Requirement of β-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2286-2291

  Bando, Toshikazu ^a   Minoshima, Masafumi ^a   Kashiwazaki, Gengo ^a   Shinohara, Ken ichi ^a   Sasaki, Shunta ^a   Fujimoto, Jun ^a   Ohtsuki, Akimichi ^a   Murakami, Masataka ^a   Nakazono, Satomi ^a   Sugiyama, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Alanine; Antitumor agent; DNA alkylation; Pyrrole imidazole; Sequence specificity

Indexed keywords

1 METHYLIMIDAZOLE; 1 METHYLPYRROLE; BETA ALANINE; DNA FRAGMENT; IMIDAZOLE DERIVATIVE; PLASMID DNA; POLYAMIDE; PYRROLE DERIVATIVE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CHEMICAL STRUCTURE; DENATURATION; DNA ALKYLATION; DNA SEQUENCE; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE SYNTHESIS;

ALANINE; ALKYLATION; BASE PAIRING; BASE SEQUENCE; DNA; IMIDAZOLES; PYRROLES; TEMPERATURE;

EID: 40749095937     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.064     Document Type: Article

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