Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2646-2651

  Orengo, James P ^a   Chambon, Pierre ^c,d   Metzger, Daniel ^c,d   Mosier, Dennis R ^a,b   Snipes, G Jackson ^a   Cooper, Thomas A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Alternative splicing; CUG binding protein 1; Microsatellite expansion; Muscle atrophy; Muscleblind like 1

Indexed keywords

BINDING PROTEIN; MYOTONIC DYSTROPHY PROTEIN KINASE; RNA; CUGBP1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; EXON; HISTOLOGY; MUSCLE ATROPHY; MYOTONIA; MYOTONIC DYSTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPLICEOSOME; 3' UNTRANSLATED REGION; ANIMAL; DISEASE COURSE; DISEASE MODEL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; RNA SPLICING; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE;

MUS;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MUSCLE, SKELETAL; MYOTONIC DYSTROPHY; PROTEIN-SERINE-THREONINE KINASES; RNA SPLICING; RNA-BINDING PROTEINS; SENSITIVITY AND SPECIFICITY;

EID: 40649083064     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708519105     Document Type: Article

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