDAZOLE DERIVATIVE; NYLON;

ARTICLE; BINDING AFFINITY; CAG REPEAT; CHEMICAL MODIFICATION; CHIRALITY; CONTROLLED STUDY; CTG REPEAT; DNA ALKYLATION; DNA BINDING; DNA DAMAGE; DNA SEQUENCE; ENZYME INHIBITION; GENOME SIZE; IN VITRO STUDY; MOLECULAR RECOGNITION; PROTEIN SYNTHESIS; SOLID PHASE SYNTHESIS; SURFACE PLASMON RESONANCE; TRANSCRIPTION TERMINATION; TRINUCLEOTIDE REPEAT; ALKYLATION; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALKYLATION; CHLORAMBUCIL; DNA; IMIDAZOLES; NYLONS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRINUCLEOTIDE REPEATS;

EID: 84906938270     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.019     Document Type: Article

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